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H

Hartmut Jaeschke

University of Kansas Medical Center

122H-index
589Paper Count
4.9WCitation Count
Published Papers 265
Publication Date
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Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice
errToxicology
IF4.6
err2026-04-28
err0
errOAAI
errNatalie Eppler; Elizabeth Jones; Forkan Ahamed; Naren Raja; Jephte Y. Akakpo; Margitta Lebofsky; Lily He; Ira Vats; Priyanka Ghosh; Yifan Yu; Kaitlyn Thomas; Colin McCoin; John Thyfault; Xiaoqing Wu; Liang Xu; Wei Cui; Rong Wang; Hartmut Jaeschke; Yuxia Zhang
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Differential Effects on Acetaminophen-induced Nephrotoxicity and Liver Injury Following Modulation of Glutathione Resynthesis
errFood and Chemical Toxicology
IF3.5
err2025-12-09
err0
errOAAI
errYasaman Etemadi; Jephte Y. Akakpo; Timothy A. Fields; Anup Ramachandran; Hartmut Jaeschke
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Special Issue Mechanistic and Prognostic Biomarkers in Liver Diseases
errLivers
IF2.4
err2025-11-24
err0
errOAAI
errJaeschke, Hartmut; McGill, Mitchell R.
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Comments on: “Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury”
errChemico-Biological Interactions
IF5.4
err2025-11-04
err0
PREAI
errHartmut Jaeschke; Anup Ramachandran
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The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure
errTOXICOLOGICAL SCIENCES
IF4.1
err2025-10-01
err1
PREAI
errUmbaugh, David S.; Nguyen, Nga T.; Curry, Steven C.; Rule, Jody A.; Lee, William M.; Ramachandran, Anup; Jaeschke, Hartmut
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Can Acetaminophen be Used as a Chemotherapeutic Agent in the Kidney?
errJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
IF2.8
err2025-10-01
err0
PREAI
errJaeschke, Hartmut; Akakpo, Jephte Y.; Ramachandran, Anup
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errSave
Influence of C57BL/6 Sub-Strain on the Innate Immune Response and Liver Recovery Following Acetaminophen-Induced Liver Injury
errJournal of Biochemical and Molecular Toxicology
IF2.8
err2025-08-18
err0
PREAI
errGiselle Sanchez-Guerrero; Diego K. Chavez; Hartmut Jaeschke; Anup Ramachandran
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Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice
errArchives of Toxicology
IF6.9
err2025-08-16
err0
PREAI
errOlamide B. Adelusi; Caitlin Schneider; Caylie McKimens; James P. Luyendyk; Anup Ramachandran; Hartmut Jaeschke
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errSave
Iron supplementation switches mode of cell death to ferroptosis during acetaminophen-induced liver injury in mice rendering it resistant to N-acetylcysteine
errToxicology
IF4.6
err2025-06-18
err0
errOAAI
errOlamide B. Adelusi; Aparna Venkatraman; Jephte Y. Akakpo; Anup Ramachandran; Hartmut Jaeschke
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The Ways to Die: Cell Death in Liver Pathophysiology
errSEMINARS IN LIVER DISEASE
IF3.7
err2025-04-28
err0
PREAI
errCao, Peng; Jaeschke, Hartmut; Ni, Hong-Min; Ding, Wen-Xing
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The Endothelial Growth Factor Angiopoeitin-2 is a Prognostic Biomarker in Patients with Acetaminophen-Induced Acute Liver Failure
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errUmbaugh, David; Nguyen, Nga; Curry, Steven; Rule, Jody; Lee, William; Ramachandran, Anup; Jaeschke, Hartmut
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errSave
Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity
errTOXICOLOGICAL SCIENCES
IF4.1
err2025-02-22
err0
PREAI
errSanchez-Guerrero, Giselle; Umbaugh, David S.; Smith, Sawyer H.; Akakpo, Jephte Y.; Jaeschke, Hartmut; Ramachandran, Anup
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Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models
errTOXICOLOGICAL SCIENCES
IF4.1
err2024-12-27
err1
PREAI
errJaeschke, Hartmut; Ramachandran, Anup
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Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2024-10-01
err7
errOAAI
errRamachandran, Anup; Akakpo, Jephte Y.; Curry, Steven C.; Rumack, Barry H.; Jaeschke, Hartmut
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Effect of ferroptosis inhibitors in a murine model of acetaminophen-induced liver injury
errJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
IF2.8
err2024-07-31
err3
PREAI
errAdelusi, Olamide B.; Etemadi, Yasaman; Akakpo, Jephte Y.; Ramachandran, Anup; Jaeschke, Hartmut
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The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration
errTOXICOLOGY
IF4.6
err2024-05-01
err1
errOAAI
errUmbaugh, David S.; Nguyen, Nga T.; Smith, Sawyer H.; Ramachandran, Anup; Jaeschke, Hartmut
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errSave
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice
errARCHIVES OF TOXICOLOGY
IF6.9
err2024-03-29
err0
PREAI
errAdelusi, Olamide B.; Akakpo, Jephte Y.; Eichenbaum, Gary; Sadaff, Ejaz; Ramachandran, Anup; Jaeschke, Hartmut
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Comments on: Unveiling the therapeutic promise of natural products in alleviating drug-induced liver injury: Present advancements and future prospects
errPHYTOTHERAPY RESEARCH
IF6.3
err2024-02-05
err0
PREAI
errJaeschke, Hartmut; Ramachandran, Anup
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Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging
errTOXICOLOGICAL SCIENCES
IF4.1
err2024-01-30
err1
PREAI
errAkakpo, Jephte Yao; Olivos, Hernando; Shrestha, Bindesh; Midey, Anthony; Jaeschke, Hartmut; Ramachandran, Anup
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Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury
errANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
IF34.5
err2024-01-24
err29
errOAAI
errJaeschke, Hartmut; Ramachandran, Anup
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Gregory J. Gores
H-index: 164 · Papers: 1.0K
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Michael P. Manns
H-index: 163 · Papers: 2.1K
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David A. Brenner
H-index: 150 · Papers: 779
T
Thirumala‐Devi Kanneganti
H-index: 138 · Papers: 453
M
Michael Trauner
H-index: 128 · Papers: 3.4K
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