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Paul Säftig

christian-albrechts-universität kiel

120H-index
483Paper Count
6.2WCitation Count
Published Papers 255
Publication Date
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Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease
errCell
IF42.5
err2025-12-04
err0
errOAAI
errKaren Lahme; Wiebke Sachs; Sarah Froembling; Desiree Loreth; Vincent Böttcher-Dierks; Katrin Neumann; Frederik-Michael Hann; Nick Arkan; Michael Brehler; Julia Reichelt; Antonia Sgries; Kristin Surmann; Simone Gaffling; Marie R. Adler; Pablo J. Sáez; Uta Wedekind; Alina Lampert; Elena Tasika; Paul Saftig; Christian Conze
errShare
errSave
Leveraging the ADAM10 prodomain for selective inhibition to enhance recovery after myocardial infarction
errBritish Journal of Pharmacology
IF7.7
err2025-10-08
err0
errOAAI
errErik Klapproth; Johanna Marks; Patrick Diaba-Nuhoho; Sören Grell; Paul Leubauer; Susanne Kämmerer; Johannes R. Soltwedel; Fred Rasmussen; Felix Mejia; Marcia L. Moss; Christopher Prince; Peter Mirtschink; Ben Wielockx; Paul Saftig; Michael Wagner; Kristina Lorenz; Ali El-Armouche
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errSave
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology
errMolecular Neurodegeneration
IF17.5
err2025-09-01
err0
errOAAI
errDenise Balta; Anish Varghese; Susy Prieto Huarcaya; Alessandro Di Spiezio; André R. A. Marques; Enes Yağız Akdaş; Doğa Tabakacilar; Alice Drobny; Christian Werner; Wei Xiang; Rebecca Mächtel; Jan Philipp Dobert; Anna Fejtova; Franziska Richter; Melanie Küspert; Philipp Arnold; Paul Saftig; Friederike Zunke
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errSave
LIMP-2 deficiency-associated glycolipid abnormalities in mice
errbiochimica et biophysica acta molecular and cell biology of lipids
IF0
err2025-07-08
err0
errOAAI
errPaulo Gaspar; André R.A. Marques; Maria J. Ferraz; Markus Damme; Gertjan Kramer; Mina Mirzaian; Marion Gijbels; Roelof Ottenhoff; Cindy van Roomen; Herman S. Overkleeft; Michael Schwake; Saskia Heybrock; Maria Carmo Macário; Paul Saftig; Johannes M. Aerts
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errSave
Regulation of podocyte surface proteins by the enzyme A Disintegrin And Metalloproteinase 10 (ADAM10)
errKidney International
IF12.6
err2025-05-06
err0
errOAAI
errDavid Rosenbaum; Julia Reichelt; Simonas Gudaitis; Stine Kühne; Stephanie Zielinski; Desiree Loreth; Lukas Blume; Johannes Brand; Helga Vitzthum; Wiebke Sachs; Alina Lampert; Lisa Seipold; Matthias Voss; Catherine Meyer-Schwesinger; Paul Saftig
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errSave
Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity (vol 16, pg 2177, 1998)
errONCOGENE
IF7.3
err2025-02-11
err0
PREAI
errWu, Gen Sheng; Saftig, Paul; Peters, Christoph; El-Deiry, Wafik S.
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errSave
The lysosomal lipid transporter LIMP-2 is part of lysosome-ER STARD3-VAPB-dependent contact sites
errJOURNAL OF CELL SCIENCE
IF3.6
err2024-11-26
err0
errOAAI
errRudnik, Soenke; Heybrock, Saskia; Coyaud, Etienne; Xu, Zizhen; Neculai, Dante; Raught, Brian; Oorschot, Viola; Heus, Cecilia; Klumperman, Judith; Saftig, Paul
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errSave
Non-canonical function of ADAM10 in presynaptic plasticity
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2024-08-09
err0
errOAAI
errBaer, Julia; Fanutza, Tomas; Reimann, Christopher C.; Seipold, Lisa; Grohe, Maja; Bolter, Janike Rabea; Delfs, Flemming; Bucher, Michael; Gee, Christine E.; Schweizer, Michaela; Saftig, Paul; Mikhaylova, Marina
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errSave
Inhibition of BACE1 affected both its Aβ producing and degrading activities and increased Aβ42 and Aβ40 levels at high-level BACE1 expression
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-08-01
err3
errOAAI
errUlku, Irem; Leung, Rocher; Herre, Fritz; Walther, Lina; Shobo, Adeola; Saftig, Paul; Hancock, Mark A.; Liebsch, Filip; Multhaup, Gerhard
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errSave
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
errNATURE CELL BIOLOGY
IF19.1
err2024-06-05
err0
errOAAI
errJungnickel, Katharina Esther Julia; Guelle, Oceane; Iguchi, Miharu; Dong, Wentao; Kotov, Vadim; Gabriel, Florian; Debacker, Cecile; Dairou, Julien; McCort-Tranchepain, Isabelle; Laqtom, Nouf N.; Chan, Sze Ham; Ejima, Akika; Sato, Kenji; Massa Lopez, David; Saftig, Paul; Mehdipour, Ahmad Reza; Abu-Remaileh, Monther; Gasnier, Bruno; Loew, Christian; Damme, Markus
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errSave
Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2024-05-22
err2
errOAAI
errGallwitz, Lisa; Bleibaum, Florian; Voss, Matthias; Schweizer, Michaela; Spengler, Katharina; Winter, Dominic; Zoephel, Frederic; Mueller, Stephan; Lichtenthaler, Stefan; Damme, Markus; Saftig, Paul
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errSave
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis
errALZHEIMERS RESEARCH & THERAPY
IF7.6
err2024-04-04
err7
errOAAI
errTerron, Heather M.; Parikh, Sagar J.; Abdul-Hay, Samer O.; Sahara, Tomoko; Kang, Dongcheul; Dickson, Dennis W.; Saftig, Paul; Laferla, Frank M.; Lane, Shelley; Leissring, Malcolm A.
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errSave
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages
errNATURE AGING
IF19.4
err2023-09-18
err6
errOAAI
errDe Silva, Nilushi S.; Siewiera, Johan; Alkhoury, Chantal; Nader, Guilherme P. F.; Nadalin, Francesca; De Azevedo, Kevin; Couty, Mickael; Izquierdo, Helena M.; Bhargava, Anvita; Conrad, Cecile; Maurin, Mathieu; Antoniadou, Konstantina; Fouillade, Charles; Londono-Vallejo, Arturo; Behrendt, Rayk; Bertotti, Karine; Serdjebi, Cindy; Lanthiez, Francois; Gallwitz, Lisa; Saftig, Paul; Herrero-Fernandez, Beatriz; Saez, Angela; Gonzalez-Granado, Jose Maria; van Niel, Guillaume; Boissonnas, Alexandre; Piel, Matthieu; Manel, Nicolas
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errSave
New insights into the function and pathophysiology of the ectodomain sheddase A Disintegrin And Metalloproteinase 10 (ADAM10)
errFEBS JOURNAL
IF4.2
err2023-06-04
err14
errOAAI
errRosenbaum, David; Saftig, Paul
errShare
errSave
Rab GTPase regulation of phagosome-lysosome fusion is bypassed in the presence of micromolar Ca2+
errJOURNAL OF CELL SCIENCE
IF3.6
err2023-05-12
err1
PREAI
errBecker, Julia; Schleinitz, Ariane; Hermsen, Christina; Rappold, Sabrina; Saftig, Paul; Jeschke, Andreas; Haas, Albert
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errSave
Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err56
errOAAI
errSchürmann, A; Koling, S; Jacobs, S; Saftig, P; Krauss, S; Wennemuth, G; Kluge, R; Joost, HG
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errSave
L1 is sequentially processed by two differently activated metalloproteases and presenilin/γ-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err233
errOAAI
errMaretzky, T; Schulte, M; Ludwig, A; Rose-John, S; Blobel, C; Hartmann, D; Altevogt, P; Saftig, P; Reiss, K
errShare
errSave
Furin-, ADAM 10-, and γ-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of β-catenin's transcriptional activity
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err106
errOAAI
errAnders, Lars; Mertins, Philipp; Lammich, Sven; Murgia, Marta; Hartmann, Dieter; Saftig, Paul; Haass, Christian; Ullrich, Axel
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errSave
RETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum (Retracted article. See vol. 31, pg. 1330, 2011)
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err73
errOAAI
errBudagian, V; Bulanova, E; Orinska, Z; Duitman, E; Brandt, K; Ludwig, A; Hartmann, D; Lemke, G; Saftig, P; Bulfone-Paus, S
errShare
errSave
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err110
errOAAI
errBech-Serra, Joan J.; Santiago-Josefat, Belen; Esselens, Cary; Saftig, Paul; Baselga, Jose; Arribas, Joaquin; Canals, Francesc
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Guido Kroemer
H-index: 283 · Papers: 2.3K
D
Dennis J. Selkoe
H-index: 171 · Papers: 674
C
Christian Weber
H-index: 160 · Papers: 1.8K
F
Fabrice André
H-index: 148 · Papers: 1.8K
H
Hidde L. Ploegh
H-index: 148 · Papers: 927
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