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Bitopic inhibitors of mTORC1 cooperate with inhibitors of mitogen-activated protein kinase kinase to drive cytotoxicity in glioblastoma Fan, Qiwen; Koach, Jessica; Luo, Karen; Clark, Sydney; Reddy, Shruthi; Ozawa, Tomoko; Wang, Linyu; Yoda, Hiroyuki; Sale, Matthew; Mccormick, Frank; Raleigh, David R.; Gustafson, William C.; Meyerowitz, Justin; Singh, Mallika; Berger, Mitchel; Shokat, Kevan M.; Weiss, William A. Share Save
DECIPHERING CELLULAR TRANSLATION CONTROL IN NEURON-GBM INTERACTIONS Guney, Ekin; Dabrowska, Adrianna; Magee, Nathan; Phua, Ronald; Wang, Linyu; Baker, Donovan L.; Lee, Kevin Y.; Cadwell, Cathryn R.; Escoubas, Caroline C.; Williams, Marcus; Nowakowski, Tomasz J.; Krishna, Saritha; Hervey-Jumper, Shawn L.; Ruggero, Davide; Weiss, William A. Share Save
DISSECTING MYC-DRIVEN EPIGENETIC MECHANISMS THAT PROMOTE GROUP 3 MEDULLOBLASTOMA UTILIZING HUMANIZED IPSC MODELS Qadeer, Zulekha; Hou, Elise; Siegel, Dara; Westelman, Samantha; Gudenas, Brian; Smith, Kyle; Ismail, Wazim Mohammed; Wang, Linyu; Beytagh, Mary Clare; Phua, Ronald; Hendrikse, Liam; Huang, Miller; Gaspar-Maia, Alexandre; Northcott, Paul; Taylor, Michael; Weiss, William Share Save
3D genome topology distinguishes molecular subgroups of medulloblastoma Lee, John J. Y.; Johnston, Michael J.; Farooq, Hamza; Chen, Huey-Miin; Younes, Subhi Talal; Suarez, Raul; Zwaig, Melissa; Juretic, Nikoleta; Weiss, William A.; Ragoussis, Jiannis; Jabado, Nada; Taylor, Michael D.; Gallo, Marco Share Save
INTEGRATIVE SINGLE NUCLEI, SPATIAL, AND FUNCTIONAL GENOMIC ANALYSES REVEAL DNA-PK DRIVES GLIOBLASTOMA RADIORESISTANCE THROUGH TUMOR CELLS AND THE MYELOID MICROENVIRONMENT Liu, J.; Majd, N.; Zou, C.; Mirchia, K.; Pak, J.; Foster, K.; Lin, K.; Casey-Clyde, T.; Seo, K.; Pan, S.; Payne, E.; Vasudevan, H.; Ozawa, T.; Berger, M.; de Groot, J.; Weiss, W.; Gilbert, L.; Raleigh, D. Share Save
In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma Liu, S. John; Zou, Christopher; Pak, Joanna; Morse, Alexandra; Pang, Dillon; Casey-Clyde, Timothy; Borah, Ashir A.; Wu, David; Seo, Kyounghee; O'Loughlin, Thomas; Lim, Daniel A.; Ozawa, Tomoko; Berger, Mitchel S.; Kamber, Roarke A.; Weiss, William A.; Raleigh, David R.; Gilbert, Luke A. Share Save
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EGFR and EGFRvIII coopt host defense pathways promoting progression in glioblastoma An, Zhenyi; Fan, Qi-Wen; Wang, Linyu; Yoda, Hiroyuki; Barata, Megumi J.; Jimenez-Morales, David; Phillips, Joanna J.; Swaney, Danielle L.; Stevenson, Erica; Lee, Ethan; Krogan, Nevan; Weiss, William A. Share Save
PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression Schmidt, Christin; Cohen, Sarah; Gudenas, Brian L.; Husain, Sarah; Carlson, Annika; Westelman, Samantha; Wang, Linyu; Phillips, Joanna J.; Northcott, Paul A.; Weiss, William A.; Schwer, Bjoern Share Save
PRDM6 PROMOTES MEDULLOBLASTOMA FORMATION IN NEUROEPITHELIAL STEM CELLS AND IS A CHROMATIN REPRESSOR BY BINDING TO HISTONE H3 LYSINE 27 TRIMETHYLATION MARKS Schmidt, Christin; Cohen, Sarah; Gudenas, Brian L.; Husain, Sarah; Carlson, Annika; Westelman, Samantha; Wang, Linyu; Phillips, Joanna J.; Northcott, Paul A.; Weiss, William A.; Schwer, Bjoern Share Save
MYC AND TGFΒ PROMOTE GROUP 3 MEDULLOBLASTOMA TUMOR RESISTANCE THROUGH DEREGULATION OF POLYCOMB TARGETS Qadeer, Zulekha A.; Westelman, Samantha; Johnson, Mackenzie O.; Hou, Elise; Grele, Shane; Smith, Kyle; Hendrikse, Liam; Siegel, Dara; Wang, Linyu; Beytagh, Mary Clare; Schmidt, Christin; Huang, Miller; Taylor, Michael D.; Northcott, Paul; Weiss, William A. Share Save
SUBGROUP AND SUBTYPE-SPECIFIC OUTCOMES IN METASTATIC INFANT MEDULLOBLASTOMA Senapati, Akanksha; Lindsay, Holly; Gilheeney, Stephen; Bale, Tejus; Taylor, Michael; Khuong-Quang, Dong-Anh; Bouffet, Eric; Khan, Sara; van Veelan, Marie-Lise; Kros, Johan M.; Vasiljevic, Alexandre; Pollack, Ian; Chambless, Lola; Gupta, Nalin; Weiss, William A.; Jabado, Nada; Sterba, Jaroslav; Zapotocky, Michal; Hansford, Jordan R.; Ramaswamy, Vijay Share Save
SOLID PEDIATRIC TUMORS IN MICE REVEAL MODEL-SPECIFIC GLOBAL DNA METHYLATION AND CNV PROFILES CORRESPONDING TO HUMAN COUNTERPARTS Schoof, Melanie; Zheng, Tuyu; Sill, Martin; Imle, Roland; Hofmann, Nina; Ernst, Kati; Vonficht, Dominik; Chan, Chun Ho; Cais, Alessia; Holland-Letz, Tim; Postlmayr, Andreas; Shiraishi, Ryo; Wang, Wanchen; Morcavallo, Alaide; Spohn, Michael; Goebel, Carolin; Niesen, Judith; Peter, Levke-Sophie; Eckhardt, Alicia; Bourdeaut, Franck; Han, Zhi-Yan; Pei, Yanxin; Murad, Najiba; Swartling, Fredrik J.; Taylor, Jessica; Gilbertson, Richard J.; Dottermusch, Matthias; Kerl, Kornelius; Glass, Rainer; Cheng, Jiying; Horstmann, Martin A.; Nollau, Peter; Wolters-Eisfeld, Gerrit; Zhao, Haotian; Sturm, Dominik; Chesler, Louis; Haas, Simon; Weiss, William A.; Northcott, Paul A.; Kutscher, Lena M.; Stuecklin, Ana Guerreiro; Ayrault, Olivier; Neumann, Julia E.; Kawauchi, Daisuke; Jones, David; Pfister, Stefan M.; Pajtler, Kristian; Banito, Ana; Schueller, Ulrich; Zuckermann, Marc Share Save
Aurora Kinase A inhibition enhances DNA damage and tumor cell death with 131I-MIBG therapy in high-risk neuroblastoma Kumar, Prerna; Koach, Jessica; Nekritz, Erin; Mukherjee, Sucheta; Braun, Benjamin S.; Dubois, Steven G.; Nasholm, Nicole; Haas-Kogan, Daphne; Matthay, Katherine K.; Weiss, William A.; Gustafson, Clay; Seo, Youngho Share Save
MYC phase separation selectively modulates the transcriptome ( may , 10.1038/s41594-024-01322-6, 2024) Yang, Junjiao; Chung, Chan-, I; Koach, Jessica; Liu, Hongjiang; Navalkar, Ambuja; He, Hao; Ma, Zhimin; Zhao, Qian; Yang, Xiaoyu; He, Liang; Mittag, Tanja; Shen, Yin; Weiss, William A.; Shu, Xiaokun Share Save
MYC phase separation selectively modulates the transcriptome Yang, Junjiao; Chung, Chan-, I; Koach, Jessica; Liu, Hongjiang; Navalkar, Ambuja; He, Hao; Ma, Zhimin; Zhao, Qian; Yang, Xiaoyu; He, Liang; Mittag, Tanja; Shen, Yin; Weiss, William A.; Shu, Xiaokun Share Save
MYC and TGF β promote group 3 medulloblastoma tumor resistance through deregulation of Polycomb targets Qadeer, Zulekha A.; Westelman, Samanta; Johnson, Mackenzie O.; Hou, Elise; Grele, Shane; Smith, Kyle; Hendrikse, Liam; Wang, Linyu; Husain, Sarah; Beytagh, Mary Clare; Schmidt, Christin; Huang, Miller; Taylor, Michael D.; Northcott, Paul; Weiss, William A. Share Save
ALK upregulates POSTN and WNT signaling to drive neuroblastoma Huang, Miller; Fang, Wanqi; Farrel, Alvin; Li, Linwei; Chronopoulos, Antonios; Nasholm, Nicole; Cheng, Bo; Zheng, Tina; Yoda, Hiroyuki; Barata, Megumi J.; Porras, Tania; Miller, Matthew L.; Zhen, Qiqi; Ghiglieri, Lisa; Mchenry, Lauren; Wang, Linyu; Asgharzadeh, Shahab; Park, Jinseok; Gustafson, W. Clay; Matthay, Katherine K.; Maris, John M.; Weiss, William A. Share Save
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