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Michael R. Duchen

university college london

103H-index
409Paper Count
4.1WCitation Count
Published Papers 129
Publication Date
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Experimental sepsis causes SERCA2 expression in white adipose tissue but not classical browning
errScientific Reports
IF3.9
err2026-07-03
err0
errOAAI
errRobert Tidswell; Ali Alqallaf; Joseph Harris; Jonathan Falconer; Pelin A. Golforoush; Nishkantha Arulkumaran; Anna Kleyman; David Brealey; Matthew S. Rodeheffer; Ketan Patel; Michael R. Duchen; Mervyn Singer
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Chromatin- and actin-mediated mitochondrial streaming leads to patterning of mitochondrial distribution in oocytes
errNature Communications
IF15.7
err2026-05-18
err0
errOAAI
errIn-Won Lee; Morteza Nazari; Jazmine Yuson; Sanjeev Uthishtran; Ross Stocker; Deepak Adhikari; Zhong-Wei Wang; Gyorgy Szabadkai; Michael R. Duchen; Senthil Arumugam; Reza Nosrati; John Carroll
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errSave
A transcription termination mechanism for maintaining homogeneous protein expression
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-11-26
err0
errOAAI
errEsteban-Serna, Sofia; Widen, Tove; Gwynne, Mags; Farquhar, Iseabail; Duchen, Michael R.; Swain, Peter S.; Granneman, Sander
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errSave
Letter Concerning Biallelic Variants in EPG5 Gene Are Associated with Parkinson's Disease
errAnnals of Neurology
IF7.7
err2025-10-29
err0
PREAI
errHormos Salimi Dafsari MD; Celine Deneubourg PhD; Kritarth Singh PhD; Reza Maroofian PhD; Michael R. Duchen PhD; Adam Antebi PhD; Henry Houlden MD, PhD; Manolis Fanto PhD; Heinz Jungbluth MD, PhD
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An iPSC-derived neuronal model reveals manganese’s role in neuronal endocytosis, calcium flux and mitochondrial bioenergetics
erriScience
IF4.1
err2025-08-06
err0
errOAAI
errDimitri Budinger; Sharmin Alhaque; Ramón González-Méndez; Chris Dadswell; Katy Barwick; Arianna Ferrini; Charlotte Roth; Conor J. McCann; Karin Tuschl; Fatma Al Jasmi; Maha S. Zaki; Julien H. Park; Russell C. Dale; Shekeeb Mohammad; John Christodoulou; Dale Moulding; Michael R. Duchen; Serena Barral; Manju A. Kurian
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errSave
Redox-dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells
errFEBS Letters
IF3
err2025-07-25
err0
errOAAI
errThomas S. Blacker; Nimit Mistry; Nicoletta Plotegher; Elizabeth R. Westbrook; Michael D. E. Sewell; John Carroll; Gyorgy Szabadkai; Angus J. Bain; Michael R. Duchen
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errSave
Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2025-02-13
err0
errOAAI
errWhitehead, Michael; Harvey, Joshua P.; Sladen, Paul E.; Becchi, Giada; Singh, Kritarth; Sun, Yujiao Jennifer; Burgoyne, Thomas; Duchen, Michael R.; Yu-Wai-Man, Patrick; Cheetham, Michael E.
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Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function
errAUTOPHAGY
IF14.3
err2024-12-12
err0
errOAAI
errChung, Chih-Yao; Singh, Kritarth; Sheshadri, Preethi; Valdebenito, Gabriel E.; Chacko, Anitta R.; Besada, Maria Alicia Costa; Liang, Xiao Fei; Kabir, Lida; Pitceathly, Robert D. S.; Szabadkai, Gyorgy; Duchen, Michael R.
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Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2024-11-19
err0
errOAAI
errBlanco, Elena; Camps, Carme; Bahal, Sameer; Kerai, Mohit D.; Ferla, Matteo P.; Rochussen, Adam M.; Handel, Adam E.; Golwala, Zainab M.; Spiridou Goncalves, Helena; Kricke, Susanne; Klein, Fabian; Zhang, Fang; Zinghirino, Federica; Evans, Grace; Keane, Thomas M.; Lizot, Sabrina; Kusters, Maaike A. A.; Iro, Mildred A.; Patel, Sanjay V.; Morris, Emma C.; Burns, Siobhan O.; Radcliffe, Ruth; Vasudevan, Pradeep; Price, Arthur; Gillham, Olivia; Valdebenito, Gabriel E.; Stewart, Grant S.; Worth, Austen; Adams, Stuart P.; Duchen, Michael; Andre, Isabelle; Adams, David J.; Santili, Giorgia; Gilmour, Kimberly C.; Hollaender, Georg A.; Davies, E. Graham; Taylor, Jenny C.; Griffiths, Gillian M.; Thrasher, Adrian J.; Dhalla, Fatima; Kreins, Alexandra Y.
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Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration
errSCIENCE ADVANCES
IF12.5
err2024-07-12
err0
errOAAI
errPingitore, Valeria; Pancholi, Jessica; Hornsby, Thomas W.; Warne, Justin; Pryce, Gareth; Mccormick, Laura J.; Hill, Julia; Bhosale, Gauri; Peng, Jing; Newton, Lydia S.; Towers, Greg J.; Coles, Simon J.; Chan, Ah Wing Edith; Duchen, Michael R.; Szabadkai, Gyorgy; Baker, David; Selwood, David L.
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errSave
Nrf2 regulates glucose uptake and metabolism in neurons and astrocytes
errREDOX BIOLOGY
IF11.9
err2023-06-01
err22
errOAAI
errEsteras, Noemi; Blacker, Thomas S.; Zherebtsov, Evgeny A.; Stelmashuk, Olga A.; Zhang, Ying; Wigley, W. Christian; Duchen, Michael R.; Dinkova-Kostova, Albena T.; Abramov, Andrey Y.
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errSave
PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington's disease
errPROGRESS IN NEUROBIOLOGY
IF6.1
err2023-06-01
err12
errOAAI
errLange, Jenny; Gillham, Olivia; Flower, Michael; Ging, Heather; Eaton, Simon; Kapadia, Sneha; Neueder, Andreas; Duchen, Michael R.; Ferretti, Patrizia; Tabrizi, Sarah J.
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errSave
The mitochondrial ATP synthase as an ATP consumer-a surprising therapeutic target
errEMBO JOURNAL
IF8.3
err2023-04-06
err6
errOAAI
errValdebenito, Gabriel E.; Chacko, Anitta R.; Duchen, Michael R.
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errSave
NAD(P)H binding configurations revealed by time-resolved fluorescence and two-photon absorption
errBIOPHYSICAL JOURNAL
IF3.1
err2023-04-01
err10
errOAAI
errBlacker, Thomas S.; Duchen, Michael R.; Bain, Angus J.
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errSave
Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2022-07-21
err4
errOAAI
errD'Acunto, E.; Gianfrancesco, L.; Serangeli, I; D'Orsi, M.; Sabato, V; Guadagno, N. A.; Bhosale, G.; Caristi, S.; Failla, A., V; De Jaco, A.; Cacci, E.; Duchen, M. R.; Lupo, G.; Galliciotti, G.; Miranda, E.
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errSave
Rewiring cell signalling pathways in pathogenic mtDNA mutations
errTRENDS IN CELL BIOLOGY
IF18.1
err2022-05-01
err13
errOAAI
errChung, Chih-Yao; Valdebenito, Gabriel E.; Chacko, Anitta R.; Duchen, Michael R.
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errSave
The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases
errBIOLOGICAL REVIEWS
IF11.7
err2022-04-26
err51
errOAAI
errAlmeida, Liliana M.; Pinho, Brigida R.; Duchen, Michael R.; Oliveira, Jorge M. A.
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errSave
Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency
errELIFE
IF0
err2022-02-21
err22
PREAI
errDe la Rossa, Andres; Laporte, Marine H.; Astori, Simone; Marissal, Thomas; Montessuit, Sylvie; Sheshadri, Preethi; Ramos-Fernandez, Eva; Mendez, Pablo; Khani, Abbas; Quairiaux, Charles; Taylor, Eric B.; Rutter, Jared; Nunes, Jose Manuel; Carleton, Alan; Duchen, Michael R.; Sandi, Carmen; Martinou, Jean-Claude
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Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation
errNATURE COMMUNICATIONS
IF15.7
err2021-11-04
err23
errOAAI
errChung, Chih-Yao; Singh, Kritarth; Kotiadis, Vassilios N.; Valdebenito, Gabriel E.; Ahn, Jee Hwan; Topley, Emilie; Tan, Joycelyn; Andrews, William D.; Bilanges, Benoit; Pitceathly, Robert D. S.; Szabadkai, Gyorgy; Yuneva, Mariia; Duchen, Michael R.
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errSave
Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation
errLIFE SCIENCES
IF5.1
err2021-11-01
err5
errOAAI
errPinho, Brigida R.; Almeida, Liliana M.; Duchen, Michael R.; Oliveira, Jorge M. A.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Michael P. Murphy
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A
Anthony H.V. Schapira
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D
Derek M. Yellon
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