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George S. Baillie

cardiovascular and metabolic health

66H-index
289Paper Count
1.5WCitation Count
Published Papers 187
Publication Date
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KTX207-mediated PDE4D degradation disrupts tumour cell migration, invasion, and angiogenic potential
errCell Communication and Signaling
IF8.9
err2026-05-21
err0
errOAAI
errAlina Zorn; Yi Zhao; Aoife Giblin; Igor Belka; Eduardo Torres; Cathy Swindlehurst; Kyle Chan; David Stirling; George S. Baillie; Yuan Yan Sin
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errSave
Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders
errJournal of Translational Autoimmunity
IF3.6
err2025-10-31
err0
errOAAI
errArvind Shakya; Qiao Liu; Chon Lai; Sherry Baker; Steven Greene; Paul Erdman; Athri Rathnayake; Angela Schoolmeesters; Connor M. Blair; Elka Kyurkchieva; Navin Rajapakse; Imelda Lam; Yuan Yan Sin; George S. Baillie; Shenlin Huang; Aparajita H. Chourasia; Leah Fung
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errSave
Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting
errfebs journal
IF0
err2025-07-27
err0
errOAAI
errMadihah Hussain; Gonzalo S. Tejeda; George S. Baillie
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errSave
Quantification and structure–function analysis of calpain-1 and calpain-2 protease subunit interactions
errJournal of Biological Chemistry
IF3.9
err2025-06-01
err0
errOAAI
errIvan Shapovalov; Prawin Rimal; Pitambar Poudel; Victoria Lewtas; Mathias Bell; Shailesh Kumar Panday; Brian J. Laight; Danielle Harper; Stacy Grieve; George S. Baillie; Kazem Nouri; Peter L. Davies; Emil Alexov; Peter A. Greer
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errSave
Enhanced cytotoxicity against cholangiocarcinoma by fifth-generation chimeric antigen receptor T cells targeting integrin αvβ6 and secreting anti-PD-L1 scFv
errJOURNAL OF TRANSLATIONAL MEDICINE
IF7.5
err2025-04-16
err0
errOAAI
errPhanthaphol, Nattaporn; Somboonpatarakun, Chalermchai; Suwanchiwasiri, Kwanpirom; Yuti, Pornpimon; Sujjitjoon, Jatuporn; Augsornworawat, Punn; Baillie, George S.; Junking, Mutita; Yenchitsomanus, Pa-thai
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RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-03-01
err0
PREAI
errLynch, Martin J.; Baillie, George S.; Mohamed, Ahmed; Li, Xiang; Maisonneuve, Charlotte; Klussmann, Enno; van Heeke, Gino; Houslay, Miles D.
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errSave
Blocking the Dkk1-LRP6 interaction prevents acute amyloid-(3-driven cognitive impairment
errCELLULAR SIGNALLING
IF3.7
err2025-03-01
err0
errOAAI
errElliott, Christina; Jackson, Joshua; Findlay, Jane; Williams, Gareth; Ghosh, Anshua; Ribe, Elena; Ulmschneider, Martin; Khan, Ayesha; Ballard, Clive; Aarsland, Dag; Baillie, George S.; Harte, Michael; Killick, Richard
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errSave
Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera
errFEBS JOURNAL
IF4.2
err2024-12-13
err1
errOAAI
errSin, Yuan Yan; Giblin, Aoife; Judina, Aleksandra; Rujirachaivej, Punchita; Corral, Laura G.; Glennon, Eliza; Tai, Zhi Xian; Feng, Tian; Torres, Eduardo; Zorn, Alina; Gorelik, Julia; Kyurkchieva, Elka; Yenchitsomanus, Pa Thai; Swindlehurst, Cathy; Chan, Kyle; Stirling, David; Baillie, George S.
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errSave
SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline
errINTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
IF2.8
err2024-11-01
err0
errOAAI
errMain, Alice; Mary, Sheon; Sin, Yuan Yan; Wright, Tom A.; Ling, Jiayue; Blair, Connor M.; Smith, Godfrey L.; Fuller, Will; Baillie, George S.
errShare
errSave
Charting the importance of filamin A posttranslational modifications
errBIOCHEMICAL JOURNAL
IF4.3
err2024-07-03
err0
errOAAI
errShead, Kyle D.; Salyahetdinova, Veneta; Baillie, George S.
errShare
errSave
Phosphodiesterase 4D activity in acrodysostosis-associated neural pathology: too much or too little?
errBRAIN COMMUNICATIONS
IF4.5
err2024-06-29
err1
errOAAI
errGardner, Oliver F. W.; Bai, Tianshu; Baillie, George S.; Ferretti, Patrizia
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errSave
Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability
errFEBS LETTERS
IF3
err2024-05-09
err2
errOAAI
errSin, Yuan Yan; Cameron, Ryan T.; Schepers, Melissa; Macleod, Ruth; Wright, Tom A.; Paes, Dean; van den Hove, Daniel; Willems, Emily; Vanmierlo, Tim; Prickaerts, Jos; Blair, Connor M.; Baillie, George S.
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errSave
Disruption of the pro-oncogenic c-RAF-PDE8A complex represents a differentiated approach to treating KRAS-c-RAF dependent PDAC
errSCIENTIFIC REPORTS
IF3.9
err2024-04-18
err0
errOAAI
errCooke, Sean F.; Wright, Thomas A.; Sin, Yuan Yan; Ling, Jiayue; Kyurkchieva, Elka; Phanthaphol, Nattaporn; Mcskimming, Thomas; Herbert, Katharine; Rebus, Selma; Biankin, Andrew V.; Chang, David K.; Baillie, George S.; Blair, Connor M.
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errSave
cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression
errMOLECULAR ONCOLOGY
IF4.5
err2024-01-05
err0
errOAAI
errGulliver, Chloe; Busiau, Tara; Byrne, Ashleigh; Findlay, Jane E.; Hoffmann, Ralf; Baillie, George S.
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errSave
Revisiting the roles of cAMP signalling in the progression of prostate cancer
errBIOCHEMICAL JOURNAL
IF4.3
err2023-10-13
err3
errOAAI
errParsons, Emma C.; Hoffmann, Ralf; Baillie, George S.
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errSave
Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation and alterations in DNA repair: implications for therapeutic strategies
errBRITISH JOURNAL OF CANCER
IF6.8
err2023-09-22
err0
errOAAI
errGulliver, Chloe; Huss, Sebastian; Semjonow, Axel; Baillie, George S.; Hoffmann, Ralf
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errSave
Cancer: Phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target
errINTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
IF2.8
err2023-09-01
err4
errOAAI
errWright, Thomas A.; Gemmell, Alistair O.; Tejeda, Gonzalo S.; Blair, Connor M.; Baillie, George S.
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errSave
Phosphodiesterase 7 as a therapeutic target-Where are we now?
errCELLULAR SIGNALLING
IF3.7
err2023-08-01
err10
errOAAI
errZorn, Alina; Baillie, George
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errSave
Short PDE4 Isoforms as Drug Targets in Disease
errFRONTIERS IN BIOSCIENCE-LANDMARK
IF3.1
err2023-07-04
err11
errOAAI
errKyurkchieva, Elka; Baillie, George S.
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errSave
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2023-06-12
err12
errOAAI
errPaes, Dean; Schepers, Melissa; Willems, Emily; Rombaut, Ben; Tiane, Assia; Solomina, Yevgeniya; Tibbo, Amy; Blair, Connor; Kyurkchieva, Elka; Baillie, George S.; Ricciarelli, Roberta; Brullo, Chiara; Fedele, Ernesto; Bruno, Olga; van den Hove, Daniel; Vanmierlo, Tim; Prickaerts, Jos
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Robert J. Lefkowitz
H-index: 213 · Papers: 858
M
Michael P. Lisanti
H-index: 161 · Papers: 799
P
Philipp E. Scherer
H-index: 151 · Papers: 707
J
Jerrold M. Olefsky
H-index: 147 · Papers: 672
C
Clive Ballard
H-index: 140 · Papers: 1.2K
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