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U

Ultan McDermott

wellcome sanger institute

81H-index
514Paper Count
6.0WCitation Count
Published Papers 127
Publication Date
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A tumour-derived organoid biobank maps cancer gene dependencies
errNature
IF48.5
err2026-08-05
err0
errOAAI
errC. Herranz-Ors; S. G. Bhosle; A. E. Beck; J. G. R. Gilbert; G. Picco; J. Espejo Valle-Inclan; F. Muyas; S. Valentini; A. E. Andres; R. Ansari; S. Barthorpe; G. Battarbee; C. M. Beaver; S. Brocklesby; J. Cantwell; C. A. Collins; J. Davis; H. G. Dimitrova; J. Doran; E. Efendi; K. Evans; M. Fekry; T. A. Fowler; M. Garcia-Casado; J. A. T. Griffiths; C. Hall; R. Hamer; C. Hardy; Z. Hewitson; E. Hitch; L. Holland; D. A. Jackson; N. Joshi; A. Kavasakali; L. Letchford; H. B. Lightfoot; H. Lingala; I. Mali; K. May; T. Mironenko; J. Morris; C. Pacini; S. Price; G. Robert-Tissot; H. A. Rogers; J. V. Smith; K. Smith; E. Souster; W. J. Spence; F. Thomas; S. F. Vieira; S. Walker; G. Alfonsin; H. Bermingham; H. Coles; D. P. Ennis; A. Freeman; G. Giannone; N. Grehan; E. A. Griffiths; J. Hall; S. L. Lee; E. Y. L. Leung; C. Loreno; C. Millington; A. Mirnezami; B. Nutzinger; K. Orzechowska; C. M. A. Pinna; A. M. Redmond; K. Roberts; S. Roy; D. A. Sanders; P. Taniere; M. Vias; K. Wanigasooriya; M. R. Stratton; L. M. Staudt; U. McDermott; J. D. Brenton; I. A. McNeish; A. Biankin; O. J. Sansom; I. Cortes-Ciriano; T. J. Underwood; R. C. Fitzgerald; A. D. Beggs; H. E. Francies; M. J. Garnett
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errSave
10 × Genomics Flex Gene Expression is a powerful tool for single-cell transcriptomics of xenografts models
errGenome Biology
IF9.4
err2026-05-08
err0
errOAAI
errOriol Llorà-Batlle; Anca Farcas; Doreth Fransen; Nicolas Floc’h; Sara Talbot; Alix Schwiening; Laura Bojko; John Calver; Natasa Josipovic; Kanstantsin Lashuk; Julia Schueler; Andrei Prodan; Dylan Mooijman; Ultan McDermott
errShare
errSave
Author Correction: The long-term effects of chemotherapy on normal blood cells
errNature Genetics
IF0
err2025-07-31
err0
errOAAI
errEmily Mitchell; My H. Pham; Anna Clay; Rashesh Sanghvi; Nicholas Williams; Sandra Pietsch; Joanne I. Hsu; Nina Friesgaard Øbro; Hyunchul Jung; Aditi Vedi; Sarah Moody; Jingwei Wang; Daniel Leonganmornlert; Michael Spencer Chapman; Ellie Dunstone; Anna Santarsieri; Alex Cagan; Heather E. Machado; E. Joanna Baxter; George Follows; Daniel J. Hodson; Ultan McDermott; Gary J. Doherty; Inigo Martincorena; Laura Humphreys; Krishnaa Mahbubani; Kourosh Saeb Parsy; Koichi Takahashi; Margaret A. Goodell; David Kent; Elisa Laurenti; Peter J. Campbell; Raheleh Rahbari; Jyoti Nangalia; Michael R. Stratton
errShare
errSave
The long-term effects of chemotherapy on normal blood cells
errNature Genetics
IF0
err2025-07-01
err0
errOAAI
errEmily Mitchell; My H. Pham; Anna Clay; Rashesh Sanghvi; Nicholas Williams; Sandra Pietsch; Joanne I. Hsu; Hyunchul Jung; Aditi Vedi; Sarah Moody; Jingwei Wang; Daniel Leonganmornlert; Michael Spencer Chapman; Ellie Dunstone; Anna Santarsieri; Alex Cagan; Heather E. Machado; E. Joanna Baxter; George Follows; Daniel J. Hodson; Ultan McDermott; Gary J. Doherty; Inigo Martincorena; Laura Humphreys; Krishnaa Mahbubani; Kourosh Saeb Parsy; Koichi Takahashi; Margaret A. Goodell; David Kent; Elisa Laurenti; Peter J. Campbell; Raheleh Rahbari; Jyoti Nangalia; Michael R. Stratton
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errSave
A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency
errBMC GENOMICS
IF3.7
err2025-02-26
err0
errOAAI
errLukasiak, Sebastian; Kalinka, Alex; Gupta, Nikhil; Papadopoulos, Angelos; Saeed, Khalid; Mcdermott, Ultan; Hannon, Gregory James; Ross-Thriepland, Douglas; Walter, David
errShare
errSave
Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis
errJOURNAL OF PATHOLOGY
IF5.2
err2024-12-22
err0
errOAAI
errSchoenpflug, Lydia A.; Chatzipli, Aikaterini; Sirinukunwattana, Korsuk; Richman, Susan; Blake, Andrew; Robineau, James; Mertz, Kirsten D.; Verrill, Clare; Leedham, Simon J.; Hardy, Claire; Whalley, Celina; Redmond, Keara; Dunne, Philip; Walker, Steven; Beggs, Andrew D.; Mcdermott, Ultan; Murray, Graeme, I; Samuel, Leslie M.; Seymour, Matthew; Tomlinson, Ian; Quirke, Philip; S CORT Consortium, Jens; Rittscher, Jens; Maughan, Tim; Domingo, Enric; Koelzer, Viktor H.
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errSave
Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errPfeifer, M.; Brammeld, J.; McDermott, U.
errShare
errSave
Understanding Mechanisms of Cancer Drug Sensitivity and Resistance Using Functional Genomic Approaches
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errRosenberg, L.; Quarantotti, V.; Garriga, L. Montava; Gianni, D.; Bradley, J.; Pilling, J.; McDermott, U.; Rees, S.
errShare
errSave
Identi fi cation and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune in fi ltrate and TGF P as key predictors
errEBIOMEDICINE
IF10.8
err2024-08-01
err1
errOAAI
errDomingo, Enric; Rathee, Sanjay; Blake, Andrew; Samuel, Leslie; Murray, Graeme; Sebag-Montefiore, David; Gollins, Simon; West, Nicholas; Begum, Rubina; Richman, Susan; Quirke, Phil; Redmond, Keara; Chatzipli, Aikaterini; Barberis, Alessandro; Hassanieh, Sylvana; Mahmood, Umair; Youdell, Michael; McDermott, Ultan; Koelzer, Viktor; Leedham, Simon; Tomlinson, Ian; Dunne, Philip; Buffa, Francesca M.; Maughan, Timothy S.
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errSave
Using pooled minimal genome-wide sgRNA libraries to drive oncology drug discovery
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errLukasiak, Sebastian; Kalinka, Alex; Gupta, Nikhil; Saeed, Khalid; Papadopoulos, Angelos; McDermott, Ultan; Hannon, Gregory J.; Ross-Thriepland, Douglas; Walter, David
errShare
errSave
Large scale pan cancer drug combination screening to identify effective and actionable combinations and biomarker hypothesis
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errBashi, Azadeh; Coker, Elizabeth A.; Bulusu, Krishna; Milo, Marta; Crafter, Claire; Lynch, James; Jenkins, David; Lightfoot, Howard; Willis, Brandon; Andersen, Courtney; Tavana, Omid; Mongeon, Kevin; Gordon, Jacob; Smith, Paul; Barry, Simon; McDermott, Ultan; Drew, Lisa; Critchlow, Susan; Garnett, Mathew J.; Mettetal, Jerome
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errSave
Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma
errJOURNAL OF PATHOLOGY
IF5.2
err2022-11-09
err5
errOAAI
errBirkealv, Sofia; Harland, Mark; Matsuyama, Larissa Satiko Alcantara Sekimoto; Rashid, Mamun; Mehta, Ishan; Laye, Jonathan P.; Haase, Kerstin; Mell, Tracey; Iyer, Vivek; Robles-Espinoza, Carla Daniela; McDermott, Ultan; van Loo, Peter; Kuijjer, Marieke L.; Possik, Patricia A.; Engler, Silvya Stuchi Maria; Bishop, D. Timothy; Newton-Bishop, Julia; Adams, David J.
errShare
errSave
Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer
errNATURE COMMUNICATIONS
IF15.7
err2022-03-29
err39
errOAAI
errGogleva, Anna; Polychronopoulos, Dimitris; Pfeifer, Matthias; Poroshin, Vladimir; Ughetto, Michael; Martin, Matthew J.; Thorpe, Hannah; Bornot, Aurelie; Smith, Paul D.; Sidders, Ben; Dry, Jonathan R.; Ahdesmaki, Miika; McDermott, Ultan; Papa, Eliseo; Bulusu, Krishna C.
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errSave
Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2022-01-27
err2
errOAAI
errGrinkevitch, Vera; Wappett, Mark; Crawford, Nyree; Price, Stacey; Lees, Andrea; McCann, Christopher; McAllister, Katherine; Prehn, Jochen; Young, Jamie; Bateson, Jess; Gallagher, Lewis; Michaut, Magali; Iyer, Vivek; Chatzipli, Aikaterini; Barthorpe, Syd; Ciznadija, Daniel; Sloma, Ido; Wesa, Amy; Tice, David A.; Wessels, Lodewyk; Garnett, Mathew; Longley, Daniel B.; McDermott, Ultan; McDade, Simon S.
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errSave
Gain and loss of function genome-wide CRISPR screens identify Hippo signalling as an important driver of resistance in EGFR mutant lung cancer
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2021-12-01
err2
PREAI
errPfeifer, Matthias; Brammeld, Jonathan; Price, Stacey; Martin, Matthew; Thorpe, Hannah; Bornot, Aurelie; Banks, Ercia; Guan, Nin; Dunn, Shanade; Guerriero, Maria Lisa; O'Neill, Daniel; Pilling, James; Gianni, Davide; Brownell, James; Smith, Paul; McDermott, Ultan
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errSave
Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
errCOMMUNICATIONS BIOLOGY
IF5.1
err2021-05-21
err16
errOAAI
errThomas, Luke W.; Esposito, Cinzia; Morgan, Rachel E.; Price, Stacey; Young, Jamie; Williams, Steven P.; Maddalena, Lucas A.; McDermott, Ultan; Ashcroft, Margaret
errShare
errSave
In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer
errCLINICAL CANCER RESEARCH
IF10.2
err2021-01-04
err15
errOAAI
errMalla, Sudhir B.; Fisher, David J.; Domingo, Enric; Blake, Andrew; Hassanieh, Sylvana; Redmond, Keara L.; Richman, Susan D.; Youdell, Michael; Walker, Steven M.; Logan, Gemma E.; Chatzipli, Aikaterina; Amirkhah, Raheleh; Humphries, Matthew P.; Craig, Stephanie G.; McDermott, Ultan; Seymour, Matthew T.; Morton, Dion G.; Quirke, Philip; West, Nicholas P.; Salto-Tellez, Manuel; Kennedy, Richard D.; Johnston, Patrick G.; Tomlinson, Ian; Koelzer, Viktor H.; Campo, Letitia; Kaplan, Richard S.; Longley, Daniel B.; Lawler, Mark; Maughan, Timothy S.; Brown, Louise C.; Dunne, Philip D.
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errSave
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer
errCELLS
IF5.2
err2020-12-15
err17
errOAAI
errClifford, Rachael E.; Govindarajah, Naren; Bowden, David; Sutton, Paul; Glenn, Mark; Darvish-Damavandi, Mahnaz; Buczacki, Simon; McDermott, Ultan; Szulc, Zdzislaw; Ogretmen, Besim; Parsons, Jason L.; Vimalachandran, Dale
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errSave
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
errELIFE
IF0
err2020-09-29
err36
errOAAI
errChai, Annie Wai Yeeng; Yee, Pei San; Price, Stacey; Yee, Shi Mun; Lee, Hui Mei; Tiong, Vivian K. H.; Goncalves, Emanuel; Behan, Fiona M.; Bateson, Jessica; Gilbert, James; Tan, Aik Choon; McDermott, Ultan; Garnett, Mathew J.; Cheong, Sok Ching
errShare
errSave
A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2020-09-02
err119
errOAAI
errNilsson, Monique B.; Sun, Huiying; Robichaux, Jacqulyne; Pfeifer, Matthias; McDermott, Ultan; Travers, Jon; Diao, Lixia; Xi, Yuanxin; Tong, Pan; Shen, Li; Hofstad, Mia; Kawakami, Masanori; Le, Xiuning; Liu, Xi; Fan, Youhong; Poteete, Alissa; Hu, Limei; Negrao, Marcelo, V; Tran, Hai; Dmitrovsky, Ethan; Peng, David; Gibbons, Don L.; Wang, Jing; Heymach, John, V
errShare
errSave

Research Directions

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Co-authors
Cooperation Journals
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Michael R. Stratton
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Douglas F. Easton
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Gregory J. Hannon
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