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Alan V. Smrcka

department of pharmacology

57H-index
244Paper Count
1.2WCitation Count
Published Papers 108
Publication Date
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Mechanisms for Enhancement of μ-Opioid Receptor-Mediated Antinociception in the Central Nervous System Through Gallein-Dependent Modulation of Downstream G Protein βγ Subunit Signaling
errMolecular Pharmacology
IF3
err2026-04-20
err0
errOAAI
errJacob A. Ormes; Alan V. Smrcka; Emily M. Jutkiewicz
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G Protein Gαq Subunits Engage Targets in the Nucleus Involved in Chromatin Remodeling and Gene Expression
errJournal of Biological Chemistry
IF3.9
err2026-02-25
err0
errOAAI
errJoseph Loomis; Naincy Chandan; Michael Burroughs; Saji Abraham; Rongxi Zhang; Yiyi Cao; Matthew J. Brody; Gregory G. Tall; Alan V. Smrcka
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Activation of GPR97/ADGRG3 by its tethered agonist; but not by beclomethasone; induces neutrophil polarization and migration
errScience Signaling
IF6.6
err2026-02-17
err0
PREAI
errTyler Bernadyn; Frank Kwarcinski; Naincy Chandan; Riya Gandhi; Yuling Feng; Michael Holinstat; Carole A. Parent; Alan V. Smrcka; Gregory G. Tall
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errSave
Biasing G-protein βγ Subunit Downstream Signaling Enhances the Analgesic Effects of Endogenous Opioid Receptor Agonists during Nitroglycerin-Induced Thermal Hypersensitivity
errMolecular Pharmacology
IF3
err2025-08-06
err0
errOAAI
errFarzanna A. Mohamed; Alan V. Smrcka; Emily M. Jutkiewicz
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errSave
GoLoco/GPR Motif-Dependent Regulation of Rap1GAP1 by Gαo is Disrupted by Gαo Encephalopathy Variants
errJournal of Biological Chemistry
IF3.9
err2025-07-01
err0
errOAAI
errNathalie L. Momplaisir; Naincy R. Chandan; Beiyun Wang; Elaine Qu; Alan V. Smrcka
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Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy
errNeurobiology of Disease
IF5.6
err2025-06-05
err0
errOAAI
errNicholas Denomme; Samantha L. Hodges; Luis Lopez-Santiago; Yukun Yuan; Julie M. Ziobro; Joe Minton; Chunling Chen; Yan Chen; Jacob M. Hull; James Offord; Alan V. Smrcka; Lori L. Isom
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Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening
errATHEROSCLEROSIS
IF5.7
err2025-04-01
err1
errOAAI
errKhan, Taslima G.; Cunha, Juliana Bragazzi; Raut, Chinmay; Burroughs, Michael; Vyas, Hitarthi S.; Leix, Kyle; Goonewardena, Sascha N.; Smrcka, Alan V.; Speliotes, Elizabeth K.; Emmer, Brian T.
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Examining Promiscuity of a G(3y Inhibitor, Gallein, for Enhancement of Antinociceptive Effects
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errOrmes, Jacob A.; Mueller, Matthew R.; Smrcka, Alan; Jutkiewicz, Emily M.
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errSave
Gaq-SPRED1 Interaction: Unraveling a Novel Mechanism in GPCR Regulation of Ras Signaling
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errZhang, Rongxi; Chandan, Naincy R.; Loomis, Joseph F.; Smrcka, Alan, V
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errSave
Encephalopathy-Associated GNAO1 Mutant Effects on Rap1GAP1 Localization
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errQu, Elaine; Momplaisir, Nathalie; Smrcka, Alan; Chandan, Nancy
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errSave
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state
errNATURE COMMUNICATIONS
IF15.7
err2024-08-05
err0
errOAAI
errKnight, Kevin M.; Krumm, Brian E.; Kapolka, Nicholas J.; Ludlam, W. Grant; Cui, Meng; Mani, Sepehr; Prytkova, Iya; Obarow, Elizabeth G.; Lefevre, Tyler J.; Wei, Wenyuan; Ma, Ning; Huang, Xi-Ping; Fay, Jonathan F.; Vaidehi, Nagarajan; Smrcka, Alan V.; Slesinger, Paul A.; Logothetis, Diomedes E.; Martemyanov, Kirill A.; Roth, Bryan L.; Dohlman, Henrik G.
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Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling
errCIRCULATION RESEARCH
IF16.2
err2024-07-05
err1
PREAI
errWei, Wenhui; Smrcka, Alan V.
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A PACAP-activated network for secretion requires coordination of Ca2+influx and Ca2+mobilization
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2024-07-01
err2
errOAAI
errChen, Xiaohuan; Bell, Nicole A.; Coffman, Breanna L.; Rabino, Agustin A.; Garcia-Mata, Rafael; Kammermeier, Paul J.; Yule, David, I; Axelrod, Daniel; V. Smrcka, Alan; Giovannucci, David R.; Anantharam, Arun
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Biasing G bc Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State
errMOLECULAR PHARMACOLOGY
IF3
err2024-07-01
err0
errOAAI
errSanchez, Gissell A.; Smrcka, Alan, V; Jutkiewicz, Emily M.
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errSave
A Genome-wide CRISPR Screen Identifies The LDL Receptor As The Primary Mediator Of Lp(a) Uptake By HuH7 Cells
errARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
IF7.4
err2024-05-01
err0
PREAI
errCunha, Juliana Bragazzi; Khan, Taslima Gani; Leix, Kyle; Burroughs, Michael; Smrcka, Alan; Emmer, Brian T.
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errSave
Stabilization of interdomain interactions in G protein α subunits as a determinant of Gαi subtype signaling specificity
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-05-01
err1
errOAAI
errLefevre, Tyler J.; Wei, Wenyuan; Mukhaleva, Elizaveta; Venkata, Sai Pranathi Meda; Chandan, Naincy R.; Abraham, Saji; Li, Yong; Dessauer, Carmen W.; Vaidehi, Nagarajan; V. Smrcka, Alan
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Identification of a sequence of the activity-dependent neuroprotective protein (ADNP) that is necessary for its interaction with G??i1
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errMomplaisir, Nathalie; Chandan, Naincy R.; Smrcka, Alan V.
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errSave
Blockade of selective Gbγ signaling pathway by gallein decreases development of opioid tolerance
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errSmrcka, Alan V.; Sanchez, Gissell; Jutkiewicz, Emily M. M.
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errSave
Opposing effects of β2-ARs on β1-ARs on phospholipase C-mediated cardiac hypertrophic signaling
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errWei, Wenhui; Smrcka, Alan V.
errShare
errSave
SMARCD3: A Link Between G??q and Chromatin Remodeling?
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errLoomis, Joseph; Chandan, Naincy R.; Smrcka, Alan V.
errShare
errSave

Research Directions

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Co-authors
Cooperation Journals
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Eliezer Masliah
H-index: 195 · Papers: 1.2K
B
Bryan L. Roth
H-index: 139 · Papers: 970
P
Peter Nürnberg
H-index: 127 · Papers: 755
R
Roger Williams
H-index: 125 · Papers: 1.2K
A
Akiko Iwasaki
H-index: 124 · Papers: 611
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