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Bryan L. Roth

university of north carolina at chapel hill

139H-index
970Paper Count
8.3WCitation Count
Published Papers 311
Publication Date
A suite of engineered mice for interrogating psychedelic drug actions
err2026-08-06
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errOAAI
errYi-Ting Chiu; Ariel Y. Deutch; Wei Wang; Gavin P. Schmitz; Karen Lu Huang; D. Dewran Kocak; Pierre Llorach; Kasey R. Bowyer; Bei Liu; Noah Sciaky; Kunjie Hua; Chongguang Chen; Sarah E. Mott; Jesse Niehaus; Jeffrey F. DiBerto; Justin English; Jessica J. Walsh; Grégory Scherrer; Melissa A. Herman; Zhuhao Wu; William C. Wetsel; Bryan L. Roth
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Structural characterization of kappa-opioid receptor dimer in complex with two G proteins
err2026-05-29
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errOAAI
errYuxi Zhao; Chanjuan Xu; Yue Wang; Hong Shan; Jing Wang; Yuxuan Liu; Xin Luo; Junrui Li; Mingyang Li; Yini Liu; Kai Wu; Bryan L. Roth; Xi-Ping Huang; H. Eric Xu; Jianfeng Liu; Youwen Zhuang
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De novo design of miniproteins targeting GPCRs
errNature
IF48.5
err2026-05-21
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PREAI
errEdin Muratspahić; David Feldman; David E. Kim; Xiangli Qu; Ana-Maria Bratovianu; Paula Rivera-Sánchez; Jan Hendrik Voss; Emil P. T. Hertz; Mads Jeppesen; Federica Dimitri; Kensuke Sakamoto; Amrita Nallathambi; Pia Peceli; Jianjun Cao; Brian P. Cary; Matthew J. Belousoff; Peter Keov; Phuc N. H. Trinh; Qingchao Chen; Yue Ren; Justyn Fine; Sudha Mishra; Annu Dalal; Shachie Sinha; Ramanuj Banerjee; Manisankar Ganguly; Karthik Varappalayam Karuppusamy; Isaac Sappington; Thomas Schlichthaerle; Jason Z. Zhang; Arvind Pillai; Brian Coventry; Ljubica Mihaljević; Magnus Bauer; Susana Vázquez Torres; Amir Motmaen; Gyu Rie Lee; Long Tran; Xinru Wang; Inna Goreshnik; Dionne K. Vafeados; Justin E. Svendsen; Parisa Hosseinzadeh; Nicolai Lindegaard; Matthäus Brandt; Yann Waltenspühl; Kristine Deibler; Lukas Deweid; Anja Bennett; Jendrik Schöppe; Tiantang Dong; Xiaoli Yan; Luke Oostdyk; William Cao; Lakshmi Anantharaman; Johan J. Weisser; Jesper Frank Bastlund; Christoffer Bundgaard; Ayodeji A. Asuni; Justin G. English; Lance Stewart; Lauren Halloran; Jamie B. Spangler; André Lieber; Arun K. Shukla; Patrick M. Sexton; Bryan L. Roth; Brian E. Krumm; Denise Wootten; Christopher G. Tate; Christoffer Norn; David Baker
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The Selectivity Implications of Docking Libraries with Greater and Lesser Similarities to Bio-like Molecules
err2026-05-08
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errOAAI
errBrendan W. Hall; Kensuke Sakamoto; Xi-Ping Huang; John J. Irwin; Brian K. Shoichet; Bryan L. Roth
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Structural insights into coffee bitter taste perception by TAS2R43 receptor
err2026-04-20
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errOAAI
errYoojoong Kim; Ryan H. Gumpper; Yuxuan Zhuang; Ron O. Dror; Bryan L. Roth
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Structure-based design of an opioid receptor modulator for enhanced morphine analgesia
err2026-02-11
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errOAAI
errYue Wang; Ping Luo; Haiyan Xu; Li Zhan; Kensuke Sakamoto; Mingyu Li; Jing Wang; Xi-Ping Huang; Jianhui Zhou; Tao Liu; Yanrui Suo; Wenjia Fan; Xinheng He; Youwei Xu; Yongjie Cai; Chao Wang; Yuxi Zhao; Antao Dai; Yali Lai; Qingning Yuan; Wen Hu; Kai Wu; Dehua Yang; Xi Cheng; Xiaojie Lu; Brian Krumm; Terry Kenakin; Jian Zhang; Bryan L. Roth; Zhaobing Gao; H. Eric Xu; Youwen Zhuang
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Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors
err2025-12-01
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PREAI
errKuijer, Michael Bram; Fulton, Camryn J.; Albert, Talia L.; Knobloch, Paloma; Wang, Jing; Krumm, Brian E.; Che, Tao; Varga, Balazs R.; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H.; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L.
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Nanobody-drug conjugates for targeting specific GPCR pairs
err2025-11-21
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PREAI
errHuang, Xianglin; Roth, Bryan L.
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Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation
err2025-10-06
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errOAAI
errGavin P. Schmitz; Yi-Ting Chiu; Mia L. Foglesong; Sarah N. Magee; Martin MacKinnon; Gabriele M. König; Evi Kostenis; Li-Ming Hsu; Yen-Yu I. Shih; Bryan L. Roth; Melissa A. Herman
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The polypharmacology of psychedelics reveals multiple targets for potential therapeutics
errNeuron
IF15
err2025-07-18
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PREAI
errManish K. Jain; Ryan H. Gumpper; Samuel T. Slocum; Gavin P. Schmitz; Jakob S. Madsen; Tia A. Tummino; Carl-Mikael Suomivuori; Xi-Ping Huang; Laura Shub; Jeffrey F. DiBerto; Kuglae Kim; Chelsea DeLeon; Brain E. Krumm; Jonathan F. Fay; Michael Keiser; Alexander S. Hauser; Ron O. Dror; Brian Shoichet; David E. Gloriam; David E. Nichols; Bryan L. Roth
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Orchestrating NTSR1 signaling from the interface
err2025-04-21
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PREAI
errHuang, Xianglin; Krumm, Brian E.; Roth, Bryan L.
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High-affinity agonists reveal recognition motifs for the MRGPRD GPCR
err2024-12-01
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errOAAI
errWang, Chunyu; Liu, Yongfeng; Lanier, Marion; Yeager, Adam; Singh, Isha; Gumpper, Ryan H.; Krumm, Brian E.; Deleon, Chelsea; Zhang, Shicheng; Boehm, Marcus; Pittner, Richard; Baron, Alain; Dvorak, Lisa; Bacon, Corinne; Shoichet, Brain K.; Martinborough, Esther; Fay, Jonathan F.; Cao, Can; Roth, Bryan L.
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Molecular glues as potential GPCR therapeutics
err2024-10-01
err4
PREAI
errRoth, Bryan L.; Krumm, Brian E.
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A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state
err2024-08-05
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errOAAI
errKnight, Kevin M.; Krumm, Brian E.; Kapolka, Nicholas J.; Ludlam, W. Grant; Cui, Meng; Mani, Sepehr; Prytkova, Iya; Obarow, Elizabeth G.; Lefevre, Tyler J.; Wei, Wenyuan; Ma, Ning; Huang, Xi-Ping; Fay, Jonathan F.; Vaidehi, Nagarajan; Smrcka, Alan V.; Slesinger, Paul A.; Logothetis, Diomedes E.; Martemyanov, Kirill A.; Roth, Bryan L.; Dohlman, Henrik G.
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A proximity proteomics pipeline with improved reproducibility and throughput
err2024-07-01
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errOAAI
errZhong, Xiaofang; Li, Qiongyu; Polacco, Benjamin J.; Patil, Trupti; Marley, Aaron; Foussard, Helene; Khare, Prachi; Vartak, Rasika; Xu, Jiewei; DiBerto, Jeffrey F.; Roth, Bryan L.; Eckhardt, Manon; von Zastrow, Mark; Krogan, Nevan J.; Huttenhain, Ruth
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Piecing together aminergic polypharmacology
err2024-05-13
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errOAAI
errFordyce, Blake A.; Roth, Bryan L.
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MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model
err2024-05-08
err2
errOAAI
errChien, Daphne Chun-Che; Limjunyawong, Nathachit; Cao, Can; Meixiong, James; Peng, Qi; Ho, Cheng-Ying; Fay, Jonathan F.; Roth, Bryan L.; Dong, Xinzhong
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