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Patrick M. Sexton

monash university

90H-index
1.7KPaper Count
3.1WCitation Count
Published Papers 277
Publication Date
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De novo design of miniproteins targeting GPCRs
errNature
IF48.5
err2026-05-21
err0
PREAI
errEdin Muratspahić; David Feldman; David E. Kim; Xiangli Qu; Ana-Maria Bratovianu; Paula Rivera-Sánchez; Jan Hendrik Voss; Emil P. T. Hertz; Mads Jeppesen; Federica Dimitri; Kensuke Sakamoto; Amrita Nallathambi; Pia Peceli; Jianjun Cao; Brian P. Cary; Matthew J. Belousoff; Peter Keov; Phuc N. H. Trinh; Qingchao Chen; Yue Ren; Justyn Fine; Sudha Mishra; Annu Dalal; Shachie Sinha; Ramanuj Banerjee; Manisankar Ganguly; Karthik Varappalayam Karuppusamy; Isaac Sappington; Thomas Schlichthaerle; Jason Z. Zhang; Arvind Pillai; Brian Coventry; Ljubica Mihaljević; Magnus Bauer; Susana Vázquez Torres; Amir Motmaen; Gyu Rie Lee; Long Tran; Xinru Wang; Inna Goreshnik; Dionne K. Vafeados; Justin E. Svendsen; Parisa Hosseinzadeh; Nicolai Lindegaard; Matthäus Brandt; Yann Waltenspühl; Kristine Deibler; Lukas Deweid; Anja Bennett; Jendrik Schöppe; Tiantang Dong; Xiaoli Yan; Luke Oostdyk; William Cao; Lakshmi Anantharaman; Johan J. Weisser; Jesper Frank Bastlund; Christoffer Bundgaard; Ayodeji A. Asuni; Justin G. English; Lance Stewart; Lauren Halloran; Jamie B. Spangler; André Lieber; Arun K. Shukla; Patrick M. Sexton; Bryan L. Roth; Brian E. Krumm; Denise Wootten; Christopher G. Tate; Christoffer Norn; David Baker
errShare
errSave
Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor Activation
errJournal of the American Chemical Society
IF15.6
err2026-05-20
err0
errOAAI
errTae Wook Kim; Elliot J. Gerrard; Jeeeun Shin; Thomas J. Gardella; Denise Wootten; Patrick M. Sexton; Brian P. Cary; Samuel H. Gellman
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errSave
Conformational Dynamics of Amylin Receptors Revealed by Hydrogen–Deuterium Exchange Mass Spectrometry
errJournal of the American Chemical Society
IF15.6
err2026-04-16
err0
PREAI
errCameron J. Fairweather; Xin Zhang; C. Dilanka Fernando; Daniel J. Garama; Patrick M. Sexton; Denise Wootten; Tracy M. Josephs
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errSave
In vivo functional profiling and structural characterization of the human GLP1R A316T variant
errScience Advances
IF12.5
err2026-02-04
err0
errOAAI
errLiliane El Eid; Yusman Manchanda; Gregory Austin; Kieran Deane-Alder; Roxana-Maria Rujan; Zamara Mariam; Affiong I. Oqua; Matthew J. Belousoff; Jorge Bernardino de la Serna; Kyle W. Sloop; Guy A. Rutter; Alex Montoya; Dominic J. Withers; Steven J. Millership; Karim Bouzakri; Ben Jones; Christopher A. Reynolds; Patrick M. Sexton; Denise Wootten; Giuseppe Deganutti; Alejandra Tomas
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errSave
Native adenosine A2A receptor solubilisation by a library of amphipathic copolymers
errBiomater. Sci.
IF5.7
err2025-10-27
err0
PREAI
errMichelle D. Farrelly; Nazanin Mohebali; Emma Dal Maso; Cameron J. Nowell; Denise Wootten; Patrick M. Sexton; Lisandra L. Martin; San H. Thang
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errSave
Contrasting roles for GLP-1R and GIPR in a model of diet-induced obesity
errJOURNAL OF MOLECULAR ENDOCRINOLOGY
IF3.8
err2025-10-01
err0
PREAI
errGao, Jie; Cree, Shelby; Ham, Seungmin; Nowell, Cameron; Parker, Alex; Zhao, Peishen; Whiting, Lynda; Sloop, Kyle W.; Samms, Ricardo J.; Sexton, Patrick M.; Wootten, Denise; Hutchinson, Dana S.
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errSave
Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor
errMolecular Pharmacology
IF3
err2025-09-10
err0
PREAI
errChirine Toufaily; Yuanyuan Ma; Emmanuel D. Barbosa; Kaleeckal G. Harikumar; Denise Wootten; Patrick M. Sexton; Wei Liu; Laurence J. Miller
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errSave
A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles
errNature Nanotechnology
IF34.9
err2025-08-04
err0
errOAAI
errMoore Z. Chen; Daniel Yuen; Victoria M. McLeod; Ken W. Yong; Cameron H. Smyth; Bruna Rossi Herling; Thomas. J. Payne; Stewart A. Fabb; Matthew J. Belousoff; Azizah Algarni; Patrick M. Sexton; Christopher J. H. Porter; Colin W. Pouton; Angus P. R. Johnston
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errSave
Cryoelectron microscopy as a tool for illuminating activation mechanisms of human class A orphan G protein-coupled receptors
errPHARMACOLOGICAL REVIEWS
IF17.3
err2025-05-01
err0
errOAAI
errRussell, Isabella C.; Lee, Dongju; Wootten, Denise; Sexton, Patrick M.; Bumbak, Fabian
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errSave
Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors (vol 150, pg 1360, 2018)
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2024-12-19
err0
errOAAI
errBurger, Wessel A. C.; Sexton, Patrick M.; Christopoulos, Arthur; Thal, David M.
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errSave
Isoquinoline small molecule ligands are agonists and probe-dependent allosteric modulators of the glucagon subfamily of GPCRs
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2024-11-01
err1
errOAAI
errYuliantie, Elita; Trinh, Phuc N. H.; Hick, Caroline; Ebenhoch, Rebecca; Nar, Herbert; Weichert, Dietmar; Christopoulos, Arthur; Sexton, Patrick M.; Wootten, Denise
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errSave
Porous Silicon Microparticles Enable Sustained Release of GLP-1R Agonist Peptides for the Treatment of Type 2 Diabetes
errADVANCED THERAPEUTICS
IF2.6
err2024-08-10
err2
errOAAI
errZangabad, Parham Sahandi; Vasani, Roshan B.; Tong, Ziqiu; Anderson, Dovile; Rudd, David; Hick, Caroline A.; Wootten, Denise; Sexton, Patrick M.; Yan, Li; Esser, Lars; Voelcker, Nicolas H.
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errSave
Impact of secretin receptor homo-dimerization on natural ligand binding
errNATURE COMMUNICATIONS
IF15.7
err2024-05-23
err0
errOAAI
errHarikumar, Kaleeckal G.; Piper, Sarah J.; Christopoulos, Arthur; Wootten, Denise; Sexton, Patrick M.; Miller, Laurence J.
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errSave
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists S
errMOLECULAR PHARMACOLOGY
IF3
err2024-05-01
err3
errOAAI
errKeov, Peter; Christopoulos, George; Hick, Caroline A.; Glendorf, Tine; Ballarin-Gonzalez, Borja; Wootten, Denise; Sexton, Patrick M.
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errSave
The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2024-04-01
err6
errOAAI
errMcneill, Samantha M.; Lu, Jessica; Carino, Carlo Marion C.; Inoue, Asuka; Zhao, Peishen; Sexton, Patrick M.; Wootten, Denise
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errSave
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
errNATURE COMMUNICATIONS
IF15.7
err2023-09-06
err10
errOAAI
errBurger, Wessel A. C.; Pham, Vi; Vuckovic, Ziva; Powers, Alexander S.; Mobbs, Jesse I.; Laloudakis, Yianni; Glukhova, Alisa; Wootten, Denise; Tobin, Andrew B.; Sexton, Patrick M.; Paul, Steven M.; Felder, Christian C.; Danev, Radostin; Dror, Ron O.; Christopoulos, Arthur; Valant, Celine; Thal, David M.
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errSave
Structural insight into selectivity of amylin and calcitonin receptor agonists
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-08-03
err3
errOAAI
errCao, Jianjun; Belousoff, Matthew J.; Gerrard, Elliot; Danev, Radostin; Fletcher, Madeleine M.; Dal Maso, Emma; Schreuder, Herman; Lorenz, Katrin; Evers, Andreas; Tiwari, Garima; Besenius, Melissa; Li, Ziyu; Johnson, Rachel M.; Wootten, Denise; Sexton, Patrick M.
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errSave
Structural basis of efficacy-driven ligand selectivity at GPCRs (Feb, 10.1038/s41589-022-01247-5, 2023)
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-03-06
err3
errOAAI
errPowers, Alexander S.; Pham, Vi; Burger, Wessel A. C.; Thompson, Geoff; Laloudakis, Yianni; Barnes, Nicholas W.; Sexton, Patrick M.; Paul, Steven M.; Christopoulos, Arthur; Thal, David M.; Felder, Christian C.; Valant, Celine; Dror, Ron O.
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errSave
Structural basis of efficacy-driven ligand selectivity at GPCRs
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-02-13
err21
errOAAI
errPowers, Alexander S.; Pham, Vi; Burger, Wessel A. C.; Thompson, Geoff; Laloudakis, Yianni; Sexton, Patrick M.; Paul, Steven M.; Christopoulos, Arthur; Thal, David M.; Felder, Christian C.; Valant, Celine; Dror, Ron O.
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errSave
Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2022-12-04
err11
PREAI
errNguyen, Huong T. M.; van der Westhuizen, Emma T.; Langmead, Christopher J.; Tobin, Andrew B.; Sexton, Patrick M.; Christopoulos, Arthur; Valant, Celine
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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David L. Kaplan
H-index: 194 · Papers: 2.4K
J
John R. Yates
H-index: 188 · Papers: 1.5K
W
William A. Catterall
H-index: 162 · Papers: 652
P
Prashant V. Kamat
H-index: 155 · Papers: 1.1K
刘彬 cover
刘彬 (Bin Liu)
H-index: 142 · Papers: 1.7K
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