Frank D. Sistare - Publications, H-index & Citations

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Frank D. Sistare

Merck & Co., Inc

41H-index

139Paper Count

6.5KCitation Count

Published Papers 56

Publication Date

Investigation of a metabolism-dependent aryl hydrocarbon receptor off-target activation for a drug development candidate and a screening strategy for de-risking backups

Toxicological Sciences

IF4.1

2026-07-20

PREAI

Amy G Aslamkhan; Wen Kang; Karin Otte; Alex Tamburino; Paul J Ciaccio; Beatrice Sacre-Salem; Zoltan Erdos; Yuexia Liang; Richard W Gundersdorf; Bridget Becker; Keith Q Tanis; Todd Pippert; Pam Lane; Binod Jacob; Kimberly B Bleicher; Zhibin Wang; Ming Su; Stephen Pacchione; David Candito; Vladimir Simov; Peter H Fuller; Matthew J Fell; J Michael Ellis; Robert Foti; Kara M Pearson; Frank D Sistare; Warren E Glaab

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Urinary Kidney Injury Biomarker Profiles in Healthy Individuals and After Nephrotoxic and Ischemic Injury

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2025-01-04

PREAI

Waikar, Sushrut S.; Mogg, Robin; Baker, Amanda F.; Frendl, Gyorgy; Topper, Michael; Adler, Scott; Sultana, Stefan; Zhao, Runqi; King, Nicholas M. P.; Piccoli, Steven P.; Sauer, John-Michael; Hoffmann, Steve; Nunes, Irene; Sistare, Frank D.

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ICH S1 prospective evaluation study and weight of evidence assessments: commentary from industry representatives

FRONTIERS IN TOXICOLOGY

IF4.6

2024-05-23

OAAI

Vahle, John L.; Dybowski, Joe; Graziano, Michael; Hisada, Shigeru; Lebron, Jose; Nolte, Thomas; Steigerwalt, Ronald; Tsubota, Kenjiro; Sistare, Frank D.

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Enabling novel paradigms: a biological questions-based approach to human chemical hazard and drug safety assessment

TOXICOLOGICAL SCIENCES

IF4.1

2023-12-22

OAAI

Berridge, Brian R.; Bucher, John R.; Sistare, Frank; Stevens, James L.; Chappell, Grace A.; Clemons, Meredith; Snow, Samantha; Wignall, Jessica; Shipkowski, Kelly A.

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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity

ARCHIVES OF TOXICOLOGY

IF6.9

2023-06-09

OAAI

Gant, Timothy W.; Auerbach, Scott S.; Von Bergen, Martin; Bouhifd, Mounir; Botham, Philip A.; Caiment, Florian; Currie, Richard A.; Harrill, Joshua; Johnson, Kamin; Li, Dongying; Rouquie, David; van Ravenzwaay, Ben; Sistare, Frank; Tralau, Tewes; Viant, Mark R.; van de Laan, Jan Willem; Yauk, Carole

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Using human genetics to improve safety assessment of therapeutics

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2022-10-19

PREAI

Carss, Keren J.; Deaton, Aimee M.; Del Rio-Espinola, Alberto; Diogo, Dorothee; Fielden, Mark; Kulkarni, Diptee A.; Moggs, Jonathan; Newham, Peter; Nelson, Matthew R.; Sistare, Frank D.; Ward, Lucas D.; Yuan, Jing

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A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies

TOXICOLOGICAL SCIENCES

IF4.1

2022-04-11

OAAI

Corton, J. Christopher; Mitchell, Constance A.; Auerbach, Scott; Bushel, J. Pierre; Ellinger-Ziegelbauer, Heidrun; Escobar, Patricia A.; Froetschl, Roland; Harrill, Alison H.; Johnson, Kamin; Klaunig, James E.; Pandiri, Arun R.; Podtelezhnikov, Alexei A.; Rager, Julia E.; Tanis, Keith Q.; van der Laan, Jan Willem; Vespa, Alisa; Yauk, Carole L.; Pettit, Syril D.; Sistare, Frank D.

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Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin

TOXICOLOGICAL SCIENCES

IF4.1

2022-03-14

PREAI

Vlasakova, Katerina; Bourque, Jennifer; Bailey, Wendy J.; Patel, Shetal; Besteman, Elizabeth G.; Gonzalez, Raymond J.; Sistare, Frank D.; Glaab, Warren E.

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Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats

TOXICOLOGICAL SCIENCES

IF4.1

2021-04-09

PREAI

Glaab, Warren E.; Holder, Daniel; He, Yudong D.; Bailey, Wendy J.; Gerhold, David L.; Beare, Carolann; Erdos, Zoltan; Lane, Pamela; Michna, Laura; Muniappa, Nagaraja; Lawrence, Jeffrey W.; Tanis, Keith Q.; Sina, Joseph F.; Skopek, Thomas R.; Sistare, Frank D.

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Evaluation of Urinary Renal Biomarkers for Early Prediction of Acute Kidney Injury Following Partial Nephrectomy: A Feasibility Study

EUROPEAN UROLOGY FOCUS

IF5.6

2020-11-01

PREAI

Lane, Brian R.; Babitz, Stephen K.; Vlasakova, Katerina; Wong, Allen; Noyes, Sabrina L.; Boshoven, William; Grady, Pam; Zimmerman, Cindy; Engerman, Susan; Gebben, Maureen; Tanen, Michael; Glaab, Warren E.; Sistare, Frank D.

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Mechanistic Investigations Support Liver Safety of Ubrogepant

TOXICOLOGICAL SCIENCES

IF4.1

2020-06-24

OAAI

Smith, Brenda; Rowe, Josh; Watkins, Paul B.; Ashina, Messoud; Woodhead, Jeffrey L.; Sistare, Frank D.; Goadsby, Peter J.

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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury

TOXICOLOGICAL SCIENCES

IF4.1

2020-06-19

OAAI

Monroe, James J.; Tanis, Keith Q.; Podtelezhnikov, Alexei A.; Truyen Nguyen; Machotka, Sam, V; Lynch, Donna; Evers, Raymond; Palamanda, Jairam; Miller, Randy R.; Pippert, Todd; Cabalu, Tamara D.; Johnson, Timothy E.; Aslamkhan, Amy G.; Kang, Wen; Tamburino, Alex M.; Mitra, Kaushik; Agrawal, Nancy G. B.; Sistare, Frank D.

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Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline

TOXICOLOGICAL SCIENCES

IF4.1

2020-06-19

PREAI

Kang, Wen; Podtelezhnikov, Alexei A.; Tanis, Keith Q.; Pacchione, Stephen; Su, Ming; Bleicher, Kimberly B.; Wang, Zhibin; Laws, George M.; Griffiths, Thomas G.; Kuhls, Matthew C.; Chen, Qing; Knemeyer, Ian; Marsh, Donald J.; Mitra, Kaushik; Lebron, Jose; Sistare, Frank D.

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Urine kidney safety biomarkers improve understanding of indirect intra-renal injury potential in dogs with a drug-induced prerenal azotemia

TOXICOLOGY

IF4.6

2020-06-01

PREAI

Gu, Yi-Zhong; Vlasakova, Katerina; Darbes, Jarig; Wang, Erjia; Ferraro, Jude; Glaab, Warren E.; Sistare, Frank D.

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Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities

TOXICOLOGICAL SCIENCES

IF4.1

2020-03-02

OAAI

Podtelezhnikov, Alexei A.; Monroe, James J.; Aslamkhan, Amy G.; Pearson, Kara; Qin, Chunhua; Tamburino, Alex M.; Loboda, Andrey P.; Glaab, Warren E.; Sistare, Frank D.; Tanis, Keith Q.

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A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2020-02-01

OAAI

Yauk, Carole L.; Harrill, Alison H.; Ellinger-Ziegelbauer, Heidrun; van der Laan, Jan Willem; Moggs, Jonathan; Froetschl, Roland; Sistare, Frank; Pettit, Syril

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Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3

TOXICOLOGICAL SCIENCES

IF4.1

2019-08-12

PREAI

Gu, Yi-Zhong; Chu, Xiaoyan; Houle, Robert; Vlasakova, Katerina; Koeplinger, Kenneth A.; Bourgeois, Isabelle; Palyada, Kiran; Anderson, Kenneth D.; Brynczka, Christopher; Bhatt, Bhavana; Chen, Feifei; Smith, Roger; Amin, Rupesh; Glaab, Warren E.; Lebron, Jose; Cox, Kathleen; Sistare, Frank D.

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Can Galactose Be Converted to Glucose in HepG2 Cells? Improving the in Vitro Mitochondria! Toxicity Assay for the Assessment of Drug Induced Liver Injury

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2019-07-04

PREAI

Xu, Quwei; Liu, Liping; Vu, Heather; Kuhls, Matthew; Aslamkban, Amy G.; Liaw, Andy; Yu, Yan; Kaczor, Allen; Ruth, Michael; Wei, Christina; Imredy, John; Lebron, Jose; Pearson, Kara; Gonzalez, Raymond; Mitra, Kaushik; Sistare, Frank D.

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AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats

TOXICOLOGICAL SCIENCES

IF4.1

2019-05-25

PREAI

Qin, Chunhua; Aslamkhan, Amy G.; Pearson, Kara; Tanis, Keith Q.; Podtelezhnikov, Alexei; Frank, Erika; Pacchione, Stephen; Pippert, Todd; Glaab, Warren E.; Sistare, Frank D.

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Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity

TOXICOLOGICAL SCIENCES

IF4.1

2019-03-23

PREAI

Li, Yutai; Evers, Raymond; Hafey, Michael J.; Cheon, Kyeongmi; Duong, Hong; Lynch, Donna; LaFranco-Scheuch, Lisa; Pacchione, Stephen; Tamburino, Alex M.; Tanis, Keith Q.; Geddes, Kristin; Holder, Daniel; Zhang, Nanyan Rena; Kang, Wen; Gonzalez, Raymond J.; Galijatovic-Idrizbegovic, Alema; Pearson, Kara M.; Lebron, Jose A.; Glaab, Warren E.; Sistare, Frank D.

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Research Directions