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Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision Shembrey, Carolyn; Yang, Ray; Casan, Joshua; Hu, Wenxin; Chen, Honglin; Singh, Gurjeet J.; Sadras, Teresa; Prasad, Krishneel; Shortt, Jake; Johnstone, Ricky W.; Trapani, Joseph A.; Ekert, Paul G.; Fareh, Mohamed Share Save
RNA kinetics influence the response to transcriptional perturbation in leukaemia cell lines Todorovski, Izabela; Tsang, Mary-Jane; Feran, Breon; Fan, Zheng; Gadipally, Sreeja; Yoannidis, David; Kong, Isabella Y.; Bjelosevic, Stefan; Rivera, Sarahi; Voulgaris, Olivia; Zethoven, Magnus; Hawkins, Edwin D.; Simpson, Kaylene J.; Arnau, Gisela Mir; Papenfuss, Anthony T.; Johnstone, Ricky W.; Vervoort, Stephin J. Share Save
Mapping the IMiD-dependent cereblon interactome using BioID-proximity labelling Costacurta, Matteo; Sandow, Jarrod J.; Maher, Belinda; Susanto, Olivia; Vervoort, Stephin J.; Devlin, Jennifer R.; Garama, Daniel; Condina, Mark R.; Steele, Joel R.; Kahrood, Hossein V.; Gough, Daniel; Johnstone, Ricky W.; Shortt, Jake Share Save
Regulation of Exhausted CD8+ T cell Differentiation by IKZF Transcription Factors Reading, Sinead M.; Munoz, Isabelle; de Menezes, Maria N.; Saw, Nicole Y. L.; Ambani, Krutika; Ahn, Antonio; Nussing, Simone; Roth, Sara; Sampurno, Shienny; Ramsbottom, Kelly M.; Trapani, Joseph A.; Good-Jacobson, Kim L.; Johnstone, Ricky W.; Goel, Shom; Beavis, Paul A.; Parish, Ian A. Share Save
PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity Djajawi, Tirta M.; Pijpers, Lizzy; Srivaths, Akash; Chisanga, David; Chan, Kok Fei; Hogg, Simon J.; Neil, Liam; Rivera, Sarahi Mendoza; Bartonicek, Nenad; Ellis, Sarah L.; Sian, Terry C. C. Lim Kam; Faridi, Pouya; Liao, Yang; Pal, Bhupinder; Behren, Andreas; Shi, Wei; Vervoort, Stephin J.; Johnstone, Ricky W.; Kearney, Conor J. Share Save
A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax Kosasih, Hansen J.; Healey, Gerry; Brennan, Margs S.; Bjelosevic, Stefan; Sadras, Teresa; Jalud, Fatimah B.; Ibnat, Tasnia; Ng, Ashley P.; Mayoh, Chelsea; Mao, Jie; Tax, Gabor; Ludlow, Louise E. A.; Johnstone, Ricky W.; Herold, Marco J.; Khaw, Seong L.; de Bock, Charles E.; Ekert, Paul G. Share Save
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity (vol 42, 113014, 2023) House, Imran G.; Derrick, Emily B.; Sek, Kevin; Chen, Amanda X. Y.; Li, Jasmine; Lai, Junyun; Todd, Kirsten L.; Munoz, Isabelle; Michie, Jessica; Chan, Cheok Weng; Huang, Yu-Kuan; Chan, Jack D.; Petley, Emma V.; Tong, Junming; Nguyen, Datminh; Engel, Sven; Savas, Peter; Hogg, Simon J.; Vervoort, Stephin J.; Kearney, Conor J.; Burr, Marian L.; Lam, Enid Y. N.; Gilan, Omer; Bedoui, Sammy; Johnstone, Ricky W.; Dawson, Mark A.; Loi, Sherene; Darcy, Phillip K.; Beavis, Paul A. Share Save
A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses Todd, Kirsten L.; Lai, Junyun; Sek, Kevin; Huang, Yu-Kuan; Newman, Dane M.; Derrick, Emily B.; Koay, Hui-Fern; Nguyen, Dat; Hoang, Thang X.; Petley, Emma V.; Chan, Cheok Weng; Munoz, Isabelle; House, Imran G.; Lee, Joel N.; Kim, Joelle S.; Li, Jasmine; Tong, Junming; N. de Menezes, Maria; Scheffler, Christina M.; Yap, Kah Min; Chen, Amanda X. Y.; Dunbar, Phoebe A.; Haugen, Brandon; Parish, Ian A.; Johnstone, Ricky W.; Darcy, Phillip K.; Beavis, Paul A. Share Save
Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma Oh, Danielle H.; Ma, Xiao; Hogg, Simon J.; He, Jackson; Kearney, Conor; Brasacchio, Daniella; Susanto, Olivia; Maher, Belinda; Jennings, Ian G.; Newbold, Andrea; Fraser, Peter; Gruber, Emily; Kats, Lev M.; Gregory, Gareth P.; Johnstone, Ricky W.; Thompson, Philip E.; Shortt, Jake Share Save
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity House, Imran G.; Derrick, Emily B.; Sek, Kevin; Chen, Amanda X. Y.; Li, Jasmine; Lai, Junyun; Todd, Kirsten L.; Munoz, Isabelle; Michie, Jessica; Chan, Cheok Weng; Huang, Yu-Kuan; Chan, Jack D.; Petley, Emma, V; Tong, Junming; Nguyen, DatMinh; Engel, Sven; Savas, Peter; Hogg, Simon J.; Vervoort, Stephin J.; Kearney, Conor J.; Burr, Marian L.; Lam, Enid Y. N.; Gilan, Omer; Bedoui, Sammy; Johnstone, Ricky W.; Dawson, Mark A.; Loi, Sherene; Darcy, Phillip K.; Beavis, Paul A. Share Save
Expression and function of the leucine zipper protein par-4 in apoptosis Sells, SF; Han, SS; Muthukkumar, S; Maddiwar, N; Johnstone, R; Boghaert, E; Gillis, D; Liu, GH; Nair, P; Monnig, S; Collini, P; Mattson, MP; Sukhatme, VP; Zimmer, SG; Wood, DP; McRoberts, JW; Shi, Y; Rangnekar, VM Share Save
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Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells Gruber, Emily; So, Joan; Lewis, Alexander C.; Franich, Rheana; Cole, Rachel; Martelotto, Luciano G.; Rogers, Amy J.; Vidacs, Eva; Fraser, Peter; Stanley, Kym; Jones, Lisa; Trigos, Anna; Thio, Niko; Li, Jason; Nicolay, Brandon; Daigle, Scott; Tron, Adriana E.; Hyer, Marc L.; Shortt, Jake; Johnstone, Ricky W.; Kats, Lev M. Share Save
Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer Hogg, Simon J.; Motorna, Olga; Kearney, Conor J.; Derrick, Emily B.; House, Imran G.; Todorovski, Izabela; Kelly, Madison J.; Zethoven, Magnus; Bromberg, Kenneth D.; Lai, Albert; Beavis, Paul A.; Shortt, Jake; Johnstone, Ricky W.; Vervoort, Stephin J. Share Save
Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis Kong, Isabella Y.; Trezise, Stephanie; Light, Amanda; Todorovski, Izabela; Arnau, Gisela Mir; Gadipally, Sreeja; Yoannidis, David; Simpson, Kaylene J.; Dong, Xueyi; Whitehead, Lachlan; Tempany, Jessica C.; Farchione, Anthony J.; Sheikh, Amania A.; Groom, Joanna R.; Rogers, Kelly L.; Herold, Marco J.; Bryant, Vanessa L.; Ritchie, Matthew E.; Willis, Simon N.; Johnstone, Ricky W.; Hodgkin, Philip D.; Nutt, Stephen L.; Vervoort, Stephin J.; Hawkins, Edwin D. Share Save
The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression Xiao, Lin; Karsa, Mawar; Ronca, Emma; Bongers, Angelika; Kosciolek, Angelika; El-Ayoubi, Ali; Revalde, Jezrael L.; Seneviratne, Janith A.; Cheung, Belamy B.; Cheung, Laurence C.; Kotecha, Rishi S.; Newbold, Andrea; Bjelosevic, Stefan; Arndt, Greg M.; Lock, Richard B.; Johnstone, Ricky W.; Gudkov, Andrei V.; Gurova, Katerina V.; Haber, Michelle; Norris, Murray D.; Henderson, Michelle J.; Somers, Klaartje Share Save