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E

Erik S. Knudsen

Roswell Park Comprehensive Cancer Center

79H-index
486Paper Count
2.1WCitation Count
Published Papers 172
Publication Date
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HNF1A is a novel BRD4 target and critical for BET-inhibitor response in pancreatic ductal adenocarcinoma
errCommunications Biology
IF5.1
err2026-07-30
err0
errOAAI
errKennedy S. Humphrey; Katherine J. Crawford; Bharani Muppavarapu; Melanie M. Mayberry; William Morris; Evan Torres; Mark D. Long; Jianxin Wang; Erik S. Knudsen; Agnieszka K. Witkiewicz; Ethan V. Abel
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errSave
Low-level Aurora kinase A amplification: CDK4/6 inhibitor resistance biomarker in hormone receptor-positive metastatic breast cancer
errnpj Precision Oncology
IF8
err2026-07-29
err0
errOAAI
errSeth A. Wander; Lisa D. Eli; Ezgi Karaesmen Rizvi; Roosheel Sandeep Patel; Emily Schultz; Agnieszka K. Witkiewicz; Georg F. Bischof; Erik S. Knudsen; Karthik V. Giridhar
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errSave
The evolving landscape of CDK inhibitor use in breast cancer therapy and beyond
errNature Reviews Drug Discovery
IF101.8
err2026-04-27
err0
PREAI
errErik S. Knudsen; Agnieszka K. Witkiewicz; Sheheryar Kabraji
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errSave
Cyclin E modulates vulnerability to CDC7 kinase inhibition
errOncogenesis
IF6.4
err2026-04-24
err0
errOAAI
errAdam P. Dommer; Robert Kyne; Jianxin Wang; Thomas N. O’Connor; Amnon Koren; Erik S. Knudsen; Agnieszka K. Witkiewicz
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errSave
Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial
errNature Communications
IF15.7
err2026-01-27
err0
errOAAI
errTim Kong; Alex Mabry; Maureen Highkin; Anthony Z. Wang; Jeremy Hoog; Zhanfang Guo; Adrian Gonzales-Gonzales; Shana Thomas; Yingduo Song; Feng Gao; Mateusz Opyrchal; Lindsay Peterson; Foluso Ademuyiwa; Julie Margenthaler; Rebecca Aft; Katherine Glover-Collins; Leslie Nehring; Yu Tao; Souzan Sanati; Ian S. Hagemann; Fouad Boulos; Matthew Holt; Li Ding; Wenge Zhu; Stephen T. Oh; Jianxin Wang; Agnieszka K. Witkiewicz; Erik S. Knudsen; Ron Bose; Jason D. Weber; Matthew Goetz; Donald Northfelt; Jingqin Luo; Cynthia X. Ma
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errSave
Intrinsic RB activation induces tumoral and stromal anti-tumor responses that limit triple-negative breast cancer
errnpj Breast Cancer
IF7.6
err2025-12-01
err0
errOAAI
errYin Wan; Jianxin Wang; Thomas N. O’Connor; Vishnu Kumarasamy; Ioannis Sanidas; Scott I. Abrams; Agnieszka K. Witkiewicz; Erik S. Knudsen
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errSave
p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1-driven ovarian cancers
errSCIENCE SIGNALING
IF6.6
err2025-11-25
err0
PREAI
errSine, Chance C.; Watts, Lotte P.; Fernandez, Brianna; Marikar, Nasreen; Wang, Jianxin; Knudsen, Erik S.; Witkiewicz, Agnieszka K.; Spencer, Sabrina L.
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errSave
RB loss sensitizes triple-negative breast cancer to apoptosis induced by cellular stress
errCell Death Discovery
IF7
err2025-11-24
err0
errOAAI
errAgnieszka K. Witkiewicz; Subrahmanya Anirudh Kaligotla Venkata; Erik S. Knudsen; Vishnu Kumarasamy
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errSave
Baseline cell cycle and immune profiles indicate CDK4/6 inhibitor response in metastatic HR + /HER2- breast cancer
errnpj Breast Cancer
IF7.6
err2025-06-12
err0
errOAAI
errStephanie L. Tzetzo; Emily Schultz; Jianxin Wang; Hanna R. Rosenheck; Sidney Mahan; Erik S. Knudsen; Agnieszka K. Witkiewicz
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errSave
VDAC2 and Bak scarcity in liver mitochondria enables targeting hepatocarcinoma while sparing hepatocytes
errNATURE COMMUNICATIONS
IF15.7
err2025-03-11
err0
errOAAI
errNaghdi, Shamim; Mishra, Piyush; Roy, Soumya Sinha; Weaver, David; Walter, Ludivine; Davies, Erika; Antony, Anil Noronha; Lin, Xuena; Moehren, Gisela; Feitelson, Mark A.; Reed, Christopher A.; Lindsten, Tullia; Thompson, Craig B.; Dang, Hien T.; Hoek, Jan B.; Knudsen, Erik S.
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errSave
A Multi-protein Biomarker Strategy to Direct Treatment of Ovarian Cancer with CDK Inhibitors
errLABORATORY INVESTIGATION
IF4.2
err2025-03-01
err0
PREAI
errWitkiewicz, Agnieszka; Wang, Jianxin; Knudsen, Erik
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errSave
Separable Cell Cycle Arrest and Immune Response Elicited through Pharmacological CDK4/6 and MEK Inhibition in RASmut Disease Models
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-08-16
err0
errOAAI
errWu, Jin; Wang, Jianxin; O'Connor, Thomas N.; Tzetzo, Stephanie L.; Gurova, Katerina V.; Knudsen, Erik S.; Witkiewicz, Agnieszka K.
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errSave
Cancer takes many paths through G1/S
errTRENDS IN CELL BIOLOGY
IF18.1
err2024-08-01
err8
PREAI
errKnudsen, Erik S.; Witkiewicz, Agnieszka K.; Rubin, Seth M.
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errSave
Composite biomarkers for the prediction of progression-free survival with CDK4/6 inhibitors in metastatic HR+/HER2-breast cancer
errCANCER RESEARCH
IF16.6
err2024-05-02
err0
PREAI
errWitkiewicz, Agnieszka; Wang, Jianxin; Knudsen, Erik; Levine, Ellis; O'Connor, Tracey
errShare
errSave
Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression
errCANCER DISCOVERY
IF33.3
err2024-04-29
err9
PREAI
errYe, Jiayu; Baer, John M.; Faget, Douglas V.; Morikis, Vasilios A.; Ren, Qihao; Melam, Anupama; Delgado, Ana Paula; Luo, Xianmin; Bagchi, Satarupa Mullick; Belle, Jad I.; Campos, Edward; Friedman, Michael; Veis, Deborah J.; Knudsen, Erik S.; Witkiewicz, Agnieszka K.; Powers, Scott; Longmore, Gregory D.; DeNardo, David G.; Stewart, Sheila A.
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errSave
The Extracellular Niche and Tumor Microenvironment Enhance KRAS Inhibitor Efficacy in Pancreatic Cancer
errCANCER RESEARCH
IF16.6
err2024-01-31
err8
errOAAI
errKumarasamy, Vishnu; Wang, Jianxin; Frangou, Costakis; Wan, Yin; Dynka, Andrew; Rosenheck, Hanna; Dey, Prasenjit; Abel, Ethan V.; Knudsen, Erik S.; Witkiewicz, Agnieszka K.
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errSave
Determinants of response to CDK4/6 inhibitors in the real-world setting
errNPJ PRECISION ONCOLOGY
IF8
err2023-09-13
err7
errOAAI
errWitkiewicz, Agnieszka K.; Schultz, Emily; Wang, Jianxin; Hamilton, Deanna; Levine, Ellis; O'Connor, Tracey; Knudsen, Erik S.
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errSave
PROTAC-mediated CDK degradation differentially impacts cancer cell cycles due to heterogeneity in kinase dependencies
errBRITISH JOURNAL OF CANCER
IF6.8
err2023-08-25
err6
errOAAI
errKumarasamy, Vishnu; Gao, Zhe; Zhao, Bosheng; Jiang, Baishan; Rubin, Seth M.; Burgess, Kevin; Witkiewicz, Agnieszka K.; Knudsen, Erik S.
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errSave
Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err293
errOAAI
errKnudsen, ES; Wang, JYJ
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errSave
Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err63
errOAAI
errSever-Chroneos, Z; Angus, SP; Fribourg, AF; Wan, HJ; Todorov, I; Knudsen, KE; Knudsen, ES
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Research Directions

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Co-authors
Cooperation Journals
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Gordon B. Mills
H-index: 231 · Papers: 3.5K
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Craig B. Thompson
H-index: 206 · Papers: 767
M
Michael P. Lisanti
H-index: 161 · Papers: 799
S
Scott W. Lowe
H-index: 156 · Papers: 977
R
Richard G. Pestell
H-index: 139 · Papers: 824
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