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Clara Locher

CHU de Rennes

28H-index
108Paper Count
4.0KCitation Count
Published Papers 50
Publication Date
Introducing the need for a consensus-based framework for protocol modifications to improve trial trustworthiness
err2026-04-24
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errOAAI
errCora Burgwinkel; Manon Gicquel; Isabelle Boutron; Sylvie Chevret; Leonhard Held; David Moher; Florian Naudet; Clara Locher
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Reusing clinical trial data to consolidate and advance medical knowledge
err2025-09-19
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PREAI
errGiulia Varvarà; Cora Burgwinkel; Clara Locher; Joseph S. Ross; Ulrich Mansmann; Florian Naudet
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Clinical research in rapid sequence during a pandemic: Lessons learned and the way forward
err2025-08-21
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PREAI
errFlorence Ader; Éloïse Aubret; Nathalie Bergaud; Maude Bouscambert-Duchamp; Sophie Circosta; Sandrine Couffin-Cadiergues; François Danion; Christelle Delmas; Alpha Diallo; Emmanuel Faure; Claire Fougerou-Leurent; Alexandre Gaymard; Karine Lacombe; Soizic Le Mestre; Clara Locher; Auriane Merelle; Nathan Peiffer-Smadja; Isabelle Pellegrin; Ventzislava Petrov-Sanchez; Linda Wittkop
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Trends of Publication of Negative Trials Over Time
err2025-01-05
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errLaviolle, Bruno; Locher, Clara; Allain, Jean-Sebastien; Le Cornu, Quentin; Charpentier, Pierre; Lefebvre, Marie; Le Pape, Clemence; Leven, Cyril; Palpacuer, Clement; Pontoizeau, Clemence; Bellissant, Eric; Naudet, Florian
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Risk of anti-TNF therapy on pregnancy, breastfeeding, live vaccines and related information in patients with inflammatory bowel disease: Real-world data from a nationwide study
err2024-12-01
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PREAI
errBendaoud, S.; Nahon, S.; Beaugerie, L.; Gornet, J. M.; Wils, P.; Amiot, A.; Peyrin-Biroulet, L.; Abitbol, V.; Hebuterne, X.; Altwegg, R.; Rosa, I.; Amil, M.; Heluwaert, F.; Plastaras, L.; Stefanescu, C.; Quentin, V.; Antoni, M.; Bideau, K.; Boualit, M.; Cuillerier, E.; Locher, C.; Skinazi, F.; Boureille, A.; Buisson, A.; Simon, M.
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Meta-analyses of phase I dose-finding studies: Application for the development of protein kinase inhibitors in oncology
err2024-08-05
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errOAAI
errCaquelin, Laura; Badra, Pauline; Poulain, Lucas; Laviolle, Bruno; Ursino, Moreno; Locher, Clara
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Reporting of interventional clinical trial results in an academic center: a survey of completed studies
err2024-04-22
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errAlix-Doucet, Anne Sophie; Vinatier, Constant; Fin, Loic; Lena, Herve; Range, Helene; Locher, Clara; Naudet, Florian
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Enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial
err2023-10-03
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errTadie, Jean-Marc; Locher, Clara; Maamar, Adel; Reignier, Jean; Asfar, Pierre; Commereuc, Morgane; Lesouhaitier, Mathieu; Gregoire, Murielle; Le Pabic, Estelle; Bendavid, Claude; Moreau, Caroline; Diehl, Jean-Luc; Gey, Alain; Tartour, Eric; Le Tulzo, Yves; Thibault, Ronan; Terzi, Nicolas; Gacouin, Arnaud; Roussel, Mikael; Delclaux, Christophe; Tarte, Karin; Cynober, Luc
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Replication of systematic reviews: is it to the benefit or detriment of methodological quality?
err2023-10-01
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errOAAI
errChapelle, Celine; Ollier, Edouard; Bonjean, Paul; Locher, Clara; Zufferey, Paul Jacques; Cucherat, Michel; Laporte, Silvy
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Making data sharing the norm in medical research The benefits to patients, science, and society are undeniable
err2023-07-11
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errOAAI
errLocher, Clara; Le Goff, Gerard; Le Louarn, Anne; Mansmann, Ulrich; Naudet, Floria
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The evidence base of US Food and Drug Administration approvals of novel cancer therapies from 2000 to 2020
err2023-02-24
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errGloy, Viktoria; Schmitt, Andreas M.; Dueblin, Pascal; Hirt, Julian; Axfors, Cathrin; Kuk, Hanna; Pereira, Tiago V.; Locher, Clara; Caquelin, Laura; Walter-Claudi, Martin; Lythgoe, Mark P.; Herbrand, Amanda; Kasenda, Benjamin; Hemkens, Lars G.
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Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health
err2023-02-14
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errVanier, Antoine; Fernandez, Judith; Kelley, Sophie; Alter, Lise; Semenzato, Patrick; Alberti, Corinne; Chevret, Sylvie; Costagliola, Dominique; Cucherat, Michel; Falissard, Bruno; Gueyffier, Francois; Lambert, Jerome; Lengline, Etienne; Locher, Clara; Naudet, Florian; Porcher, Raphael; Thiebaut, Rodolphe; Vray, Muriel; Zohar, Sarah; Cochat, Pierre; Le Guludec, Dominique
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Implementing clinical trial data sharing requires training a new generation of biomedical researchers
err2023-02-02
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errMansmann, Ulrich; Locher, Clara; Prasser, Fabian; Weissgerber, Tracey; Sax, Ulrich; Posch, Martin; Decullier, Evelyne; Cristea, Ioana A. A.; Debray, Thomas P. A.; Held, Leonhard; Moher, David; Ioannidis, John P. A.; Ross, Joseph S. S.; Ohmann, Christian; Naudet, Florian
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Data-sharing and re-analysis for main studies assessed by the European Medicines Agency-a cross-sectional study on European Public Assessment Reports
err2022-05-20
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errSiebert, Maximilian; Gaba, Jeanne; Renault, Alain; Laviolle, Bruno; Locher, Clara; Moher, David; Naudet, Florian
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Tivozanib in renal cell carcinoma: a systematic review of the evidence and its dissemination in the scientific literature
err2022-04-09
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errCaquelin, Laura; Gewily, Mohamed; Mottais, Wendy; Tebaldi, Chloe; Laviolle, Bruno; Naudet, Florian; Locher, Clara
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FOLFIRINOX with or without targeted therapy as first line for metastatic colorectal cancer: An AGEO multicenter realworld study
err2021-09-01
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errVarnier, R.; Toullec, C.; Fonnesu, M.; Philonenko, S.; Artru, P.; Hafliger, E.; Drouillard, A.; Torregrosa, C.; Pernot, S.; McLellan, P.; Lecomte, T.; Moulin, V.; Lecaille, C.; Touchefeu, Y.; Locher, C.; Turpin, A.; Taieb, J.; Coutzac, C.
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Hypothermic Oxygenated Perfusion Improves Extended Criteria Donor Liver Graft Function and Reduces Duration of Hospitalization Without Extra Cost: The PERPHO Study
err2021-03-12
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errRayar, Michel; Beaurepaire, Jean-Marie; Bajeux, Emma; Hamonic, Stephanie; Renard, Thomas; Locher, Clara; Desfourneaux, Veronique; Merdrignac, Aude; Bergeat, Damien; Lakehal, Mohamed; Sulpice, Laurent; Houssel-Debry, Pauline; Jezequel, Caroline; Camus, Christophe; Bardou-Jacquet, Edouard; Meunier, Bernard
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Bevacizumab (bev) continuation with FOLFIRI or switch to aflibercept (afli) with FOLFIRI as second-line treatment (L2) after first line of FOLFOX-bev (L1) for metastatic colorectal cancer (mCRC): An AGEO multicenter study
err2020-09-01
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errTorregrosa, C.; Pernot, S.; Perret, A.; Randrian, V.; Doat, S. Racine; Auberger, B.; Godet, T.; Jaffrelot, M.; Dubreuil, O.; Turpin, A.; Palmieri, L-J.; Bouche, O.; Lecomte, T.; Sefrioui, D.; Locher, C.; Neuzillet, C.; Nassif, E.; Lecaille, C.; Taieb, J.; Auclin, E.
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First-line chemotherapy with raltitrexed in metastatic colorectal cancer: An AGEO multicentre study
err2020-09-01
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errGallois, C.; Hafliger, E.; Auclin, E.; Perret, A.; Artru, P.; Coutzac, C.; Turpin, A.; Pellat, A.; Randrian, V.; Basile, D.; Faroux, R.; Locher, C.; Hautefeuille, V.; Dubreuil, O.; Palmieri, L-J.; Dior, M.; Taieb, J.
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