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M

Malcolm G. Dunlop

University of Edinburgh

91H-index
677Paper Count
3.6WCitation Count
Published Papers 199
Publication Date
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Germline haploinsufficiency of MUTYH causes mutational signature SBS18 in multiple tumour types and specifically raises colorectal cancer risk
errnpj Precision Oncology
IF8
err2026-05-06
err0
errOAAI
errKitty Sherwood; Juan Fernandez-Tajes; Güler Gül; Steve Thorn; Joseph C. Ward; James F. Wilson; Claire Palles; D. Timothy Bishop; Richard S. Houlston; Malcolm G. Dunlop; Ian P. M. Tomlinson
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Non-gonadal PIWIL1/Aubergine drives regenerative and tumorigenic stem cell proliferation and tumorigenesis in the intestine
errCell Reports
IF6.9
err2026-03-26
err0
errOAAI
errKaren Bellec; Lynsey R. Carroll; Kathryn A.F. Pennel; Yuanliangzi Tian; Yachuan Yu; Aslihan Bastem Akan; Caroline V. Billard; Nora Doleschall; Alexander R. Cameron; Fabiana Herédia; Alisson M. Gontijo; Anna M. Ochocka-Fox; James P. Blackmur; Farhat V.N. Din; Malcolm G. Dunlop; Joanne Edwards; Kevin Myant; Rippei Hayashi; Julia B. Cordero
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Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility
errNature Communications
IF15.7
err2026-01-15
err0
errOAAI
errZhishan Chen; Wenqiang Song; Qing Li; Chao Li; Wanqing Wen; Jeroen R. Huyghe; Philip J. Law; Ceres Fernandez-Rozadilla; Maria N. Timofeeva; Minta Thomas; Stephanie L. Schmit; Vicente Martin; Matthew Devall; Christopher Dampier; Ferran Moratalla-Navarro; Qiuyin Cai; Jifeng Wang; Jiajun Shi; Sun-Seog Kweon; Chizu Tanikawa; Wei-Hua Jia; Xiang Shu; Jirong Long; Jing Gao; Jeongseon Kim; Aesun Shin; Keitaro Matsuo; Sun Ha Jee; Keum Ji Jung; Nan Wang; Dong-Hyun Kim; Jie Ping; Gong Yang; Min-Ho Shin; Zefang Ren; Jae Hwan Oh; Isao Oze; Yoon-Ok Ahn; Yu-Tang Gao; Zhi-Zhong Pan; Yoichiro Kamatani; Luc Van Kaer; Lan Wu; Bingshan Li; Koichi Matsuda; Xiao-Ou Shu; Li Hsu; Malcolm G. Dunlop; Stephen B. Gruber; Richard Houlston; Ian Tomlinson; Li Li; Ken S. Lau; Victor Moreno; Graham Casey; Ulrike Peters; Wei Zheng; Xingyi Guo
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errSave
Promises under pressure: the modest predictive power of polygenic risk scores
errEuropean Journal of Human Genetics
IF4.6
err2026-01-08
err0
PREAI
errRachel Horton; Malcolm Dunlop; Margaret McCartney; Amit Sud; Richard Sullivan; Ian Tomlinson; Clare Turnbull; Richard Houlston; Anneke Lucassen
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errSave
Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure
errNature Communications
IF15.7
err2025-11-28
err0
errOAAI
errRasha Shraim; Maria Timofeeva; Cathy Wyse; Jos van Geffen; Michiel van Weele; Roman Romero-Ortuno; Lorna M. Lopez; Marcus E. Kleber; Stefan Pilz; Winfried März; Benjamin S. Fletcher; James F. Wilson; Evropi Theodoratou; Malcolm G. Dunlop; Ross McManus; Lina Zgaga
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Accelerated biological aging and its hallmarks in DNA methylation drive the association between unhealthy lifestyles and the onset of colorectal cancer
erreBioMedicine
IF10.8
err2025-11-05
err0
errOAAI
errJing Sun; Min Liu; Xiaoqian Zhang; Xinxuan Li; Jingyu Ye; Jianhui Zhao; Siyun Zhou; Haosen Ji; Yuqian Tan; Zilong Bian; Dongfeng Zhang; Malcolm G. Dunlop; Mingyang Song; Stephanie A. Smith-Warner; Hao Wu; Evropi Theodoratou; Qian Cao; Xue Li
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errSave
Single and double faecal immunochemical test strategies are effective in risk stratification for patients with symptoms of per rectal bleeding suggestive of colorectal cancer
errBJS OPEN
IF4.5
err2025-10-01
err0
errOAAI
errShah, Fatima; Gunn, Frances; Dunlop, Malcolm G.; Din, Farhat V. N.; Gerrard, Adam D.
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errSave
Risk factors and clinical consequences of interval cancers arising within faecal immunochemical testing-based colorectal cancer screening programme
errBJS OPEN
IF4.5
err2025-10-01
err0
errOAAI
errGerrard, Adam D.; Garau, Roberta; Maeda, Yasuko; Thomson, Alastair; Theodoratou, Evropi; Dunlop, Malcolm G.; Din, Farhat V. N.
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errSave
Clinical impact of double-faecal immunochemical testing following implementation into standard triage and investigation of primary care referrals in patients with lower gastrointestinal symptoms
errBJS Open
IF4.5
err2025-09-08
err0
errOAAI
errAdam D Gerrard; Yasuko Maeda; Colin Noble; Frances Gunn; Lorna Porteous; Rebecca Cheesbrough; Alastair Thomson; Malcolm G Dunlop; Farhat V N Din; Edinburgh Colorectal Group
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Trans-ancestry transcriptome-wide association and functional studies to uncover novel susceptibility genes and therapeutic targets for colorectal cancer (vol 9, 124, 2025)
errNPJ PRECISION ONCOLOGY
IF8
err2025-05-27
err0
errOAAI
errWang, Lijuan; Hu, Lidan; Sun, Jing; Zhao, Jianhui; Zhou, Siyun; Liu, Lexin; Yu, Wei; Hu, Yeting; Zhou, Dan; Meng, Xiangrui; Yuan, Zhongshang; Zhang, Honghe; Farrington, Susan; Timofeeva, Maria; Ding, Kefeng; Little, Julian; Dunlop, Malcolm; Theodoratou, Evropi; Li, Xue
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Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank (vol 16, 99, 2025)
errNATURE COMMUNICATIONS
IF15.7
err2025-05-09
err0
errOAAI
errXu, Wei; Mesa-Eguiagaray, Ines; Morris, David M.; Wang, Chengjia; Gray, Calum D.; Sjostrom, Samuel; Papanastasiou, Giorgos; Badr, Sammy; Paccou, Julien; Li, Xue; Timmers, Paul R. H. J.; Timofeeva, Maria; Farrington, Susan M.; Dunlop, Malcolm G.; Semple, Scott I.; MacGillivray, Tom; Theodoratou, Evropi; Cawthorn, William P.
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errSave
Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer
errBMC MEDICINE
IF8.3
err2025-04-29
err0
errOAAI
errZhou, Siyun; Yu, Lili; Zhao, Jianhui; Xiao, Qian; Sun, Jing; Wang, Lijuan; Zhou, Yuan; Lu, Yadong; Dunlop, Malcolm G.; Theodoratou, Evropi; Zhang, Honghe; Ding, Kefeng; Li, Xue
errShare
errSave
Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank
errNATURE COMMUNICATIONS
IF15.7
err2025-01-02
err0
errOAAI
errXu, Wei; Mesa-Eguiagaray, Ines; Morris, David M.; Wang, Chengjia; Gray, Calum D.; Sjostrom, Samuel; Papanastasiou, Giorgos; Badr, Sammy; Paccou, Julien; Li, Xue; Timmers, Paul R. H. J.; Timofeeva, Maria; Farrington, Susan M.; Dunlop, Malcolm G.; Semple, Scott I.; Macgillivray, Tom; Theodoratou, Evropi; Cawthorn, William P.
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errSave
Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region
errEBIOMEDICINE
IF10.8
err2024-12-01
err0
PREAI
errChen, Jie; Zhang, Han; Fu, Tian; Zhao, Jianhui; Nowak, Jan Krzysztof; Kalla, Rahul; Wellens, Judith; Yuan, Shuai; Noble, Alexandra; Ventham, Nicholas T.; Dunlop, Malcolm G.; Halfvarson, Jonas; Mao, Ren; Theodoratou, Evropi; Satsangi, Jack; Li, Xue
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errSave
Diagnostic Performance of Faecal Immunochemical Testing (FIT) in Patients with Lynch Syndrome Scheduled for Colonoscopic Surveillance
errDIAGNOSTICS
IF3.3
err2024-10-30
err1
errOAAI
errGerrard, Adam D.; Maeda, Yasuko; Strachan, Judith; Speake, Doug; Dunlop, Malcolm G.; Din, Farhat V. N.
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errSave
Colorectal cancer prevalence in faecal immunochemical test non-returners: potential for health inequality in symptomatic referral pathways
errBJS OPEN
IF4.5
err2024-10-15
err0
errOAAI
errGerrard, Adam D.; Coxon, Jonty; Maeda, Yasuko; Theodoratou, Evropi; Dunlop, Malcolm G.; Din, Farhat V. N.
errShare
errSave
Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk
errNATURE GENETICS
IF31.8
err2024-09-16
err0
errOAAI
errLaw, Philip J.; Studd, James; Smith, James; Vijayakrishnan, Jayaram; Harris, Bradley T.; Mandelia, Maria; Mills, Charlie; Dunlop, Malcolm G.; Houlston, Richard S.
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errSave
Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study
errEBIOMEDICINE
IF10.8
err2024-05-01
err9
errOAAI
errJiang, Fangyuan; Zhao, Jianhui; Sun, Jing; Chen, Wenxi; Zhao, Yuyuan; Zhou, Siyun; Yuan, Shuai; Timofeeva, Maria; Law, Philip J.; Larsson, Susanna C.; Chen, Dong; Houlston, Richard S.; Dunlop, Malcolm G.; Theodoratou, Evropi; Li, Xue
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errSave
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
errNATURE COMMUNICATIONS
IF15.7
err2024-04-26
err4
errOAAI
errChen, Zhishan; Guo, Xingyi; Tao, Ran; Huyghe, Jeroen R.; Law, Philip J.; Fernandez-Rozadilla, Ceres; Ping, Jie; Jia, Guochong; Long, Jirong; Li, Chao; Shen, Quanhu; Xie, Yuhan; Timofeeva, Maria N.; Thomas, Minta; Schmit, Stephanie L.; Diez-Obrero, Virginia; Devall, Matthew; Moratalla-Navarro, Ferran; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah E. W.; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan M.; Blackmur, James; Vaughan-Shaw, Peter G.; Shu, Xiao-Ou; Lu, Yingchang; Broderick, Peter; Studd, James; Harrison, Tabitha A.; Conti, David V.; Schumacher, Fredrick R.; Melas, Marilena; Rennert, Gad; Obon-Santacana, Mireia; Martin-Sanchez, Vicente; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun-Seog; Shin, Min-Ho; Shin, Aesun; Ahn, Yoon-Ok; Kim, Dong-Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu-Tang; Jia, Wei-Hua; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko; Pai, Rish K.; Figueiredo, Jane C.; Haile, Robert W.; Gallinger, Steven; Woods, Michael O.; Newcomb, Polly A.; Duggan, David; Cheadle, Jeremy P.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Kirac, Iva; Bohm, Jan; Mecklin, Jukka-Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri A.; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan G.; Cajuso, Tatiana; Hanninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Mannisto, Satu; Albanes, Demetrius; Weinstein, Stephanie J.; Ruiz-Narvaez, Edward; Palmer, Julie R.; Buchanan, Daniel D.; Platz, Elizabeth A.; Visvanathan, Kala; Ulrich, Cornelia M.; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter T.; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha L.; Potter, John D.; Tsilidis, Kostas K.; Schulze, Matthias B.; Gunter, Marc J.; Murphy, Neil; Castells, Antoni; Castellvi-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Bishop, D. Timothy; Giles, Graham G.; Southey, Melissa C.; Idos, Gregory E.; McDonnell, Kevin J.; Abu-Ful, Zomoroda; Greenson, Joel K.; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu-Ru; Steinfelder, Robert; Keku, Temitope O.; van Guelpen, Bethany; Hudson, Thomas J.; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja I.; Hayes, Richard B.; Martinez, Marie Elena; Thomas, Sushma S.; Pharoah, Paul D. P.; Larsson, Susanna C.; Yen, Yun; Lenz, Heinz-Josef; White, Emily; Li, Li; Doheny, Kimberly F.; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew T.; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David J.; Joshi, Amit D.; Schafmayer, Clemens; Scacheri, Peter C.; Kundaje, Anshul; Schoen, Robert E.; Hampe, Jochen; Stadler, Zsofia K.; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Edlund, Christopher K.; Gauderman, W. James; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen J.; van Duijnhoven, Franzel; Feskens, Edith J. M.; Sakoda, Lori C.; Gago-Dominguez, Manuela; Wolk, Alicja; Pardini, Barbara; FitzGerald, Liesel M.; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie A.; Kooperberg, Charles; Li, Christopher I.; Lin, Yi; Prentice, Ross; Qu, Conghui; Bezieau, Stephane; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Le Marchand, Loic; Wu, Anna H.; Qu, Chenxu; McNeil, Caroline E.; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian J.; Harris, Sarah E.; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Lau, Ken S.; Zhao, Hongyu; Hsu, Li; Cai, Qiuyin; Dunlop, Malcolm G.; Gruber, Stephen B.; Houlston, Richard S.; Moreno, Victor; Casey, Graham; Peters, Ulrike; Tomlinson, Ian; Zheng, Wei
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Systematic investigation of genetically determined plasma and urinary metabolites to discover potential interventional targets for colorectal cancer
errJNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
IF7.2
err2024-04-22
err2
errOAAI
errSun, Jing; Zhao, Jianhui; Zhou, Siyun; Li, Xinxuan; Li, Tengfei; Wang, Lijuan; Yuan, Shuai; Chen, Dong; Law, Philip J.; Larsson, Susanna C.; Farrington, Susan M.; Houlston, Richard S.; Dunlop, Malcolm G.; Theodoratou, Evropi; Li, Xue
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
L
Luigi Ferrucci
H-index: 237 · Papers: 2.6K
M
Mark I. McCarthy
H-index: 222 · Papers: 1.5K
J
John Hardy
H-index: 207 · Papers: 1.9K
H
Hermann Brenner
H-index: 202 · Papers: 3.3K
M
Michael Marmot
H-index: 194 · Papers: 1.4K
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