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Single intravenous administration of oncolytic adenovirus TILT-123 results in systemic tumor transduction and immune response in patients with advanced solid tumors Jirovec, Elise; Quixabeira, Dafne C. A.; Clubb, James H. A.; Pakola, Santeri A.; Kudling, Tatiana; Arias, Victor; Haybout, Lyna; Jalkanen, Katriina; Alanko, Tuomo; Monberg, Tine; Khammari, Amir; Dreno, Brigitte; Svane, Inge Marie; Block, Matthew S.; Adamo, Daniel A.; Maenpaa, Johanna; Kistler, Claudia; Sorsa, Suvi; Hemminki, Otto; Kanerva, Anna; Santos, Joao M.; Cervera-Carrascon, Victor; Hemminki, Akseli Share Save
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Overcoming effector T cell exhaustion in ovarian cancer ascites with a novel adenovirus encoding for a MUC1 bispecific antibody engager and IL-2 cytokine Basnet, Saru; Van der Heijden, Mirte; Quixabeira, Dafne C. A.; Jirovec, Elise; Gronberg-Vaha-Koskela, Susanna A. M.; Clubb, James H. A.; Kanerva, Anna; Pakola, Santeri; Haybout, Lyna; Arias, Victor; Hemminki, Otto; Kudling, Tatiana; Zafar, Sadia; Cervera-Carrascon, Victor; Santos, Joao M.; Hemminki, Akseli Share Save
Overcoming effector T cell exhaustion in ovarian cancer ascites with a novel adenovirus encoding for a MUC1 bispecific antibody engager and IL-2 cytokine (vol 32, 10.1016/j.ymthe.2024.06.029, 2024) Basnet, Saru; Van der Heijden, Mirte; Quixabeira, Dafne C. A.; Jirovec, Elise; Gronberg-Vaha-Koskela, Susanna A. M.; Clubb, James H. A.; Kanerva, Anna; Pakola, Santeri; Haybout, Lyna; Arias, Victor; Hemminki, Otto; Kudling, Tatiana; Zafar, Sadia; Cervera-Carrascon, Victor; Santos, Joao M.; Hemminki, Akseli Share Save
Safety, Efficacy, and Biological Data of T-Cell-Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial Pakola, Santeri A.; Peltola, Katriina J.; Clubb, James H. A.; Jirovec, Elise; Haybout, Lyna; Kudling, Tatiana V.; Alanko, Tuomo; Korpisaari, Riitta; Juteau, Susanna; Jaakkola, Marjut; Sormunen, Jorma; Kemppainen, Jukka; Hemmes, Annabrita; Pellinen, Teijo; van der Heijden, Mirte; Quixabeira, Dafne C. A.; Kistler, Claudia; Sorsa, Suvi; Havunen, Riikka; Santos, Joao M.; Cervera-Carrascon, Victor; Hemminki, Akseli Share Save
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Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer Quixabeira, D. C. A.; Pakola, S.; Jirovec, E.; Havunen, R.; Basnet, S.; Santos, J. M.; Kudling, T. V.; Clubb, J. H. A.; Haybout, L.; Arias, V.; Gronberg-Vaha-Koskela, S.; Cervera-Carrascon, V.; Kerkela, E.; Pasanen, A.; Anttila, M.; Tapper, J.; Kanerva, A.; Hemminki, A. Share Save
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Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine Quixabeira, D. C. A.; Jirovec, E.; Pakola, S.; Havunen, R.; Basnet, S.; Santos, J. M.; Kudling, T. V.; Clubb, J. H. A.; Haybout, L.; Arias, V.; Gronberg-Vaha-Koskela, S.; Cervera-Carrascon, V.; Pasanen, A.; Anttila, M.; Tapper, J.; Kanerva, A.; Hemminki, A. Share Save
Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer Kudling, Tatiana V.; Clubb, James H. A.; Pakola, Santeri; Quixabeira, Dafne C. A.; Lahdeniemi, Iris A. K.; Heinio, Camilla; Arias, Victor; Havunen, Riikka; Cervera-Carrascon, Victor; Santos, Joao M.; Sutinen, Eva; Raesaenen, Jari; Borenius, Kristian; Mayranpaa, Mikko I.; Aaltonen, Eero; Sorsa, Suvi; Hemminki, Otto; Kanerva, Anna; Verschuren, Emmy W.; Ilonen, Ilkka; Hemminki, Akseli Share Save
An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage Pakola, Santeri; Quixabeira, Dafne C. A.; Kudling, Tatiana V.; Clubb, James H. A.; Gronberg-Vaha-Koskela, Susanna; Basnet, Saru; Jirovec, Elise; Arias, Victor; Haybout, Lyna; Heinioe, Camilla; Santos, Joao M.; Cervera-Carrascon, Victor; Havunen, Riikka; Anttila, Marjukka; Hemminki, Akseli Share Save
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Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors Basnet, Saru; Santos, Joao M.; Quixabeira, Dafne C. A.; Clubb, James H. A.; Gronberg-Vaha-Koskela, Susanna A. M.; Arias, Victor; Pakola, Santeri; Kudling, Tatiana V.; Heinio, Camilla; Havunen, Riikka; Cervera-Carrascon, Victor; Sorsa, Suvi; Anttila, Marjukka; Kanerva, Anna; Hemminki, Akseli Share Save
Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting Clubb, James H. A.; Kudling, Tatiana V.; Girych, Mykhailo; Haybout, Lyna; Pakola, Santeri; Hamdan, Firas; Cervera-Carrascon, Victor; Hemmes, Annabrita; Gronberg-Vaha-Koskela, Susanna; Santos, Joao Manuel; Quixabeira, Dafne C. A.; Basnet, Saru; Heinio, Camilla; Arias, Victor; Jirovec, Elise; Kaptan, Shreyas; Havunen, Riikka; Sorsa, Suvi; Erikat, Abdullah; Schwartz, Joel; Anttila, Marjukka; Aro, Katri; Viitala, Tapani; Vattulainen, Ilpo; Cerullo, Vincenzo; Kanerva, Anna; Hemminki, Akseli Share Save
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