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Themistocles L. Assimes

VA Palo Alto Health Care System

99H-index
578Paper Count
6.9WCitation Count
Published Papers 226
Publication Date
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Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans
errAmerican Journal of Human Genetics
IF8.1
err2026-07-01
err0
PREAI
errHasan Alkhairo; Satoshi Koyama; Kruthika Iyer; Austin T. Hilliard; Pik Fang Kho; Shoa Clarke; Firdous M. Abdulwahab; Themistocles L. Assimes; Julie A. Lynch; Michèle Ramsay; Kyong-Mi Chang; Philip S. Tsao; Fowzan S. Alkuraya; Kaoru Ito; Neil Risch; Catherine Tcheandjieu
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Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations
errNature Genetics
IF29
err2026-05-25
err0
errOAAI
errSatoshi Koyama; Zhi Yu; Seung Hoan Choi; Sean J. Jurgens; Margaret Sunitha Selvaraj; Derek Klarin; Jennifer E. Huffman; Shoa L. Clarke; Selena K. Zhang; Michael N. Trinh; Akshaya Ravi; Jacqueline S. Dron; Catherine Spinks; Ida Surakka; Aarushi Bhatnagar; Kim Lannery; Whitney Hornsby; Scott M. Damrauer; Kyong-Mi Chang; Julie A. Lynch; Themistocles L. Assimes; Philip S. Tsao; Daniel J. Rader; Kelly Cho; Gina M. Peloso; Patrick T. Ellinor; Yan V. Sun; Peter W. F. Wilson; Pradeep Natarajan
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Causal relationship between epigenetic markers and type 2 diabetes in West African populations: a Mendelian randomisation analysis
errDiabetologia
IF10.2
err2026-04-24
err0
errOAAI
errKarlijn A. C. Meeks; Eva L. van der Linden; Amy R. Bentley; Ayo P. Doumatey; Peter Henneman; Nora Franceschini; Themistocles L. Assimes; Felix P. Chilunga; Charles F. Hayfron-Benjamin; Ellis Owusu-Dabo; Guanjie Chen; Charles Agyemang; Adebowale A. Adeyemo; Charles N. Rotimi
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Simulated patient systems powered by large language model-based AI agents offer potential for transforming medical education
errCommunications Medicine
IF6.3
err2025-12-19
err0
errOAAI
errHuizi Yu; Jiayan Zhou; Lingyao Li; Shan Chen; Jack Gallifant; Anye Shi; Jie Sun; Xiang Li; Jingxian He; Wenyue Hua; Mingyu Jin; Guang Chen; Yang Zhou; Zhao Li; Trisha Gupte; Ming-Li Chen; Zahra Azizi; Qi Dou; Bryan P. Yan; Yanqiu Xing; Yongfeng Zhang; Themistocles L. Assimes; Danielle S. Bitterman; Xin Ma; Lin Lu; Lizhou Fan
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An Exploratory Study for Proteomic-Based Markers of Joint Pain and Chronic Back Pain
errEuropean Journal of Pain
IF3.4
err2025-10-31
err0
errOAAI
errTessa Schillemans; Ann-Sofie Rönnegård; Themistocles L. Assimes; Magnus Peterson; Per Wändell; Lars Lind; Johan Ärnlöv
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Polygenic risk score for type 2 diabetes shows context-dependent effects across populations
errNature Communications
IF15.7
err2025-10-01
err0
errOAAI
errBoya Guo; Yanwei Cai; Daeeun Kim; Roelof A. J. Smit; Zhe Wang; Kruthika R. Iyer; Austin T. Hilliard; Jeffrey Haessler; Ran Tao; K. Alaine Broadaway; Yujie Wang; Nikita Pozdeyev; Frederik F. Stæger; Chaojie Yang; Brett Vanderwerff; Amit D. Patki; Lauren Stalbow; Meng Lin; Nicholas Rafaels; Jonathan Shortt; Laura Wiley; Maggie Stanislawski; Jack Pattee; Lea Davis; Peter S. Straub; Megan M. Shuey; Nancy J. Cox; Nanette R. Lee; Marit E. Jørgensen; Peter Bjerregaard; Christina Larsen; Torben Hansen; Ida Moltke; James B. Meigs; Daniel O. Stram; Xianyong Yin; Xiang Zhou; Kyong-Mi Chang; Shoa L. Clarke; Rodrigo Guarischi-Sousa; Joanna Lankester; Philip S. Tsao; Steven Buyske; Mariaelisa Graff; Laura M. Raffield; Quan Sun; Lynne R. Wilkens; Christopher S. Carlson; Charles B. Easton; Simin Liu; JoAnn E. Manson; Loïc L. Marchand; Christopher A. Haiman; Karen L. Mohlke; Penny Gordon-Larsen; Anders Albrechtsen; Michael Boehnke; Stephen S. Rich; Ani Manichaikul; Jerome I. Rotter; Noha A. Yousri; Ryan M. Irvin; Chris Gignoux; Kari E. North; Ruth J. F. Loos; Themistocles L. Assimes; Ulrike Peters; Charles Kooperberg; Sridharan Raghavan; Heather M. Highland; Burcu F. Darst
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Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems
errNature Aging
IF19.4
err2025-09-15
err0
PREAI
errRaghav Sehgal; Yaroslav Markov; Chenxi Qin; Margarita Meer; Courtney Hadley; Aladdin H. Shadyab; Ramon Casanova; JoAnn E. Manson; Parveen Bhatti; Ann Z. Moore; Eileen M. Crimmins; Sara Hagg; Themistocles L. Assimes; Eric A. Whitsel; Albert T. Higgins-Chen; Morgan Levine
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CYP2C19 Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention in the Million Veteran Program
errClinical Pharmacology & Therapeutics
IF5.5
err2025-06-03
err0
errOAAI
errCatherine Chanfreau-Coffinier; Kevin A. Friede; Mary E. Plomondon; Kyung Min Lee; Zhenyu Lu; Tia Dinatale; Scott L. DuVall; Jason L. Vassy; Stephen W. Waldo; John H. Cleator; Thomas M. Maddox; Daniel J. Rader; Themistocles L. Assimes; Scott M. Damrauer; Philip S. Tsao; Kyong-Mi Chang; Deepak Voora; Julie A. Lynch; Jay Giri; VA Million Veteran Program; Sony Tuteja
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errSave
Bidirectional associations of zinc supplement intake with biological ageing interacted by metabolic equivalent of task: A large-scale population-based Biobank study
errClinical Nutrition
IF7.4
err2025-05-02
err0
errOAAI
errYang Zhou; Jiayan Zhou; Zhao Li; Jingyi Wang; Hongzheng Li; Xiangjun Yin; Jialiang Gao; Ying Wu; Jinlin Li; Ya Xuan Sun; Yige Li; Weiguang Wang; Pinar O. Eser; Themistocles L. Assimes; Jie He; Guang Chen
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Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk
errGENOME MEDICINE
IF11.2
err2025-03-21
err1
errOAAI
errGeorgakis, Marios K.; Malik, Rainer; Bounkari, Omar El; Hasbani, Natalie R.; Li, Jiang; Huffman, Jennifer E.; Shakt, Gabrielle; Tack, Reinier W. P.; Kimball, Tamara N.; Asare, Yaw; Morrison, Alanna C.; Tsao, Noah L.; Judy, Renae; Mitchell, Braxton D.; Xu, Huichun; Montasser, May E.; Do, Ron; Kenny, Eimear E.; Loos, Ruth J. F.; Terry, James G.; Carr, John Jeffrey; Bis, Joshua C.; Psaty, Bruce M.; Longstreth, W. T.; Young, Kendra A.; Lutz, Sharon M.; Cho, Michael H.; Broome, Jai; Khan, Alyna T.; Wang, Fei Fei; Heard-Costa, Nancy; Seshadri, Sudha; Vasan, Ramachandran S.; Palmer, Nicholette D.; Freedman, Barry I.; Bowden, Donald W.; Yanek, Lisa R.; Kral, Brian G.; Becker, Lewis C.; Peyser, Patricia A.; Bielak, Lawrence F.; Ammous, Farah; Carson, April P.; Hall, Michael E.; Raffield, Laura M.; Rich, Stephen S.; Post, Wendy S.; Tracy, Russel P.; Taylor, Kent D.; Guo, Xiuqing; Mahaney, Michael C.; Curran, Joanne E.; Blangero, John; Clarke, Shoa L.; Haessler, Jeffrey W.; Hu, Yao; Assimes, Themistocles L.; Kooperberg, Charles; Bernhagen, Juergen; Anderson, Christopher D.; Damrauer, Scott M.; Zand, Ramin; Rotter, Jerome I.; de Vries, Paul S.; Dichgans, Martin
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Premorbid predictors of death at initial presentation of coronary heart disease in the Women's Health Initiative study
errAMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
IF5.9
err2025-03-01
err0
errOAAI
errChen, Ming-Li; Li, Jin; Iyer, Kruthika R.; Tcheandjieu, Catherine; Jimenez, Shirin; Salfati, Elias Levy Itshak; Del Gobbo, Liana C.; Stefanick, Marcia L.; Desai, Manisha; Xue, Xiaonan; Assimes, Themistocles L.
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Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height
errNPJ GENOMIC MEDICINE
IF4.8
err2025-02-27
err0
errOAAI
errPapadopoulou, A.; Litkowski, E. M.; Graff, M.; Wang, Z.; Smit, R. A. J.; Chittoor, G.; Dinsmore, I.; Josyula, N. S.; Lin, M.; Shortt, J.; Zhu, W.; Vedantam, S. L.; Yengo, L.; Wood, A. R.; Berndt, S. I.; Holm, I. A.; Mentch, F. D.; Hakonarson, H.; Kiryluk, K.; Weng, C.; Jarvik, G. P.; Crosslin, D.; Carrell, D.; Kullo, I. J.; Dikilitas, O.; Hayes, M. G.; Wei, W. Q.; Edwards, D. R. V.; Assimes, T. L.; Hirschhorn, J. N.; Below, J. E.; Gignoux, C. R.; Justice, A. E.; Loos, R. J. F.; Sun, Y. V.; Raghavan, S.; Deloukas, P.; North, K. E.; Marouli, E.
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errSave
Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants
errJOURNAL OF THE AMERICAN HEART ASSOCIATION
IF5.3
err2025-02-18
err1
errOAAI
errIyer, Kruthika R.; Clarke, Shoa L.; Guarischi-Sousa, Rodrigo; Gjoni, Ketrin; Heath, Adam S.; Young, Erica P.; Stitziel, Nathan O.; Laurie, Cecelia; Broome, Jai G.; Khan, Alyna T.; Lewis, Joshua P.; Xu, Huichun; Montasser, May E.; Ashley, Kellan E.; Hasbani, Natalie R.; Boerwinkle, Eric; Morrison, Alanna C.; Chami, Nathalie; Do, Ron; Rocheleau, Ghislain; Lloyd-Jones, Donald M.; Lemaitre, Rozenn N.; Bis, Joshua C.; Floyd, James S.; Kinney, Gregory L.; Bowden, Donald W.; Palmer, Nicholette D.; Benjamin, Emelia J.; Nayor, Matthew; Yanek, Lisa R.; Kral, Brian G.; Becker, Lewis C.; Kardia, Sharon L. R.; Smith, Jennifer A.; Bielak, Lawrence F.; Norwood, Arnita F.; Min, Yuan-I; Carson, April P.; Post, Wendy S.; Rich, Stephen S.; Herrington, David; Guo, Xiuqing; Taylor, Kent D.; Manson, JoAnn E.; Franceschini, Nora; Pollard, Katherine S.; Mitchell, Braxton D.; Loos, Ruth J. F.; Fornage, Myriam; Hou, Lifang; Psaty, Bruce M.; Young, Kendra A.; Regan, Elizabeth A.; Freedman, Barry I.; Vasan, Ramachandran S.; Levy, Daniel; Mathias, Rasika A.; Peyser, Patricia A.; Raffield, Laura M.; Kooperberg, Charles; Reiner, Alex P.; Rotter, Jerome I.; Jun, Goo; de Vries, Paul S.; Assimes, Themistocles L.
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Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans
errFRONTIERS IN ENDOCRINOLOGY
IF4.6
err2025-01-20
err0
errOAAI
errKho, Pik Fang; Stell, Laurel; Jimenez, Shirin; Zanetti, Daniela; Panyard, Daniel J.; Watson, Kathleen L.; Sarraju, Ashish; Chen, Ming-Li; Lind, Lars; Petrie, John R.; Chan, Khin N.; Fonda, Holly; Kent, Kyla; Myers, Jonathan N.; Palaniappan, Latha; Abbasi, Fahim; Assimes, Themistocles L.
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Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries
errNATURE GENETICS
IF31.8
err2024-12-02
err0
PREAI
errGorman, Bryan R.; Voloudakis, Georgios; Igo, Robert P., Jr.; Kinzy, Tyler; Halladay, Christopher W.; Bigdeli, Tim B.; Zeng, Biao; Venkatesh, Sanan; Bailey, Jessica N. Cooke; Crawford, Dana C.; Markianos, Kyriacos; Dong, Frederick; Schreiner, Patrick A.; Zhang, Wen; Hadi, Tamer; Anger, Matthew D.; Stockwell, Amy; Melles, Ronald B.; Yin, Jie; Choquet, Helene; Kaye, Rebecca; Patasova, Karina; Patel, Praveen J.; Yaspan, Brian L.; Jorgenson, Eric; Hysi, Pirro G.; Lotery, Andrew J.; Gaziano, J. Michael; Tsao, Philip S.; Fliesler, Steven J.; Sullivan, Jack M.; Greenberg, Paul B.; Wu, Wen-Chih; Assimes, Themistocles L.; Pyarajan, Saiju; Roussos, Panos; Peachey, Neal S.; Iyengar, Sudha K.
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Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study
errBRITISH JOURNAL OF CANCER
IF6.8
err2024-11-23
err0
errOAAI
errChan, Wing Ching; Liu, Lili; Bouras, Emmanouil; Zuber, Verena; Wen, Wanqing; Long, Jirong; Gill, Dipender; Murphy, Neil; Gunter, Marc J.; Assimes, Themistocles L.; Bujanda, Luis; Gruber, Stephen B.; Kury, Sebastien; Lynch, Brigid M.; Qu, Conghui; Thomas, Minta; White, Emily; Woods, Michael O.; Peters, Ulrike; Li, Christopher I.; Chan, Andrew T.; Brenner, Hermann; Tsilidis, Konstantinos K.; Zheng, Wei
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Integrating Multi-Omics, Phenotypic, and Social Determinants for Stroke Prediction in Atrial Fibrillation: Advancing Precision Health Using Machine Learning
errCIRCULATION
IF38.6
err2024-11-12
err0
PREAI
errAzizi, Zahra; Gupte, Trisha; Zhou, Jiayan; Kho, Pik Fang; Guarischi-Sousa, Rodrigo; Chen, Estella; Panyard, Daniel; Clarke, Shoa; Assimes, Themistocles
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Exome-wide association study of over a million individuals identified effector genes and variants for blood lipids
errCIRCULATION
IF38.6
err2024-11-12
err0
PREAI
errKoyama, Satoshi; Yu, Zhi; Choi, Seung Hoan; Jurgens, Sean; Selvaraj, Margaret; Klarin, Derek; Huffman, Jennifer; Trinh, Michael; Ravi, Akshaya; Dron, Jacqueline; Spinks, Catherine; Surakka, Ida; Hornsby, Whitney; Damrauer, Scott; Chang, Kyong-Mi; Assimes, Themistocles; Tsao, Philip; Rader, Daniel; Kim, Kelly; Peloso, Gina; Ellinor, Patrick; Sun, Yan; Wilson, Peter; Natarajan, Pradeep
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errSave
Variant-enhancer-gene mapping at the 9p21 locus in smooth muscle cells reveals new enhancer-gene pairs and mechanistic insights for coronary artery disease
errCIRCULATION
IF38.6
err2024-11-12
err0
PREAI
errRamste, Markus; Weldy, Chad; Zhao, Quanyi; Ranta, Amanda; Li, Daniel; Sharma, Disha; Monteiro, Joao; Worssam, Matthew; Amgalan, Dulguun; Qin, Guyu; Nguyen, Trieu; Kim, Juyong; Engreitz, Jesse; Assimes, Themistocles; Park, Chong; Quertermous, Thomas
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Association of Age at Diabetes Diagnosis and All-cause and Cardiovascular Mortality among 600,000 US Adults
errCIRCULATION
IF38.6
err2024-11-12
err0
PREAI
errThomson, Blake; Bragg, Fiona; Clarke, Shoa; Herrington, William; Assimes, Themistocles; Emberson, Jonathan; Geldsetzer, Pascal
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Research Directions

No research directions
Co-authors
Cooperation Journals
L
Luigi Ferrucci
H-index: 237 · Papers: 2.6K
C
Cyrus Cooper
H-index: 236 · Papers: 3.2K
D
Daniel Levy
H-index: 230 · Papers: 1.6K
M
Mark I. McCarthy
H-index: 222 · Papers: 1.5K
M
M Snyder
H-index: 210 · Papers: 3.3K
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