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Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study Chanchlani, Neil; Lin, Simeng; Bewshea, Claire; Hamilton, Benjamin; Thomas, Amanda; Smith, Rebecca; Roberts, Christopher; Bishara, Maria; Nice, Rachel; Lees, Charlie W.; Sebastian, Shaji; Irving, Peter M.; Russell, Richard K.; McDonald, Timothy J.; Goodhand, James R.; Ahmad, Tariq; Kennedy, Nicholas A. Share Save
A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial Noor, Nurulamin M.; Lee, James C.; Bond, Simon; Dowling, Francis; Brezina, Biljana; Patel, Kamal, V; Ahmad, Tariq; Banim, Paul J.; Berrill, James W.; Cooney, Rachel; Negro, Juan De La Revilla; de Silva, Shanika; Din, Shahida; Durai, Dharmaraj; Gordon, John N.; Irving, Peter M.; Johnson, Matthew; Kent, Alexandra J.; Kok, Klaartje B.; Moran, Gordon W.; Mowat, Craig; Patel, Pritash; Probert, Chris S.; Raine, Tim; Saich, Rebecca; Seward, Abigail; Sharpstone, Dan; Smith, Melissa A.; Subramanian, Sreedhar; Upponi, Sara S.; Wiles, Alan; Williams, Horace R. T.; van den Brink, Gijs R.; Vermeire, Severine; Jairath, Vipul; D'Haens, Geert R.; McKinney, Eoin F.; Lyons, Paul A.; Lindsay, James; Kennedy, Nicholas A.; Smith, Kenneth G. C.; Parkes, Miles Share Save
Antibody Responses to Influenza Vaccination are Diminished in Patients With Inflammatory Bowel Disease on Infliximab or Tofacitinib Liu, Zhigang; Alexander, James L.; Eng, Kai Yee; Ibraheim, Hajir; Anandabaskaran, Sulak; Saifuddin, Aamir; Constable, Laura; Seoane, Rocio Castro; Bewshea, Claire; Nice, Rachel; D'Mello, Andrea; Jones, Gareth R.; Balarajah, Sharmili; Fiorentino, Francesca; Sebastian, Shaji; Irving, Peter M.; Hicks, Lucy C.; Williams, Horace R. T.; Kent, Alexandra J.; Linger, Rachel; Parkes, Miles; Kok, Klaartje; Patel, Kamal, V; Teare, Julian P.; Altmann, Daniel M.; Boyton, Rosemary J.; Hart, Ailsa L.; Lees, Charlie W.; Goodhand, James R.; Kennedy, Nicholas A.; Pollock, Katrina M.; Ahmad, Tariq; Powell, Nick Share Save
Neutralising antibody responses against SARS-CoV-2 Omicron BA.4/5 and wild-type virus in patients with inflammatory bowel disease following three doses of COVID-19 vaccine (VIP): a prospective, multicentre, cohort study Liu, Zhigang; Alexander, James L.; Le, Kaixing; Zhou, Xin; Ibraheim, Hajir; Anandabaskaran, Sulak; Saifuddin, Aamir; Lin, Kathy Weitung; McFarlane, Leon R.; Constable, Laura; Seoane, Rocio Castro; Anand, Nikhil; Bewshea, Claire; Nice, Rachel; D'Mello, Andrea; Jones, Gareth R.; Balarajah, Sharmili; Fiorentino, Francesca; Sebastian, Shaji; Irving, Peter M.; Hicks, Lucy C.; Williams, Horace R. T.; Kent, Alexandra J.; Linger, Rachel; Parkes, Miles; Kok, Klaartje; Patel, Kamal V.; Teare, Julian P.; Altmann, Daniel M.; Boyton, Rosemary J.; Hart, Ailsa L.; Lees, Charlie W.; Goodhand, James R.; Kennedy, Nicholas A.; Pollock, Katrina M.; Ahmad, Tariq; Powell, Nick Share Save
Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease Patients Bai, Benjamin Y. H.; Reppell, Mark; Smaoui, Nizar; Waring, Jeffrey F.; Pivorunas, Valerie; Guay, Heath; Lin, Simeng; Chanchlani, Neil; Bewshea, Claire; Goodhand, James R.; Kennedy, Nicholas A.; Ahmad, Tariq; Anderson, Carl A. Share Save
Whole Blood DNA Methylation Changes Are Associated with Anti-TNF Drug Concentration in Patients with Crohn's Disease Lin, Simeng; Hannon, Eilis; Reppell, Mark; Waring, Jeffrey F.; Smaoui, Nizar; Pivorunas, Valerie; Guay, Heath; Chanchlani, Neil; Bewshea, Claire; Bai, Benjamin Y. H.; Kennedy, Nicholas A.; Goodhand, James R.; Mill, Jonathan; Ahmad, Tariq Share Save
Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis Yu, Natalie; Sriranganathan, Danujan; Walker, Gareth J.; Sazonovs, Aleksejs; Wilding, Helen; Roberts, Christopher; Kennedy, Nicholas A.; Ahmad, Tariq; Boyapati, Ray K.; Ding, Nik S.; Segal, Jonathan P. Share Save
Neutralising antibody potency against SARS-CoV-2 wild- type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study Liu, Zhigang; Le, Kaixing; Zhou, Xin; Alexander, James L.; Lin, Simeng; Bewshea, Claire; Chanchlani, Neil; Nice, Rachel; McDonald, Timothy J.; Lamb, Christopher A.; Sebastian, Shaji; Kok, Klaartje; Lees, Charlie W.; Hart, Ailsa L.; Pollok, Richard C.; Boyton, Rosemary J.; Altmann, Daniel M.; Pollock, Katrina M.; Goodhand, James R.; Kennedy, Nicholas A.; Ahmad, Tariq; Powell, Nick Share Save
The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients Alexander, James L.; Mullish, Benjamin H.; Danckert, Nathan P.; Liu, Zhigang; Olbei, Marton L.; Saifuddin, Aamir; Torkizadeh, Melissa; Ibraheim, Hajir; Blanco, Jesus Miguens; Roberts, Lauren A.; Bewshea, Claire M.; Nice, Rachel; Lin, Simeng; Prabhudev, Hemanth; Sands, Caroline; Horneffer-van der Sluis, Verena; Lewis, Matthew; Sebastian, Shaji; Lees, Charlie W.; Teare, Julian P.; Hart, Ailsa; Goodhand, James R.; Kennedy, Nicholas A.; Korcsmaros, Tamas; Marchesi, Julian R.; Ahmad, Tariq; Powell, Nick Share Save
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COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective, case-control study Alexander, James L.; Liu, Zhigang; Sandoval, Diana Munoz; Reynolds, Catherine; Ibraheim, Hajir; Anandabaskaran, Sulak; Saifuddin, Aamir; Seoane, Rocio Castro; Anand, Nikhil; Nice, Rachel; Bewshea, Claire; D'Mello, Andrea; Constable, Laura; Jones, Gareth R.; Balarajah, Sharmili; Fiorentino, Francesca; Sebastian, Shaji; Irving, Peter M.; Hicks, Lucy C.; Williams, Horace R. T.; Kent, Alexandra J.; Linger, Rachel; Parkes, Miles; Kok, Klaartje; Patel, Kamal V.; Teare, Julian P.; Altmann, Daniel M.; Goodhand, James R.; Hart, Ailsa L.; Lees, Charlie W.; Boyton, Rosemary J.; Kennedy, Nicholas A.; Ahmad, Tariq; Powell, Nick Share Save
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility Sazonovs, Aleksejs; Stevens, Christine R.; Venkataraman, Guhan R.; Yuan, Kai; Avila, Brandon; Abreu, Maria T.; Ahmad, Tariq; Allez, Matthieu; Ananthakrishnan, Ashwin N.; Atzmon, Gil; Baras, Aris; Barrett, Jeffrey C.; Barzilai, Nir; Beaugerie, Laurent; Beecham, Ashley; Bernstein, Charles N.; Bitton, Alain; Bokemeyer, Bernd; Chan, Andrew; Chung, Daniel; Cleynen, Isabelle; Cosnes, Jacques; Cutler, David J.; Daly, Allan; Damas, Oriana M.; Datta, Lisa W.; Dawany, Noor; Devoto, Marcella; Dodge, Sheila; Ellinghaus, Eva; Fachal, Laura; Farkkila, Martti; Faubion, William; Ferreira, Manuel; Franchimont, Denis; Gabriel, Stacey B.; Ge, Tian; Georges, Michel; Gettler, Kyle; Giri, Mamta; Glaser, Benjamin; Goerg, Siegfried; Goyette, Philippe; Graham, Daniel; Hamalainen, Eija; Haritunians, Talin; Heap, Graham A.; Hiltunen, Mikko; Hoeppner, Marc; Horowitz, Julie E.; Irving, Peter; Iyer, Vivek; Jalas, Chaim; Kelsen, Judith; Khalili, Hamed; Kirschner, Barbara S.; Kontula, Kimmo; Koskela, Jukka T.; Kugathasan, Subra; Kupcinskas, Juozas; Lamb, Christopher A.; Laudes, Matthias; Levesque, Chloe; Levine, Adam P.; Lewis, James D.; Liefferinckx, Claire; Loescher, Britt-Sabina; Louis, Edouard; Mansfield, John; May, Sandra; McCauley, Jacob L.; Mengesha, Emebet; Mni, Myriam; Moayyedi, Paul; Moran, Christopher J.; Newberry, Rodney D.; O'Charoen, Sirimon; Okou, David T.; Oldenburg, Bas; Ostrer, Harry; Palotie, Aarno; Paquette, Jean; Pekow, Joel; Peter, Inga; Pierik, Marieke J.; Ponsioen, Cyriel Y.; Pontikos, Nikolas; Prescott, Natalie; Pulver, Ann E.; Rahmouni, Souad; Rice, Daniel L.; Saavalainen, Paivi; Sands, Bruce; Sartor, R. Balfour; Schiff, Elena R.; Schreiber, Stefan; Schumm, L. Philip; Segal, Anthony W.; Seksik, Philippe; Shawky, Rasha; Sheikh, Shehzad Z.; Silverberg, Mark S.; Simmons, Alison; Skeiceviciene, Jurgita; Sokol, Harry; Solomonson, Matthew; Somineni, Hari; Sun, Dylan; Targan, Stephan; Turner, Dan; Uhlig, Holm H.; van der Meulen, Andrea E.; Vermeire, Severine; Verstockt, Sare; Voskuil, Michiel D.; Winter, Harland S.; Young, Justine; Duerr, Richard H.; Franke, Andre; Brant, Steven R.; Cho, Judy; Weersma, Rinse K.; Parkes, Miles; Xavier, Ramnik J.; Rivas, Manuel A.; Rioux, John D.; McGovern, Dermot P. B.; Huang, Hailiang; Anderson, Carl A.; Daly, Mark J. Share Save
Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease: Results from the IMmunogenicity to Second Anti-TNF therapy (IMSAT) therapeutic drug monitoring study Chanchlani, Neil; Lin, Simeng; Auth, Marcus K.; Lee, Chai Leng; Robbins, Helena; Looi, Shi; Murugesan, Senthil, V; Riley, Tom; Preston, Cathryn; Stephenson, Sophie; Cardozo, Wendy; Sonwalkar, Sunil A.; Allah-Ditta, Mohammed; Mansfield, Lynne; Durai, Dharmaraj; Baker, Mark; London, Ian; London, Emily; Gupta, Sanjay; Di Mambro, Alex; Murphy, Aisling; Gaynor, Edward; Jones, Kelsey D. J.; Claridge, Andrew; Sebastian, Shaji; Ramachandran, Sankaranarayanan; Selinger, Christian P.; Borg-Bartolo, Simon P.; Knight, Paul; Sprakes, Michael B.; Burton, Julie; Kane, Patricia; Lupton, Stephanie; Fletcher, Aimee; Gaya, Daniel R.; Colbert, Roghan; Seenan, John Paul; MacDonald, Jonathan; Lynch, Lucy; McLachlan, Iain; Shields, Stephanie; Hansen, Richard; Gervais, Lisa; Jere, Mwansa; Akhtar, Muhammad; Black, Karen; Henderson, Paul; Russell, Richard K.; Lees, Charlie W.; Derikx, Lauranne A. A. P.; Lockett, Melanie; Betteridge, Frederica; De Silva, Aminda; Hussenbux, Arif; Beckly, John; Bendall, Oliver; Hart, James W.; Thomas, Amanda; Hamilton, Ben; Gordon, Claire; Chee, Desmond; McDonald, Timothy J.; Nice, Rachel; Parkinson, Marian; Gardner-Thorpe, Helen; Butterworth, Jeff R.; Javed, Asima; Al-Shakhshir, Sarah; Yadagiri, Rekha; Maher, Sebrene; Pollok, Richard C. G.; Ng, Tze; Appiahene, Priscilla; Donovan, Fiona; Lok, James; Chandy, Rajiv; Jagdish, Reema; Baig, Daniyal; Mahmood, Zahid; Marsh, Liane; Moss, Allison; Abdulgader, Amin; Kitchin, Angus; Walker, Gareth J.; George, Becky; Lim, Yuen-Hui; Gulliver, James; Bloom, Stuart; Theaker, Holly; Carlson, Sean; Cummings, J. R. Fraser; Livingstone, Robert; Beale, Amanda; Carter, Josiah O.; Bell, Andrew; Coulter, Archibald; Snook, Jonathon; Stone, Helen; Kennedy, Nicholas A.; Goodhand, James R.; Ahmad, Tariq Share Save
Understanding anti-TNF treatment failure: Does serum triiodothyronine-to-thyroxine (T3/T4) ratio predict therapeutic outcome to anti-TNF therapies in biologic-naive patients with active luminal Crohn's disease? Lin, Simeng; Chanchlani, Neil; Carbery, Isabel; Janjua, Malik; Nice, Rachel; McDonald, Timothy J.; Bewshea, Claire; Kennedy, Nicholas A.; Ahmad, Tariq; Selinger, Christian P.; Goodhand, James R. Share Save
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