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Defective Notch1 signaling in endothelial cells drives pathogenesis in a mouse model of Adams-Oliver Solano, Alyssa F.; Preusse, Kristina; Cain, Brittany; Hotz, Rebecca; Gavini, Parthav; Yuan, Zhenyu; Bowen, Benjamin; Maco, Gabrielle; Neal, Hope; Gagliani, Ellen K.; Ahn, Christopher; Lim, Hee-Woong; Southgate, Laura; Kovall, Rhett A.; Kopan, Raphael; Gebelein, Brian Share Save
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Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration Swaminathan, Bhairavi; Youn, Seock-Won; Naiche, L. A.; Du, Jing; Villa, Stephanie R.; Metz, Jordan B.; Feng, Huijuan; Zhang, Chaolin; Kopan, Raphael; Sims, Peter A.; Kitajewski, Jan K. Share Save
TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk Murrison, Liza Bronner; Ren, Xiaomeng; Preusse, Kristina; He, Hua; Kroner, John; Chen, Xiaoting; Jenkins, Seth; Johansson, Elisabet; Biagini, Jocelyn M.; Weirauch, Matthew T.; Kopan, Raphael; Martin, Lisa J.; Hershey, Gurjit K. Khurana Share Save
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Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor Kuang, Yi; Pyo, Anna; Eafergan, Natanel; Cain, Brittany; Gutzwiller, Lisa M.; Axelrod, Ofri; Gagliani, Ellen K.; Weirauch, Matthew T.; Kopan, Raphael; Kovall, Rhett A.; Sprinzak, David; Gebelein, Brian Share Save
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Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis Mukherjeel, Malini; Ratnayake, Ishara; Janga, Madhusudhana; Fogarty, Eric; Scheidt, Shania; Grassmeyer, Justin; DeRiso, Jennifer; Chandrasekar, Indra; Ahrenkiel, S. Phil; Kopan, Raphael; Surendran, Kameswaran Share Save
Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism Yi Kuang; Golan, Ohad; Preusse, Kristina; Cain, Brittany; Christensen, Collin J.; Salomone, Joseph; Campbell, Ian; Okwubido-Williams, FearGod, V; Hass, Matthew R.; Yuan, Zhenyu; Eafergan, Nathanel; Moberg, Kenneth H.; Kovall, Rhett A.; Kopan, Raphael; Sprinzak, David; Gebelein, Brian Share Save
Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors Seymour, Philip Allan; Collin, Caitlin Alexis; Egeskov-Madsen, Anuska la Rosa; Jorgensen, Mette Christine; Shimojo, Hiromi; Imayoshi, Itaru; de Lichtenberg, Kristian Honnens; Kopan, Raphael; Kageyama, Ryoichiro; Serup, Palle Share Save
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Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number Combes, Alexander N.; Wilson, Sean; Phipson, Belinda; Binnie, Brandon B.; Ju, Adler; Lawlor, Kynan T.; Cebrian, Cristina; Walton, Sarah L.; Smyth, Ian M.; Moritz, Karen M.; Kopan, Raphael; Oshlack, Alicia; Little, Melissa H. Share Save
Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling Farber, Gregory; Hurtado, Romulo; Loh, Sarah; Monette, Sebastien; Mtui, James; Kopan, Raphael; Quaggin, Susan; Meyer-Schwesinger, Catherine; Herzlinger, Doris; Scott, Rizaldy P.; Blobel, Carl P. Share Save
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