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D

David Komander

Walter and Eliza Hall Institute of Medical Research

77H-index
251Paper Count
3.1WCitation Count
Published Papers 109
Publication Date
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ZnF-UBP domains regulate deubiquitinase activity by relieving ubiquitin product inhibition
errNature Communications
IF15.7
err2026-07-17
err0
errOAAI
errJack A. Alexandrovics; Rashmi Agrata; Jan André Hane; Philipp Schenk; Anthony Cerra; Ueli Nachbur; Malte Gersch; Jeffrey J. Babon; David Komander
errShare
errSave
Ubiquitination of glycogen and metabolites in cells and tissues
errNature
IF48.5
err2026-04-22
err0
PREAI
errMarco Jochem; Simon A. Cobbold; Craig A. Goodman; Catharina Kueng; Anthony Cerra; Laura F. Fielden; Man Lyang Kim; Philipp Schenk; Ria Agarwal; Xiangyi S. Wang; Simon R. Scutts; Michael Pandos; Lin Tang; Thomas Hermanns; Shane M. Devine; Martin Brzozowski; Yuri Shibata; Niall D. Geoghegan; Catriona A. McLean; Bernhard C. Lechtenberg; Kay Hofmann; Paul Gregorevic; David Komander
errShare
errSave
GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum
errNature Communications
IF15.7
err2026-04-15
err0
errOAAI
errDanushka S. Marapana; Sash Lopaticki; Balu Balan; Kitsanapong Reaksudsan; Simon A. Cobbold; Niall D. Geoghegan; Sachin Khurana; Stephen W. Scally; Peter Hickey; Niva Jayakrishnan; Vineet Vaibhav; Sukhdeep Spall; Jumana M. Yousef; Laura F. Dagley; Christopher D. Goodman; Anton Cozijnsen; Geoffrey I. McFadden; Kelly L. Rogers; Aaron Jex; David Komander; James S. McCarthy; Christopher J. Tonkin; Matthew W. A. Dixon; Alan F. Cowman
errShare
errSave
USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-11-17
err0
errOAAI
errKumari, Nishi; Wright, Sarah C. E.; Witham, Christopher M.; Monserrat, Laia; Palafox, Marta; Richard, John L. C.; Costa, Carlotta; Elkabets, Moshe; Agostino, Mark; Klemm, Theresa; Eccles, Melissa; Garnham, Alex; Wu, Ting; Nilsson, Jonas A.; Walz, Nikita; Venugopal, Veena; Cerra, Anthony; Vasilevski, Natali; Bridgeman, Stephanie; Bassi, Sona; Saei, Azad; Helal, Moutaz; Neundorf, Philipp; Riedel, Angela; Rosenfeldt, Mathias; Gill, Jespal; Pahor, Nikolett; Hartmann, Oliver; Chung, Jacky; Sidhu, Sachdev S.; Moderau, Nina; Jha, Sudhakar; Rodon, Jordi; Diefenbacher, Markus E.; Komander, David; Serra, Violeta; Eichhorn, Pieter Johan Adam
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errSave
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro
errLIFE SCIENCE ALLIANCE
IF2.9
err2025-04-01
err0
errOAAI
errWang, Xiangyi S.; Jiou, Jenny; Cerra, Anthony; Cobbold, Simon A.; Jochem, Marco; Mak, Ka Hin Toby; Corcilius, Leo; Silke, John; Payne, Richard J.; Goddard-Borger, Ethan D.; Komander, David; Lechtenberg, Bernhard C.
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errSave
Reassessing kinetin's effect on PINK1 and mitophagy
errAUTOPHAGY
IF14.3
err2024-09-29
err0
PREAI
errGan, Zhong Yan; Komander, David; Callegari, Sylvie
errShare
errSave
Secondary interactions in ubiquitin-binding domains achieve linkage or substrate specificity
errCELL REPORTS
IF6.9
err2024-08-01
err0
PREAI
errMichel, Martin A.; Scutts, Simon; Komander, David
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errSave
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape
errNATURE COMMUNICATIONS
IF15.7
err2024-07-23
err1
errOAAI
errWu, Xinyu; Go, Margareta; Nguyen, Julie V.; Kuchel, Nathan W.; Lu, Bernadine G. C.; Zeglinski, Kathleen; Lowes, Kym N.; Calleja, Dale J.; Mitchell, Jeffrey P.; Lessene, Guillaume; Komander, David; Call, Matthew E.; Call, Melissa J.
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errSave
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4
errEMBO REPORTS
IF6.2
err2024-07-11
err2
errOAAI
errNguyen-Dien, Giang Thanh; Townsend, Brendan; Kulkarni, Prajakta Gosavi; Kozul, Keri-Lyn; Ooi, Soo Siang; Eldershaw, Denaye N.; Weeratunga, Saroja; Liu, Meihan; Jones, Mathew J. K.; Millard, S. Sean; Ng, Dominic C. H.; Pagano, Michele; Bonfim-Melo, Alexis; Schneider, Tobias; Komander, David; Lazarou, Michael; Collins, Brett M.; Pagan, Julia K.
errShare
errSave
Just how big is the ubiquitin system?
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-02-12
err3
PREAI
errLechtenberg, Bernhard C.; Komander, David
errShare
errSave
Interaction of PINK1 with nucleotides and kinetin
errSCIENCE ADVANCES
IF12.5
err2024-01-19
err2
errOAAI
errGan, Zhong Yan; Callegari, Sylvie; Nguyen, Thanh N.; Kirk, Nicholas S.; Leis, Andrew; Lazarou, Michael; Dewson, Grant; Komander, David
errShare
errSave
Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth
errELIFE
IF0
err2023-12-15
err0
errOAAI
errFrank, Daniel; Bergamasco, Maria; Mlodzianoski, Michael J.; Kueh, Andrew; Tsui, Ellen; Hall, Cathrine; Kastrappis, Georgios; Voss, Anne Kathrin; McLean, Catriona; Faux, Maree; Rogers, Kelly L.; Tran, Bang; Vincan, Elizabeth; Komander, David; Dewson, Grant; Tran, Hoanh
errShare
errSave
Deubiquitinases in cancer
errNATURE REVIEWS CANCER
IF66.8
err2023-11-07
err65
PREAI
errDewson, Grant; Eichhorn, Pieter J. A.; Komander, David
errShare
errSave
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err126
errOAAI
errBayascas, Jose R.; Wullschleger, Stephan; Sakamoto, Kei; Garcia-Martinez, Juan M.; Clacher, Carol; Komander, David; van Aalten, Daan M. F.; Boini, Krishna M.; Lan, Florian; Lipina, Christopher; Logie, Lisa; Sutherland, Calum; Chudek, John A.; van Diepen, Janna A.; Voshol, Peter J.; Lucocq, John M.; Alessi, Dario R.
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errSave
Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes
errNATURE COMMUNICATIONS
IF15.7
err2023-03-25
err7
errOAAI
errvan Tol, Bianca D. M.; van Doodewaerd, Bjorn R.; Lageveen-Kammeijer, Guinevere S. M.; Jansen, Bas C.; Talavera Ormeno, Cami M. P.; Hekking, Paul J. M.; Sapmaz, Aysegul; Kim, Robbert Q.; Moutsiopoulou, Angeliki; Komander, David; Wuhrer, Manfred; van der Heden van Noort, Gerbrand J.; Ovaa, Huib; Geurink, Paul P.
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errSave
Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii
errLIFE SCIENCE ALLIANCE
IF2.9
err2023-03-23
err7
errOAAI
errWilde, Mary-Louise; Ruparel, Ushma; Klemm, Theresa; Lee, V. Vern; Calleja, Dale J.; Komander, David; Tonkin, Christopher J.
errShare
errSave
LUBAC
errCURRENT BIOLOGY
IF7.5
err2022-06-01
err7
errOAAI
errShibata, Yuri; Komander, David
errShare
errSave
Inhibitors of SARS-CoV-2 PLpro
errFRONTIERS IN CHEMISTRY
IF4.2
err2022-04-26
err57
errOAAI
errCalleja, Dale J.; Lessene, Guillaume; Komander, David
errShare
errSave
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
errFRONTIERS IN CHEMISTRY
IF4.2
err2022-04-12
err22
errOAAI
errCalleja, Dale J.; Kuchel, Nathan; Lu, Bernadine G. C.; Birkinshaw, Richard W.; Klemm, Theresa; Doerflinger, Marcel; Cooney, James P.; Mackiewicz, Liana; Au, Amanda E.; Yap, Yu Q.; Blackmore, Timothy R.; Katneni, Kasiram; Crighton, Elly; Newman, Janet; Jarman, Kate E.; Call, Melissa J.; Lechtenberg, Bernhard C.; Czabotar, Peter E.; Pellegrini, Marc; Charman, Susan A.; Lowes, Kym N.; Mitchell, Jeffrey P.; Nachbur, Ueli; Lessene, Guillaume; Komander, David
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errSave
Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis
errEMBO JOURNAL
IF8.3
err2021-10-26
err48
errOAAI
errLiu, Zikou; Dagley, Laura F.; Shield-Artin, Kristy; Young, Samuel N.; Bankovacki, Aleksandra; Wang, Xiangyi; Tang, Michelle; Howitt, Jason; Stafford, Che A.; Nachbur, Ueli; Fitzgibbon, Cheree; Garnish, Sarah E.; Webb, Andrew, I; Komander, David; Murphy, James M.; Hildebrand, Joanne M.; Silke, John
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Philip Cohen
H-index: 156 · Papers: 581
P
Peter Vandenabeele
H-index: 154 · Papers: 669
J
J. Wade Harper
H-index: 141 · Papers: 461
D
Dario R. Alessi
H-index: 141 · Papers: 541
D
D. Grahame Hardie
H-index: 140 · Papers: 643
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