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Timothy P. Hughes

South Australian Health and Medical Research Institute

94H-index
803Paper Count
5.6WCitation Count
Published Papers 160
Publication Date
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Programmable and selective silencing of oncogenic fusion transcripts by CRISPR-Cas13b via breakpoint sequence recognition
errScience Advances
IF12.5
err2026-10-16
err0
errOAAI
errWenxin Hu (胡文欣); Honglin Chen (陈竑霖); Steven He; Joshua M. L. Casan; Carolyn Shembrey; Sharon Li; Lauren M. Brown; Andrea Zhao; Lynda Truong; Isabella Buchner; Dane Vassiliadis; Timothy P. Hughes; Deborah L. White; Catherine L. Carmichael; Antoine De Weck; Ilia Voskoboinik; Quentin Gouil; Joseph A. Trapani; Paul G. Ekert; Teresa Sadras; Mohamed Fareh
errShare
errSave
Mitochondrial DNA mutations are associated with impaired oxidative phosphorylation and enhanced imatinib response in chronic myeloid leukemia
errHemaSphere
IF14.6
err2026-09-08
err0
errOAAI
errIlaria S. Pagani; Vaidehi Krishnan; John F. Ouyang; Chung H. Kok; BeiJun Chen; Kian Leong Lee; Cong M. Pham; Paul Wang; Elyse Page; Phuong Dang; Verity A. Saunders; Jane James; Kelly Lim; Stefano Mangiola; Yingnan Gao; Naranie Shanmuganathan; Agnes Yong; Susan Branford; Charles Chuah; David T. Yeung; Deborah L. White; Vignir G. Helgason; Daniel Thomas; S. Tiong Ong; Timothy P. Hughes; David M. Ross
errShare
errSave
Asciminib monotherapy in patients with BCR::ABL1 T315I-mutated chronic-phase chronic myeloid leukemia: phase 1 trial final results
errLeukemia
IF13.4
err2026-07-16
err0
errOAAI
errJorge E. Cortes; Delphine Rea; Michael J. Mauro; Andreas Hochhaus; Dong-Wook Kim; Koji Sasaki; Fabian Lang; Michael C. Heinrich; Massimo Breccia; Michael Deininger; Yeow-Tee Goh; Jeroen J. W. M. Janssen; Moshe Talpaz; Valle Gómez García de Soria; Philipp le Coutre; Francois-Xavier Mahon; Daniel J. DeAngelo; Andrea Damon; Shruti Kapoor; Gessami Sanchez-Olle; Matthias Hoch; Nithya Agrawal; Sara Quenet; Timothy P. Hughes
errShare
errSave
The partner gene modulates response to asciminib in ABL1-rearranged Acute Lymphoblastic Leukemia
errNeoplasia
IF7.7
err2026-07-01
err0
PREAI
errEadie, Laura N.; McDougal, Daniel P.; Lagonik, Elias; Schutz, Caitlin E.; Page, Elyse C.; Conlin, Tace S.; Rehn, Jacqueline; Bruning, John B.; Moore, Andrew S.; Yeung, David T.; Hughes, Timothy P.; White, Deborah L.
errShare
errSave
Direct measurement of in vivo BCR::ABL1 kinase inhibition reveals stronger potency of asciminib as compared with imatinib and nilotinib
errLeukemia
IF13.4
err2026-06-11
err0
errOAAI
errChung Hoow Kok; Naranie Shanmuganathan; Verity A. Saunders; Phuong Dang; Deborah White; Susan Branford; David Yeung; Timothy P. Hughes
errShare
errSave
From fatal disease to functional cure: 25 years of tyrosine kinase inhibition in chronic myeloid leukemia
errLeukemia
IF13.4
err2026-05-22
err0
errOAAI
errAndreas Hochhaus; Moshe Talpaz; Giuseppe Saglio; Jorge E. Cortes; Timothy Hughes; Jane Apperley; Oliver Hantschel; Delphine Rea; Peter Schuld; Hagop Kantarjian
errShare
errSave
Allosteric and ATP-Pocket BCR::ABL1 Inhibition In Vitro, and Characterising Ex Vivo Thrombo-Inflammatory Biomarkers and Thrombin Generation in Asciminib-Treated CML Patients
errInternational Journal of Molecular Sciences
IF4.9
err2026-04-18
err0
errOAAI
errMusab M. A. Omar; Majed A. Alanazi; David T. Yeung; Timothy P. Hughes; Denise E. Jackson
errShare
errSave
Asciminib Demonstrates Superior Efficacy and Safety in Newly Diagnosed Chronic Myeloid Leukemia in ASC4FIRST
errBlood
IF23.1
err2025-12-17
err0
errOAAI
errJorge E. Cortes; Timothy P. Hughes; Jianxiang Wang; Dong-Wook Kim; Dennis Dong Hwan Kim; Jiri Mayer; Yeow-Tee Goh; Philipp le Coutre; Gabriel Etienne; Inho Kim; David J. Andorsky; Felice Bombaci; Ghayas C. Issa; Naoto Takahashi; Shruti Kapoor; Rajendra Jinwal; Kamel Malek; Tracey McCulloch; Lillian Yau; Richard A. Larson
errShare
errSave
Enhanced detection of splice altering variants in hematologic malignancies using targeted RNA-seq data
errThe Journal of Molecular Diagnostics
IF0
err2025-10-10
err0
PREAI
errMuneeza Maqsood; John Toubia; Carol Wadham; Naranie Shanmuganathan; Nur Hezrin Shahrin; Adelina Fernandes; Joe McConnell; Verity Saunders; Dominik Kaczorowski; Rosalie R. Kenyon; Ming Lin; Timothy P. Hughes; Chung Hoow Kok; Susan Branford
errShare
errSave
Asciminib for Philadelphia chromosome-positive leukemias
errHAEMATOLOGICA
IF7.9
err2025-10-01
err0
errOAAI
errHughes, Timothy P.; White, Deborah L.; Yeung, David T.
errShare
errSave
Lipid Storage and Therapy Resistance in Chronic Myeloid Leukaemia: A Novel Perspective on Targeting Metabolic Vulnerabilities
errCancers 2025, Vol. 17, Page 3033
IF0
err2025-09-23
err0
errOAAI
errMolly Tolland; David M. Ross; Deborah White; Timothy P. Hughes; Ilaria S. Pagani
errShare
errSave
Impact of ASXL1 at diagnosis in CML patients receiving frontline potent TKIs: high risk of kinase domain mutations
errBlood
IF23.1
err2025-09-04
err0
PREAI
errNaranie Shanmuganathan; David T. Yeung; Carol Wadham; Adelina Fernandes; Muneeza Maqsood; NurHezrin Shahrin; Verity Saunders; Rosalie R. Kenyon; Ming Lin; John Toubia; Joe McConnell; Dominic Kaczorowski; David M. Ross; Agnes S. M. Yong; Lynette Chee; Jake Shortt; Nicholas Viiala; Jodi Braley; Chung Hoow Kok; Timothy P. Hughes
errShare
errSave
2025 European LeukemiaNet recommendations for the management of chronic myeloid leukemia
errLeukemia
IF13.4
err2025-07-11
err0
errOAAI
errJane F. Apperley; Dragana Milojkovic; Nicholas C. P. Cross; Henrik Hjorth-Hansen; Andreas Hochhaus; Hagop Kantarjian; Jeffrey H. Lipton; Hemant Malhotra; Dietger Niederwieser; Jerald Radich; Philippe Rousselot; Susanne Saussele; Charles A. Schiffer; Richard Silver; Simona Soverini; Leif Stenke; Anna Turkina; Luis Felipe Casado; Fausto Castagnetti; Francisco Cervantes; Richard E. Clark; Jorge Cortes; Michael Deininger; Timothy P. Hughes; Jeroen Janssen; Qian Jiang; Dong-Wook Kim; Richard A. Larson; Francois X. Mahon; Michael Mauro; Jiri Mayer; Franck E. Nicolini; Fabrizio Pane; Delphine Rea; Johan Richter; Gianantonio Rosti; Giuseppe Saglio; Rüdiger Hehlmann
errShare
errSave
Asciminib remained superior vs bosutinib in late-line CML-CP after nearly 4 years of follow-up in ASCEMBL
errBlood Advances
IF7.1
err2025-05-09
err0
errOAAI
errMichael J. Mauro; Yosuke Minami; Andreas Hochhaus; Elza Lomaia; Sergey Voloshin; Anna Turkina; Dong-Wook Kim; Jane F. Apperley; Jorge E. Cortes; Andre Abdo; Laura Maria Fogliatto; Dennis Dong Hwan Kim; Philipp le Coutre; Susanne Saussele; Mario Annunziata; Timothy P. Hughes; Naeem Chaudhri; Lynette Chee; Valentin García-Gutiérrez; Koji Sasaki; Carla Boquimpani; Shruti Kapoor; Noemi Espurz; Vishal Dhamal; Delphine Rea
errShare
errSave
The evolution of treatment-free remission
errBLOOD
IF23.1
err2025-02-27
err0
PREAI
errHughes, Timothy P.; Yong, Agnes S. M.; Ross, David M.
errShare
errSave
Asciminib add-on to imatinib demonstrates sustained high rates of ongoing therapy and deep molecular responses with prolonged follow-up in the ASC4MORE study
errJOURNAL OF HEMATOLOGY & ONCOLOGY
IF40.4
err2024-12-18
err0
errOAAI
errHughes, Timothy P.; Saglio, Giuseppe; Geissler, Jan; Kim, Dong-Wook; Lomaia, Elza; Mayer, Jiri; Turkina, Anna; Kapoor, Shruti; Cardoso, Ana Paula; Nieman, Becki; Quenet, Sara; Cortes, Jorge E.
errShare
errSave
CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errLim, Kelly; Kutyna, Monika; Kan, Winnie; Lopez, Angel F.; Brown, Anna; Yong, Agnes S. M.; Lane, Steven W.; Fong, Chun Yew; Hughes, Timothy P.; Yeung, David T.; Ross, David M.; Hiwase, Devendra; Thomas, Daniel
errShare
errSave
Imatinib-Sensitive Chronic Myeloid Leukaemia Is Associated with mtDNA Mutations and Reduced Oxphos Capacity
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errPagani, Ilaria Stefania; Krishnan, Vaidehi; Ouyang, John; Kok, Chung How; Chen, Beijun; Page, Elyse C.; Dang, Phuong; Saunders, Verity A.; James, Jane; Lim, Kelly; Shanmuganathan, Naranie; Branford, Susan; Chuah, Charles; Yeung, David T.; Thomas, Daniel; Hughes, Timothy P.; Ong, Sin Tiong; Ross, David M.
errShare
errSave
Asciminib monotherapy in patients with chronic-phase chronic myeloid leukemia with the T315I mutation after ≥1 prior tyrosine kinase inhibitor: 2-year follow-up results
errLEUKEMIA
IF13.4
err2024-05-16
err8
errOAAI
errCortes, Jorge E.; Sasaki, Koji; Kim, Dong-Wook; Hughes, Timothy P.; Etienne, Gabriel; Mauro, Michael J.; Hochhaus, Andreas; Lang, Fabian; Heinrich, Michael C.; Breccia, Massimo; Deininger, Michael; Goh, Yeow Tee; Janssen, Jeroen J. W. M.; Talpaz, Moshe; de Soria, Valle Gomez Garcia; le Coutre, Philipp; Deangelo, Daniel J.; Damon, Andrea; Cacciatore, Silvia; Polydoros, Fotis; Agrawal, Nithya; Rea, Delphine
errShare
errSave
Are there new relevant therapeutic endpoints in the modern era of the BCR::ABL1 tyrosine kinase inhibitors in chronic myeloid leukemia?
errLEUKEMIA
IF13.4
err2024-03-26
err5
PREAI
errKantarjian, Hagop; Branford, Susan; Breccia, Massimo; Cortes, Jorge; Haddad, Fadi G.; Hochhaus, Andreas; Hughes, Timothy; Issa, Ghayas C.; Jabbour, Elias; Nicolini, Franck E.; Sasaki, Koji; Xavier-Mahon, Francois
errShare
errSave

Research Directions

The data has not been retrieved yet.
Co-authors
Cooperation Journals
H
Hagop M. Kantarjian
H-index: 230 · Papers: 5.5K
M
Matthew Meyerson
H-index: 223 · Papers: 1.9K
E
Elaine R. Mardis
H-index: 197 · Papers: 1.7K
J
Jörge E. Cortes
H-index: 179 · Papers: 3.6K
T
Todd R. Golub
H-index: 176 · Papers: 749
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