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P

Patrick Seale

University of Pennsylvania

65H-index
172Paper Count
2.9WCitation Count
Published Papers 68
Publication Date
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TRF2 couples muscle stem cell identity to regenerative repair
errScience Advances
IF12.5
err2026-07-31
err0
errOAAI
errJi-Hyung Lee; Kiran Kumar Nakka; Ryan P. Calhoun; Sarah Hachmer; Adity Gupta; Eric Arreza; Lynn A. Megeney; Patrick Seale; Roger A. Greenberg; F. Jeffrey Dilworth; Foteini Mourkioti
errShare
errSave
ILC2s regulate a fibroblast progenitor niche in the pancreas
errScience
IF45.8
err2026-07-02
err0
PREAI
errThomas Yip; Julie Stockis; Charlotte Simpson; Erika E. McCartney; Shwetha Raghunathan; Martha M. Rangel-Sosa; Sydney N. Hummel; Julia Moreno-Vicente; Gianmarco Raddi; Celine Garcia; Rugile Linkute; Silvain Pinaud; Maye F. Cheng; Lesley A. Hill; T. Michael Underhill; Hans-Reimer Rodewald; Christoph Schneider; Claus Jørgensen; Andrew N.J. McKenzie; Sophie E. Acton; Patrick Seale; Menna R. Clatworthy; Matthew B. Buechler; Timotheus Y. F. Halim
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errSave
Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variant
errMolecular Metabolism
IF6.6
err2026-06-18
err0
errOAAI
errDominic Santoleri; Sarah Traynor; Ryan Calhoun; Matthew J. Gavin; David Merrick; Patrick Seale; Paul M. Titchenell
errShare
errSave
The Innate Thermogenic Capacity of Brown Adipose Tissue Develops Independently of Sympathetic Signaling
errMolecular Metabolism
IF6.6
err2025-12-09
err0
errOAAI
errEthan C. Fein; Sarmistha Mukherjee; Joseph A. Baur; Patrick Seale
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errSave
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility
errGenome Biology
IF9.4
err2025-12-08
err0
errOAAI
errKhanh B. Trang; Prabhat Sharma; Laura Cook; Zachary Mount; Rajan M. Thomas; Nikhil N. Kulkarni; Emylette Cruz Cabrera; Suzanna Rachimi; Matthew C. Pahl; James A. Pippin; Chun Su; Klaus H. Kaestner; Joan M. O’Brien; Yadav Wagley; Kurt D. Hankenson; Ashley Jermusyk; Jason W. Hoskins; Laufey T. Amundadottir; Mai Xu; Kevin M. Brown; Stewart A. Anderson; Wenli Yang; Paul M. Titchenell; Patrick Seale; Babette S. Zemel; Alessandra Chesi; Neil Romberg; Megan K. Levings; Struan F. A. Grant; Andrew D. Wells
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errSave
The Transcription Factor CUX1 Exerts Opposing Roles in Human and Mouse Adipocyte Differentiation
errMolecular Metabolism
IF6.6
err2025-11-27
err0
errOAAI
errYang Chen; Lin Liu; Ryan Calhoun; Lan Cheng; David Steger; Patrick Seale
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errSave
PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition
errNature Cardiovascular Research
IF10.8
err2025-10-17
err0
errOAAI
errJosephine M. E. Tan; Lan Cheng; Ryan P. Calhoun; Angela H. Weller; Karima Drareni; Skylar Fong; Eirlys Barbara; Hee-Woong Lim; Chenyi Xue; Hanna Winter; Gaëlle Auguste; Clint L. Miller; Muredach P. Reilly; Lars Maegdefessel; Esther Lutgens; Patrick Seale
errShare
errSave
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
errELIFE
IF0
err2025-01-15
err0
errOAAI
errTrang, Khanh B.; Pahl, Matthew C.; Pippin, James A.; Su, Chun; Littleton, Sheridan H.; Sharma, Prabhat; Kulkarni, Nikhil N.; Ghanem, Louis R.; Terry, Natalie A.; O'Brien, Joan M.; Wagley, Yadav; Hankenson, Kurt D.; Jermusyk, Ashley; Hoskins, Jason; Amundadottir, Laufey T.; Xu, Mai; Brown, Kevin; Anderson, Stewart; Yang, Wenli; Titchenell, Paul; Seale, Patrick; Kaestner, Klaus H.; Cook, Laura; Levings, Megan; Zemel, Babette S.; Chesi, Alessandra; Wells, Andrew D.; Grant, Struan F. A.
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errSave
The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis
errNPJ AGING
IF6
err2024-07-15
err8
errOAAI
errWang, Magnolia G.; Seale, Patrick; Furman, David
errShare
errSave
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
errELIFE
IF0
err2024-05-22
err6
errOAAI
errHolman, Corey D.; Sakers, Alexander P.; Calhoun, Ryan P.; Cheng, Lan; Fein, Ethan C.; Jacobs, Christopher; Tsai, Linus; Rosen, Evan D.; Seale, Patrick
errShare
errSave
Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism
errMOLECULAR METABOLISM
IF6.6
err2024-02-01
err19
errOAAI
errNunn, Elizabeth; Jaiswal, Natasha; Gavin, Matthew; Uehara, Kahealani; Stefkovich, Megan; Drareni, Karima; Calhoun, Ryan; Lee, Michelle; Holman, Corey D.; Baur, Joseph A.; Seale, Patrick; Titchenell, Paul M.
errShare
errSave
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2024-01-24
err16
PREAI
errTang, Su'an; Yao, Lutian; Ruan, Jianzhao; Kang, Jingliang; Cao, Yumei; Nie, Xiaoyu; Lan, Weiren; Zhu, Zhaohua; Han, Weiyu; Liu, Yongguang; Tian, Jing; Seale, Patrick; Qin, Ling; Ding, Changhai
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errSave
Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis
errJOURNAL OF BONE AND MINERAL RESEARCH
IF5.9
err2024-01-04
err15
errOAAI
errLi, Jun; Gui, Tao; Yao, Lutian; Guo, Hanli; Lin, Yu-Lieh; Lu, Jiawei; Duffy, Michael; Zgonis, Miltiadis; Mauck, Robert; Dyment, Nathaniel; Zhang, Yejia; Scanzello, Carla; Seale, Patrick; Qin, Ling
errShare
errSave
IRF2BP2 Regulates Hormone Sensitive Lipase and Lipolysis in Human Adipocytes and in Mice
errCIRCULATION
IF38.6
err2023-11-07
err0
PREAI
errChen, Yang; Liu, Lin; Steger, David; Cheng, Lan; Stewart, Alexandre F.; Seale, Patrick
errShare
errSave
Control of murine brown adipocyte development by GATA6
errDEVELOPMENTAL CELL
IF8.7
err2023-11-01
err5
PREAI
errJun, Seoyoung; Angueira, Anthony R.; Fein, Ethan C.; Tan, Josephine M. E.; Weller, Angela H.; Cheng, Lan; Batmanov, Kirill; Ishibashi, Jeff; Sakers, Alexander P.; Stine, Rachel R.; Seale, Patrick
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errSave
A subpopulation of lipogenic brown adipocytes drives thermogenic memory
errNATURE METABOLISM
IF20.8
err2023-10-02
err10
errOAAI
errLundgren, Patrick; Sharma, Prateek V.; Dohnalova, Lenka; Coleman, Kyle; Uhr, Giulia T.; Kircher, Susanna; Litichevskiy, Lev; Bahnsen, Klaas; Descamps, Helene C.; Demetriadou, Christina; Chan, Jacqueline; Chellappa, Karthikeyani; Cox, Timothy O.; Heyman, Yael; Pather, Sarshan R.; Shoffler, Clarissa; Petucci, Christopher; Shalem, Ophir; Raj, Arjun; Baur, Joseph A.; Snyder, Nathaniel W.; Wellen, Kathryn E.; Levy, Maayan; Seale, Patrick; Li, Mingyao; Thaiss, Christoph A.
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errSave
Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err111
errOAAI
errSabourin, LA; Seale, P; Wagner, J; Rudnicki, MA
errShare
errSave
The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err85
errOAAI
errDiPilato, Lisa M.; Ahmad, Faiyaz; Harms, Matthew; Seale, Patrick; Manganiello, Vincent; Birnbaum, Morris J.
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errSave
An Evil-C/EBPβ Complex Controls Perwdsome Proliferator-Activated Receptor γ2 Gene Expression To Initiate White Fat Cell Differentiation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err28
errOAAI
errIshibashi, Jeff; Firtina, Zeynep; Rajakumari, Sona; Wood, Kathleen H.; Conroe, Heather M.; Steger, David J.; Seale, Patrick
errShare
errSave
Interplay between intestinal microbiota and PRDM16-mediated metabolic regulation of intestinal stem and progenitor cells
errFASEB JOURNAL
IF4.2
err2022-05-13
err0
PREAI
errStine, Rachel R.; Seale, Patrick
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
B
Bruce M. Spiegelman
H-index: 186 · Papers: 471
J
Johan Auwerx
H-index: 183 · Papers: 913
M
Mitchell A. Lazar
H-index: 138 · Papers: 407
J
Joshua D. Rabinowitz
H-index: 127 · Papers: 769
K
Klaus H. Kaestner
H-index: 126 · Papers: 602
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