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Klaus H. Kaestner

University of Pennsylvania

126H-index
602Paper Count
5.2WCitation Count
Published Papers 308
Publication Date
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Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G
errNature Communications
IF15.7
err2026-07-23
err0
errOAAI
errYihan Xie; Anna K. Leonard; Omar Guessoum; Kyle A. Windisch; Johnathan Schug; Hilana El-Mekkoussi; Adrienne Jo; D. Kacy Cullen; Klaus H. Kaestner; Julie A. Blendy
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Conditional deletion of linked, non-contiguous genes using the Cre-lox system
errCellular and Molecular Gastroenterology and Hepatology
IF7.4
err2026-05-26
err0
errOAAI
errGuoli Zhu; Avital Swisa; Hannah M. Kolev; Eric L. Waite; Mark A. Tigue; Hilana El-Mekkoussi; Catherine Lee May; Klaus H. Kaestner
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A mitochondrial ROS–dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetes
errScience Translational Medicine
IF14.6
err2026-05-20
err0
PREAI
errLeslie E. Wagner; Olha Melnyk; Alissa N. Muncy; Abigail Turner; Bryce E. Duffett; Charanya Muralidharan; Michelle M. Martinez-Irizarry; Matthew C. Arvin; Kara S. Orr; Wenting Wu; Elisabetta Manduchi; Estefania Quesada-Masachs; Jon D. Piganelli; Klaus H. Kaestner; Joseph T. Brozinick; Amelia K. Linnemann
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Addendum: Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1
errNature Communications
IF15.7
err2026-05-01
err0
errOAAI
errRiham Smoom; Catherine Lee May; Vivian Ortiz; Mark Tigue; Hannah M. Kolev; Melissa Rowe; Yitzhak Reizel; Ashleigh Morgan; Nachshon Egyes; Dan Lichtental; Emmanuel Skordalakes; Klaus H. Kaestner; Yehuda Tzfati
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Epigenetic adaptation of beta cells across lifespan and disease
errNature Metabolism
IF20.8
err2026-04-01
err3
errOAAI
errManduchi, Elisabetta; Descamps, Helene C.; Liu, Jinping; Schug, Jonathan; Da, Tong; Lahori, Deeksha; El-Mekkoussi, Hilana; Lee, Michelle; Feleke, Eseye; Bernstein, Diana; Liu, Chengyang; Naji, Ali; Glaser, Benjamin; Kaestner, Klaus H.; Avrahami, Dana
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errSave
Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup
errNature
IF48.5
err2026-04-01
err0
PREAI
errDumoulin, Bernhard; Levinsohn, Jonathan; Klotzer, Konstantin A.; Li, Chenyu; Mao, Liran; Ha, Eunji; Mohandes, Samer; Nguyen, Thao; Paruzzo, Luca; Hirohama, Daigoro; Fang, Victoria; Bhoj, Vijay G.; Parhiz, Hamideh; Andrade-Silva, Magaiver; Abedini, Amin; Bergeson, Andi; Traum, Daniel; May, Michael J.; Kaestner, Klaus H.; Ruella, Marco; McAllister, Fiona Elizabeth; Hakimi, A. Ari; Li, Mingyao; Palmer, Matthew; Wherry, E. John; Hunter, Christopher A.; Cancro, Michael Paul; Susztak, Katalin
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3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility
errGenome Biology
IF9.4
err2025-12-08
err0
errOAAI
errKhanh B. Trang; Prabhat Sharma; Laura Cook; Zachary Mount; Rajan M. Thomas; Nikhil N. Kulkarni; Emylette Cruz Cabrera; Suzanna Rachimi; Matthew C. Pahl; James A. Pippin; Chun Su; Klaus H. Kaestner; Joan M. O’Brien; Yadav Wagley; Kurt D. Hankenson; Ashley Jermusyk; Jason W. Hoskins; Laufey T. Amundadottir; Mai Xu; Kevin M. Brown; Stewart A. Anderson; Wenli Yang; Paul M. Titchenell; Patrick Seale; Babette S. Zemel; Alessandra Chesi; Neil Romberg; Megan K. Levings; Struan F. A. Grant; Andrew D. Wells
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Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
errScience Immunology
IF16.3
err2025-11-21
err0
errOAAI
errMaryam Abedi; Priyadarshini Rai; Yeqiao Zhou; Chengyang Liu; Isabelle Johnson; Aditi Chandra; Maria Fasolino; Susan Rostami; Wei Wang; Zaw Min; Yanjing Li; Ming Yu; Atishay Jay; Vung Lian; Michael Silverman; Klaus H. Kaestner; Ali Naji; Robert B. Faryabi; Golnaz Vahedi
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errSave
Human-length Telomeres Limit Regeneration of Liver Epithelial Cells in Mice
errCellular and Molecular Gastroenterology and Hepatology
IF7.4
err2025-09-30
err0
errOAAI
errMichael Y. Hu; Melissa Rowe; Mark Tigue; Yitzhak Reizel; Riham Smoom; Yehuda Tzfati; Klaus H. Kaestner
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errSave
The house mouse maintains constant telomere length throughout life
errNucleic Acids Research
IF13.1
err2025-08-27
err0
errOAAI
errRiham Smoom; Dan Lichtental; Klaus H Kaestner; Yehuda Tzfati
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errSave
RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells
errMolecular Metabolism
IF6.6
err2025-06-09
err0
errOAAI
errShani Peleg; Liza Zamashanski; Jonathan Belin; Roy Novoselsky; Roni Cohen-Fultheim; Udi Ehud Knebel; Benjamin Glaser; Shalev Itzkovitz; Klaus H. Kaestner; Alvin C. Powers; Erez Y. Levanon; Agnes Klochendler; Yuval Dor
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errSave
Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
errNATURE COMMUNICATIONS
IF15.7
err2025-05-18
err0
errOAAI
errGolden, Gregory J.; Wu, Vincent H.; Hamilton, Jacob T.; Amses, Kevin R.; Shapiro, Melanie R.; Japp, Alberto Sada; Liu, Chengyang; Pampena, M. Betina; Kuri-Cervantes, Leticia; Knox, James J.; Gardner, Jay S.; Atkinson, Mark A.; Brusko, Todd M.; Prak, Eline T. Luning; Kaestner, Klaus H.; Naji, Ali; Betts, Michael R.
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errSave
No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data
errDIABETES
IF7.5
err2025-02-20
err0
PREAI
errManduchi, Elisabetta; Descamps, Helene C.; Schug, Jonathan; Da, Tong; Lahori, Deeksha; El-Mekkoussi, Hilana; Betts, Michael R.; Kaestner, Klaus H.
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errSave
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
errELIFE
IF0
err2025-01-15
err0
errOAAI
errTrang, Khanh B.; Pahl, Matthew C.; Pippin, James A.; Su, Chun; Littleton, Sheridan H.; Sharma, Prabhat; Kulkarni, Nikhil N.; Ghanem, Louis R.; Terry, Natalie A.; O'Brien, Joan M.; Wagley, Yadav; Hankenson, Kurt D.; Jermusyk, Ashley; Hoskins, Jason; Amundadottir, Laufey T.; Xu, Mai; Brown, Kevin; Anderson, Stewart; Yang, Wenli; Titchenell, Paul; Seale, Patrick; Kaestner, Klaus H.; Cook, Laura; Levings, Megan; Zemel, Babette S.; Chesi, Alessandra; Wells, Andrew D.; Grant, Struan F. A.
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errSave
The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets
errDIABETES
IF7.5
err2024-11-21
err0
PREAI
errWaite, Eric L.; Tigue, Mark; Yu, Ming; Lahori, Deeksha; Kelly, Kai; May, Catherine Lee; Naji, Ali; Roman, Jeffrey; Doliba, Nicolai; Avrahami, Dana; Nguyen-Ngoc, Kim-Vy; Sander, Maike; Glaser, Benjamin; Kaestner, Klaus H.
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errSave
Foxa deficiency restricts hepatitis B virus biosynthesis through epigenic silencing
errJOURNAL OF VIROLOGY
IF3.8
err2024-11-19
err0
PREAI
errMatrenec, Rachel; Oropeza, Claudia E.; Dekoven, Eddie; Matrenec, Carly; Maienschein-Cline, Mark; Chau, Cecilia S.; Green, Stefan J.; Kaestner, Klaus H.; Mclachlan, Alan
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The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation
errDEVELOPMENTAL CELL
IF8.7
err2024-08-01
err1
PREAI
errSwisa, Avital; Kieckhaefer, Julia; Daniel, Scott G.; El-Mekkoussi, Hilana; Kolev, Hannah M.; Tigue, Mark; Jin, Chunsheng; Assenmacher, Charles-Antoine; Dohnalova, Lenka; Thaiss, Christoph A.; Karlsson, Niclas G.; Bittinger, Kyle; Kaestner, Klaus H.
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errSave
No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data
errDIABETES
IF7.5
err2024-07-31
err2
PREAI
errManduchi, Elisabetta; Descamps, Helene C.; Schug, Jonathan; Da, Tong; Lahori, Deeksha; El-Mekkoussi, Hilana; Betts, Michael R.; Kaestner, Klaus H.
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errSave
Author Correction: Intra-islet α-cell Gs signaling promotes glucagon release( vol 15, 5129, 2024)
errNATURE COMMUNICATIONS
IF15.7
err2024-07-29
err0
errOAAI
errLiu, Liu; Ei, Kimberley; Dattaroy, Diptadip; Barella, Luiz F.; Cui, Yinghong; Gray, Sarah M.; Guedikian, Carla; Chen, Min; Weinstein, Lee S.; Knuth, Emily; Jin, Erli; Merrins, Matthew J.; Roman, Jeffrey; Kaestner, Klaus H.; Doliba, Nicolai; Campbell, Jonathan E.; Wess, Jurgen
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errSave
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression
errNATURE GENETICS
IF31.8
err2024-07-24
err4
PREAI
errAbedini, Amin; Levinsohn, Jonathan; Klotzer, Konstantin A.; Dumoulin, Bernhard; Ma, Ziyuan; Frederick, Julia; Dhillon, Poonam; Balzer, Michael S.; Shrestha, Rojesh; Liu, Hongbo; Vitale, Steven; Bergeson, Andi M.; Devalaraja-Narashimha, Kishor; Grandi, Paola; Bhattacharyya, Tanmoy; Hu, Erding; Pullen, Steven S.; Boustany-Kari, Carine M.; Guarnieri, Paolo; Karihaloo, Anil; Traum, Daniel; Yan, Hanying; Coleman, Kyle; Palmer, Matthew; Sarov-Blat, Lea; Morton, Lori; Hunter, Christopher A.; Kaestner, Klaus H.; Li, Mingyao; Susztak, Katalin
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Research Directions

No research directions
Co-authors
Cooperation Journals
M
Michael Karin
H-index: 254 · Papers: 902
I
Irving L. Weissman
H-index: 215 · Papers: 1.3K
P
Peter W.F. Wilson
H-index: 188 · Papers: 1.2K
G
Gerald I. Shulman
H-index: 183 · Papers: 819
D
Daniel J. Rader
H-index: 172 · Papers: 1.5K
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