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S

Simon J. Boulton

The Francis Crick Institute

78H-index
224Paper Count
2.3WCitation Count
Published Papers 124
Publication Date
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Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2026-06-30
err0
errOAAI
errSandra Segura-Bayona; Marija Maric; Tohru Takaki; Zornitsa Manova; Tyler H. Stanage; Aurora I. Idilli; Shudong Li; Graeme Hewitt; Feras E. Machour; Rhona Millar; Marek Adamowicz; Ronnie Ren Jie Low; Phil Ruis; Benura Azeroglu; Todd Fallesen; Harshil Patel; Steven Howell; Panagiotis Kotsantis; Michael Howell; Simon J. Boulton
errShare
errSave
RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress
errNature Cell Biology
IF19.1
err2026-01-09
err0
errOAAI
errTyler H. Stanage; Shudong Li; Sandra Segura-Bayona; Aurora I. Idilli; Rhona Millar; Graeme Hewitt; Simon J. Boulton
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errSave
Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes
errStem Cell Reports
IF5.1
err2025-12-04
err0
errOAAI
errHannah D. Franklin; Hamish Crerar; Nishita Parnandi; Michael Lattke; Stanislaw Majewski; Benjamin E. Clarke; Husayn Pallikonda; Michael Howell; Simon J. Boulton; Rickie Patani
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errSave
Cryo–electron microscopic visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2
errScience
IF45.8
err2025-11-06
err0
PREAI
errLuke A. Greenhough; Lorenzo Galanti; Chih-Chao Liang; Simon J. Boulton; Stephen C. West
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errSave
ART6043: a first-in-class clinical DNA Polymerase Theta polymerase domain inhibitor for potentiating PARP inhibitor efficacy
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errRobinson, H.; Grinkevich, V.; Holt, S.; Majithiya, J.; McWhirter, C.; Rajendra, E.; Ranzani, M.; Stockley, M.; Costales, P.; Elinati, E.; Galbiati, A.; Rego, A. Toste; Charles, M.; Finch, H.; Higgins, G.; Boulton, S.; Heald, R.; Langford, G.; Martin, N.; Smith, G.
errShare
errSave
HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
errMOLECULAR CELL
IF16.6
err2024-08-01
err1
PREAI
errBai, Gongshi; Endres, Theresa; Kuhbacher, Ulrike; Mengoli, Valentina; Greer, Briana H.; Peacock, Emma M.; Newton, Matthew D.; Stanage, Tyler; Dello Stritto, Maria Rosaria; Lungu, Roxana; Crossley, Magdalena P.; Sathirachinda, Ataya; Cortez, David; Boulton, Simon J.; Cejka, Petr; Eichman, Brandt F.; Cimprich, Karlene A.
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errSave
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING
errMOLECULAR CELL
IF16.6
err2024-06-01
err5
errOAAI
errTakaki, Tohru; Millar, Rhona; Hiley, Crispin T.; Boulton, Simon J.
errShare
errSave
Extraordinary collateral mutagenesis induced by CX-5461
errNATURE GENETICS
IF31.8
err2023-12-21
err0
PREAI
errBoulton, Simon J.
errShare
errSave
Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells
errNUCLEIC ACIDS RESEARCH
IF13.1
err2023-12-18
err2
errOAAI
errRajendra, Eeson; Grande, Diego; Mason, Bethany; Di Marcantonio, Daniela; Armstrong, Lucy; Hewitt, Graeme; Elinati, Elias; Galbiati, Alessandro; Boulton, Simon J.; Heald, Robert A.; Smith, Graeme C. M.; Robinson, Helen M. R.
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errSave
Negative DNA supercoiling induces genome-wide Cas9 off-target activity
errMOLECULAR CELL
IF16.6
err2023-10-01
err13
errOAAI
errNewton, Matthew D.; Losito, Marialucrezia; Smith, Quentin M.; Parnandi, Nishita; Taylor, Benjamin J.; Akcakaya, Pinar; Maresca, Marcello; van Eijk, Patrick; Reed, Simon H.; Boulton, Simon J.; King, Graeme A.; Cuomo, Maria Emanuela; Rueda, David S.
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errSave
Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein
errMOLECULAR CELL
IF16.6
err2023-08-01
err8
errOAAI
errBelan, Ondrej; Greenhough, Luke; Kuhlen, Lucas; Anand, Roopesh; Kaczmarczyk, Artur; Gruszka, Dominika T.; Yardimci, Hasan; Zhang, Xiaodong; Rueda, David S.; West, Stephen C.; Boulton, Simon J.
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errSave
The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining
errMOLECULAR CELL
IF16.6
err2023-05-01
err14
errOAAI
errFleury, Hubert; MacEachern, Myles K.; Stiefel, Clara M.; Anand, Roopesh; Sempeck, Colin; Nebenfuehr, Benjamin; Maurer-Alcala, Kelper; Ball, Kerri; Proctor, Bruce, III; Belan, Ondrej; Taylor, Erin; Ortega, Raquel; Dodd, Benjamin; Weatherly, Laila; Dansoko, Djelika; Leung, Justin W.; Boulton, Simon J.; Arnoult, Nausica
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errSave
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
errNATURE COMMUNICATIONS
IF15.7
err2023-04-20
err19
errOAAI
errZiff, Oliver J.; Neeves, Jacob; Mitchell, Jamie; Tyzack, Giulia; Martinez-Ruiz, Carlos; Luisier, Raphaelle; Chakrabarti, Anob M.; McGranahan, Nicholas; Litchfield, Kevin; Boulton, Simon J.; Al-Chalabi, Ammar; Kelly, Gavin; Humphrey, Jack; Patani, Rickie
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errSave
DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err109
errOAAI
errYouds, Jillian L.; Barber, Louise J.; Ward, Jordan D.; Collis, Spencer J.; O'Neil, Nigel J.; Boulton, Simon J.; Rose, Ann M.
errShare
errSave
RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err172
errOAAI
errMartin, JS; Winkelmann, N; Petalcorin, MIR; McIlwraith, MJ; Boulton, SJ
errShare
errSave
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta (vol 65, pg 13879, 2022)
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-02-23
err1
PREAI
errStockley, Martin L.; Benedetti, Giovanni; Blencowe, Peter; Boulton, Simon J.; Boyd, Susan M.; Calder, Mat; Charles, Mark D.; Edwardes, Lucy, V; Ekwuru, Tennyson; Ferdinand, Amanda; Finch, Harry; Galbiati, Alessandro; Geo, Lerin; Grande, Diego; Grinkevich, Vera; Higgins, Geoff S.; Holliday, Nicholas D.; Krajewski, Wojciech W.; MacDonald, Ellen; Majithiya, Jayesh B.; McCarron, Hollie; McWhirter, Claire L.; Patel, Viral; Pedder, Chris; Rajendra, Eeson; Ranzani, Marco; Rigoreau, Laurent J. M.; Robinson, Helen M. R.; Schaedler, Theresia; Sirina, Julija; Smith, Graeme C. M.; Swarbrick, Martin E.; Turnbull, Andrew P.; Willis, Simon; Zemla, Aleksandra; Heald, Robert A.
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errSave
Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways
errCELL REPORTS
IF6.9
err2023-02-01
err17
errOAAI
errSchimmel, Joost; Munoz-Subirana, Nuria; Kool, Hanneke; van Schendel, Robin; van der Vlies, Sven; Kamp, Juliette A.; de Vrij, Femke; Kushner, Steven A.; Smith, Graeme C. M.; Boulton, Simon J.; Tijsterman, Marcel
errShare
errSave
Small-Molecule Polu Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
errCLINICAL CANCER RESEARCH
IF10.2
err2023-01-23
err14
errOAAI
errRodriguez-Berriguete, Gonzalo; Ranzani, Marco; Prevo, Remko; Puliyadi, Rathi; Machado, Nicole; Bolland, Hannah R.; Millar, Val; Ebner, Daniel; Boursier, Marie; Cerutti, Aurora; Cicconi, Alessandro; Galbiati, Alessandro; Grande, Diego; Grinkevich, Vera; Majithiya, Jayesh B.; Piscitello, Desiree; Rajendra, Eeson; Stockley, Martin L.; Boulton, Simon J.; Hammond, Ester M.; Heald, Robert A.; Smith, Graeme C. M.; Robinson, Helen M. R.; Higgins, Geoff S.
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errSave
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
errMOLECULAR CELL
IF16.6
err2022-12-01
err60
errOAAI
errBelan, Ondrej; Sebald, Marie; Adamowicz, Marek; Anand, Roopesh; Vancevska, Aleksandra; Neves, Joana; Grinkevich, Vera; Hewitt, Graeme; Segura-Bayona, Sandra; Bellelli, Roberto; Robinson, Helen M. R.; Higgins, Geoff S.; Smith, Graeme C. M.; West, Stephen C.; Rueda, David S.; Boulton, Simon J.
errShare
errSave
Search and processing of Holliday junctions within long DNA by junction-resolving enzymes
errNATURE COMMUNICATIONS
IF15.7
err2022-10-07
err12
errOAAI
errKaczmarczyk, Artur P.; Declais, Anne-Cecile; Newton, Matthew D.; Boulton, Simon J.; Lilley, David M. J.; Rueda, David S.
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errSave

Research Directions

No research directions
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