Not logged in Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK-driven lung cancer by concurrent integrin and MET signaling Hu, Qianqian; Remsing Rix, Lily L.; Desai, Bina; Miroshnychenko, Daria; Li, Xueli; Welsh, Eric A.; Fang, Bin; Wright, Gabriela M.; Chaudhary, Neelkamal; Kroeger, Jodi L.; Doebele, Robert C.; Koomen, John M.; Haura, Eric B.; Marusyk, Andriy; Rix, Uwe Share Save
Oncogenic EML4-ALK assemblies suppress growth factor perception and modulate drug tolerance Gonzalez-Martinez, David; Roth, Lee; Mumford, Thomas R.; Guan, Juan; Le, Anh; Doebele, Robert C.; Huang, Bo; Tulpule, Asmin; Niewiadomska-Bugaj, Magdalena; Bivona, Trever G.; Bugaj, Lukasz J. Share Save
Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer (vol 24, pg 638, 2018) Robichaux, Jacqulyne P.; Elamin, Yasir Y.; Tan, Zhi; Carter, Brett W.; Zhang, Shuxing; Liu, Shengwu; Li, Shuai; Chen, Ting; Poteete, Alissa; Estrada-Bernal, Adriana; Le, Anh T.; Truini, Anna; Nilsson, Monique B.; Sun, Huiying; Roarty, Emily; Goldberg, Sarah B.; Brahmer, Julie R.; Altan, Mehmet; Lu, Charles; Papadimitrakopoulou, Vassiliki; Politi, Katerina; Doebele, Robert C.; Wong, Kwok-Kin; Heymach, John V. Share Save
Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2 Liao, Yi; Rix, Lily L. Remsing; Li, Xueli; Fang, Bin; Izumi, Victoria; Welsh, Eric A.; Monastyrskyi, Andrii; Haura, Eric B.; Koomen, John M.; Doebele, Robert C.; Rix, Uwe Share Save
A phase 2 basket study of the oral MDM2 inhibitor milademetan for MDM2-amplified advanced solid tumors (MANTRA-2) Dumbrava, Ecaterina E.; Chen, Christopher T.; Cote, Gregory M.; Hanna, Glenn J.; Stinchcombe, Thomas E.; Sumrall, Bradley; Wise-Draper, Trisha; Kanaan, Mohammed; Duffy, Steven; Sumey, Christopher; Cobb, Patrick; Shah, Naisargee; Zhang, Bo; Ku, Nora; Doebele, Robert C.; Gounder, Mrinal Share Save
Efficacy and safety findings from MANTRA: A global, randomized, multicenter, phase III study of the MDM2 inhibitor milademetan vs trabectedin in patients with dedifferentiated liposarcomas Chen, T. W-W.; Sanfilippo, R.; Jones, R. L.; Schuetze, S. M.; Sebio Garcia, A.; Alvarez, R. M.; Bui, N.; Ahn, J-H.; Loong, H. H. F.; Yen, C-C.; Hong, J. Y.; Kim, H. S.; Patel, S.; Bryce, R. P.; Xu, F.; Zhang, B.; Shah, N. V.; Doebele, R. C.; Schwartz, G.; Gounder, M. Share Save
Efficacy and safety findings from MANTRA: A global, randomized, multicenter, phase III study of the MDM2 inhibitor milademetan vs trabectedin in patients with dedifferentiated liposarcomas Jones, R. L.; Sanfilippo, R.; Schuetze, S. M.; Sebio, A.; Alvarez, R. M.; Bui, N.; Wagner, A. J.; Chawla, S. P.; Chen, T. W-W.; Pink, D.; Le Cesne, A.; Italiano, A.; Vincenzi, B.; Kiladze, I. Z.; Patel, S.; Bryce, R.; Xu, F.; Doebele, R. C.; Schwartz, G.; Gounder, M. Share Save
MIG6 Mediates Adaptive and Acquired Resistance to ALK/ROS1 Fusion Kinase Inhibition through EGFR Bypass Signaling Chen, Nan; Tyler, Logan C.; Le, Anh T.; Welsh, Eric A.; Fang, Bin; Elliott, Andrew; Davies, Kurtis D.; Danhorn, Thomas; Riely, Gregory J.; Ladanyi, Marc; Haura, Eric B.; Doebele, Robert C. Share Save
ERBB family fusions are recurrent and actionable oncogenic targets across cancer types Schubert, Laura; Elliott, Andrew; Le, Anh T.; Estrada-Bernal, Adriana; Doebele, Robert C.; Lou, Emil; Borghaei, Hossein; Demeure, Michael J.; Kurzrock, Razelle; Reuss, Joshua E.; Ou, Sai-Hong Ignatius; Braxton, David R.; Thomas, Christian A.; Darabi, Sourat; Korn, Wolfgang Michael; El-Deiry, Wafik S.; Liu, Stephen V. Share Save
ALK fusion oncogene driven SERPINB4 expression enhances tumor survival in NSCLC Chuang, Tzu-Po; Lai, Wei-Yun; Gabre, Jonatan L.; Lind, Dan E.; Umapathy, Ganesh; Bokhari, Abdulmalik A.; Bergman, Bengt; Kristenson, Linnea; Thoren, Fredrik B.; Le, Anh; Doebele, Robert; Eynden, Jimmy V.; Palmer, Ruth H.; Hallberg, Bengt Share Save
Cell-free DNA detection of GATA3 mutations in metastatic hormone receptor positive breast cancer: a retrospective, observational multi-institutional analysis Medford, Arielle J.; Velimirovic, Marko; Niemierko, Andrzej; Hensing, Whitney L.; Davis, Andrew A.; Clifton, Katherine K.; Keenan, Jennifer C.; Dai, Charles S.; Kiedrowski, Lesli A.; Shah, Ami N.; Gerratana, Lorenzo; Spring, Laura M.; Ellisen, Leif; Doebele, Robert C.; Cristofanilli, Massimo; Bardia, Aditya Share Save
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ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression Chuang, Tzu-Po; Lai, Wei-Yun; Gabre, Jonatan L.; Lind, Dan E.; Umapathy, Ganesh; Bokhari, Abdulmalik A.; Bergman, Bengt; Kristenson, Linnea; Thoren, Fredrik B.; Le, Anh; Doebele, Robert C.; Eynden, Jimmy Van den; Palmer, Ruth H.; Hallberg, Bengt Share Save
Evolution of acquired resistance in a ROS1+ KRAS G12C+ NSCLC through the MAPK pathway Priest, Katherine; Le, Anh; Gebregzabheir, Amanuail; Nijmeh, Hala; Reis, Gregory B. B.; Mandell, Melanie; Davies, Kurtis D. D.; Lawrence, Carolyn; O'Donnell, Emily; Doebele, Robert C. C.; Bao, Liming; Aisner, Dara L. L.; Schenk, Erin L. L. Share Save
James DeCaprio1,2,3 1 . 2 . 3 . 4 . 5 Ananthapadmanabhan, Varsha; Frost, Thomas C.; Soroko, Kara M.; Knott, Aine; Magliozzi, Brianna J.; Gokhale, Prafulla C.; Tirunagaru, Vijaya G.; Doebele, Robert C.; DeCaprio, James A. Share Save
GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers (vol 5, 373, 2022) Bianco, Gaia; Coto-Llerena, Mairene; Gallon, John; Kancherla, Venkatesh; Taha-Mehlitz, Stephanie; Marinucci, Mattia; Konantz, Martina; Srivatsa, Sumana; Montazeri, Hesam; Panebianco, Federica; Tirunagaru, Vijaya G.; De Menna, Marta; Paradiso, Viola; Ercan, Caner; Dahmani, Ahmed; Montaudon, Elodie; Beerenwinkel, Niko; Kruithof-de Julio, Marianna; Terracciano, Luigi M.; Lengerke, Claudia; Jeselsohn, Rinath M.; Doebele, Robert C.; Bidard, Francois-Clement; Marangoni, Elisabetta; Ng, Charlotte K. Y.; Piscuoglio, Salvatore Share Save
Long-Term Efficacy and Safety of Entrectinib in ROS1 Fusion-Positive NSCLC Drilon, Alexander; Chiu, Chao-Hua; Fan, Yun; Cho, Byoung Chul; Lu, Shun; Ahn, Myung-Ju; Krebs, Matthew G.; Liu, Stephen, V; John, Thomas; Otterson, Gregory A.; Tan, Daniel S. W.; Patil, Tejas; Dziadziuszko, Rafal; Massarelli, Erminia; Seto, Takashi; Doebele, Robert C.; Pitcher, Bethany; Kurtsikidze, Nino; Heinzmann, Sebastian; Siena, Salvatore Share Save
Pre- and post-treatment blood-based genomic landscape of patients with ROS1 or NTRK fusion-positive solid tumours treated with entrectinib Dziadziuszko, Rafal; Hung, Tiffany; Wang, Kun; Choeurng, Voleak; Drilon, Alexander; Doebele, Robert C.; Barlesi, Fabrice; Wu, Charlie; Dennis, Lucas; Skoletsky, Joel; Woodhouse, Ryan; Li, Meijuan; Chang, Ching-Wei; Simmons, Brian; Riehl, Todd; Wilson, Timothy R. Share Save
GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers Bianco, Gaia; Coto-Llerena, Mairene; Gallon, John; Kancherla, Venkatesh; Taha-Mehlitz, Stephanie; Marinucci, Mattia; Konantz, Martina; Srivatsa, Sumana; Montazeri, Hesam; Panebianco, Federica; Tirunagaru, Vijaya G.; De Menna, Marta; Paradiso, Viola; Ercan, Caner; Dahmani, Ahmed; Montaudon, Elodie; Beerenwinkel, Niko; Kruithof-de Julio, Marianna; Terracciano, Luigi M.; Lengerke, Claudia; Jeselsohn, Rinath M.; Doebele, Robert C.; Bidard, Francois-Clement; Marangoni, Elisabetta; Ng, Charlotte K. Y.; Piscuoglio, Salvatore Share Save
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