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SaveThe CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction
Maisonneuve, Pierre; Sahmi, Malha; Bergeron-Labrecque, Fanny; Ma, Xianjie Iris; Queguiner, Juliette; Arseneault, Genevieve; Lefrancois, Martin; Kurinov, Igor; Fronzes, Remi; Sicheri, Frank; Therrien, Marc Share Save CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signallingSerwe, Guillaume; Kachaner, David; Gagnon, Jessica; Plutoni, Cedric; Lajoie, Driss; Durame, Eloise; Sahmi, Malha; Garrido, Damien; Lefrancois, Martin; Arseneault, Genevieve; Saba-El-Leil, Marc K.; Meloche, Sylvain; Emery, Gregory; Therrien, Marc Share Save Share Save Functional characterization of a PROTAC directed against BRAF mutant V600EPosternak, Ganna; Tang, Xiaojing; Maisonneuve, Pierre; Jin, Ting; Lavoie, Hugo; Daou, Salima; Orlicky, Stephen; de Rugy, Theo Goullet; Caldwell, Lauren; Chan, Kin; Aman, Ahmed; Prakesch, Michael; Poda, Gennady; Mader, Pavel; Wong, Cassandra; Maier, Stefan; Kitaygorodsky, Julia; Larsen, Brett; Colwill, Karen; Yin, Zhe; Ceccarelli, Derek F.; Batey, Robert A.; Taipale, Mikko; Kurinov, Igor; Uehling, David; Wrana, Jeff; Durocher, Daniel; Gingras, Anne-Claude; Al-Awar, Rima; Therrien, Marc; Sicheri, Frank Share Save Share Save Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1Daou, Salima; Barbour, Haithem; Ahmed, Oumaima; Masclef, Louis; Baril, Caroline; Sen Nkwe, Nadine; Tchelougou, Damehan; Uriarte, Maxime; Bonneil, Eric; Ceccarelli, Derek; Mashtalir, Nazar; Tanji, Mika; Masson, Jean-Yves; Thibault, Pierre; Sicheri, Frank; Yang, Haining; Carbone, Michele; Therrien, Marc; Affar, El Bachir Share Save Share Save Share Save Inhibition of RAS function through targeting an allosteric regulatory siteSpencer-Smith, Russell; Koide, Akiko; Zhou, Yong; Eguchi, Raphael R.; She, Fern; Gajwani, Priyanka; Santana, Dianicha; Gupta, Ankit; Jacobs, Miranda; Herrero-Garcia, Erika; Cobbert, Jacqueline; Lavoie, Hugo; Smith, Matthew; Rajakulendran, Thanashan; Dowdell, Evan; Okur, Mustafa Nazir; Dementieva, Irina; Sicheri, Frank; Therrien, Marc; Hancock, John F.; Ikura, Mitsuhiko; Koide, Shohei; O'Bryan, John P. Share Save Share Save Share Save Share Save Share Save Share Save Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerizationLavoie, Hugo; Thevakumaran, Neroshan; Gavory, Gwenalle; Li, John J.; Padeganeh, Abbas; Guiral, Sebastien; Duchaine, Jean; Mao, Daniel Y. L.; Bouvier, Michel; Sicheri, Frank; Therrien, Marc Share Save Share Save Share Save Share Save Share Save 
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