logo
CanyamAI summaries for academic research
language
MobileMobile
  • Phone FeatureWeChat Mini Program
EnglishEnglish
noticeNotice
BlogBlog
delete
arrow
Back
J

James A. Spudich

stanford university school of medicine

94H-index
386Paper Count
3.7WCitation Count
Published Papers 137
Publication Date
logo
Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy
errNature Cardiovascular Research
IF10.8
err2026-07-07
err0
PREAI
errLaura Sen-Martín; Ángel Fernández-Trasancos; Miguel Á. López-Unzu; Agata Bak; Magdalena Zafra-Castellano; Rajiven Srikantharajah; Divya Pathak; Annika Klotz; Michel N. Kuehn; Alessia Ferrarini; Verónica Labrador-Cantarero; David Sánchez-Ortiz; María Rosaria Pricolo; Natalia Vicente; Diana Velázquez-Carreras; Lucía Sánchez-García; Jon Sicilia; José Ángel Nicolás-Ávila; María Sánchez-Díaz; Saskia Schlossarek; Lorena Cussó; Manuel Desco; María Villalba-Orero; Gabriela Guzmán-Martínez; Enrique Calvo; Roberto Barriales-Villa; Jesús Vázquez; Fátima Sánchez-Cabo; Andrés Hidalgo; Pieter P. de Tombe; Lucie Carrier; James A. Spudich; Kathleen M. Ruppel; Florian Weinberger; Olivier Cazorla; Anthony L. Hessel; Jorge Alegre-Cebollada
errShare
errSave
Dynamics of the β-cardiac myosin auto-inhibited state explain cardiomyopathy pathogenesis
errNature Communications
IF15.7
err2026-06-04
err0
errOAAI
errDaniel Auguin; Laurie Lannes; Carlos Kikuti; Nour Ayoub; Marie Juillé; Stéphane Réty; Neha Nandwani; Divya Pathak; Kathleen M. Ruppel; James A. Spudich; Julien Robert-Paganin; Anne Houdusse
errShare
errSave
The hypertrophic cardiomyopathy myosin variant G256E prolongs cardiac muscle relaxation via altered nucleotide handling
errCommunications Chemistry
IF6.2
err2026-05-05
err0
errOAAI
errKerry Y. Kao; Matthew Carter Childers; Divya Pathak; Rama Reddy Goluguri; Timothy S. McMillen; Joseph D. Powers; Kathleen M. Ruppel; James A. Spudich; Michael Regnier
errShare
errSave
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically
errNature Communications
IF15.7
err2025-10-01
err0
errOAAI
errNeha Nandwani; Debanjan Bhowmik; Camille Glaser; Matthew Carter Childers; Rama Reddy Goluguri; Aminah Dawood; Michael Regnier; Anne Houdusse; James A. Spudich; Kathleen M. Ruppel
errShare
errSave
From amoeboid myosin to unique targeted medicines for a genetic cardiac disease
errFRONTIERS IN PHYSIOLOGY
IF3.4
err2024-10-28
err0
errOAAI
errSpudich, James A.
errShare
errSave
Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy
errEMBO JOURNAL
IF8.3
err2024-08-27
err2
PREAI
errSpudich, James A.; Nandwani, Neha; Robert-Paganin, Julien; Houdusse, Anne; Ruppel, Kathleen M.
errShare
errSave
One must reconstitute the functions of interest from purified proteins
errFRONTIERS IN PHYSIOLOGY
IF3.4
err2024-05-17
err2
errOAAI
errSpudich, James A.
errShare
errSave
Incomplete- penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-04-29
err3
errOAAI
errLee, Soah; Roestd, Alison S. Vander; Blair, Cheavar A.; Kaoh, Kerry; Bremner, Samantha B.; Childers, Matthew C.; Pathak, Divya; Heinrich, Paul; Lee, Daniel; Chirikian, Orlando; Mohran, Saffie E.; Roberts, Brock; Smith, Jacqueline E.; Jahng, James W.; Paik, David T.; Wu, Joseph C.; Gunawardane, Ruwanthi N.; Ruppel, Kathleen M.; Mack, David L.; Pruitt, Beth L.; Regnier, Michael; Wu, Sean M.; Spudich, James A.; Bernstein, Daniel
errShare
errSave
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-02-20
err1
errOAAI
errLiu, Chao; Karabina, Anastasia; Meller, Artur; Bhattacharjee, Ayan; Agostino, Colby J.; Bowman, Greg R.; Ruppel, Kathleen M.; Spudich, James A.; Leinwand, Leslie A.
errShare
errSave
Distinct Molecular Signatures Of HCM- And DCM-causing Mutations At The Same Residue In The Transducer Of Cardiac Myosin
errCIRCULATION RESEARCH
IF16.2
err2023-08-04
err0
PREAI
errKawana, Masataka; Goluguri, Rama Reddy; Dawood, Aminah; Spudich, James A.; Ruppel, Kathleen
errShare
errSave
Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients
errSCIENCE ADVANCES
IF12.5
err2023-07-28
err18
errOAAI
errNag, Suman; Gollapudi, Sampath K.; del Rio, Carlos L.; Spudich, James A.; McDowell, Robert
errShare
errSave
Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies
errFRONTIERS IN PHYSIOLOGY
IF3.4
err2022-09-26
err31
errOAAI
errKawana, Masataka; Spudich, James A.; Ruppel, Kathleen M.
errShare
errSave
Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
errELIFE
IF0
err2022-06-29
err11
errOAAI
errMorck, Makenna M.; Bhowmik, Debanjan; Pathak, Divya; Dawood, Aminah; Spudich, James; Ruppel, Kathleen M.
errShare
errSave
Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-06-11
err46
errOAAI
errVander Roest, Alison Schroer; Liu, Chao; Morck, Makenna M.; Kooiker, Kristina Bezold; Jung, Gwanghyun; Song, Dan; Dawood, Aminah; Jhingran, Arnav; Pardon, Gaspard; Ranjbarvaziri, Sara; Fajardo, Giovanni; Zhao, Mingming; Campbell, Kenneth S.; Pruitt, Beth L.; Spudich, James A.; Ruppel, Kathleen M.; Bernstein, Daniel
errShare
errSave
Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy
errACS NANO
IF16
err2021-06-01
err16
errOAAI
errSuay-Corredera, Carmen; Pricolo, Maria Rosaria; Velazquez-Carreras, Diana; Pathak, Divya; Nandwani, Neha; Pimenta-Lopes, Carolina; Sanchez-Ortiz, David; Urrutia-Irazabal, Inigo; Vilches, Silvia; Dominguez, Fernando; Frisso, Giulia; Monserrat, Lorenzo; Garcia-Pavia, Pablo; de Sancho, David; Spudich, James A.; Ruppel, Kathleen M.; Herrero-Galan, Elias; Alegre-Cebollada, Jorge
errShare
errSave
Hypertrophic Cardiomyopathy, a Disease of Altered Cardiac Energetics
errCIRCULATION RESEARCH
IF16.2
err2020-07-31
err0
PREAI
errRanjbarvaziri, Sara; Ellenberger, Mathew; Kooiker, Kristi; Fajardo, Giovanni; Zhao, Mingming; Schroer, Alison; Woo, Y. Joseph Y.; Ruppel, Kathleen M.; Spudich, James A.; Snyder, Michael; Contrepois, Kevin; Bernstein, Daniel
errShare
errSave
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
errSCIENCE ADVANCES
IF12.5
err2020-04-03
err61
errOAAI
errSarkar, Saswata S.; Trivedi, Darshan, V; Morck, Makenna M.; Adhikari, Arjun S.; Pasha, Shaik N.; Ruppel, Kathleen M.; Spudich, James A.
errShare
errSave
Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2019-11-01
err24
errOAAI
errVera, Carlos D.; Johnson, Chloe A.; Walklate, Jonathan; Adhikari, Arjun; Svicevic, Marina; Mijailovich, Srboljub M.; Combs, Ariana C.; Langer, Stephen J.; Ruppel, Kathleen M.; Spudich, James A.; Geeves, Michael A.; Leinwand, Leslie A.
errShare
errSave
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
errNATURE COMMUNICATIONS
IF15.7
err2019-06-18
err51
errOAAI
errAdhikari, Arjun S.; Trivedi, Darshan V.; Sarkar, Saswata S.; Song, Dan; Kooiker, Kristina B.; Bernstein, Daniel; Spudich, James A.; Ruppel, Kathleen M.
errShare
errSave
The Myosin Mesa and Hypertrophic Cardiomyopathy: Mutations to Mechanisms to Therapies
errBIOPHYSICAL JOURNAL
IF3.1
err2019-02-01
err0
errOAAI
errSpudich, James
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
M
M Snyder
H-index: 210 · Papers: 3.3K
J
Joseph C. Wu
H-index: 139 · Papers: 1.2K
C
Carlos D. Bustamante
H-index: 138 · Papers: 519
J
Jennifer Lippincott‐Schwartz
H-index: 134 · Papers: 444
J
Jonathan G. Seidman
H-index: 132 · Papers: 534
View more