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J

James E. Bear

University of North Carolina

48H-index
203Paper Count
1.2WCitation Count
Published Papers 81
Publication Date
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Optogenetic control of PLC-γ1 activity directs cell motility
errJournal of Cell Biology
IF6.4
err2026-05-05
err1
PREAI
errAppalabhotla, Ravikanth; Siesser, Priscila F.; Truscott, Harrison; Hajicek, Nicole; Sondek, John; Bear, James E.; Haugh, Jason M.
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errSave
Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion (vol. 10, 11958, 2020)
errScientific Reports
IF3.9
err2026-05-01
err0
errOAAI
errTagliatela, Alicia C.; Hempstead, Stephanie C.; Hibshman, Priya S.; Hockenberry, Max A.; Brighton, Hailey E.; Pecot, Chad V.; Bear, James E.
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errSave
When two worlds collide: actin dynamics on endomembranes regulates membrane trafficking
errCurrent Opinion in Cell Biology
IF4.3
err2025-11-01
err0
PREAI
errMichelle F. Marchan; James E. Bear
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errSave
Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis
errJOURNAL OF CELL BIOLOGY
IF6.4
err2025-10-14
err0
PREAI
errHo, Chris T.; Evans, Elliot B.; Lukasik, Kimberly; O'Shaughnessy, Ellen C.; Shah, Aneri; Hsu, Chih-Hsuan; Temple, Brenda; Bear, James E.; Gupton, Stephanie L.
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errSave
The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function
errEMBO REPORTS
IF6.2
err2024-07-18
err0
errOAAI
errRead, Tracy-Ann; Cisterna, Bruno A.; Skruber, Kristen; Ahmadieh, Samah; Liu, Tatiana M.; Vitriol, Josefine A.; Shi, Yang; Black, Joseph B.; Butler, Mitchell T.; Lindamood, Halli L.; Lefebvre, Austin E. Y. T.; Cherezova, Alena; Ilatovskaya, Daria, V; Bear, James E.; Weintraub, Neal L.; Vitriol, Eric A.
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errSave
Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules
errJOURNAL OF CELL BIOLOGY
IF6.4
err2024-05-09
err4
errOAAI
errCisterna, Bruno A.; Skruber, Kristen; Jane, Makenzie L.; Camesi, Caleb I.; Nguyen, Ivan D.; Liu, Tatiana M.; Warp, Peyton V.; Black, Joseph B.; Butler, Mitchell T.; Bear, James E.; Mor, Danielle E.; Read, Tracy-Ann; Vitriol, Eric A.
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errSave
Viral airway injury promotes cell engraftment in an in vitro model of cystic fibrosis cell therapy
errAMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
IF3.5
err2024-03-01
err0
errOAAI
errLee, Rhianna E.; Mascenik, Teresa M.; Major, Sidra C.; Galiger, Jacob R.; Bulik-Sullivan, Emily; Siesser, Priscila F.; Lewis, Catherine A.; Bear, James E.; Le Suer, Jake A.; Hawkins, Finn J.; Pickles, Raymond J.; Randell, Scott H.
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errSave
Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly
errJOURNAL OF CELL BIOLOGY
IF6.4
err2024-02-14
err4
errOAAI
errQuintanilla, Melissa A.; Patel, Hiral; Wu, Huini; Sochacki, Kem A.; Chandrasekar, Shreya; Akamatsu, Matthew; Rotty, Jeremy D.; Korobova, Farida; Bear, James E.; Taraska, Justin W.; Oakes, Patrick W.; Beach, Jordan R.
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errSave
G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions
errBIOPHYSICAL JOURNAL
IF3.1
err2023-09-01
err2
errOAAI
errAppalabhotla, Ravikanth; Butler, Mitchell T.; Bear, James E.; Haugh, Jason M.
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errSave
A Photopolymerized Hydrogel System with Dual Stiffness Gradients Reveals Distinct Actomyosin-Based Mechano-Responses in Fibroblast Durotaxis
errACS NANO
IF16
err2022-12-07
err7
errOAAI
errHakeem, Reem M.; Subramanian, Bhagawat C.; Hockenberry, Max A.; King, Zayna T.; Butler, Mitchell T.; Legant, Wesley R.; Bear, James E.
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errSave
Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover
errJOURNAL OF CELL BIOLOGY
IF6.4
err2022-06-03
err10
errOAAI
errKing, Zayna T.; Butler, Mitchell T.; Hockenberry, Max A.; Subramanian, Bhagawat C.; Siesser, Priscila F.; Graham, David M.; Legant, Wesley R.; Bear, James E.
errShare
errSave
A kinetic model of phospholipase C-?1 linking structure-based insights to dynamics of enzyme autoinhibition and activation
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-05-01
err2
errOAAI
errNosbisch, Jamie L.; Bear, James E.; Haugh, Jason M.
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errSave
Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling
errBIOPHYSICAL JOURNAL
IF3.1
err2022-01-01
err12
errOAAI
errChandra, Ankit; Butler, Mitchell T.; Bear, James E.; Haugh, Jason M.
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errSave
The principles of directed cell migration
errNATURE REVIEWS MOLECULAR CELL BIOLOGY
IF90.2
err2021-05-14
err325
errOAAI
errSenGupta, Shuvasree; Parent, Carole A.; Bear, James E.
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errSave
An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation
errGENOME RESEARCH
IF5.5
err2020-10-05
err12
errOAAI
errLerner, Andrew M.; Hepperla, Austin J.; Keele, Gregory R.; Meriesh, Hashem A.; Yumerefendi, Hayretin; Restrepo, David; Zimmerman, Seth; Bear, James E.; Kuhlman, Brian; Davis, Ian J.; Strahl, Brian D.
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errSave
Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation
errJCI INSIGHT
IF6.1
err2020-02-27
err27
errOAAI
errTessier, Steven; Doolittle, Alexandra C.; Sao, Kimheak; Rotty, Jeremy D.; Bear, James E.; Ulici, Veronica; Loeser, Richard F.; Shapiro, Irving M.; Diekman, Brian O.; Risbud, Makarand, V
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errSave
Simulating Emergent Spatiotemporal Actomyosin Dynamics to Understand Spatial Regulation of Non-Muscle Myosin II
errBIOPHYSICAL JOURNAL
IF3.1
err2019-02-01
err0
errOAAI
errMiller, Callie J.; LaFosse, Paul; Asokan, Sreeja; Haugh, Jason; Bear, James E.; Elston, Timothy C.
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errSave
Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function
errONCOGENE
IF7.3
err2018-07-31
err40
errOAAI
errCastagnino, Alessia; Castro-Castro, Antonio; Irondelle, Marie; Guichard, Alan; Lodillinsky, Catalina; Fuhrmann, Laetitia; Vacher, Sophie; Aguera-Gonzalez, Sonia; Zagryazhskaya-Masson, Anna; Romao, Maryse; El Kesrouani, Carole; Noegel, Angelika A.; Dubois, Thierry; Raposo, Graca; Bear, James E.; Clemen, Christoph S.; Vincent-Salomon, Anne; Bieche, Ivan; Chavrier, Philippe
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errSave
Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction
errJOURNAL OF CELL BIOLOGY
IF6.4
err2018-01-19
err95
errOAAI
errGraham, David M.; Andersen, Tomas; Sharek, Lisa; Uzer, Gunes; Rothenberg, Katheryn; Hoffman, Brenton D.; Rubin, Janet; Balland, Martial; Bear, James E.; Burridge, Keith
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errSave
Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration
errJOURNAL OF CELL SCIENCE
IF3.6
err2017-09-15
err27
errOAAI
errZimmerman, Seth P.; Asokan, Sreeja B.; Kuhlman, Brian; Bear, James E.
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errSave

Research Directions

No research directions
Co-authors
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H-index: 262 · Papers: 2.0K
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Richard O. Hynes
H-index: 150 · Papers: 757
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Stefan W. Hell
H-index: 137 · Papers: 729
D
Douglas A. Lauffenburger
H-index: 126 · Papers: 1.1K
D
David E. Housman
H-index: 120 · Papers: 436
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