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GutkindJ.Silvio (J. Silvio Gutkind)

university of california san diego

140H-index
1.3KPaper Count
6.7WCitation Count
Published Papers 403
Publication Date
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A Phase II Trial of Defactinib Combined with Avutometinib in Patients with Metastatic Uveal Melanoma
errCancers
IF4.4
err2026-07-28
err0
errOAAI
errRino S. Seedor; Mizue Terai; Sergei Koshkin; Andrew E. Aplin; Marlana Orloff; Erin Sharpe-Mills; Madeleine Naccarato; Aurora Mills; Alfredo A. Molinolo; J. Silvio Gutkind; Takami Sato
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Protein Kinase A regulates Cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTP
errJournal of Biological Chemistry
IF3.9
err2025-12-18
err0
errOAAI
errSendi Rafael Adame-Garcia; Thomas S. Hoang; Pham Thuy Thien Vo; Valeria Burghi; Rodolfo Daniel Cervantes-Villagrana; Lennis Beatriz Orduña-Castillo; Dana J. Ramms; JoAnn Trejo; J.Silvio Gutkind
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Interactions of Antibody Drug Conjugate Anti-Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy
errAdvanced Science
IF14.1
err2025-10-24
err0
errOAAI
errJacqueline Lesperance; Bryan S. Yung; Michael M. Allevato; Marcus M Cheng; Maria F. Camargo; Robert Saddawi-Konefka; Kanika Dhawan; Ashwyn K. Sharma; Mahsa Mortaja; Sophie Bice; Daniel J. Scanderbeg; Diego Alvarado; Jyoti Mayadev; Ramez N. Eskander; Stephen R. Adams; Pippa F. Cosper; J. Silvio Gutkind; Sunil J. Advani
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errSave
PROTACs in cancer immunotherapy: a minireview
errBIOCHEMICAL SOCIETY TRANSACTIONS
IF4.3
err2025-10-01
err0
errOAAI
errKockenberger, J. E.; Alcoser, E. S. Cardenas; Chang, E.; Gutkind, J. S.; Ferguson, F. M.
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errSave
Chemokine-chemokine receptor networks in conventional type I dendritic cells: An opportunity to prime and boost anti-cancer immunity
errThe Journal of Pharmacology and Experimental Therapeutics
IF0
err2025-09-25
err0
PREAI
errNing Kuo; Cheyanne Kristen Shinn; Shiruyeh Schokrpur; Juliana Idoyaga; Tracy Handel; J.Silvio Gutkind
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Inhibition of anti-apoptotic BCL2 overcomes adaptive resistance to co-targeting of the protein kinase FAK and MEK in GNAQ-driven uveal melanoma
errJournal of Biological Chemistry
IF3.9
err2025-09-11
err0
errOAAI
errSimone Lubrano; Rodolfo Daniel Cervantes-Villagrana; Nadia Arang; Adam Officer; Sendi Rafael Adame-Garcia; Gabriela Cuesta-Margolles; Andrew E. Aplin; J.Silvio Gutkind
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Noncanonical Pathways of Proteasome Inhibition in HPV-Negative Head & Neck Cancer
errMolecular Carcinogenesis
IF3.2
err2025-08-19
err0
errOAAI
errHye-Yeon Lee; Ji-Yeong Kim; Zhiyong Wang; Panomwat Amornphimoltham; J. Silvio Gutkind; Woo-Jin Jeong
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Multistate oral carcinogenesis-A prospective cohort study and a parallel case-control study in Taiwan
errORAL ONCOLOGY
IF3.9
err2025-03-01
err0
PREAI
errWang, Cheng-Ping; Yu, Kelly J.; Chen, Tseng-Cheng; Tsai, Ming-shui; Kang, Chung-Jan; Chien, Chi-Yen; Engels, Eric A.; Hua, Chun-Hung; Hsu, Wan-Lun; Chang, Yih-Leong; Dawsey, Sanford M.; Wentzensen, Nicolas; Shi, Jianxin; Mao, Fangya; Cheung, Li C.; Katki, Hormuzd A.; Boyd, Eric; Wu, Chen-Tu; Gutkind, J. Silvio; Molinolo, Alfredo; Limbach, Abberly-Lott; Lingen, Mark W.; Lou, Pei-Jen; Chen, Chien-Jen; Hildesheim, Allan; Chaturvedi, Anil K.
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Tumor-Targeted Cell-Penetrating Peptides Reveal That Monomethyl Auristatin E Temporally Modulates the Tumor Immune Microenvironment
errMOLECULES
IF4.6
err2024-11-27
err0
errOAAI
errMortaja, Mahsa; Cheng, Marcus M.; Ali, Alina; Lesperance, Jacqueline; Hingorani, Dina V.; Allevato, Mike M.; Dhawan, Kanika; Camargo, Maria F.; Mckay, Rana R.; Adams, Stephen R.; Gutkind, J. Silvio; Advani, Sunil J.
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errSave
A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death
errCANCER LETTERS
IF10.1
err2024-08-01
err1
PREAI
errAllevato, Michael M.; Trinh, Sally; Koshizuka, Keiichi; Nachmanson, Daniela; Nguyen, Thien-Tu C.; Yokoyama, Yumi; Wu, Xingyu; Andres, Allen; Wang, Zhiyong; Watrous, Jeramie; Molinolo, Alfredo A.; Mali, Prashant; Harismendy, Olivier; Jain, Mohit; Wild, Robert; Gutkind, J. Silvio
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Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
errNPJ SYSTEMS BIOLOGY AND APPLICATIONS
IF3.5
err2024-07-16
err2
errOAAI
errTrogdon, Michael; Abbott, Kodye; Arang, Nadia; Lande, Kathryn; Kaur, Navneet; Tong, Melinda; Bakhoum, Mathieu; Gutkind, J. Silvio; Stites, Edward C.
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errSave
Pan-RAF:MEK Molecular Glues Take Center Stage
errCANCER DISCOVERY
IF33.3
err2024-07-01
err0
PREAI
errHangauer, Matthew J.; Gutkind, Jorge Silvio; Ferguson, Fleur M.
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errSave
Mouse Models for Head and Neck Squamous Cell Carcinoma
errJOURNAL OF DENTAL RESEARCH
IF5.9
err2024-05-09
err1
PREAI
errZhou, J.; Liu, C.; Amornphimoltham, P.; Cheong, S. C.; Gutkind, J. S.; Chen, Q.; Wang, Z.
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errSave
Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer
errNATURE COMMUNICATIONS
IF15.7
err2024-05-03
err10
errOAAI
errHaderk, Franziska; Chou, Yu-Ting; Cech, Lauren; Fernandez-Mendez, Celia; Yu, Johnny; Olivas, Victor; Meraz, Ismail M.; Rabago, Dora Barbosa; Kerr, D. Lucas; Gomez, Carlos; Allegakoen, David V.; Guan, Juan; Shah, Khyati N.; Herrington, Kari A.; Gbenedio, Oghenekevwe M.; Nanjo, Shigeki; Majidi, Mourad; Tamaki, Whitney; Pourmoghadam, Yashar K.; Rotow, Julia K.; McCoach, Caroline E.; Riess, Jonathan W.; Gutkind, J. Silvio; Tang, Tracy T.; Post, Leonard; Huang, Bo; Santisteban, Pilar; Goodarzi, Hani; Bandyopadhyay, Sourav; Kuo, Calvin J.; Roose, Jeroen P.; Wu, Wei; Blakely, Collin M.; Roth, Jack A.; Bivona, Trever G.
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The landscape of cancer-rewired GPCR signaling axes
errCELL GENOMICS
IF9
err2024-05-01
err2
errOAAI
errArora, Chakit; Matic, Marin; Bisceglia, Luisa; Di Chiaro, Pierluigi; Rosa, Natalia De Oliveira; Carli, Francesco; Clubb, Lauren; Fard, Lorenzo Amir Nemati; Kargas, Giorgos; Diaferia, Giuseppe R.; Vukotic, Ranka; Licata, Luana; Wu, Guanming; Natoli, Gioacchino; Gutkind, J. Silvio; Raimondi, Francesco
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Illuminating the tumor immune GPCRome: Novel immunotherapy targets
errCANCER RESEARCH
IF16.6
err2024-04-05
err0
PREAI
errGutkind, J. Silvio
errShare
errSave
A phase II trial of defactinib combined with avutometinib in patients with metastatic uveal melanoma
errCANCER RESEARCH
IF16.6
err2024-04-05
err0
PREAI
errSeedor, Rino S.; Terai, Mizue; Majeed, Amry; Tanaka, Ryota; Aplin, Andrew E.; Orloff, Marlana; Molinolo, Alfredo A.; Gutkind, J. Silvio; Sato, Takami
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errSave
Genome-wide CRISPR screening reveals a central role for ferroptotic cell death in the anti-tumor response to mTOR inhibitors in HNSCC
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errKoshizuka, Keiichi; Wu, Xingyu; Sato, Kuniaki; Pham Thuy Vo; Murawska, Gosia M.; Ishikawa, Tomohiko; Wang, Zhiyong; Molinolo, Alfredo A.; Dennis, Edward A.; Mali, Prashant; Gutkind, J. Silvio
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An ex-vivo organotypic culture platform of mucinous carcinomatosis peritonei identifies CDK4-6 inhibition as a novel treatment
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errWeitz, Jonathan; Nishizaki, Daisuke; Patel, Jay; Ng, Isabella; Sun, Siming; Ramms, Dana; Zou, Jingjing; Baumgartner, Joel; Kelly, Kaitlyn; Patel, Hitendra; White, Rebekah; Veerapong, Jula; Vu, Peter; Gutkind, Silvio; Tiriac, Herve; Kato, Shumei; Lowy, Andrew
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A novel combination therapy targeting RAF, MEK and FAK to overcome skin cutaneous melanoma treatment resistance
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errLubrano, Simone; Faraji, Farhoud; Cervantes-Villagrana, Rodolfo Daniel; Ramirez, Sydney; Arang, Nadia; Officer, Adam; Rigiracciolo, Damiano C.; Quiroz, Paola Y. Anguiano; Bacchiocchi, Antonieta; Halaban, Ruth; Coma, Silvia; Holmen, Sheri; Martini, Claudia; Pachter, Jonathan; Aplin, Andrew; Gutkind, J. Silvio
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Research Directions

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