logo
CanyamAI summaries for academic research
language
MobileMobile
  • Phone FeatureWeChat Mini Program
EnglishEnglish
noticeNotice
BlogBlog
arrow
G

Gregory J. Cost

Casebia Therapeutics
H-index:33
Citation Count:1.2万
Views:0

Biography

No content for now.

Education

No content for now.

Work Experience

No content for now.

Honors & Awards

No content for now.

Preclinical efficacy and safety assessment of engineered regulatory T cells for treatment of IPEX and other autoimmune disorders

工程化调节性T细胞治疗IPEX及其他自身免疫性疾病的疗效与安全性评估

Molecular Therapy
IF12
2026-03-130
PRE
Yuchi Honaker; Noelle P. Dahl; Swati Singh; Akhilesh K. Singh; Christina Lopez; David Gruber; Samuel C. Scharffenberger; Shivani Patel; Harold Jones; Iram F. Khan; Michelle L. Christian; Su Jung Yang; Karen Sommer; Troy R. Torgerson; Eric J. Allenspach; Cade Ellis K. Ito; Gene I. Uenishi; Gregory J. Cost; Peter J. Cook; David J. Rawlings
Integration of therapeutic cargo into the human genome with programmable type V-K CAST

利用可编程V-K型CAST将治疗性载荷整合到人类基因组中

NATURE COMMUNICATIONS
IF15.7
2025-03-131
OA
Liu, Jason; Goltsman, Daniela S. Aliaga; Alexander, Lisa M.; Khayi, Khak Khak; Hong, Jennifer H.; Dunham, Drew T.; Romano, Christine A.; Temoche-Diaz, Morayma M.; Chadha, Shailaja; Ocampo, Rodrigo Fregoso; Oki-O'Connell, Jennifer; Janson, Owen P.; Turcios, Keirstinne; Gonzalez-Osorio, Liliana; Muysson, Jared; Rahman, Jenat; Laperriere, Sarah M.; Devoto, Audra E.; Castelle, Cindy J.; Butterfield, Cristina N.; Cost, Gregory J.; Brown, Christopher T.; Thomas, Brian C.
AFNT-212: A TRAC-knocked-in KRASG12D-specific TCR-T cell product enhanced with CD8αß and a chimeric cytokine receptor for treatment of solid cancers
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Drain, Allison; Rouillard, Nicholas; Swanson, Nathaniel; Canestraro, Martina; Narayan, Santosh; Warner, Tyler; Danek, Nicole; Gareau, Ken; Liang, Jinsheng; Shen, Luhua; Tetrault, Tanya; Priyata, Iqraa; Vidyasagar, Sarah; Riggins-Walker, Taylor; Liu, Hui-Wen; Pechhold, Klaus; Brown, Lauren; Francis, Joshua; He, Xingyue; Browne, Patrick; Lamothe, Rebecca; Storlie, Meghan; Cost, Gregory; Schmitt, Thomas M.; Greenberg, Philip D.; Chandran, Smita S.; Klebanoff, Christopher A.; Lam, Hubert; Gupta, Ankit; Hallet, Damien; Shapiro, Gary; Nguyen, Kim; Vincent, Loic
Non-viral engineered T cell therapy specific for the hotspot mutation p53 R175H that integrates signal 1 (TCR), signal 2 ( co-stimulation) and signal 3 (cytokine) and co-opts FasL-dependent apoptosis to achieve a coordinated antitumor CD4/8 T cell response
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Narayan, Santosh; Gareau, Ken; Gupta, Ankit; Ferrell, Josh; Rouillard, Nicholas; Warner, Tyler; Liang, Jinsheng; Shen, Luhua; Tetrault, Tanya; Francis, Joshua; He, Xingyue; Browne, Patrick J.; Lamothe, Rebecca; Storlie, Meghan D.; Cost, Gregory J.; Schmitt, Thomas M.; Greenberg, Philip D.; Chandran, Smita S.; Hallet, Damien; Gormally, Michael; Klebanoff, Chistopher A.; Shapiro, Gary; Nguyen, Kim; Vincent, Loic
Novel and Engineered Type II CRISPR Systems from Uncultivated Microbes with Broad Genome Editing Capability
CRISPR JOURNAL
IF4
2023-06-012
OAAI
Alexander, Lisa M. M.; Goltsman, Daniela S. Aliaga S.; Liu, Jason; Lin, Jyun-Liang; Temoche-Diaz, Morayma M. M.; Laperriere, Sarah M. M.; Neerincx, Andreas; Bednarski, Christien; Knyphausen, Philipp; Cohnen, Andre; Albers, Justine; Gonzalez-Osorio, Liliana; Ocampo, Rodrigo Fregoso; Oki, Jennifer; Devoto, Audra E. E.; Castelle, Cindy J. J.; Lamothe, Rebecca C. C.; Cost, Gregory J. J.; Butterfield, Cristina N. N.; Thomas, Brian C. C.; Brown, Christopher T. T.
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering
CRISPR JOURNAL
IF4
2023-06-014
OAAI
Lamothe, Rebecca C.; Storlie, Meghan D.; Espinosa, Diego A.; Rudlaff, Rachel; Browne, Patrick; Liu, Jason; Rivas, Andres; Devoto, Audra; Oki, Jennifer; Khoubyari, Ashcon; Goltsman, Daniela S. Aliaga; Lin, Jyun-Liang; Butterfield, Cristina N.; Brown, Christopher T.; Thomas, Brian C.; Cost, Gregory J.
Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency
HEPATOLOGY COMMUNICATIONS
IF4.6
2023-03-010
OAAI
Li, Yanfeng; Guha, Chandan; Asp, Patrik; Wang, Xia; Tchaikovskya, Tatyana L.; Kim, Kenneth; Mendel, Matthew; Cost, Gregory J.; Perlmutter, David H.; Roy-Chowdhury, Namita; Fox, Ira J.; Conway, Anthony; Roy-Chowdhury, Jayanta
Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes
NATURE COMMUNICATIONS
IF15.7
2022-12-1512
OAAI
Goltsman, Daniela S. Aliaga; Alexander, Lisa M.; Lin, Jyun-Liang; Fregoso Ocampo, Rodrigo; Freeman, Benjamin; Lamothe, Rebecca C.; Perez Rivas, Andres; Temoche-Diaz, Morayma M.; Chadha, Shailaja; Nordenfelt, Natalie; Janson, Owen P.; Barr, Ian; Devoto, Audra E.; Cost, Gregory J.; Butterfield, Cristina N.; Thomas, Brian C.; Brown, Christopher T.
Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs
SCIENTIFIC REPORTS
IF3.9
2018-03-1933
OAAI
Montag, J.; Petersen, B.; Floegel, A. K.; Becker, E.; Lucas-Hahn, A.; Cost, G. J.; Muehlfeld, C.; Kraft, T.; Niemann, H.; Brenner, B.
A Genome Edited Pig with the Hypertrophic Cardiomyopathy-Mutation R723G in the MYH7-gene
BIOPHYSICAL JOURNAL
IF3.1
2018-02-010
OAAI
Montag, Judith; Petersen, Bjorn; Floegel, Anna Katharina; Becker, Edgar; Lucas-Hahn, Andrea; Cost, Gregory J.; Muehlfeld, Christian; Kraft, Theresia; Niemann, Heiner; Brenner, Bernhard
Towards Clinical Translation of Hematopoietic Stem Cell Gene Editing for the Correction of SCID-X1 Mutations
MOLECULAR THERAPY
IF12
2016-05-010
OAAI
Genovese, Pietro; Schiroli, Giulia; Conway, Anthony; Ferrari, Samuele; Guschin, Dmitry Y.; Di Tomaso, Tiziano; Albano, Luisa; Marin, Virna; Giuliani, Erica; Gregory, Philip D.; Holmes, Michael C.; Gentner, Bernhard; Bovolenta, Chiara; Cost, Gregory J.; Lombardo, Angelo; Naldini, Luigi
Valproic Acid Treatment Enhances Hematopoietic Stem and Progenitor Cell Multipotency Ex Vivo for Enhanced Long-Term Engraftment of Gene-Modified Cells
MOLECULAR THERAPY
IF12
2016-05-010
OAAI
Conway, Anthony; Boyko, Alisa; Hardin, Jeremy; Holmes, Michael C.; Cost, Gregory J.
A NOVEL IN VIVO CHEMOSELECTION STRATEGY FOR GENETICALLY MODIFIED HEMATOPOIETIC STEM CELLS
CYTOTHERAPY
IF3.2
2015-06-011
PREAI
Hacke, K.; Treger, J.; Bogan, B.; Rezek, V.; Narukawa, M.; Shimizu, S.; Liu, P-Q; Reik, A.; Lieber, A.; Crooks, G.; Kohn, D.; An, D. S.; Kitchen, S.; Gregory, P.; Cost, G.; Holmes, M.; Kasahara, N.
AAVHSC Vectors Encoding Zinc-Finger Nucleases Mediate Efficient Targeted Integration at the Human AAVS1 Locus in CD34+Human Hematopoietic Stem Cells
MOLECULAR THERAPY
IF12
2015-05-010
OAAI
Smith, Laura; Chandra, Manasa; Ul-Hasan, Taihra; Cost, Gregory; Holmes, Michael; Gregory, Philip; Wong, K. K.; Chatterjee, Saswati
Correction of the Sickle-Cell Disease Mutation in Human Hematopoietic Stem/Progenitor Cells
MOLECULAR THERAPY
IF12
2015-05-010
OAAI
Hoban, Megan D.; Mendel, Matthew C.; Romero, Zulema; Kaufman, Michael L.; Joglekar, Alok V.; Ho, Michelle; Lumaquin, Dianne; Gray, David; Lill, Georgia R.; Cooper, Aaron R.; Urbinati, Fabrizia; Senadheera, Shantha; Zhu, Allen; Liu, Pei-Qi; Paschon, David E.; Zhang, Lei; Rebar, Edward J.; Wilber, Andrew; Wang, Xiaoyan; Gregory, Philip D.; Holmes, Michael C.; Reik, Andreas; Hollis, Roger P.; Kohn, Donald B.; Cost, Gregory J.
Gene Correction of IL2RG in Human Hematopoietic Stem and Progenitor Cells
MOLECULAR THERAPY
IF12
2015-05-010
OAAI
Conway, Anthony; Guschin, Dmitry Y.; Genovese, Pietro; Lombardo, Angelo; Naldini, Luigi; Gregory, Philip D.; Holmes, Michael C.; Cost, Gregory J.
Genome Editing-Enabled HIS Assays Expand Drug Target Pathways for Charcot-Marie-Tooth Disease
ACS CHEMICAL BIOLOGY
IF3.8
2014-09-1633
OAAI
Inglese, James; Dranchak, Patricia; Moran, John J.; Jang, Sung-Wook; Srinivasan, Rajini; Santiago, Yolanda; Zhang, Lei; Guha, Rajarshi; Martinez, Natalia; MacArthur, Ryan; Cost, Gregory J.; Svaren, John
Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases
GENOME RESEARCH
IF5.5
2014-07-0245
OAAI
Remy, Severine; Tesson, Laurent; Menoret, Severine; Usal, Claire; De Cian, Anne; Thepenier, Virginie; Thinard, Reynald; Baron, Daniel; Charpentier, Marine; Renaud, Jean-Baptiste; Buelow, Roland; Cost, Gregory J.; Giovannangeli, Carine; Fraichard, Alexandre; Concordet, Jean-Paul; Anegon, Ignacio
Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells (vol 2, pg 838, 2014)
STEM CELL REPORTS
IF5.1
2014-07-011
OAAI
Forster, Ryan; Chiba, Kunitoshi; Schaeffer, Lorian; Regalado, Samuel G.; Lai, Christine S.; Gao, Qing; Kiani, Samira; Farin, Henner F.; Clevers, Hans; Cost, Gregory J.; Chan, Andy; Rebar, Edward J.; Urnov, Fyodor D.; Gregory, Philip D.; Pachter, Lior; Jaenisch, Rudolf; Hockemeyer, Dirk
Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells
STEM CELL REPORTS
IF5.1
2014-06-0180
OAAI
Forster, Ryan; Chiba, Kunitoshi; Schaeffer, Lorian; Regalado, Samuel G.; Lai, Christine S.; Gao, Qing; Kiani, Samira; Farin, Henner F.; Clevers, Hans; Cost, Gregory J.; Chan, Andy; Rebar, Edward J.; Urnov, Fyodor D.; Gregory, Philip D.; Pachter, Lior; Jaenisch, Rudolf; Hockemeyer, Dirk

Research Directions

The data has not been retrieved yet.
P
Philip D. Gregory
H-index:78Papers:230Citations:3.6万
M
Michael C. Holmes
H-index:57Papers:156Citations:2.3万
Y
Yolanda Santiago
H-index:13Papers:30Citations:3,444
F
Fyodor D. Urnov
H-index:54Papers:213Citations:2.4万
J
Jeffrey C. Miller
H-index:56Papers:163Citations:2.2万
E
Edward J. Rebar
H-index:52Papers:116Citations:2.2万
R
Rebecca Lamothe
H-index:7Papers:26Citations:518
C
Cristina N. Butterfield
H-index:13Papers:34Citations:3,788
B
Brian C. Thomas
H-index:70Papers:171Citations:2.3万
C
Christopher T. Brown
H-index:41Papers:149Citations:1.4万