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D

Daniel J. McGrail

Harvard University

35H-index
266Paper Count
4.7KCitation Count
Published Papers 87
Publication Date
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Targeting RNase H2: A dual-mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in TNBC
errCell Reports Medicine
IF10.6
err2026-04-20
err0
errOAAI
errThai Quynh Anh Nguyen; Jing Zhang; Hui Dai; Aysegul Murat; Yong Du; Daniel J. McGrail; Funda Meric-Bernstam; Shiaw-Yih Lin
errShare
errSave
eSIG-Net: an interaction language model that decodes the protein code of single mutations
errNature Methods
IF32.1
err2026-04-01
err0
PREAI
errPan, Xingxin; Shrawat, Aditya; Raghavan, Sidharth; Dong, Chuanpeng; Yang, Yuntao; Li, Zhao; Zheng, W. Jim; Eckhardt, S. Gail; Wu, Erxi; Fuxman Bass, Juan I.; Jarosz, Daniel F.; Chen, Sidi; McGrail, Daniel J.; Sheynkman, Gloria M.; Huang, Jason H.; Sahni, Nidhi; Yi, S. Stephen
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errSave
Tumor ecosystem and microbiome features associated with efficacy and resistance to avelumab plus chemoradiotherapy in head and neck cancer
errNature Cancer
IF28.5
err2026-01-02
err0
PREAI
errNadeem Riaz; Tyler J. Alban; Robert I. Haddad; Michelle Saul; Vladimir Makarov; Yingjie Zhu; Ezra E. W. Cohen; Robert L. Ferris; Peter Mu-Hsing Chang; Jin-Ching Lin; Amanda Psyrri; Prerana Bangalore Parthasarathy; Ardijana Novaj; Mruniya Gawali; Douglas Hoen; Phineas Hamilton; Natalie L. Silver; Ivan Juric; Daniel Chawla; Ana Gradissimo; Jennifer Ko; Daniel J. McGrail; Craig B. Davis; Nancy Y. Lee; Timothy A. Chan
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errSave
Neutrophil to lymphocyte ratio varies in magnitude and biomarker utility based on patient demographics
errJournal of Clinical Investigation
IF13.6
err2026-01-02
err2
errOAAI
errAng, William; Kerr, Travis D.; Kodiboyena, Ananya; Valero, Cristina; Vos, Joris L.; Makarov, Vladimir; Adjei, Alex A.; Morris, Luc G. T.; Schmit, Stephanie L.; Silver, Natalie L.; Patil, Sujata; McGrail, Daniel J.
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errSave
Intratumoral bacteria are immunosuppressive and promote immunotherapy resistance in head and neck squamous cell carcinoma
errNature Cancer
IF28.5
err2026-01-02
err0
errOAAI
errNatalie L. Silver; Jin Dai; Travis D. Kerr; Jessica Altemus; Rekha Garg; Hannah Simmons; Tyler Alban; Laura Noel-Romas; Vladimir Makarov; David J. H. Shih; Shwetha V. Kumar; Akeem Santos; Rehan Akbani; Adam Burgener; Mohammed Dwidar; Neil Gross; Andrew G. Sikora; Elias J. Sayour; Apollo Stacy; Christian Jobin; Timothy A. Chan; Renata Ferrarotto; Daniel J. McGrail
errShare
errSave
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
errMolecular Cell
IF16.6
err2025-10-28
err0
PREAI
errMushtaq A. Nengroo; Austin T. Klein; Heather S. Carr; Olivia Vidal-Cruchez; Umakant Sahu; Daniel J. McGrail; Nidhi Sahni; Niklas B. Thompson; Peter A. Faull; Peng Gao; John M. Asara; Hardik Shah; Marc L. Mendillo; Issam Ben-Sahra
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errSave
Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell-Induced Ferroptosis in Ovarian Cancer
errAdvanced Science
IF14.1
err2025-10-03
err0
errOAAI
errJiakai Hou; Cheng-Wei Ju; Nicholas A. Egan; Yanjun Wei; Yunfei Wang; Minghao Dang; Tianyi Zhou; Leilei Shi; Ningbo Zheng; Si Chen; Ashley M. Guerrero; Xiaofang Liang; Wanfu Wu; Areej Akhtar; Chitra Dhiman; Debanwita Roy Burman; Andro E. Gerges; Mason D. Flores; Han Li; Li-Sheng Zhang; Marleen Kok; Xiaobo Mao; Linghua Wang; Qin Feng; Yiwen Chen; Sanghoon Lee; Daniel J. McGrail; Nidhi Sahni; Chuan He; Amir A. Jazaeri; Weiyi Peng
errShare
errSave
Chemosensitization is not associated with improved adjuvant radiation outcomes for cutaneous squamous cell carcinoma: a dual-center retrospective cohort study
errJournal of the American Academy of Dermatology
IF11.8
err2025-09-11
err0
PREAI
errEmily E. Granger; Emily Y. Kim; Nina A. Ran; Karina Brito; David M. Wang; Ann W. Silk; Danielle N. Margalit; Roy B. Tishler; Jonathan D. Schoenfeld; Shauna Campbell; Allison Vidimos; Daniel McGrail; Shlomo Koyfman; Emily S. Ruiz
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errSave
Exploring TROP2 expression in oropharyngeal squamous cell carcinoma: Association with prognosis and tumor immune microenvironment composition
errOral Oncology
IF3.9
err2025-08-26
err0
PREAI
errJuliana Mota Siqueira; Daniele Heguedusch; Mateus Trinconi Cunha; Luana Guimaraes de Sousa; Mario L. Marques-Piubelli; Giovanna Lopes Carvalho; Camilla Oliveira Hoff; Flavia Bonini; Yoshitsugu Mitani; Michael T. Spiotto; Ryan Goepfert; Fabio Daumas Nunes; Leandro Luongo Matos; Luiz Paulo Kowalski; Daniel J McGrail; Adel K. El-Naggar; Renata Ferrarotto
errShare
errSave
KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer
errCancer Cell
IF44.5
err2025-07-10
err0
errOAAI
errAna Galan-Cobo; Natalie I. Vokes; Yu Qian; David Molkentine; Kavya Ramkumar; Alvaro G. Paula; Marlese Pisegna; Daniel J. McGrail; Alissa Poteete; Sungnam Cho; Minh Truong Do; Amirali Karimi; Yifan Kong; Anisha Solanki; Ankur Karmokar; Nicolas Floc’h; Adina Hughes; Rebecca Sargeant; Lucy Young; Li Shen; Gozde Kar; Caezaan Keshvani; Claudio Arrechedera; Sharia Hernandez; Katharina Schlacher; Jing Wang; Sonia Iyer; James Conway; Mohamed Reda Keddar; Marta Milo; Ilario de Toma; Susan E. Critchlow; J. Carl Barrett; Jan Cosaert; Alan Lau; Viia Valge-Archer; Lauren A. Byers; Simon T. Barry; John V. Heymach
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errSave
TROP2 Expression in Salivary Gland Adenoid Cystic Carcinoma (ACC) According to Histologic Subtype: Therapeutic Implications
errJournal of Oral Pathology & Medicine
IF2.3
err2025-07-08
err0
errOAAI
errJuliana Mota Siqueira; Yoshitsugu Mitani; Mario L. Marques-Piubelli; Camilla Oliveira Hoff; Flavia Bonini; Luana Guimaraes de Sousa; Mutsumi Mitani; Giovanna Lopes Carvalho; Fabio Daumas Nunes; Leandro Luongo Matos; Shiaw-Yih Lin; Michael T. Spiotto; Ehab Y. Hanna; Daniel J. McGrail; Adel K. El-Naggar; Renata Ferrarotto
errShare
errSave
Building research infrastructure to advance precision medicine in colorectal cancer
errJNCI CANCER SPECTRUM
IF4.1
err2025-06-01
err0
errOAAI
errSchmit, Stephanie L.; Lorona, Nicole C.; Sobieski, Daniel; Matejcic, Marco; Nguyen, Nathalie T.; Hoehn, Hannah J.; Diaz, Diana B.; Shankar, Kritika; Cockman, Eric M.; Jean-Baptiste, Esther; Tsai, Ya-Yu; Buchalter, R. Blake; Brito, Karina; Wilson, Rusche; Coppola, Domenico; Fulmer, Clifton; Saglam, Ozlen; Tassielli, Alexandra F.; Beato, Francisca; Dai, Ruifan; Freedman, Jennifer A.; Purrington, Kristen; Hu, Bo; Mcgrail, Daniel; Gibson, Heather; Jiang, Kun; Munoz-Antonia, Teresita; Flores, Idhaliz; Gordian, Edna; Oliveras Torres, Jose A.; Cheng, Iona; Van Blarigan, Erin L.; Felder, Seth I.; Sanchez, Julian A.; Fleming, Jason B.; Siegel, Erin M.; Cress, Douglas; Thompson, Patricia; Stern, Mariana C.; Teer, Jamie K.; Figueiredo, Jane C.
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errSave
UBA1 inhibition sensitizes cancer cells to PARP inhibitors
errCELL REPORTS MEDICINE
IF10.6
err2024-12-01
err1
PREAI
errAwasthi, Sharad; Dobrolecki, Lacey E.; Sallas, Christina; Zhang, Xudong; Li, Yang; Khazaei, Sima; Ghosh, Sumanta; Jeter, Collene R.; Liu, Jinsong; Mills, Gordon B.; Westin, Shannon N.; Lewis, Michael T.; Peng, Weiyi; Sood, Anil K.; Yap, Timothy A.; Yi, S. Stephen; McGrail, Daniel J.; Sahni, Nidhi
errShare
errSave
Uncovering cell-type-specific immunomodulatory variants and molecular phenotypes in COVID-19 using structurally resolved protein networks
errCELL REPORTS
IF6.9
err2024-11-01
err0
errOAAI
errChhibbar, Prabal; Roy, Priyamvada Guha; Harioudh, Munesh K.; McGrail, Daniel J.; Yang, Donghui; Singh, Harinder; Hinterleitner, Reinhard; Gong, Yi-Nan; Yi, S. Stephen; Sahni, Nidhi; Sarkar, Saumendra N.; Das, Jishnu
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errSave
Clinical and biomarker analyses of intratumoral CD40 agonist sotigalimab in combination with pembrolizumab in metastatic melanoma: A phase I/II trial
errANNALS OF ONCOLOGY
IF65.4
err2024-09-01
err0
PREAI
errBentebibel, S-E.; McGrail, D.; Wahab, R. Abdel; Kochat, V.; Arslan, E.; Pazdrak, B.; Tahon, N. H.; Amaria, R. N.; Glitza, I. C.; Patel, S.; Wong, M. K. K.; Tawbi, H. A.; Mcquade, J.; Davies, M.; Bernatchez, C.; Burks, J.; Rai, K.; Ekmekcioglu, S.; Lizee, L.; Diab, A.
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Notch inhibitor AL101 prior to surgery in patients (pts) with Notch1 activated adenoid cystic carcinoma (ACC): Safety and efficacy in a window of opportunity study
errANNALS OF ONCOLOGY
IF65.4
err2024-09-01
err0
PREAI
errFerrarotto, R.; McGrail, D.; Mitani, Y.; Santos, E.; Johnson, F.; Chen, M.; Li, K.; Lin, S-Y; Frank, S.; Lee, J. J.; Williams, M.; Esmaeli, B.; El-Naggar, A.; Hanna, E.
errShare
errSave
UBA1 blockade induces homologous recombination deficiency and is synthetic lethal with PARP inhibition
errCANCER RESEARCH
IF16.6
err2024-04-05
err0
PREAI
errAwasthi, Sharad; McGrail, Daniel J.; Yi, S. Stephen; Sahni, Nidhi
errShare
errSave
Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA binding proteins
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errKaundal, Babita; McGrail, Daniel J.; Li, Yang; Smith, Roger S.; Feng, Bin; Dai, Hui; Hu, Limei; Dennehey, Briana; Awasthi, Sharad; Mendillo, Marc L.; Sood, Anil K.; Mills, Gordon B.; Lin, Shiaw-Yih; Yi, S. Stephen; Sahni, Nidhi
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errSave
A functional atlas of cancer mutation-rewired protein interactome networks
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errAgrawal, Anjali; McGrail, Daniel; Sahni, Nidhi; Yi, S. Stephen
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errSave
PRMT blockade induces defective DNA replication stress response via ATR suppression and synergizes with PARP inhibition
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errBisht, Deepa; Li, Yang; Dobrolecki, Lacey E.; Sallas, Christina; Zhang, Xudong; Kerr, Travis D.; Wang, Yalong; Awasthi, Sharad; Kaundal, Babita; Wu, Siqi; Peng, Weiyi; Mendillo, Marc L.; Lu, Yiling; Jeter, Collene R.; Peng, Guang; Liu, Jinsong; Westin, Shannon N.; Sood, Anil K.; Lewis, Michael T.; Das, Jishnu; Yi, S. Stephen; Bedford, Mark T.; McGrail, Daniel J.; Sahni, Nidhi
errShare
errSave

Research Directions

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Co-authors
Cooperation Journals
G
Gordon B. Mills
H-index: 231 · Papers: 3.5K
C
Charles M. Perou
H-index: 193 · Papers: 2.0K
C
Chris Sander
H-index: 191 · Papers: 849
A
Anil K. Sood
H-index: 174 · Papers: 3.3K
C
Chuan He
H-index: 161 · Papers: 978
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