Brian D. Strahl - Publications, H-index & Citations

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Brian D. Strahl

university of north carolina at chapel hill

74H-index

380Paper Count

3.4WCitation Count

Published Papers 143

Publication Date

Discovery of Small-Molecule Antagonists of PHF1 and 19 Demonstrates the Ligandability of PRC2 Accessory Proteins

ACS Bio & Med Chem Au

IF4.3

2026-03-02

OAAI

Isabelle E. Amick; Rebecca L. Johnson; Jiuyang Liu; Cameron R. Bussey-Sutton; Ikeer Y. Mancera-Ortiz; Jacqueline L. Norris-Drouin; Shelton R. Boyd; Stephanie H. Cholensky; Cathy J. Spangler; Robert K. McGinty; Brian D. Strahl; Tatiana G. Kutateladze; Stephen V. Frye; Lindsey I. James

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HMGN1 and HMGN2 are recruited to acetylated and histone variant H2A.Z-containing nucleosomes to regulate chromatin state and transcription

Journal of Biological Chemistry

IF3.9

2025-11-29

OAAI

Riya Gohil; Zhihan Gao; Rebecca A. Lewis; Nathaniel T. Burkholder; Brian D. Strahl; Jill M. Dowen

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A needed nomenclature for nucleosomes

Molecular Cell

IF16.6

2025-10-02

PREAI

Michael-Christopher Keogh; Genevieve Almouzni; Andrew J. Andrews; Karim-Jean Armache; Cheryl H. Arrowsmith; Sung Hee Baek; Mark T. Bedford; Emily Bernstein; Jacques Côté; Yael David; John M. Denu; Beat Fierz; Benjamin A. Garcia; Karen C. Glass; Or Gozani; Kristian Helin; Steven Henikoff; Ole N. Jensen; Steven Z. Josefowicz; Neil L. Kelleher; Tatiana G. Kutateladze; Herbert H. Lindner; Chao Lu; Karolin Luger; Parag Mallick; Catherine A. Musselman; Tom W. Muir; Ljiljana Paša-Tolić; Robert Schneider; Xiaobing Shi; Yang Shi; Simone Sidoli; Lloyd M. Smith; Jessica K. Tyler; Cynthia Wolberger; Jerry L. Workman; Brian D. Strahl; Nicolas L. Young

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SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

ELIFE

IF0

2025-09-15

OAAI

Mack, Ricardo J.; Flores, Natasha M.; Fox, Geoffrey C.; Dong, Hanyang; Cebeci, Metehan; Hausmann, Simone; Chasan, Tourkian; Dowen, Jill M.; Strahl, Brian D.; Mazur, Pawel K.; Gozani, Or

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A SETD2–CDK1–lamin axis maintains nuclear morphology and genome stability

Nature Cell Biology

IF19.1

2025-08-11

PREAI

Abid Khan; Cheng Zhang; Phu G. Nguyen; James M. Metts; Lucas C. Collins; Kanishk Jain; C. Allie Mills; Logan Vlach; Kelin Li; Amanda L. Brademeyer; Brittany M. Bowman; Michael B. Major; Jeffrey Aubé; Laura E. Herring; W. Kimryn Rathmell; Frank M. Mason; Ian J. Davis; Qing Zhang; Brian D. Strahl

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Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response

NUCLEIC ACIDS RESEARCH

IF13.1

2025-07-22

PREAI

Jain, Kanishk; Tchara, Pata-Eting Kougnassoukou; Khan, Abid; Mengistalem, Amanuel B.; Holland, Aidan P.; Bowman, Christopher N.; Marunde, Matthew R.; Engel, Tiffany A.; Popova, Irina K.; Cooke, Spencer W.; Krajewski, Krzysztof; Keogh, Michael-Christopher; Lambert, Jean-Philippe; Strahl, Brian D.

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Written in chromatin: The enduring legacy of C. David Allis

Journal of Biological Chemistry

IF3.9

2025-07-01

OAAI

Brian D. Strahl; Gang Greg Wang

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Spt6-Spn1 interaction is required for RNA polymerase II association and precise nucleosome positioning along transcribed genes

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2025-05-01

OAAI

Chen, Boning; Dronamraju, Raghuvar; Smith-Kinnaman, Whitney R.; Justice, Sarah A. Peck; Hepperla, Austin J.; Macalpine, Heather K.; Simon, Jeremy M.; Mosley, Amber L.; MacAlpine, David M.; Strahl, Brian D.

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H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium

NATURE CELL BIOLOGY

IF19.1

2025-01-08

PREAI

Pashos, Alison R. S.; Meyer, Anne R.; Bussey-Sutton, Cameron; O'Connor, Erin S.; Coradin, Mariel; Coulombe, Marilyne; Riemondy, Kent A.; Potlapelly, Sanjana; Strahl, Brian D.; Hansson, Gunnar C.; Dempsey, Peter J.; Brumbaugh, Justin

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Histone H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-08-01

OAAI

Fox, Geoffrey C.; Poncha, Karl F.; Smith, B. Rutledge; van der Maas, Lara N.; Robbins, Nathaniel N.; Graham, Bria; Dowen, Jill M.; Strahl, Brian D.; Young, Nicolas L.; Jain, Kanishk

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Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex

NATURE COMMUNICATIONS

IF15.7

2024-06-24

OAAI

Nguyen, Minh Chau; Rostamian, Hosein; Raman, Ana; Wei, Pengcheng; Becht, Dustin C.; Erbse, Annette H.; Klein, Brianna J.; Gilbert, Tonya M.; Zhang, Gongyi; Blanco, M. Andres; Strahl, Brian D.; Taverna, Sean D.; Kutateladze, Tatiana G.

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The histone methyltransferase SETD2 regulates HIV expression and latency

PLOS PATHOGENS

IF4.9

2024-06-07

OAAI

Bussey-Sutton, Cameron R.; Ward, Airlie; Fox, Joshua A.; Turner, Anne-Marie W.; Peterson, Jackson J.; Emery, Ann; Longoria, Arturo R.; Gomez-Martinez, Ismael; Jones, Corbin; Hepperla, Austin; Margolis, David M.; Strahl, Brian D.; Browne, Edward P.

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Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment

NATURE COMMUNICATIONS

IF15.7

2024-05-16

OAAI

Daugird, Timothy A.; Shi, Yu; Holland, Katie L.; Rostamian, Hosein; Liu, Zhe; Lavis, Luke D.; Rodriguez, Joseph; Strahl, Brian D.; Legant, Wesley R.

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Chromatin mechanisms and genome maintenance functions of histone code writers

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-03-01

OAAI

Strahl, Brian

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Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation

CELL CHEMICAL BIOLOGY

IF7.2

2023-12-01

OAAI

Muneer, Adil; Wang, Li; Xie, Ling; Zhang, Feng; Wu, Bing; Mei, Liu; Lenarcic, Erik M.; Feng, Emerald Hillary; Song, Juan; Xiong, Yan; Yu, Xufen; Wang, Charles; Jain, Kanishk; Strahl, Brian D.; Cook, Jeanette Gowen; Wan, Yisong Y.; Moorman, Nathaniel John; Song, Hongjun; Jin, Jian; Chen, Xian

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SETD2 safeguards the genome against isochromosome formation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-09-18

OAAI

Mason, Frank M.; Kounlavong, Emily S.; Tebeje, Anteneh T.; Dahiya, Rashmi; Guess, Tiffany; Khan, Abid; Vlach, Logan; Norris, Stephen R.; Lovejoy, Courtney A.; Dere, Ruhee; Strahl, Brian D.; Ohi, Ryoma; Ly, Peter; Walker, Cheryl Lyn; Rathmell, W. Kimryn

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The bromo-adjacent homology domains of PBRM1 associate with histone tails and contribute to PBAF-mediated gene regulation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-08-01

OAAI

Petell, Christopher J.; Burkholder, Nathaniel T.; Ruiz, Paloma A.; Skela, Jessica; Foreman, Jake R.; Southwell, Lauren E.; Temple, Brenda R.; Krajewski, Krzysztof; Strahl, Brian D.

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Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4 (vol 9, 51, 2023)

CELL DISCOVERY

IF12.5

2023-06-30

OAAI

Chen, Zhenzhen; Lundy, Taylor; Zhu, Zhongliang; Hoskins, Victoria E. E.; Zhang, Jiahai; Yao, Xuebiao; Strahl, Brian D. D.; Xu, Chao

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Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4

CELL DISCOVERY

IF12.5

2023-05-26

OAAI

Chen, Zhenzhen; Lundy, Taylor; Zhu, Zhongliang; Hoskins, Victoria E.; Zhang, Jiahai; Yao, Xuebiao; Strahl, Brian D.; Xu, Chao

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An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

ELIFE

IF0

2023-05-19

OAAI

Jain, Kanishk; Marunde, Matthew R.; Burg, Jonathan M.; Gloor, Susan L.; Joseph, Faith M.; Poncha, Karl F.; Gillespie, Zachary B.; Rodriguez, Keli L.; Popova, Irina K.; Hall, Nathan W.; Vaidya, Anup; Howard, Sarah A.; Taylor, Hailey F.; Mukhsinova, Laylo; Onuoha, Ugochi C.; Patteson, Emily F.; Cooke, Spencer W.; Taylor, Bethany C.; Weinzapfel, Ellen N.; Cheek, Marcus A.; Meiners, Matthew J.; Fox, Geoffrey C.; Namitz, Kevin E. W.; Cowles, Martis W.; Krajewski, Krzysztof; Sun, Zu-Wen; Cosgrove, Michael S.; Young, Nicolas L.; Keogh, Michael-Christopher; Strahl, Brian D.

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Research Directions