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Alex S. Holehouse

Washington University School of Medicine

51H-index
288Paper Count
1.8WCitation Count
Published Papers 90
Publication Date
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Rational design of disordered proteins for sequence–function investigation
errNature
IF48.5
err2026-07-29
err0
PREAI
errKara Hunter; Trevor Brandt; Karina Guadalupe; Kavindu C. Kolamunna; Jeffrey M. Lotthammer; Nora M. Shamoon; Jessica K. Niblo; Brooke Nicholson; Lea M. Day; Alec Martinez; Alex S. Holehouse; Shahar Sukenik; Ryan J. Emenecker
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errSave
Accurate predictions of disordered protein ensembles with STARLING
errNature
IF48.5
err2026-02-18
err0
errOAAI
errBorna Novak; Jeffrey M. Lotthammer; Ryan J. Emenecker; Alex S. Holehouse
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errSave
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions
errNature Cell Biology
IF19.1
err2026-02-12
err0
errOAAI
errIris Langstein-Skora; Andrea Schmid; Frauke Huth; Drin Shabani; Lorenz Spechtenhauser; Mariia Likhodeeva; Franziska Kunert; Felix J. Metzner; Ryan J. Emenecker; Mary O. Richardson; Wasim Aftab; Maximilian J. Götz; Sarah K. Payer; Niccoló Pietrantoni; Valentina Valka; Sakthi K. Ravichandran; Till Bartke; Karl-Peter Hopfner; Ulrich Gerland; Philipp Korber; Alex S. Holehouse
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The filamentous ultrastructure of the PopZ condensate is required for its cellular function
errNature Structural & Molecular Biology
IF10.1
err2026-02-02
err0
errOAAI
errDaniel Scholl; Tumara Boyd; Andrew P. Latham; Alexandra Salazar; Asma M. A. M. Khan; Steven Boeynaems; Alex S. Holehouse; Gabriel C. Lander; Andrej Sali; Donghyun Park; Ashok A. Deniz; Keren Lasker
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errSave
Protein surface chemistry encodes an adaptive tolerance to desiccation
errCell Systems
IF7.7
err2025-10-02
err0
PREAI
errPaulette Sofía Romero-Pérez; Haley M. Moran; David P. Cordone; Azeem Horani; Alexander Truong; Edgar Manriquez-Sandoval; John F. Ramirez; Alec Martinez; Edith Gollub; Kara Hunter; Kavindu C. Kolamunna; Jeffrey M. Lotthammer; Ryan J. Emenecker; Hui Liu; Janet H. Iwasa; Thomas C. Boothby; Alex S. Holehouse; Stephen D. Fried; Shahar Sukenik
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errSave
A phase transition modulates the protective function of a tardigrade disordered protein during desiccation
errProtein Science
IF5.2
err2025-09-13
err0
errOAAI
errKenny Nguyen; Sourav Biswas; Shraddha KC; Annie Walgren; Vincent Nicholson; Charles Childs; Bryan X. Medina-Rodriguez; Vladimir Alvarado; Shahar Sukenik; Alex Holehouse; Thomas C. Boothby
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errSave
The dimerization domain of SARS-CoV-2 nucleocapsid protein is partially disordered and forms a dynamic high-affinity dimer
errCell Reports Physical Science
IF7.3
err2025-07-16
err0
errOAAI
errJasmine Cubuk; J. Jeremías Incicco; Kathleen B. Hall; Alex S. Holehouse; Melissa D. Stuchell-Brereton; Andrea Soranno
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errSave
Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms
errMOLECULAR CELL
IF16.6
err2025-04-01
err0
PREAI
errLambourne, Luke; Mattioli, Kaia; Santoso, Clarissa; Sheynkman, Gloria; Inukai, Sachi; Kaundal, Babita; Berenson, Anna; Spirohn-Fitzgerald, Kerstin; Bhattacharjee, Anukana; Rothman, Elisabeth; Shrestha, Shaleen; Laval, Florent; Carroll, Brent S.; Plassmeyer, Stephen P.; Emenecker, Ryan J.; Yang, Zhipeng; Bisht, Deepa; Sewell, Jared A.; Li, Guangyuan; Prasad, Anisa; Phanor, Sabrina; Lane, Ryan; Moyer, Devlin C.; Hunt, Toby; Balcha, Dawit; Gebbia, Marinella; Twizere, Jean-Claude; Hao, Tong; Holehouse, Alex S.; Frankish, Adam; Riback, Josh A.; Salomonis, Nathan; Calderwood, Michael A.; Hill, David E.; Sahni, Nidhi; Vidal, Marc; Bulyk, Martha L.; Bass, Juan I. Fuxman
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errSave
Disentangling Folding from Energetic Traps in Simulations of Disordered Proteins
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-03-01
err0
PREAI
errLotthammer, Jeffrey M.; Holehouse, Alex S.
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errSave
LEA_4 motifs function alone and in conjunction with synergistic cosolutes to protect a labile enzyme during desiccation
errPROTEIN SCIENCE
IF5.2
err2025-01-22
err1
errOAAI
errNicholson, Vincent; Nguyen, Kenny; Gollub, Edith; Mccoy, Mary; Yu, Feng; Holehouse, Alex S.; Sukenik, Shahar
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errSave
Phosphorylation of disordered proteins tunes local and global intramolecular interactions
errBIOPHYSICAL JOURNAL
IF3.1
err2024-12-01
err1
errOAAI
errUsher, Emery T.; Fossat, Martin J.; Holehouse, Alex S.
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errSave
Molecular insights into the interaction between a disordered protein and a folded RNA
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-11-26
err0
errOAAI
errMitra, Rishav; Usher, Emery T.; Dedeoglu, Selin; Crotteau, Matthew J.; Fraser, Olivia A.; Yennawar, Neela H.; Gadkari, Varun V.; Ruotolo, Brandon T.; Holehouse, Alex S.; Salmon, Loic; Showalter, Scott A.; Bardwell, James C. A.
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errSave
Disordered proteins interact with the chemical environment to tune their protective function during drying
errELIFE
IF0
err2024-11-19
err2
errOAAI
errShraddha, K. C.; Nguyen, Kenny H.; Nicholson, Vincent; Walgren, Annie; Trent, Tony; Gollub, Edith; Romero-Perez, Paulette Sofia; Holehouse, Alex S.; Sukenik, Shahar; Boothby, Thomas C.
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errSave
Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain
errGENOME RESEARCH
IF5.5
err2024-09-25
err0
PREAI
errShepherdson, James L.; Granas, David M.; Li, Jie; Shariff, Zara; Plassmeyer, Stephen P.; Holehouse, Alex S.; White, Michael A.; Cohen, Barak A.
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errSave
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-07-11
err0
errOAAI
errChadda, Rahul; Kaushik, Vikas; Ahmad, Iram Munir; Deveryshetty, Jaigeeth; Holehouse, Alex S.; Sigurdsson, Snorri Th; Biswas, Gargi; Levy, Yaakov; Bothner, Brian; Cooley, Richard B.; Mehl, Ryan A.; Dastvan, Reza; Origanti, Sofia; Antony, Edwin
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Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors
errCANCER DISCOVERY
IF33.3
err2024-07-09
err0
errOAAI
errChang, Ju-Fang; Landmann, Jack H.; Chang, Tien-Ching; Selli, Mehmet Emrah; Tenzin, Yangdon; Warrington, John M.; Ritchey, Julie; Hsu, Yu-Sung; Slade, Michael; Gupta, Deepesh Kumar; Dipersio, John F.; Holehouse, Alex S.; Singh, Nathan
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errSave
Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator
errNATURE COMMUNICATIONS
IF15.7
err2024-04-25
err1
errOAAI
errJankowski, Meaghan S.; Griffith, Daniel; Shastry, Divya G.; Pelham, Jacqueline F.; Ginell, Garrett M.; Thomas, Joshua; Karande, Pankaj; Holehouse, Alex S.; Hurley, Jennifer M.
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errSave
Dissecting the biophysics and biology of intrinsically disordered proteins
errTRENDS IN BIOCHEMICAL SCIENCES
IF11
err2024-02-01
err1
PREAI
errBanerjee, Priya R.; Holehouse, Alex S.; Kriwacki, Richard; Robustelli, Paul; Jiang, Hao; Sobolevsky, Alexander I.; Hurley, Jennifer M.; Mendell, Joshua T.
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errSave
Direct prediction of intrinsically disordered protein conformational properties from sequences
errNATURE METHODS
IF32.1
err2024-01-31
err26
errOAAI
errLotthammer, Jeffrey M.; Ginell, Garrett M.; Griffith, Daniel; Emenecker, Ryan J.; Holehouse, Alex S.
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errSave
Structural biases in disordered proteins are prevalent in the cell
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-01-04
err12
errOAAI
errMoses, David; Guadalupe, Karina; Yu, Feng; Flores, Eduardo; Perez, Anthony R.; McAnelly, Ralph; Shamoon, Nora M.; Kaur, Gagandeep; Cuevas-Zepeda, Estefania; Merg, Andrea D.; Martin, Erik W.; Holehouse, Alex S.; Sukenik, Shahar
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Research Directions

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Co-authors
Cooperation Journals
M
Marco Colonna
H-index: 170 · Papers: 848
A
Al-BassamJawdat (Anthony A. Hyman)
H-index: 144 · Papers: 549
A
Andrej Săli
H-index: 129 · Papers: 684
J
John F. DiPersio
H-index: 126 · Papers: 1.4K
D
David R. Liu
H-index: 124 · Papers: 378
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