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C

Carl‐Henrik Heldin

Science for Life Laboratory

144H-index
652Paper Count
7.6WCitation Count
Published Papers 210
Publication Date
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SNAI1 ablation alters integrin-mediated adhesion and endocytic fate
errCell Death & Disease
IF9.6
err2026-08-12
err0
errOAAI
errChrysoula Tsirigoti; Mohamad Moustafa Ali; Anita Morén; Staffan Johansson; Michael J. Munson; Carl-Henrik Heldin; Aristidis Moustakas; Dorival Mendes Rodrigues-Junior
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SHP2 negatively regulates TGF-β signaling by destabilizing the TGF-β type I receptor
errCell Communication and Signaling
IF8.9
err2026-07-03
err0
errOAAI
errCen Zhao; Ihor Yakymovych; Mariya Yakymovych; Pengwei Xing; Carl-Henrik Heldin
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errSave
TGFβ signaling promotes cell cycle progression and resistance to the CDK4/6 inhibitor palbociclib through SOX4 transcriptional modulation in breast cancer cells
errCell Death & Disease
IF9.6
err2026-02-04
err0
errOAAI
errMohamad Moustafa Ali; Yuka Itoh; Aisha Mariama Pereira Badji; Sarah Gallant; Chrysoula Tsirigoti; Yu Bai; Beata Filipek-Górniok; Keiji Miyazawa; Carl-Henrik Heldin; Aristidis Moustakas
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The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
errCELL DEATH AND DIFFERENTIATION
IF15.4
err2025-03-28
err0
errOAAI
errOhata, Yae; Ali, Mohamad M.; Tsubakihara, Yutaro; Itoh, Yuka; Rosen, Gabriela; Bergstrom, Tobias; Moren, Anita; Golan-Cancela, Irene; Nakada, Ayana; Voytyuk, Oleksandr; Tsuchiya, Maiko; Fukui, Rei; Yamamoto, Kouhei; Martin-Rubio, Paula; Sancho, Patricia; Strell, Carina; Micke, Patrick; Wechsler-Reya, Robert J.; Hashizume, Yoshinobu; Miyazono, Kohei; Caja, Laia; Heldin, Carl-Henrik; Swartling, Fredrik J.; Moustakas, Aristidis
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errSave
Targeting TGF-β signaling components to ameliorate Palbociclib resistance in breast cancer
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errAli, M.; Itoh, Y.; Heldin, C. H.; Moustakas, A.
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errSave
ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
errCELL COMMUNICATION AND SIGNALING
IF8.9
err2024-08-23
err2
errOAAI
errVasilaki, Eleftheria; Bai, Yu; Ali, Mohamad Moustafa; Sundqvist, Anders; Moustakas, Aristidis; Heldin, Carl-Henrik
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errSave
Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-07-01
err0
errOAAI
errVoytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter; Heldin, Carl-Henrik
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errSave
The TGF-β/BMP signaling cascades induce opposing fates in breast cancer and medulloblastoma through chromatin and cell cycle modulatio
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errAli, Mohamad Moustafa; Ohata, Yae; Heldin, Carl-Henrik; Moustakas, Aristidis
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errSave
The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
errCELL COMMUNICATION AND SIGNALING
IF8.9
err2023-10-02
err8
errOAAI
errGelabert, Caroline; Papoutsoglou, Panagiotis; Golan, Irene; Ahlstrom, Eric; Ameur, Adam; Heldin, Carl-Henrik; Caja, Laia; Moustakas, Aristidis
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errSave
Nuclear factor YY1 inhibits transforming growth factor β- and bone morphogenetic protein-induced cell differentiation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err160
errOAAI
errKurisaki, K; Kurisaki, A; Valcourt, U; Terentiev, AA; Pardali, K; ten Dijke, P; Heldin, CH; Ericsson, J; Moustakas, A
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errSave
Interaction between smad7 and β-catenin:: Importance for transforming growth factor β-induced apoptosis
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err133
errOAAI
errEdlund, S; Lee, SY; Grimsby, S; Zhang, SH; Aspenström, P; Heldin, CH; Landström, M
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errSave
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err106
errOAAI
errKurisaki, A; Kurisaki, K; Kowanetz, M; Sugino, H; Yoneda, Y; Heldin, CH; Moustakas, A
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errSave
Site-selective regulation of platelet-derived growth factor β receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err99
errOAAI
errPersson, C; Sävenhed, C; Bourdeau, A; Tremblay, ML; Markova, B; Böhmer, FD; Haj, FG; Neel, BG; Elson, A; Heldin, CH; Rönnstrand, L; Östman, A; Hellberg, C
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errSave
Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err25
errOAAI
errKrampert, Monika; Chirasani, Sridhar Reddy; Wachs, Frank-Peter; Aigner, Robert; Bogdahn, Ulrich; Yingling, Jonathan M.; Heldin, Carl-Henrik; Aigner, Ludwig; Heuchel, Rainer
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errSave
The type II TGF-β receptor phosphorylates Tyr182 in the type I receptor to activate downstream Src signaling
errSCIENCE SIGNALING
IF6.6
err2022-11-15
err6
errOAAI
errYakymovych, Ihor; Yakymovych, Mariya; Hamidi, Anahita; Landstrom, Marene; Heldin, Carl-Henrik
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errSave
Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
errCELL DEATH & DISEASE
IF9.6
err2022-09-28
err12
errOAAI
errTsirigoti, Chrysoula; Ali, Mohamad Moustafa; Maturi, Varun; Heldin, Carl-Henrik; Moustakas, Aristidis
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errSave
The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
errEBIOMEDICINE
IF10.8
err2022-08-01
err10
errOAAI
errSong, Jie; Zhou, Yang; Yakymovych, Ihor; Schmidt, Alexej; Li, Chunyan; Heldin, Carl-Henrik; Landstrom, Marene
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errSave
TGFβ selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
errMOLECULAR ONCOLOGY
IF4.5
err2022-04-10
err6
errOAAI
errTsubakihara, Yutaro; Ohata, Yae; Okita, Yukari; Younis, Shady; Eriksson, Jens; Sellin, Mikael E.; Ren, Jiang; Ten Dijke, Peter; Miyazono, Kohei; Hikita, Atsuhiko; Imamura, Takeshi; Kato, Mitsuyasu; Heldin, Carl-Henrik; Moustakas, Aristidis
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errSave
Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2022-01-21
err8
errOAAI
errSarri, Niki; Wang, Kehuan; Tsioumpekou, Maria; Castillejo-Lopez, Casimiro; Lennartsson, Johan; Heldin, Carl-Henrik; Papadopoulos, Natalia
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errSave
BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells
errCELLULAR SIGNALLING
IF3.7
err2021-11-01
err13
errOAAI
errFukuda, Tomohiko; Fukuda, Risa; Koinuma, Daizo; Moustakas, Aristidis; Miyazono, Kohei; Heldin, Carl-Henrik
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Research Directions

No research directions
Co-authors
Cooperation Journals
K
Kari Alitalo
H-index: 187 · Papers: 1.1K
P
Peter ten Dijke
H-index: 147 · Papers: 794
K
Kohei Miyazono
H-index: 138 · Papers: 709
P
Patrice D. Cani
H-index: 129 · Papers: 603
H
Hiroyuki Aburatani
H-index: 129 · Papers: 1.1K
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