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Philippe Froguel

lille university hospital

163H-index
1.2KPaper Count
13.1WCitation Count
Published Papers 450
Publication Date
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Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes
errNature Communications
IF15.7
err2026-06-03
err0
errOAAI
errLucas Maurin; Lorella Marselli; Mathilde Boissel; Vincent Pascat; Mara Suleiman; Emma Henriques; Carmela De Luca; Lijiao Ning; Marie Fourcot; Marta Tesi; Bénédicte Toussaint; Souhila Amanzougarene; Mehdi Derhourhi; Frédérik Oger; Frederic Burdet; Mickael Canouil; Miriam Cnop; Mark Ibberson; Amélie Bonnefond; Piero Marchetti; Philippe Froguel; Amna Khamis
errShare
errSave
The genetics of obesity: aetiology, prevention and therapy
errNature Metabolism
IF20.8
err2026-03-24
err0
PREAI
errAmélie Bonnefond; Winter S. Bruner; Struan F. A. Grant; Anita Morandi; Philippe Froguel
errShare
errSave
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases
errNature Communications
IF15.7
err2026-03-05
err0
errOAAI
errKanta Chechi; Rima Chakaroun; Antonis Myridakis; Sofia K. Forslund-Startceva; Sebastien Fromentin; Trine Nielsen; Judith Aron-Wisneswky; Eugeni Belda; Edi Prifti; Pierre Bel Lassen; Gwen Falony; Sara Vieira-Silva; Julien Chilloux; Kazuhiro Sonomura; Lesley Hoyles; Laura Martinez-Gili; Francesco Pallotti; Petros Andrikopoulos; Francesc Puig-Castellví; Romina Pacheco Tapia; Inés Castro-Dionicio; Hugo Roume; Nicolas Pons; Emmanuelle Le Chatelier; Benoit Quinquis; Nathalie Galleron; Magali Berland; Michael T. Olanipekun; Manyi Jia; Angelos Manolias; Bridget Holmes; Solia Adriouch; Matthias Blüher; Luis Pedro Coelho; Kévin Da Silva; Pilar Galan; Boyang Ji; Ana Luisa Neves; Christine Rouault; Joe-Elie Salem; Valentina Tremaroli; Tue H. Hansen; Nadja B. Søndertoft; Christian Lewinter; Helle K. Pedersen; Peter D. Mark; Jens P. Goetze; Lars Køber; Henrik Vestergaard; Torben Hansen; Jean-Daniel Zucker; Taka-Aki Sato; Serge Hercberg; Fredrik Bäckhed; Ivica Letunic; Jean-Michel Oppert; Jens Nielsen; Jeroen Raes; Ioanna Tzoulaki; Abbas Dehghan; Verena Zuber; Emmanuelle Bouzigon; Mark Lathrop; Parminder Raina; Philippe Froguel; Fumihiko Matsuda; Florence Demenais; Dominique Gauguier; Michael Stumvoll; Peer Bork; Oluf Pedersen; S. Dusko Ehrlich; Karine Clément; Marc-Emmanuel Dumas
errShare
errSave
Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity
errNature Communications
IF15.7
err2026-02-09
err0
errOAAI
errVincent Pascat; Liudmila Zudina; Lucas Maurin; Anna Ulrich; Jared G. Maina; Ayse Demirkan; Zhanna Balkhiyarova; Igor Pupko; Yevheniya Sharhorodska; François Pattou; Bart Staels; Marika Kaakinen; Amna Khamis; Amélie Bonnefond; Patricia Munroe; Philippe Froguel; Inga Prokopenko
errShare
errSave
Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes
errGUT MICROBES
IF11
err2025-12-31
err0
PREAI
errAdriouch, Solia; Belda, Eugeni; Swartz, Timothy D.; Forslund, Sofia; Prifti, Edi; Aron-Wisnewsky, Judith; Chakaroun, Rima; Nielsen, Trine; Poitou, Christine; Bel-Lassen, Pierre; Rouault, Christine; Le Roy, Tiphaine; Andrikopoulos, Petros; Chechi, Kanta; Puig-Castellvi, Francesc; Dionicio, Ines Castro; Froguel, Philippe; Holmes, Bridget; Alili, Rohia; Andreelli, Fabrizio; Soula, Hedi; Salem, Joe-Elie; Falony, Gwen; Vieira-Silva, Sara; Raes, Jeroen; Bork, Peer; Stumvoll, Michael; Pedersen, Oluf; Ehrlich, S. Dusko; Dumas, Marc-Emmanuel; Oppert, Jean-Michel; Dao, Maria Carlota; Zucker, Jean-Daniel; Clement, Karine
errShare
errSave
OBEClust: joining forces to prevent obesity
errNature Reviews Endocrinology
IF31.8
err2025-11-11
err0
PREAI
errManuel Tena-Sempere; Dimitrios-Dionyssios Koutsouris; George Dedoussis; Jeroen Lakerveld; Karl-Heinz Wagner; Itziar Tueros; Philippe Froguel; Torsten Bohn; Paulo J. Oliveira
errShare
errSave
Human liver perfluorooctane sulfonate associates with steatotic liver disease in a sex-dependent manner
errEnvironment International
IF9.7
err2025-10-09
err0
errOAAI
errEmily Flam; Viktor Liénard; Violeta Raverdy; Mehdi Derhourhi; Philippe Froguel; Amélie Bonnefond; Philippe Lefebvre; François Pattou; Delphine Eberlé; Joel T. Haas; Bart Staels
errShare
errSave
Exploring the role of readthrough-inducing molecule 2,6-diaminopurine to increase immune response against cancer cells
errMolecular Therapy
IF12
err2025-09-12
err0
errOAAI
errCarmen Sandoval Pacheco; Alice M. Leroy; Mehdi Derhourhi; Tristan Cardon; Catherine Leroy; Nathalie Jouy; Emmanuelle Com; Blandine Guevel; Roland Bourette; Julie Carrard; Daniela Barros; Belinda Duchêne; Bénédicte Toussaint; Philippe Froguel; Nicolas Jonckheere; Thierry Chassat; Isabelle Van Seuningen; Régis Lavigne; Charles Pineau; Philippe Pierre; Fabrice Soncin; Michel Salzet; Amélie Bonnefond; Fabrice Lejeune
errShare
errSave
The role of SLC19A2 variants in the wide spectrum of non-autoimmune abnormalities of glucose homeostasis
errDiabetologia
IF10.2
err2025-07-02
err0
PREAI
errAntonella Marucci; Mehdi Derhourhi; Claudia Menzaghi; Grazia Fini; Marina Valenzano; Simona Zampetti; Alessandro Doria; Philippe Froguel; Amélie Bonnefond; Vincenzo Trischitta; Rosa Di Paola
errShare
errSave
Biallelic pathogenic variants in POMC can cause combined pituitary hormonal deficiency associated with severe obesity
errEUROPEAN JOURNAL OF ENDOCRINOLOGY
IF5.2
err2025-07-01
err0
PREAI
errVitellius, Geraldine; Poitou, Christine; Clement, Karine; Petit, Jean Michel; Gatta Cherifi, Blandine; Amanzougarene, Souhila; Derhourhi, Mehdi; Saveanu, Alexandru; Froguel, Philippe; Bonnefond, Amelie; Delemer, Brigitte; Le Collen, Lauriane
errShare
errSave
Canine genome-wide association study identifies <i>DENND1B</i> as an obesity gene in dogs and humans
errScience
IF45.8
err2025-03-28
err0
PREAI
errNatalie J. Wallis; Alyce McClellan; Alexander Mörseburg; Katherine A. Kentistou; Aqfan Jamaluddin; Georgina K. C. Dowsett; Ellen Schofield; Anna Morros-Nuevo; Sadia Saeed; Brian Y. H. Lam; Natasha T. Sumanasekera; Justine Chan; Sambhavi S. Kumar; Rey M. Zhang; Jodie F. Wainwright; Marie Dittmann; Gabriella Lakatos; Kara Rainbow; David Withers; Rebecca Bounds; Marcella Ma; Alexander J. German; Jane Ladlow; David Sargan; Philippe Froguel; I. Sadaf Farooqi; Ken K. Ong; Giles S. H. Yeo; John A. Tadross; John R. B. Perry; Caroline M. Gorvin; Eleanor Raffan
errShare
errSave
Rare ZMPSTE24 variants increase risk of hypertriglyceridemia and metabolic syndrome
errEUROPEAN JOURNAL OF ENDOCRINOLOGY
IF5.2
err2025-02-24
err0
PREAI
errLe Collen, Lauriane; Desgrouas, Camille; Lukas Croisier, Celine; Creugnet, Brunot; Dechaume, Aurelie; Toussaint, Benedicte; Vaillant, Emmanuel; Amanzougarene, Souhila; Buse Falay, Emmanuel; Derhourhi, Mehdi; Lourdelle, Alexandre; Delemer, Brigitte; Bonello-Palot, Nathalie; Vaxillaire, Martine; Badens, Catherine; Froguel, Philippe; Bonnefond, Amelie
errShare
errSave
Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease
errMOLECULAR METABOLISM
IF6.6
err2025-02-01
err0
errOAAI
errDeslande, Maxime; Puig-Castellvi, Francesc; Castro-Dionicio, Ines; Pacheco-Tapia, Romina; Raverdy, Violeta; Caiazzo, Robert; Lassailly, Guillaume; Leloire, Audrey; Andrikopoulos, Petros; Kahoul, Yasmina; Zaibi, Nawel; Toussaint, Benedicte; Oger, Frederik; Gambardella, Nicolas; Lefebvre, Philippe; Derhourhi, Mehdi; Amanzougarene, Souhila; Staels, Bart; Pattou, Francois; Froguel, Philippe; Bonnefond, Amelie; Dumas, Marc-Emmanuel
errShare
errSave
Towards the recognition of oligogenic forms of type 2 diabetes
errTRENDS IN ENDOCRINOLOGY AND METABOLISM
IF12.6
err2025-02-01
err2
PREAI
errLe Collen, Lauriane; Froguel, Philippe
errShare
errSave
Monoallelic pathogenic variants in LEPR do not cause obesity
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2024-12-01
err1
PREAI
errDelplanque, Jerome; Le Collen, Lauriane; Loiselle, Helene; Leloire, Audrey; Toussaint, Benedicte; Vaillant, Emmanuel; Charpentier, Guillaume; Franc, Sylvia; Balkau, Beverley; Marre, Michel; Henriques, Emma; Falay, Emmanuel Buse; Derhourhi, Mehdi; Froguel, Philippe; Bonnefond, Amelie
errShare
errSave
Genetics brings new insight to β-cell function
errNATURE METABOLISM
IF20.8
err2024-10-17
err0
PREAI
errBonnefond, Amelie; Froguel, Philippe
errShare
errSave
Obesity: exploring its connection to brain function through genetic and genomic perspectives
errMOLECULAR PSYCHIATRY
IF10.1
err2024-09-05
err0
errOAAI
errSaeed, Sadia; Bonnefond, Amelie; Froguel, Philippe
errShare
errSave
PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism
errDIABETES
IF7.5
err2024-08-13
err1
PREAI
errMaurin, Lucas; Marselli, Lorella; Boissel, Mathilde; Ning, Lijiao; Boutry, Raphael; Fernandes, Justine; Suleiman, Mara; De Luca, Carmela; Leloire, Audrey; Pascat, Vincent; Toussaint, Benedicte; Amanzougarene, Souhila; Derhourhi, Mehdi; Joerns, Anne; Lenzen, Sigurd; Pattou, Francois; Kerr-Conte, Julie; Canouil, Mickael; Marchetti, Piero; Bonnefond, Amelie; Froguel, Philippe; Khamis, Amna
errShare
errSave
Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function
errNATURE COMMUNICATIONS
IF15.7
err2024-08-05
err0
errOAAI
errMeulebrouck, Sarah; Merrheim, Judith; Queniat, Gurvan; Bourouh, Cyril; Derhourhi, Mehdi; Boissel, Mathilde; Yi, Xiaoyan; Badreddine, Alaa; Boutry, Raphael; Leloire, Audrey; Toussaint, Benedicte; Amanzougarene, Souhila; Vaillant, Emmanuel; Durand, Emmanuelle; Loiselle, Helene; Huyvaert, Marlene; Dechaume, Aurelie; Scherrer, Victoria; Marchetti, Piero; Balkau, Beverley; Charpentier, Guillaume; Franc, Sylvia; Marre, Michel; Roussel, Ronan; Scharfmann, Raphael; Cnop, Miriam; Canouil, Mickael; Baron, Morgane; Froguel, Philippe; Bonnefond, Amelie
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errSave
CONTRIBUTION OF RARE EXONIC VARIANTS IN TELOMERE-RELATED GENES TO INTERSTITIAL LUNG DISEASE RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS AND IDIOPATHIC PULMONARY FIBROSIS
errANNALS OF THE RHEUMATIC DISEASES
IF20.6
err2024-06-01
err0
PREAI
errJuge, P. A.; Kawano-Dourado, L.; Stockwell, A.; Lee, J. S.; Gazal, S.; Mcdermott, G.; Hayashi, K.; Cui, J.; Granger, B.; Kannengiesser, C.; Borie, R.; Stervinou, L. Wemeau; Debray, M. P.; Wolters, P. J.; Marchand-Adam, S.; Richez, C.; Nunes, H.; Froguel, P.; Avouac, J.; Flipo, R. M.; Cottin, V.; Boissier, M. C.; Schaeverbeke, T.; Kermanac'h, N. Saidenberg; Crestani, B.; Doyle, T.; Raychaudhuri, S.; Karlson, E.; Yaspan, B. L.; Dieude, P.
errShare
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Research Directions

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Co-authors
Cooperation Journals
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Mark I. McCarthy
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Mika Kivimäki
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Panos Deloukas
H-index: 197 · Papers: 764
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