Not logged in Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2 Klebba, Joseph E.; Roy, Nilotpal; Bernard, Steffen M.; Grabow, Stephanie; Hoffman, Melissa A.; Miao, Hui; Tamiya, Junko; Wang, Jinwei; Berry, Cynthia; Esparza-Oros, Antonio; Lin, Richard; Liu, Yongsheng; Pariollaud, Marie; Parker, Holly; Mochalkin, Igor; Rana, Sareena; Snead, Aaron N.; Walton, Eric J.; Wyrick, Taylor E.; Aitichson, Erick; Bedke, Karl; Brannon, Jacyln C.; Chick, Joel M.; Hee, Kenneth; Horning, Benjamin D.; Ismail, Mohamed; Lamb, Kelsey N.; Lin, Wei; Lu, Justine; Pastuszka, Martha K.; Pollock, Jonathan; Sigler, John J.; Tomaschko, Mona; Tran, Eileen; Yue, Chanyu; Kinsella, Todd M.; Molina-Arcas, Miriam; Cook, Brian N.; Simon, Gabriel M.; Weinstein, David S.; Downward, Julian; Patricelli, Matthew P. Share Save
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α (vol 13, 1889, 2023) Ismail, Mohamed; Martin, Stephen R.; George, Roger; Houghton, Francesca; Kelly, Geoff; Chaleil, Raphael A. G.; Anastasiou, Panayiotis; Wang, Xinyue; O'Reilly, Nicola; Federico, Stefania; Joshi, Dhira; Nagaraj, Hemavathi; Cooley, Rachel; Hui, Ning Sze; Molina-Arcas, Miriam; Hancock, David C.; Tavassoli, Ali; Downward, Julian Share Save
Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses Cole, Megan; Anastasiou, Panayiotis; Lee, Claudia; Yu, Xiaofei; de Castro, Andrea; Roelink, Jannes; Moore, Chris; Mugarza, Edurne; Jones, Martin; Valand, Karishma; Rana, Sareena; Colliver, Emma; Angelova, Mihaela; Enfield, Katey S. S.; Magness, Alastair; Mullokandov, Asher; Kelly, Gavin; de Gruijl, Tanja D.; Molina-Arcas, Miriam; Swanton, Charles; Downward, Julian; van Maldegem, Febe Share Save
Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade Anastasiou, Panayiotis; Moore, Christopher; Rana, Sareena; Tomaschko, Mona; Pillsbury, Claire E.; de Castro, Andrea; Boumelha, Jesse; Mugarza, Edurne; Trecesson, Sophie de Carne; Mikolajczak, Ania; Blaj, Cristina; Goldstone, Robert; Smith, Jacqueline A. M.; Quintana, Elsa; Molina-Arcas, Miriam; Downward, Julian Share Save
Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX Magness, Alastair; Colliver, Emma; Enfield, Katey S. S.; Lee, Claudia; Shimato, Masako; Daly, Emer; Moore, David A.; Sivakumar, Monica; Valand, Karishma; Levi, Dina; Hiley, Crispin T.; Hobson, Philip S.; van Maldegem, Febe; Reading, James L.; Quezada, Sergio A.; Downward, Julian; Sahai, Erik; Swanton, Charles; Angelova, Mihaela Share Save
LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis Xu, Zijian; Davies, Elizabeth R.; Yao, Liudi; Zhou, Yilu; Li, Juanjuan; Alzetani, Aiman; Marshall, Ben G.; Hancock, David; Wallis, Tim; Downward, Julian; Ewing, Rob M.; Davies, Donna E.; Jones, Mark G.; Wang, Yihua Share Save
Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis Tomi, Goran; Sheridan, Clare; Refermat, Alice Y.; Baggelaar, Marc P.; Sipthorp, James; Sudarshan, Bhuvana; Ocasio, Cory A.; Suarez-Bonnet, Alejandro; Priestnall, Simon L.; Herbert, Eleanor; Tate, Edward W.; Downward, Julian Share Save
CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer Boumelha, Jesse; de Castro, Andrea; Bah, Nourdine; Cha, Hongui; Trecesson, Sophie de Carne; Rana, Sareena; Tomaschko, Mona; Anastasiou, Panayiotis; Mugarza, Edurne; Moore, Christopher; Goldstone, Robert; East, Phil; Litchfield, Kevin; Lee, Se-Hoon; Molina-Arcas, Miriam; Downward, Julian Share Save
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer Enfield, Katey S. S.; Colliver, Emma; Lee, Claudia; Magness, Alastair; Moore, David A.; Sivakumar, Monica; Grigoriadis, Kristiana; Pich, Oriol; Karasaki, Takahiro; Hobson, Philip S.; Levi, Dina; Veeriah, Selvaraju; Puttick, Clare; Nye, Emma L.; Green, Mary; Dijkstra, Krijn K.; Shimato, Masako; Akarca, Ayse U.; Marafioti, Teresa; Salgado, Roberto; Hackshaw, Allan; Jamal-Hanjani, Mariam; van Maldegem, Febe; Mcgranahan, Nicholas; Glass, Benjamin; Pulaski, Hanna; Walk, Eric; Reading, James L.; Quezada, Sergio A.; Hiley, Crispin T.; Downward, Julian; Sahai, Erik; Swanton, Charles; Angelova, Mihaela Share Save
Investigating therapeutic strategies to promote immune rejection of KRASG12C inhibitor-resistant subpopulations in lung cancer Tomaschko, Mona; Moore, Christopher; Pillsbury, Claire E.; Ng, Kangbo; de Carne, Sophie; Rana, Sareena; de Castro, Andrea; Anastasiou, Panayiotis; Molina-Arcas, Miriam; Downward, Julian Share Save
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Ocasio, Cory A.; Baggelaar, Marc P.; Sipthorp, James; de la Lastra, Ana Losada; Tavares, Manuel; Volaric, Jana; Soudy, Christelle; Storck, Elisabeth M.; Houghton, Jack W.; Palma-Duran, Susana A.; MacRae, James I.; Tomic, Goran; Carr, Lotte; Downward, Julian; Eggert, Ulrike S.; Tate, Edward W. Share Save
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance Caswell, Deborah R.; Gui, Philippe; Mayekar, Manasi K.; Law, Emily K.; Pich, Oriol; Bailey, Chris; Boumelha, Jesse; Kerr, D. Lucas; Blakely, Collin M.; Manabe, Tadashi; Martinez-Ruiz, Carlos; Bakker, Bjorn; Villcas, Juan De Dios Palomino; I. Vokes, Natalie; Dietzen, Michelle; Angelova, Mihaela; Gini, Beatrice; Tamaki, Whitney; Allegakoen, Paul; Wu, Wei; Humpton, Timothy J.; Hill, William; Tomaschko, Mona; Lu, Wei-Ting; Haderk, Franziska; Al Bakir, Maise; Nagano, Ai; Gimeno-Valiente, Francisco; Trecesson, Sophie de Carne; Vendramin, Roberto; Barbe, Vittorio; Mugabo, Miriam; Weeden, Clare E.; Rowan, Andrew; McCoach, Caroline E.; Almeida, Bruna; Green, Mary; Gomez, Carlos; Nanjo, Shigeki; Barbosa, Dora; Moore, Chris; Przewrocka, Joanna; Black, James R. M.; Gronroos, Eva; Suarez-Bonnet, Alejandro; Priestnall, Simon L.; Zverev, Caroline; Lighterness, Scott; Cormack, James; Olivas, Victor; Cech, Lauren; Andrews, Trisha; Rule, Brandon; Jiao, Yuwei; Zhang, Xinzhu; Ashford, Paul; Durfee, Cameron; Venkatesan, Subramanian; Temiz, Nuri Alpay; Tan, Lisa; Larson, Lindsay K.; Argyris, Prokopios P.; Brown, William L.; Yu, Elizabeth A.; Rotow, Julia K.; Guha, Udayan; Roper, Nitin; Yu, Johnny; Vogel, Rachel I.; Thomas, Nicholas J.; Marra, Antonio; Selenica, Pier; Yu, Helena; Bakhoum, Samuel F.; Chew, Su Kit; Reis-Filho, Jorge S.; Jamal-Hanjani, Mariam; Vousden, Karen H.; McGranahan, Nicholas; Van Allen, Eliezer M.; Kanu, Nnennaya; Harris, Reuben S.; Downward, Julian; Bivona, Trever G.; Swanton, Charles Share Save
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective p110a isoform binders that block its interaction with KRAS Ismail, Mohamed (Soly) Soliman; Downward, Julian; Tart, Jonathan; Davies, Gareth; Monteverde, Tiziana; Hancock, David; Adhikari, Santosh; Stubbs, Christopher; Blackett, Carolyn; Holdgate, Geoff; Kettle, Jason Share Save
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High throughput application of the NanoBiT Biochemical Assay for the discovery of selective p110α isoform binders that block its interaction with KRAS Ismail, Mohamed (Soly) Soliman; Tart, Jonathan; Davies, Gareth; Sproat, Graham; Monterverde, Tiziana; Hancock, David; Adhikari, Santosh; Stubbs, Christopher; Blackett, Carolyn; Holdgate, Geoff; Kettle, Jason; Downward, Julian Share Save
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 Chauhan, Jitesh; Grandits, Melanie; Palhares, Lais C. G. F.; Mele, Silvia; Nakamura, Mano; Lopez-Abente, Jacobo; Crescioli, Silvia; Laddach, Roman; Romero-Clavijo, Pablo; Cheung, Anthony; Stavraka, Chara; Chenoweth, Alicia M. M.; Sow, Heng Sheng; Chiaruttini, Giulia; Gilbert, Amy E. E.; Dodev, Tihomir; Koers, Alexander; Pellizzari, Giulia; Ilieva, Kristina M. M.; Man, Francis; Ali, Niwa; Hobbs, Carl; Lombardi, Sara; Lionarons, Daniel A.; Gould, Hannah J. J.; Beavil, Andrew J. J.; Geh, Jenny L. C.; Ross, Alastair D. MacKenzie D.; Healy, Ciaran; Calonje, Eduardo; Downward, Julian; Nestle, Frank O. O.; Tsoka, Sophia; Josephs, Debra H. H.; Blower, Philip J. J.; Karagiannis, Panagiotis; Lacy, Katie E. E.; Spicer, James; Karagiannis, Sophia N. N.; Bax, Heather J. J. Share Save
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