Sanford M. Simon - Publications, H-index & Citations

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Sanford M. Simon

rockefeller university

62H-index

225Paper Count

1.7WCitation Count

Published Papers 107

Publication Date

Global Re-Analysis Confirms Absence of the DNAJB1::PRKACA Fusion in Hepatoblastoma. Comment on Fleifil et al. DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways. Cancers 2025, 17, 83

Cancers

IF4.4

2026-03-12

OAAI

Waqar Arif; Sanford M. Simon; Allison F. O’Neill; Juan Putra; Dolores H. López-Terrada; Mark Yarchoan; Jessica Zucman-Rossi; Theo Z. Hirsch

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Liver cancer multiomics reveals diverse protein kinase A disruptions convergently produce fibrolamellar hepatocellular carcinoma

NATURE COMMUNICATIONS

IF15.7

2024-12-30

OAAI

Requena, David; Medico, Jack A.; Soto-Ugaldi, Luis F.; Shirani, Mahsa; Saltsman III, James A.; Torbenson, Michael S.; Coffino, Philip; Simon, Sanford M.

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Emerging therapies for the treatment of the fusion protein driven cancer, fibrolamellar carcinoma

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Shirani, Mahsa; Tomasini, Michael; Neumayer, Christoph; Ng, Denise; Lalazar, Gadi; Shebl, Bassem; Coffino, Philip; Lyons, Barbara A.; Simon, Sanford

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Precision medicine for the fusion protein driven cancer, fibrolamellar carcinoma (FLC): Beyond sequencing

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Simon, Sanford; Shirani, Mahsa; Requena, David; Ng, Denise; Lalazar, Gadi; Levin, Solomon; Torbenson, Michael S.; Singhi, Aatur D.; Molina, Henrik; Rice, Charles M.; Coffino, Philip; Lyons, Barbara A.

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Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC

ACS CHEMICAL BIOLOGY

IF3.8

2024-08-13

OAAI

Whittaker, Matthew K.; Bendzunas, George N.; Shirani, Mahsa; Leclair, Timothy J.; Shebl, Bassem; Dill, Taylor C.; Coffino, Philip; Simon, Sanford M.; Kennedy, Eileen J.

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Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB1

CANCER RESEARCH

IF16.6

2024-06-18

OAAI

Shirani, Mahsa; Levin, Solomon; Shebl, Bassem; Requena, David; Finkelstein, Tova M.; Johnson, Daniel S.; Ng, Denise; Lalazar, Gadi; Heissel, Soren; Hojrup, Peter; Molina, Henrik; de Jong, Ype P.; Rice, Charles M.; Singhi, Aatur D.; Torbenson, Michael S.; Coffino, Philip; Lyons, Barbara; Simon, Sanford M.

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Increased activity of protein kinase A is sufficient to cause fibrolamellar carcinoma

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Shirani, Mahsa; Tomasini, Michael; Levin, Solomon; Heissel, Soeren; Molina, Henrik; De Jong, Ype; Rice, Charles; Coffino, Philip; Lyons, Barbara; Simon, Sanford

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GalNAc-conjugated siRNA targeting the DNAJB1-PRKACA fusion junction in fibrolamellar hepatocellular carcinoma

MOLECULAR THERAPY

IF12

2024-01-01

OAAI

Neumayer, Christoph; Ng, Denise; Requena, David; Jiang, Caroline S.; Qureshi, Adam; Vaughan, Roger; Prakash, Thazha P.; Revenko, Alexey; Simon, Sanford M.

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Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma

SCIENCE ADVANCES

IF12.5

2023-06-23

OAAI

Levin, Solomon N.; Tomasini, Michael D.; Knox, James; Shirani, Mahsa; Shebl, Bassem; Requena, David; Clark, Jackson; Heissel, Soren; Alwaseem, Hanan; Surjan, Rodrigo; Lahasky, Ron; Molina, Henrik; Torbenson, Michael S.; Lyons, Barbara; Migler, Rachael D.; Coffino, Philip; Simon, Sanford M.

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Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma (Mar, 10.1038/s41568-023-00554-w, 2023)

NATURE REVIEWS CANCER

IF66.8

2023-04-20

OAAI

Simon, Sanford M.

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Urea cycle metabolism is disturbed in Fibrolamellar carcinoma

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Shirani, Mahsa; Levin, Solomon; Tomasini, Michael D.; Knox, James; Shebl, Bassem; Requena, David; Clark, Jackson; Heissel, Soren; Alwaseem, Hanan; Surjan, Rodrigo; Lahasky, Ron; Molina, Henrik; Lyons, Barbara; Migler, Rachael D.; Coffino, Philip; Simon, Sanford M.

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Bulk and spatial single-cell transcriptomic characterization of fibrolamellar hepatocellular carcinoma

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Requena, David; Medico, Aldhair; Soto, Luis F.; Shirani, Mahsa; Saltsman, James A.; Lalazar, Gadi; LaQuaglia, Michael P.; Simon, Sanford M.

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A novel blood diagnostic method for fibrolamellar hepatocellular carcinoma

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Wang, Ruisi; Hurley, Arlene M.; Simon, Sanford M.

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Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma

NATURE REVIEWS CANCER

IF66.8

2023-03-17

OAAI

Simon, Sanford M.

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Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA

CLINICAL CANCER RESEARCH

IF10.2

2022-10-27

OAAI

Neumayer, Christoph; Ng, Denise; Jiang, Caroline S.; Qureshi, Adam; Lalazar, Gadi; Vaughan, Roger; Simon, Sanford M.

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Clinical and demographic predictors of survival for fibrolamellar carcinoma patients-A patient community, registry-based study

HEPATOLOGY COMMUNICATIONS

IF4.6

2022-10-17

OAAI

Berkovitz, Amichai; Migler, Rachael D.; Qureshi, Adam; Rosemore, Carly; Torbenson, Michael S.; Vaughan, Roger; Marcotte, Erin; Simon, Sanford M.

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Single molecule microscopy reveals diverse actions of substrate sequences that impair ClpX AAA plus ATPase function

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-10-01

OAAI

Wang, Xiao; Simon, Sanford M.; Coffino, Philip

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Targeting BCL-XL in fibrolamellar hepatocellular carcinoma

JCI INSIGHT

IF6.1

2022-09-08

OAAI

Shebl, Bassem; Ng, Denise; Lalazar, Gadi; Rosemore, Carly; Finkelstein, Tova M.; Migler, Rachael D.; Zheng, Guangrong; Zhang, Peiyi; Jiang, Caroline S.; Qureshi, Adam; Vaughan, Roger; Yarchoan, Mark; de Jong, Ype P.; Rice, Charles M.; Coffino, Philip; Ortiz, Michael V.; Zhou, Daohong; Simon, Sanford M.

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Human liver organoids for disease modeling of fibrolamellar carcinoma

STEM CELL REPORTS

IF5.1

2022-08-01

OAAI

Narayan, Nicole J. C.; Requena, David; Lalazar, Gadi; Ramos-Espiritu, Lavoisier; Ng, Denise; Levin, Solomon; Shebl, Bassem; Wang, Ruisi; Hammond, William J.; Saltsman III, James A.; Gehart, Helmuth; Torbenson, Michael S.; Clevers, Hans; LaQuaglia, Michael P.; Simon, Sanford M.

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Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening

CANCER DISCOVERY

IF33.3

2021-06-14

OAAI

Lalazar, Gadi; Requena, David; Ramos-Espiritu, Lavoisier; Ng, Denise; Bhola, Patrick D.; de Jong, Ype P.; Wang, Ruisi; Narayan, Nicole J. C.; Shebl, Bassem; Levin, Solomon; Michailidis, Eleftherios; Kabbani, Mohammad; Vercauteren, Koen O. A.; Hurley, Arlene M.; Farber, Benjamin A.; Hammond, William J.; Saltsman, James A., III; Weinberg, Ethan M.; Glickman, J. Fraser; Lyons, Barbara A.; Ellison, Jessica; Schadde, Erik; Hertl, Martin; Leiting, Jennifer L.; Truty, Mark J.; Smoot, Rory L.; Tierney, Faith; Kato, Tomoaki; Wendel, Hans-Guido; LaQuaglia, Michael P.; Rice, Charles M.; Letai, Anthony; Coffino, Philip; Torbenson, Michael S.; Ortiz, Michael, V; Simon, Sanford M.

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Research Directions