Robert K. Bradley - Publications, H-index & Citations

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Robert K. Bradley

fred hutchinson cancer center

52H-index

190Paper Count

1.9WCitation Count

Published Papers 57

Publication Date

Mutant SRSF2-associated impaired erythropoiesis is defined by increased mTORC1 signaling due to FYN missplicing

Leukemia

IF13.4

2026-02-26

PREAI

Jonas S. Jutzi; Edie Crosse; Chulwoo J. Kim; Bob van Gasteren; Charles Laurore; Benjamin Rolles; Frederike Kramer; Anastasia Tishena; Azucena V. Rocha; Mohammed Wazir; Lachelle D. Weeks; Joan How; Maximilian Stahl; Marlise R. Luskin; R. Coleman Lindsley; Olga Pozdnyakova; Sumit Rai; Timothy A. Graubert; Robert K. Bradley; Ann Mullally; Anna E. Marneth

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Muscleblind-like proteins are novel modulators of the tumor-immune microenvironment

PLOS ONE

IF2.6

2025-04-30

OAAI

Gabel, Austin M.; Crosse, Edie I.; Belleville, Andrea E.; Hogg, Simon J.; Mckellar, Siegen A.; Abdel-Wahab, Omar; Thomas, James D.; Bradley, Robert K.

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Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA

ACR OPEN RHEUMATOLOGY

IF2.8

2025-01-12

OAAI

Najjar, R; Wang, XX; Pineda, JMB; Alessi, H; Bays, A; Bradley, RK; Jarvis, JN; Mustelin, T

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Alternative polyadenylation as a therapeutic target in cancer

MOLECULAR CANCER THERAPEUTICS

IF5.5

2024-11-14

PREAI

Banjo, Toshihiro; Kaito, Satoshi; Gabel, Austin M.; Abdel-Wahab, Omar; Bradley, Robert K.

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APC mutations dysregulate alternative polyadenylation in cancer

MOLECULAR CANCER THERAPEUTICS

IF5.5

2024-11-14

PREAI

Gabel, Austin M.; Belliville, Andrea E.; Thomas, James D.; Pineda, Jose Mario B.; Bradley, Robert K.

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TNFα Apoptotic Signaling By Antigen-Engaged CAR T-Cells Mediates Clearance of Target Antigen-Negative Acute Myeloid Leukemia

BLOOD

IF23.1

2024-11-05

PREAI

Kimble, Erik L.; Fiorenza, Salvatore; Hirayama, Alexandre V. Vinaud; Gabel, Austin M.; Gauthier, Jordan; Torkelson, Aiko; Chutnik, Abigail; Di, Henna; Wright, Jocelyn H.; Pender, Barbara; Radtke, Stefan; Walter, Roland B.; Kiem, Hans-Peter; Maloney, David G.; Bradley, Robert K.; Turtle, Cameron J.

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APC mutations dysregulate alternative polyadenylation in cancer

GENOME BIOLOGY

IF9.4

2024-10-07

OAAI

Gabel, Austin M.; Belleville, Andrea E.; Thomas, James D.; Pineda, Jose Mario Bello; Bradley, Robert K.

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An autoregulatory poison exon in Smndc1 is conserved across kingdoms and influences organism growth

PLOS GENETICS

IF3.7

2024-08-16

OAAI

Belleville, Andrea E.; Thomas, James D.; Tonnies, Jackson; Gabel, Austin M.; Borrero Rossi, Andrea; Singh, Priti; Queitsch, Christine; Bradley, Robert K.

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Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition

BLOOD CANCER DISCOVERY

IF11.5

2024-06-07

OAAI

Sarchi, Martina; Clough, Courtnee A.; Crosse, Edie I.; Kim, Jason; Galvis, Laura D. Baquero; Aydinyan, Nelli; Wellington, Rachel; Yang, Feini; Galli, Anna; Creamer, J. Philip; Stewart, Sintra; Bradley, Robert K.; Malcovati, Luca; Doulatov, Sergei

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DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers

ELIFE

IF0

2024-06-03

OAAI

Pineda, Jose Mario Bello; Bradley, Robert K.

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GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies

MOLECULAR CELL

IF16.6

2024-05-01

OAAI

Benbarche, Salima; Pineda, Jose Mario Bello; Galvis, Laura Baquero; Biswas, Jeetayu; Liu, Bo; Wang, Eric; Zhang, Qian; Hogg, Simon J.; Lyttle, Kadeen; Dahi, Ariana; Lewis, Alexander M.; Saechi, Martina; Rahman, Jahan; Fox, Nina; Ai, Yuxi; Mehta, Sanjoy; Garippa, Ralph; Ortiz-Pacheco, Juliana; Li, Zhuoning; Monetti, Mara; Stanley, Robert F.; Doulatov, Sergei; Bradley, Robert K.; Abdel-Wahab, Omar

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Dysregulated RNA splicing promotes AML quiescence and chemoresistance

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Wang, Eric; Han, Cuijuan; Calderon, Alexander; Lawal, Abimbo; Hariramani, Nidhi; Crosse, Edie; Bradley, Robert

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Multiplexed screening reveals how cancer-specific alternative polyadenylation shapes tumor growth in vivo

NATURE COMMUNICATIONS

IF15.7

2024-02-01

OAAI

Gabel, Austin M.; Belleville, Andrea E.; Thomas, James D.; Mckellar, Siegen A.; Nicholas, Taylor R.; Banjo, Toshihiro; Crosse, Edie I.; Bradley, Robert K.

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SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis

LEUKEMIA

IF13.4

2023-11-28

OAAI

Sui, Pinpin; Ge, Guo; Chen, Shi; Bai, Jiaojiao; Rubalcava, Ivan P.; Yang, Hui; Guo, Ying; Zhang, Peng; Li, Ying; Medina, Edward A.; Xu, Mingjiang; Abdel-Wahab, Omar; Bradley, Robert; Yang, Feng-Chun

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The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response

JCI INSIGHT

IF6.1

2023-06-22

OAAI

Dunker, William; Zaver, Shivam A.; Pineda, Jose Mario Bello; Howard, Cameron J.; Bradley, Robert K.; Woodward, Joshua J.

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Recursive splicing discovery using lariats in total RNA sequencing

LIFE SCIENCE ALLIANCE

IF2.9

2023-05-03

OAAI

Hoppe, Emma R.; Udy, Dylan B.; Bradley, Robert K.

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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Thomas, James D.; Lu, Sydney X.; De Neef, Emma; Sabio, Erich; Rousseau, Benoit; Gigoux, Mathieu; Knorr, David A.; Greenbaum, Benjamin; Elhanati, Yuval; Hogg, Simon J.; Chow, Andrew; Ghosh, Arnab; Xie, Abigail; Zamarin, Dmitriy; Cui, Daniel; Erickson, Caroline; Singer, Michael; Cho, Hana; Wang, Eric; Lu, Bin; Durham, Benjamin H.; Shah, Harshal; Chowell, Diego; Gabel, Austin M.; Shen, Yudao; Liu, Jing; Jin, Jian; Rhodes, Matthew C.; Taylor, Richard E.; Molina, Henrik; Wolchok, Jedd D.; Merghoub, Taha; Diaz, Luis A., Jr.; Abdel-Wahab, Omar; Bradley, Robert K.

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RNA splicing dysregulation and the hallmarks of cancer

NATURE REVIEWS CANCER

IF66.8

2023-01-10

154

OAAI

Bradley, Robert K.; Anczukow, Olga

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Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations

ELIFE

IF0

2022-08-30

OAAI

Choudhary, Gaurav S.; Pellagatti, Andrea; Agianian, Bogos; Smith, Molly A.; Bhagat, Tushar D.; Gordon-Mitchell, Shanisha; Sahu, Srabani; Pandey, Sanjay; Shah, Nishi; Aluri, Srinivas; Aggarwal, Ritesh; Aminov, Sarah; Schwartz, Leya; Steeples, Violetta; Booher, Robert N.; Ramachandra, Murali; Samson, Maria; Carbajal, Milagros; Pradhan, Kith; Bowman, Teresa, V; Pillai, Manoj M.; Will, Britta; Wickrema, Amittha; Shastri, Aditi; Bradley, Robert K.; Martell, Robert E.; Steidl, Ulrich G.; Gavathiotis, Evripidis; Boultwood, Jacqueline; Starczynowski, Daniel T.; Verma, Amit

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Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells

NATURE BIOTECHNOLOGY

IF41.7

2022-03-03

OAAI

North, Khrystyna; Benbarche, Salima; Liu, Bo; Pangallo, Joseph; Chen, Sisi; Stahl, Maximilian; Bewersdorf, Jan Philipp; Stanley, Robert F.; Erickson, Caroline; Cho, Hana; Pineda, Jose Mario Bello; Thomas, James D.; Polaski, Jacob T.; Belleville, Andrea E.; Gabel, Austin M.; Udy, Dylan B.; Humbert, Olivier; Kiem, Hans-Peter; Abdel-Wahab, Omar; Bradley, Robert K.

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Research Directions