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Christine A. Iacobuzio–Donahue

utmd anderson cancer center

135H-index
1.0KPaper Count
9.2WCitation Count
Published Papers 195
Publication Date
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Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial
errNature Medicine
IF50
err2026-03-25
err0
errOAAI
errWungki Park; Catherine A. O’Connor; Joanne F. Chou; Marc Hilmi; Zeynep Tarcan; Carly Schwartz; Mary Larsen; Ramzi Homsi; Karthigayini Sivaprakasam; Shigeaki Umeda; Maria A. Perry; Anna M. Varghese; Kenneth H. Yu; Fiyinfolu Balogun; Alice Zervoudakis; Seth S. Katz; Tae-Hyung Kim; Ken Zhao; Allison L. Richards; Nicolas Lecomte; Daniel Martin Muldoon; Elias Karnoub; Walid Chatila; Jessica Yang; Imane El-Dika; Devika Rao; Smita Joshi; Michael B. Foote; Ryan Sugarman; James J. Harding; Andrew S. Epstein; David Kelsen; Sree Chalassani; Fergus Keane; Joshua D. Schoenfeld; Anupriya Singhal; Erin Diguglielmo; Chaitanya Bandlamudi; Junmin Song; Hulya Sahin Ozkan; Junguei Hong; Haochen Zhang; Agustin III Cardenas; Maria Lao; Jerry Melchor; Ronak Shah; Wenfei Kang; Francesca Mazzoni; Kevin Soares; Mark TA Donoghue; Ernesto Santos; Vineet Rolston; Marsha Reyngold; Alice Chia-chi Wei; Murray Tipping; Olca Basturk; Michael Berger; Richard Kihn Do; Mark Schattner; William R. Jarnagin; Nadeem Riaz; Vinod Balachandran; Dana Pe’er; Marinela Capanu; Christine Iacobuzio-Donahue; Eileen M. O’Reilly
errShare
errSave
Evidence that extra copies of chromosome 1q play a role in the early phases of pancreatic neoplasia
errScience Advances
IF12.5
err2026-02-20
err0
errOAAI
errChristopher Douville; Jeeun Parksong; Marco Dal Molin; Sarah Graham; Patricia T. Greipp; Ryan Knudson; Samuel Curtis; Yuxuan Wang; Lisa Dobbyn; Maria Popoli; Janine Ptak; Natalie Silliman; Katharine Romans; Christine A. Iacobuzio-Donahue; Alvin P. Makoohon-Moore; Anne Marie Lennon; Michael Goggins; Ralph H. Hruban; Ashley Kiemen; Chetan Bettegowda; Kenneth W. Kinzler; Nickolas Papadopoulos; Laura D. Wood; Bert Vogelstein
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errSave
Syndecan-1 Is a Key Mediator of Entosis and Cellular Competition in Pancreatic Cancer
errPancreas
IF1.7
err2026-02-01
err0
PREAI
errLi, Kara; Li, Chenyang; Umeda, Shigeaki; Kappagantula, Rajya L.; Paku, Masakatsu; Zeng, Yue; Iacobuzio-Donahue, Christine; Yao, Wantong
errShare
errSave
Genomic evolution of pancreatic cancer at single-cell resolution
errNature Genetics
IF29
err2026-01-22
err0
errOAAI
errHaochen Zhang; Palash Sashittal; Elias-Ramzey Karnoub; Akhil Jakatdar; Shigeaki Umeda; Jungeui Hong; Anne Marie Noronha; Agustin Cardenas; Amanda Erakky; Caitlin A. McIntyre; Akimasa Hayashi; Nicolas Lecomte; Marc Hilmi; Wungki Park; Nan Pang; Eileen M. O’Reilly; Alice C. Wei; Benjamin J. Raphael; Christine A. Iacobuzio-Donahue
errShare
errSave
Safety and Feasibility of Intra-Arterial Treatment of Pancreatic Cancer Using an Emulsion of Ethiodized Oil plus Bumetanide in an Oncopig Model
errJournal of Vascular and Interventional Radiology
IF2.6
err2025-11-05
err0
PREAI
errHooman Yarmohammadi; Sam Y. Son; Aaron W.P. Maxwell; Ahmed S. Elsakka; Vlasios S. Sotirchos; Olivier Chevallier; Fuad Nurili; Fourat Ridouani; Etay Ziv; Joseph P. Erinjeri; Ken Zhao; Christopher Cheleuitte-Nieves; Renata Mammone; Adam Michel; Christine A. Iacobuzio-Donahue; Alice C. Wei; Eileen M. O’Reilly; Stephen B. Solomon; F.Edward Boas
errShare
errSave
The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions
errCANCER RESEARCH COMMUNICATIONS
IF0
err2025-10-01
err0
PREAI
errHayashi, Akimasa; Ho, Yu-Jui; Makohon-Moore, Alvin P.; Zucker, Amanda; Hong, Jungeui; Umeda, Shigeaki; Karnoub, Elias-Ramzey; Huang, Jinlong; Baez, Priscilla; Kappagantula, Rajya; Melchor, Jerry P.; Park, Wungki; O'Reilly, Eileen M.; Socci, Nicholas D.; Oki, Shinya; Iacobuzio-Donahue, Christine A.
errShare
errSave
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence
errNature Cancer
IF28.5
err2025-09-25
err0
errOAAI
errKaloyan M. Tsanov; Francisco M. Barriga; Yu-Jui Ho; Direna Alonso-Curbelo; Geulah Livshits; Sha Tian; Richard P. Koche; Timour Baslan; Janelle Simon; Alexandra N. Wuest; José Reyes; Jin Park; Wei Luan; John E. Wilkinson; Umesh Bhanot; Jordana Ray-Kirton; Ignas Masilionis; Nevenka Dimitrova; Christine A. Iacobuzio-Donahue; Ronan Chaligné; Dana Pe’er; Joan Massagué; Scott W. Lowe
errShare
errSave
Author Correction: Clonal evolution during metastatic spread in high-risk neuroblastoma
errNature Genetics
IF0
err2025-08-05
err0
PREAI
errGunes Gundem; Max F. Levine; Stephen S. Roberts; Irene Y. Cheung; Juan S. Medina-Martínez; Yi Feng; Juan E. Arango-Ossa; Loic Chadoutaud; Mathieu Rita; Georgios Asimomitis; Joe Zhou; Daoqi You; Nancy Bouvier; Barbara Spitzer; David B. Solit; Filemon Dela Cruz; Michael P. LaQuaglia; Brian H. Kushner; Shakeel Modak; Neerav Shukla; Christine A. Iacobuzio-Donahue; Andrew L. Kung; Nai-Kong V. Cheung; Elli Papaemmanuil
errShare
errSave
Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
errIMMUNITY
IF26.3
err2024-12-01
err2
errOAAI
errSun, Siyu; You, Eunae; Hong, Jungeui; Hoyos, David; Del Priore, Isabella; Tsanov, Kaloyan M.; Mattagajasingh, Om; Di Gioacchino, Andrea; Marhon, Sajid A.; Chacon-Barahona, Jonathan; Li, Hao; Jiang, Hua; Hozeifi, Samira; Rosas-Bringas, Omar; Xu, Katherine H.; Song, Yuhui; Lang, Evan R.; Rojas, Alexandra S.; Nieman, Linda T.; Patel, Bidish K.; Murali, Rajmohan; Chanda, Pharto; Karacay, Ali; Vabret, Nicolas; De Carvalho, Daniel D.; Zenklusen, Daniel; Lacava, John; Lowe, Scott W.; Ting, David T.; lacobuzio-Donahue, Christine A.; Solovyov, Alexander; Greenbaum, Benjamin D.
errShare
errSave
Altered mRNA splicing mimics chromosome loss and drives pancreatic cancer
errCANCER RESEARCH
IF16.6
err2024-09-15
err0
PREAI
errMedici, Natasha Pinto; Martinez-Saucedo, Diana; Lee, Danny; Chu, Tianyi; Tseng, Robert; Cannataro, Vincent; Townsend, Jeffrey; Iacobuzio-Donahue, Christine; Robert, Marie; Abdel-Wahab, Omar; Leach, Steven D.; Escobar-Hoyos, Luisa
errShare
errSave
Phase II trial of Pembrolizumab and OLApaRib (POLAR) maintenance for select patients (pts) with metastatic pancreatic cancer (mPC) with (A) homologous recombination deficiency (HRD), (B) non-core HRD (ncHRD) and (C) exceptional response to platinum
errANNALS OF ONCOLOGY
IF65.4
err2024-09-01
err0
PREAI
errPark, W.; Connor, C. O'; Chou, J.; Schwartz, C.; Larsen, M.; Varghese, A.; Yu, K.; Balogun, F.; Yang, J.; Katz, S.; Kelsen, D.; Umeda, S.; Bandlamudi, C.; Riaz, N.; Berger, M.; Balachandran, V.; Peer, D.; Capanu, M.; Iacobuzio-Donahue, C.; O'Reilly, E. M.
errShare
errSave
A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention
errCANCER DISCOVERY
IF33.3
err2024-07-22
err0
PREAI
errYamaguchi, Norihiro; Wu, Y. Gloria; Ravetch, Ethan; Takahashi, Mai; Khan, Abdul G.; Hayashi, Akimasa; Mei, Wenbin; Hsu, Dennis; Umeda, Shigeaki; de Stanchina, Elisa; Lorenz, Ivo C.; Iacobuzio-Donahue, Christine A.; Tavazoie, Sohail F.
errShare
errSave
Combination immunohistochemistry for CK5/6, p63, GATA6, and HNF4a predicts clinical outcome in treatment-naïve pancreatic ductal adenocarcinoma
errSCIENTIFIC REPORTS
IF3.9
err2024-07-06
err1
errOAAI
errShibayama, Takahiro; Hayashi, Akimasa; Toki, Masao; Kitahama, Keiichiro; Ho, Yu-Jui; Kato, Kenichiro; Yamada, Takahiro; Kawamoto, Sho; Kambayashi, Komei; Ochiai, Kazushige; Gondo, Koichi; Okano, Naohiro; Melchor, Jerry P.; Iacobuzio-Donahue, Christine A.; Sakamoto, Yoshihiro; Hisamatsu, Tadakazu; Shibahara, Junji
errShare
errSave
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
errNATURE MEDICINE
IF50
err2024-06-28
err4
errOAAI
errBojmar, Linda; Zambirinis, Constantinos P.; Hernandez, Jonathan M.; Chakraborty, Jayasree; Shaashua, Lee; Kim, Junbum; Johnson, Kofi Ennu; Hanna, Samer; Askan, Gokce; Burman, Jonas; Ravichandran, Hiranmayi; Zheng, Jian; Jolissaint, Joshua S.; Srouji, Rami; Song, Yi; Choubey, Ankur; Kim, Han Sang; Cioffi, Michele; van Beek, Elke; Sigel, Carlie; Jessurun, Jose; Velasco Riestra, Paulina; Blomstrand, Hakon; Joensson, Carolin; Joensson, Anette; Lauritzen, Pernille; Buehring, Weston; Ararso, Yonathan; Hernandez, Dylanne; Vinagolu-Baur, Jessica P.; Friedman, Madison; Glidden, Caroline; Firmenich, Laetitia; Lieberman, Grace; Mejia, Dianna L.; Nasar, Naaz; Mutvei, Anders P.; Paul, Doru M.; Bram, Yaron; Costa-Silva, Bruno; Basturk, Olca; Boudreau, Nancy; Zhang, Haiying; Matei, Irina R.; Hoshino, Ayuko; Kelsen, David; Sagi, Irit; Scherz, Avigdor; Scherz-Shouval, Ruth; Yarden, Yosef; Oren, Moshe; Egeblad, Mikala; Lewis, Jason S.; Keshari, Kayvan; Grandgenett, Paul M.; Hollingsworth, Michael A.; Rajasekhar, Vinagolu K.; Healey, John H.; Bjoernsson, Bergthor; Simeone, Diane M.; Tuveson, David A.; Iacobuzio-Donahue, Christine A.; Bromberg, Jaqueline; Vincent, C. Theresa; O'Reilly, Eileen M.; DeMatteo, Ronald P.; Balachandran, Vinod P.; D'Angelica, Michael I.; Kingham, T. Peter; Allen, Peter J.; Simpson, Amber L.; Elemento, Olivier; Sandstroem, Per; Schwartz, Robert E.; Jarnagin, William R.; Lyden, David
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errSave
A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
errCLINICAL CANCER RESEARCH
IF10.2
err2024-06-12
err1
PREAI
errSong, Yi; Boerner, Thomas; Drill, Esther; Shin, Paul; Kumar, Sandeep; Sigel, Carlie; Cercek, Andrea; Kemeny, Nancy; Abou-Alfa, Ghassan; Iacobuzio-Donahue, Christine; Cowzer, Darren; Schultz, Nikolaus; Walch, Henry; Balachandran, Vinod; Koerkamp, Bas Groot; Kingham, Peter; Soares, Kevin; Wei, Alice; D'Angelica, Michael; Drebin, Jeffrey; Chandwani, Rohit; Harding, James J.; Jarnagin, William
errShare
errSave
Mapping the tumor stress network reveals dynamic shifts in the stromal oxidative stress response
errCELL REPORTS
IF6.9
err2024-05-01
err5
errOAAI
errLior, Chen; Barki, Debra; Halperin, Coral; Iacobuzio-Donahue, Christine A.; Kelsen, David; Scherz-Shouval, Ruth
errShare
errSave
Supporting Convergence Science
errCANCER RESEARCH
IF16.6
err2024-04-01
err0
PREAI
errIacobuzio-Donahue, Christine A.
errShare
errSave
Rapid autopsy reveals the interplay of tumor heterogeneity at genomic, transcriptomic, and spatial dimensions
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errYao, Ning; Vanguri, Rami; Patel, Juber; Lihm, Jayon; Fisher, Andrew; Jarchum, Irene; Umeda, Shigeaki; Li, Hao; Ely, Scott; Hollmann, Travis; Iacobuzio-Donahue, Christine; Greenbaum, Benjamin
errShare
errSave
A targetable secreted protein drives pancreatic cancer metastatic colonization and HIF1a nuclear retention
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errYamaguchi, Norihiro; Wu, Gloria; Ravetch, Ethan; Takahashi, Mai; Khan, Abdul G.; Hayashi, Akimasa; Mei, Wenbin; Hsu, Dennis; de Stanchina, Elisa; Lorenz, Ivo C.; Iacobuzio-Donahue, Christine; Tavazoie, Sohail F.
errShare
errSave
CRISPR-cas9 genetic targeting of metastatic pancreatic cancer
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errBowland, Kirsten; Lai, Jiaying; Teh, Selina Shiqing K.; Bennett, Alexis; Skaist, Alyza; Zhang, Yan; Thompson, Elizabeth; Hruban, Ralph H.; Roberts, Nicholas J.; Karchin, Rachel; Iacobuzio-Donahue, Christine A.; Eshleman, James R.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
B
Bert Vogelstein
H-index: 255 · Papers: 1.0K
H
Hans Clevers
H-index: 236 · Papers: 1.3K
K
Kenneth W. Kinzler
H-index: 213 · Papers: 785
R
Ralph H. Hruban
H-index: 209 · Papers: 2.0K
S
Stephen B. Baylin
H-index: 182 · Papers: 1.3K
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