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Alan Melcher

Institute of Cancer Research

71H-index
550Paper Count
1.6WCitation Count
Published Papers 183
Publication Date
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Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity
errScience Advances
IF12.5
err2026-06-05
err0
errOAAI
errOlivia Liseth; Elizabeth Appleton; Benjamin Kendall; Jill Thompson; Thanich Sangsuwannukul; Jason Tonne; Rosa Maria Diaz; Laura Evgin; Anton Patrikeev; Nicolas Sarbia; Shane Foo; Kevin Harrington; Masahiro Ono; Alan Melcher; Richard Vile
errShare
errSave
Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy
errNature Communications
IF15.7
err2026-03-01
err0
errOAAI
errFernando, Winnie; Clucas, Jarama; Rizzo, Alberto; Singer, Ramsay; Goode, Emily; Tiu, Crescens; Layzell, Scott; Konecnik, Joshua; Wilson, Rebecca; John, Sidonie Wicky; Jouny, Samuel; Guppy, Naomi; Boulat, Victoire; Mannion, Jonathan; Goicoechea, Maria; Tan, Shaun; Lawson, Sam; Starling, Chris; Elshtein, Gabrielle; Ravindran, Nivedita; Montgomery, Anna B.; Andres-Ejarque, Rosa; Allen, Mark; Lumbard, Steven; Wallberg, Fredrik; Betteridge, Kai; Scrimgeour, Ross; Robertson, David; Ward, George; Sims, Martin; Smyth, Tomoko; Samson, Andre L.; Murphy, James M.; Ivankovic, Daniela Kolarevic; Arwert, Esther N.; Calado, Dinis P.; Grigoriadis, Anita; Smalley, Matthew J.; Melcher, Alan; Haider, Syed; Lawrence, Toby; Roxanis, Ioannis; Tutt, Andrew N. J.; Tenev, Tencho; Meier, Pascal
errShare
errSave
Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma
errInternational Journal of Cancer
IF4.7
err2026-02-01
err0
errOAAI
errScott, Karen J.; West, Emma J.; Brownlie, Rebecca J.; Ismail, Fay; Ralph, Christy; Heineman, Thomas; Coffey, Matt; Melcher, Alan A.; Taylor, Alison; Papa, Salvatore; Samson, Adel
errShare
errSave
Using oncolytic viruses to exploit endogenous TCR signaling for modulation of CAR T phenotype and function against solid tumors
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errLiseth, Olivia; Appleton, Elizabeth; Thompson, Jill; Kendall, Luke; Evgin, Laura; Ono, Masahiro; Melcher, Alan; Vile, Richard
errShare
errSave
Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
errCancer Research Communications
IF0
err2025-11-01
err0
errOAAI
errChan Wah Hak, Charleen; Patin, Emmanuel C.; Patrikeev, Anton; Nicastri, Annalisa; Kozik, Zuza; Baldock, Holly; Kyula-Currie, Joan N.; Roulstone, Victoria; Wongariyapak, Amarin; Gifford, Valentina; Tenev, Tencho; Appleton, Elizabeth S.; Hubbard, Lisa C.; Foo, Shane; Pedersen, Malin; Choudhary, Jyoti S.; Ono, Masahiro; Melcher, Alan A.; Rullan, Antonio; Harrington, Kevin J.
errShare
errSave
Oncolytic viruses as anticancer agents: clinical progress and remaining challenges
errlancet
IF0
err2025-09-18
err0
PREAI
errElizabeth Appleton; E Antonio Chiocca; Guy Ungerechts; Alan Melcher; Richard Vile
errShare
errSave
Modulating T-cell Responses to Enhance the Effects of Radiotherapy
errThe Cancer Journal
IF0
err2025-08-11
err0
PREAI
errFernández Muñoz, Matías MSc; Bishr, Mai K. MD, MSc, MRCP; O’Leary, Ben MD, PhD†; Melcher, Alan MD, PhD†; Harrington, Kevin MD, PhD†
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errSave
Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial
errNature Communications
IF15.7
err2025-08-01
err0
errOAAI
errMagnus T. Dillon; Emmanuel C. Patin; Kabir Mohammed; Jeane Guevara; Simon A. Smith; Emma Dean; Heba Soliman; Pablo Nenclares; Motoko Ryugenji; Davina Northcote; Neel Shah; Lorna Grove; Christopher J. Lord; Stephen Pettit; Matt Tall; Karen E. Swales; Udai Banerji; Alan A. Melcher; Mark Saunders; Martin D. Forster; Kevin J. Harrington
errShare
errSave
The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer
errnpj Breast Cancer
IF7.6
err2025-07-24
err0
errOAAI
errMatthew Fenton; Miki Yoneyama; Erik Wennerberg; Tom Lund; Andrew Tutt; Alan Melcher; Sandra Demaria; Navita Somaiah
errShare
errSave
Author Correction: Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion
errNature Communications
IF15.7
err2025-07-15
err0
errOAAI
errVictoria Roulstone; Joan Kyula-Currie; James Wright; Emmanuel C. Patin; Isaac Dean; Lu Yu; Aida Barreiro-Alonso; Miriam Melake; Jyoti Choudhary; Richard Elliott; Christopher J. Lord; David Mansfield; Nik Matthews; Ritika Chauhan; Victoria Jennings; Charleen Chan Wah Hak; Holly Baldock; Francesca Butera; Elizabeth Appleton; Pablo Nenclares; Malin Pedersen; Shane Foo; Amarin Wongariyapak; Antonio Rullan; Tencho Tenev; Pascal Meier; Richard Vile; Hardev Pandha; Alan Melcher; Martin McLaughlin; Kevin J. Harrington
errShare
errSave
The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models
errNature Communications
IF15.7
err2025-07-08
err0
errOAAI
errJoan Kyula-Currie; Victoria Roulstone; James Wright; Francesca Butera; Arnaud Legrand; Richard Elliott; Martin McLaughlin; Galabina Bozhanova; Dragomir Krastev; Stephen Pettitt; Tencho Tenev; Magnus Dillon; Shane Foo; Emmanuel C. Patin; Victoria Jennings; Charleen Chan Wah Hak; Elizabeth Appleton; Amarin Wongariyapak; Malin Pedersen; Antonio Rullan; Jyoti Choudhary; Chris Bakal; Pascal Meier; Christopher J. Lord; Alan Melcher; Kevin J. Harrington
errShare
errSave
Updates on radiotherapy-immunotherapy combinations: Proceedings of 8th Annual ImmunoRad Conference
errOncoImmunology
IF6.3
err2025-05-22
err0
errOAAI
errFereshteh Talebi; Fabiana Gregucci; Jalal Ahmed; Nir Ben Chetrit; Brian D. Brown; Timothy A. Chan; Dhan Chand; Julie Constanzo; Sandra Demaria; Dmitry I. Gabrilovich; Encouse Golden; Andrew Godkin; Chandan Guha; Gaorav P. Gupta; Aisha Hasan; Fernanda G. Herrera; Howard Kaufman; Donna Li; Alan A. Melcher; Sierra McDonald; Taha Merghoub; Arta M. Monjazeb; Sébastien Paris; Sean Pitroda; Anguraj Sadanandam; Dörthe Schaue; Laura Santambrogio; Phillippe Szapary; Julien Sage; James W. Welsh; Anna Wilkins; Kristina H. Young; Eric Wennerberg; Laurence Zitvogel; Lorenzo Galluzzi; Eric Deutsch; Silvia C. Formenti
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errSave
Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment (vol 15, 1500570, 2024)
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2025-04-22
err0
errOAAI
errJennings, Victoria A.; Rumbold-Hall, Reah; Migneco, Gemma; Barr, Tyler; Reilly, Katrina; Ingram, Nicola; Hilare, Isabelle St; Heaton, Samuel; Alzamel, Noura; Jackson, David; Ralph, Christy; Banerjee, Susan; McNeish, Iain; Bell, John C.; Melcher, Alan A.; Ilkow, Carolina; Cook, Graham P.; Errington-Mais, Fiona
errShare
errSave
CXCL12-Targeted Immunomodulatory Gene Therapy Reduces Radiation-Induced Fibrosis in Healthy Tissues
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2025-01-27
err0
PREAI
errPaget, James T.; Ward, Joseph A.; Mckean, Andrew R.; Mansfield, David C.; Mclaughlin, Martin; Kyula-Currie, Joan N.; Smith, Henry G.; Roulstone, Victoria; Li, Chunhei; Zhou, You; Hardiman, Thomas; Grigoriadis, Anita; Coon, Devin O'Brien; Irshad, Sheeba; Melcher, Alan A.; Harrington, Kevin J.; Khan, Aadil
errShare
errSave
Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprograming of the tumour microenvironment
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2024-12-23
err0
errOAAI
errJennings, Victoria A.; Rumbold-Hall, Reah; Migneco, Gemma; Barr, Tyler; Reilly, Katrina; Ingram, Nicola; St Hilare, Isabelle; Heaton, Samuel; Alzamel, Noura; Jackson, David; Ralph, Christy; Banerjee, Susan; Mcneish, Iain; Bell, John C.; Melcher, Alan A.; Ilkow, Carolina; Cook, Graham P.; Errington-Mais, Fiona
errShare
errSave
Longitudinal Assessment of Tumor-Infiltrating fi ltrating Lymphocytes in Primary Breast Cancer Following Neoadjuvant Radiation Therapy
errINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
IF6.5
err2024-11-01
err1
PREAI
errYoneyama, Miki; Zormpas-Petridis, Konstantinos; Robinson, Ruth; Sobhani, Faranak; Provenzano, Elena; Steel, Harriet; Lightowlers, Sara; Towns, Catherine; Castillo, Simon P.; Anbalagan, Selvakumar; Lund, Tom; Wennerberg, Erik; Melcher, Alan; Coles, Charlotte E.; Roxanis, Ioannis; Yuan, Yinyin; Somaiah, Navita
errShare
errSave
Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy
errNATURE COMMUNICATIONS
IF15.7
err2024-08-13
err0
errOAAI
errPatin, Emmanuel C.; Nenclares, Pablo; Hak, Charleen Chan Wah; Dillon, Magnus T.; Patrikeev, Anton; Mclaughlin, Martin; Grove, Lorna; Foo, Shane; Soliman, Heba; Barata, Joao P.; Marsden, Joanna; Baldock, Holly; Gkantalis, Jim; Roulstone, Victoria; Kyula, Joan; Burley, Amy; Hubbard, Lisa; Pedersen, Malin; Smith, Simon A.; Clancy-Thompson, Eleanor; Melcher, Alan A.; Ono, Masahiro; Rullan, Antonio; Harrington, Kevin J.
errShare
errSave
Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling
errJOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
err2024-07-25
err0
errOAAI
errArmstrong, Edward; Chiu, Matthew K. L.; Foo, Shane; Appleton, Lizzie; Nenclares, Pablo; Patrikeev, Anton; Mohan, Nitya; Mclaughlin, Martin; Bozhanova, Galabina; Hoebart, Julia; Roulstone, Victoria; Patin, Emmanuel; Pedersen, Malin; Kyula, Joan; Ono, Masahiro; Errington-Mais, Fiona; Bell, John; Harrington, Kevin J.; Melcher, Alan; Jennings, Victoria
errShare
errSave
Expression of tumor antigens within an oncolytic virus enhances the anti-tumor T cell response
errNATURE COMMUNICATIONS
IF15.7
err2024-06-27
err4
errOAAI
errWebb, Mason J.; Sangsuwannukul, Thanich; van Vloten, Jacob; Evgin, Laura; Kendall, Benjamin; Tonne, Jason; Thompson, Jill; Metko, Muriel; Moore, Madelyn; Yerovi, Maria P. Chiriboga; Olin, Michael; Borgatti, Antonella; McNiven, Mark; Monga, Satdarshan P. S.; Borad, Mitesh J.; Melcher, Alan; Roberts, Lewis R.; Vile, Richard
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errSave
Intratumoral therapies in head and neck squamous cell carcinoma: A systematic review and future perspectives
errCANCER TREATMENT REVIEWS
IF10.5
err2024-06-01
err2
PREAI
errJimenez-Labaig, Pablo; Rullan, Antonio; Brana, Irene; Hernando-Calvo, Alberto; Moreno, Victor; Doger, Bernard; Bitar, George; Ap Dafydd, Derfel; Melcher, Alan; Harrington, Kevin J.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Guido Kroemer
H-index: 283 · Papers: 2.3K
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Michael Karin
H-index: 254 · Papers: 902
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Mark J. Smyth
H-index: 172 · Papers: 1.4K
L
Laurence Zitvogel
H-index: 165 · Papers: 1.2K
J
Johann S. de Bono
H-index: 160 · Papers: 2.5K
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