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SaveShare Save A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity
Al Qureshah, Fahd; Le Pen, Jeremie; de Weerd, Nicole A.; Moncada-Velez, Marcela; Materna, Marie; Lin, Daniel C.; Milisavljevic, Baptiste; Vianna, Fernanda; Bizien, Lucy; Lorenzo, Lazaro; Lecuit, Marc; Pommier, Jean-David; Keles, Sevgi; Ozcelik, Tayfun; Pedraza-Sanchez, Sigifredo; de Prost, Nicolas; El Zein, Loubna; Hammoud, Hassan; Ng, Lisa F. P.; Halwani, Rabih; Saheb Sharif-Askari, Narjes; Lau, Yu Lung; Tam, Anthony R.; Singh, Neha; Bhattad, Sagar; Berkun, Yackov; Chantratita, Wasun; Aguilar-Lopez, Raul; Shahrooei, Mohammad; Abel, Laurent; Bastard, Paul; Jouanguy, Emmanuelle; Beziat, Vivien; Zhang, Peng; Rice, Charles M.; Cobat, Aurelie; Zhang, Shen-Ying; Hertzog, Paul J.; Casanova, Jean-Laurent; Zhang, Qian Share Save ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosisGuillet, Stephanie; Lazarov, Tomi; Jordan, Natasha; Boisson, Bertrand; Tello, Maria; Craddock, Barbara; Zhou, Ting; Nishi, Chihiro; Bareja, Rohan; Yang, Hairu; Rieux-Laucat, Frederic; Fregel Lorenzo, Rosa Irene; Dyall, Sabrina D.; Isenberg, David; D'Cruz, David; Lachmann, Nico; Elemento, Olivier; Viale, Agnes; Socci, Nicholas D.; Abel, Laurent; Nagata, Shigekazu; Huse, Morgan; Miller, W. Todd; Casanova, Jean-Laurent; Geissmann, Frederic Share Save Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus diseaseGervais, Adrian; Bastard, Paul; Bizien, Lucy; Delifer, Celine; Tiberghien, Pierre; Rodrigo, Chaturaka; Trespidi, Francesca; Angelini, Micol; Rossini, Giada; Lazzarotto, Tiziana; Conti, Francesca; Cassaniti, Irene; Baldanti, Fausto; Rovida, Francesca; Ferrari, Alessandro; Mileto, Davide; Mancon, Alessandro; Abel, Laurent; Puel, Anne; Cobat, Aurelie; Rice, Charles M.; Cadar, Daniel; Schmidt-Chanasit, Jonas; Scheid, Johannes F.; Lemieux, Jacob E.; Rosenberg, Eric S.; Agudelo, Marianna; Tangye, Stuart G.; Borghesi, Alessandro; Durand, Guillaume Andre; Duburcq-Gury, Emilie; Valencia, Braulio M.; Lloyd, Andrew R.; Nagy, Anna; MacDonald, Margaret M.; Simonin, Yannick; Zhang, Shen-Ying; Casanova, Jean-Laurent Share Save Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERIC-mediated monocyte activationBohlen, Jonathan; Bagaric, Ivan; Vatovec, Taja; Ogishi, Masato; Ahmed, Syed F.; Cederholm, Axel; Buetow, Lori; Sobrino, Steicy; Le Floc'h, Corentin; Arango-Franco, Carlos A.; Seabra, Luis; Michelet, Marine; Barzaghi, Federica; Leardini, Davide; Saettini, Francesco; Vendemini, Francesca; Baccelli, Francesco; Catala, Albert; Gambineri, Eleonora; Veltroni, Marinella; de la Red, Purena Aguilar; Rice, Gillian I.; Consonni, Filippo; Berteloot, Laureline; Largeaud, Laetitia; Conti, Francesca; Roullion, Cecile; Masson, Cecile; Bessot, Boris; Seeleuthner, Yoann; Le Voyer, Tom; Rinchai, Darawan; Rosain, Jeremie; Neehus, Anna-Lena; Erazo-Borras, Lucia; Li, Hailun; Janda, Zarah; Cho, En-Jui; Muratore, Edoardo; Soudee, Camille; Laine, Candice; Delabesse, Eric; Goulvestre, Claire; Ma, Cindy S.; Puel, Anne; Tangye, Stuart G.; Andre, Isabelle; Bole-Feysot, Christine; Abel, Laurent; Erlacher, Miriam; Zhang, Shen-Ping; Beziat, Vivien; Lagresle-Peyrou, Chantal; Six, Emmanuelle; Pasquet, Marlene; Alsina, Laia; Aiuti, Alessandro; Zhang, Peng; Crow, Yanick J.; Landegren, Nils; Masetti, Riccardo; Huang, Danny T.; Casanova, Jean-Laurent; Bustamante, Jacinta Share Save IL-7-dependent and -independent lineages of IL-7R-dependent human T cellsArango-Franco, Carlos A.; Ogishi, Masato; Unger, Susanne; Delmonte, Ottavia M.; Orrego, Julio Cesar; Yatim, Ahmad; Velasquez-Lopera, Margarita M.; Zea-Vera, Andres F.; Bohlen, Jonathan; Chbihi, Marwa; Fayand, Antoine; Sanchez, Juan Pablo; Rojas, Julian; Seeleuthner, Yoann; Le Voyer, Tom; Philippot, Quentin; Payne, Kathryn J.; Gervais, Adrian; Erazo-Borras, Lucia, V; Correa-Londono, Luis A.; Cederholm, Axel; Gallon-Duque, Alejandro; Goncalves, Pedro; Doisne, Jean-Marc; Horev, Liran; Charmeteau-de Muylder, Benedicte; Alvarez, Jesus A.; Arboleda, Diana M.; Perez-Zapata, Lizet; Vasquez-Echeverri, Estefania; Moncada-Velez, Marcela; Lopez, Juan A.; Caicedo, Yolanda; Palterer, Boaz; Patino, Pablo J.; Montoya, Carlos J.; Chaldebas, Matthieu; Zhang, Peng; Nguyen, Tina; Ma, Cindy S.; Jeljeli, Mohamed; Alzate, Juan F.; Cabarcas, Felipe; Khan, Taushif; Rinchai, Darawan; Pretet, Jean-Luc; Boisson, Bertrand; Marr, Nico; Ibrahim, Ruba; Molho-Pessach, Vered; Boisson-Dupuis, Stephanie; Kiritsi, Dimitra; Barata, Joao T.; Landegren, Nils; Neven, Benedicte; Abe, Laurent; Lisco, Andrea; Beziat, Vivien; Jouanguy, Emmanuelle; Bustamante, Jacinta; Di Santo, James P.; Tangye, Stuart G.; Notarangelo, Luigi D.; Cheynier, Remi; Natsuga, Ken; Arias, Andres A.; Franco, Jose Luis; Warnatz, Klaus; Casanova, Jean-Laurent; Puel, Anne Share Save Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseasesRosain, Jeremie; Le Voyer, Tom; Liu, Xian; Gervais, Adrian; Polivka, Laura; Cederholm, Axel; Berteloot, Laureline; Parent, Audrey V.; Pescatore, Alessandra; Spinosa, Ezia; Minic, Snezana; Kiszewski, Ana Elisa; Tsumura, Miyuki; Thibault, Chloe; Azcoiti, Maria Esnaola; Martinovic, Jelena; Philippot, Quentin; Khan, Taushif; Marchal, Astrid; Charmeteau-De Muylder, Benedicte; Bizien, Lucy; Deswarte, Caroline; Hadjem, Lillia; Fauvarque, Marie-Odile; Dorgham, Karim; Eriksson, Daniel; Falcone, Emilia Liana; Puel, Mathilde; Uenal, Sinem; Geraldo, Amyrath; Le Floc'h, Corentin; Li, Hailun; Rheault, Sylvie; Muti, Christine; Bobrie-Moyrand, Claire; Welfringer-Morin, Anne; Fuleihan, Ramsay L.; Levy, Romain; Roelens, Marie; Gao, Liwei; Materna, Marie; Pellegrini, Silvia; Piemonti, Lorenzo; Catherinot, Emilie; Goffard, Jean-Christophe; Fekkar, Arnaud; Sacko-Sow, Aissata; Soudee, Camille; Boucherit, Soraya; Neehus, Anna-Lena; Has, Cristina; Huebner, Stefanie; Blanchard-Rohner, Geraldine; Amador-Borrero, Blanca; Utsumi, Takanori; Taniguchi, Maki; Tani, Hiroo; Izawa, Kazushi; Yasumi, Takahiro; Kanai, Sotaro; Migaud, Melanie; Aubart, Melodie; Lambert, Nathalie; Gorochov, Guy; Picard, Capucine; Soudais, Claire; L'Honneur, Anne-Sophie; Rozenberg, Flore; Milner, Joshua D.; Zhang, Shen-Ying; Vabres, Pierre; Trpinac, Dusan; Marr, Nico; Boddaert, Nathalie; Desguerre, Isabelle; Pasparakis, Manolis; Miller, Corey N.; Poziomczyk, Claudia S.; Abel, Laurent; Okada, Satoshi; Jouanguy, Emmanuelle; Cheynier, Remi; Zhang, Qian; Cobat, Aurelie; Beziat, Vivien; Boisson, Bertrand; Steffann, Julie; Fusco, Francesca; Ursini, Matilde Valeria; Hadj-Rabia, Smail; Bodemer, Christine; Bustamante, Jacinta; Luche, Herve; Puel, Anne; Courtois, Gilles; Bastard, Paul; Landegren, Nils; Anderson, Mark S.; Casanova, Jean-Laurent Share Save Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patientsGervais, Adrian; Marchal, Astrid; Fortova, Andrea; Berankova, Michaela; Krbkova, Lenka; Pychova, Martina; Salat, Jiri; Zhao, Shuxiang; Kerrouche, Nacim; Le Voyer, Tom; Stiasny, Karin; Raffl, Simon; Schieber Pachart, Anne; Fafi-Kremer, Samira; Gravier, Simon; Robbiani, Davide F.; Abel, Laurent; MacDonald, Margaret R.; Rice, Charles M.; Weissmann, Gaia; Kamal Eldin, Tarek; Robatscher, Eva; Erne, Elke Maria; Pagani, Elisabetta; Borghesi, Alessandro; Puel, Anne; Bastard, Paul; Velay, Aurelie; Martinot, Martin; Hansmann, Yves; Aberle, Judith H.; Ruzek, Daniel; Cobat, Aurelie; Zhang, Shen-Ying; Casanova, Jean-Laurent Share Save Share Save Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupusDavid, Clemence; Arango-Franco, Carlos A.; Badonyi, Mihaly; Fouchet, Julien; Rice, Gillian I.; Didry-Barca, Blaise; Maisonneuve, Lucie; Seabra, Luis; Kechiche, Robin; Masson, Cecile; Cobat, Aurelie; Abel, Laurent; Talouarn, Estelle; Beziat, Vivien; Deswarte, Caroline; Livingstone, Katie; Paul, Carle; Malik, Gulshan; Ross, Alison; Adam, Jane; Walsh, Jo; Kumar, Sathish; Bonnet, Damien; Bodemer, Christine; Bader-Meunier, Brigitte; Marsh, Joseph A.; Casanova, Jean-Laurent; Crow, Yanick J.; Manoury, Benedicte; Fremond, Marie-Louise; Bohlen, Jonathan; Lepelley, Alice Share Save Helper T cell immunity in humans with inherited CD4 deficiencyGuerin, Antoine; Moncada-Velez, Marcela; Jackson, Katherine; Ogishi, Masato; Rosain, Jeremie; Mancini, Mathieu; Langlais, David; Nunez, Andrea; Webster, Samantha; Goyette, Jesse; Khan, Taushif; Marr, Nico; Avery, Danielle T.; Rao, Geetha; Waterboer, Tim; Michels, Birgitta; Neves, Esmeralda; Morais, Catia Iracema; London, Jonathan; Mestrallet, Stephanie; Maire, Pierre Quartier Dit; Neven, Benedicte; Rapaport, Franck; Seeleuthner, Yoann; Lev, Atar; Simon, Amos J.; Montoya, Jorge; Barel, Ortal; Gomez-Rodriguez, Julio; Orrego, Julio C.; L'Honneur, Anne-Sophie; Soudee, Camille; Rojas, Jessica; Velez, Alejandra C.; Sereti, Irini; Terrier, Benjamin; Marin, Nancy; Garcia, Luis F.; Abel, Laurent; Boisson-Dupuis, Stephanie; Reis, Joel; Marinho, Antonio; Lisco, Andrea; Faria, Emilia; Goodnow, Christopher C.; Vasconcelos, Julia; Beziat, Vivien; Ma, Cindy S.; Somech, Raz; Casanova, Jean-Laurent; Bustamante, Jacinta; Franco, Jose Luis; Tangye, Stuart G. Share Save Neutralizing IFN-γ autoantibodies are rare and in HLA-DRB1*15:02 or 16:02 individualsPeel, Jessica N.; Yang, Rui; Le Voyer, Tom; Gervais, Adrian; Rosain, Jeremie; Bastard, Paul; Behere, Anish; Cederholm, Axel; Bodansky, Aaron; Seeleuthner, Yoann; Conil, Clement; Ding, Jing-Ya; Lei, Wei-Te; Bizien, Lucy; Soudee, Camille; Migaud, Melanie; Ogishi, Masato; Yatim, Ahmad; Lee, Danyel; Bohlen, Jonathan; Perpoint, Thomas; Perez, Laura; Messina, Fernando; Genet, Roxana; Karkowski, Ludovic; Blot, Mathieu; Lafont, Emmanuel; Toullec, Laurie; Goulvestre, Claire; Mehlal-Sedkaoui, Souad; Sallette, Jerome; Martin, Fernando; Puel, Anne; Jouanguy, Emmanuelle; Anderson, Mark S.; Landegren, Nils; Tiberghien, Pierre; Abel, Laurent; Boisson-Dupuis, Stephanie; Bustamante, Jacinta; Ku, Cheng-Lung; Casanova, Jean-Laurent Share Save Human autoantibodies neutralizing type I IFNs: From 1981 to 2023Bastard, Paul; Gervais, Adrian; Le Voyer, Tom; Philippot, Quentin; Cobat, Aurelie; Rosain, Jeremie; Jouanguy, Emmanuelle; Abel, Laurent; Zhang, Shen-Ying; Zhang, Qian; Puel, Anne; Casanova, Jean-Laurent Share Save Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNsBastard, Paul; Vazquez, Sara; Liu, Jamin; Laurie, Matthew T.; Wang, Chung Yu; Gervais, Adrian; Le Voyer, Tom; Bizien, Lucy; Zamecnik, Colin; Philippot, Quentin; Rosain, Jeremie; Catherinot, Emilie; Willmore, Andrew; Mitchell, Anthea M.; Bair, Rebecca; Garcon, Pierre; Kenney, Heather; Fekkar, Arnaud; Salagianni, Maria; Poulakou, Garyphallia; Siouti, Eleni; Sahanic, Sabina; Tancevski, Ivan; Weiss, Gunter; Nagl, Laurenz; Manry, Jeremy; Duvlis, Sotirija; Arroyo-Sanchez, Daniel; Paz Artal, Estela; Rubio, Luis; Perani, Cristiano; Bezzi, Michela; Sottini, Alessandra; Quaresima, Virginia; Roussel, Lucie; Vinh, Donald C.; Felipe Reyes, Luis; Garzaro, Margaux; Hatipoglu, Nevin; Boutboul, David; Tandjaoui-Lambiotte, Yacine; Borghesi, Alessandro; Aliberti, Anna; Cassaniti, Irene; Venet, Fabienne; Monneret, Guillaume; Halwani, Rabih; Sharif-Askari, Narjes Saheb; Danielson, Jeffrey; Burrel, Sonia; Morbieu, Caroline; Stepanovskyy, Yurii; Bondarenko, Anastasia; Volokha, Alla; Boyarchuk, Oksana; Gagro, Alenka; Neuville, Mathilde; Neven, Benedicte; Keles, Sevgi; Hernu, Romain; Bal, Antonin; Novelli, Antonio; Novelli, Giuseppe; Saker, Kahina; Ailioaie, Oana; Antoli, Arnau; Jeziorski, Eric; Rocamora-Blanch, Gemma; Teixeira, Carla; Delaunay, Clarisse; Lhuillier, Marine; Le Turnier, Paul; Zhang, Yu; Mahevas, Matthieu; Pan-Hammarstrom, Qiang; Abolhassani, Hassan; Bompoil, Thierry; Dorgham, Karim; Group, French Covid Study; Gorochov, Guy; Laouenan, Cedric; Rodriguez-Gallego, Carlos; Ng, Lisa F. P.; Renia, Laurent; Pujol, Aurora; Belot, Alexandre; Raffi, Francois; Allende, Luis M.; Martinez-Picado, Javier; Ozcelik, Tayfun; Keles, Sevgi; Imberti, Luisa; Notarangelo, Luigi D.; Troya, Jesus; Solanich, Xavier; Zhang, Shen-Ying; Puel, Anne; Wilson, Michael R.; Trouillet-Assants, Sophie; Abe, Laurent; Jouanguy, Emmanuelle; Ye, Chun Jimmie; Cobat, Aurelie; Thompson, Leslie M.; Andreakos, Evangelos; Zhang, Qian; Anderson, Mark S.; Casanova, Jean-Laurent; DeRisi, Joseph L. Share Save High sera levels of SARS-CoV-2 N antigen are associated with death in hospitalized COVID-19 patientsChenane, Houssem Redha; Lingas, Guillaume; Menidjel, Reyene; Laouenan, Cedric; Tubiana, Sarah; Descamps, Diane; Le Hingrat, Quentin; Abel, Laurent; Guedj, Jeremie; Malhotra, Surbhi; Kumar-Singh, Samir; Visseaux, Benoit; Ghosn, Jade; Charpentier, Charlotte; Lebourgeois, Samuel Share Save Genome-wide detection of human intronic AG-gain variants located between splicing branchpoints and canonical splice acceptor sitesZhang, Peng; Chaldebas, Matthieu; Ogishi, Masato; Al Qureshah, Fahd; Ponsin, Khoren; Feng, Yi; Rinchai, Darawan; Milisavljevic, Baptiste; Han, Ji Eun; Moncada-Velez, Marcela; Keles, Sevgi; Schroeder, Bernd; Stenson, Peter D.; Cooper, David N.; Cobat, Aurelie; Boisson, Bertrand; Zhang, Qian; Boisson-Dupuis, Stephanie; Abel, Laurent; Casanova, Jean- Laurent Share Save A novel pediatric polycystic lung disease caused by CCR2 deficiencyNeehus, Anna-Lena; Landekic, Marija; Rinchai, Darawan; Panikulam, Patricia; Philippot, Quentin; Le Voyer, Tom; Ogishi, Masato; Rosain, Jeremie; Momenilandi, Mana; Franco, Carlos Andres Arango; Martin-Fernandez, Marta; Khan, Taushif; Bohlen, Jonathan; Manry, Jeremy; Han, Ji Eun; Deslys, Alexandre; Gajardo-Carrasco, Tania; Soudee, Camille; Migaud, Melanie; Seeleuthner, Yoann; Nikolouli, Eirini; Seyedpour, Simin; Begueret, Hugues; Brouzes, Chantal; Vargas, Pablo; Lachmann, Nico; Boire, Raphael; Marr, Nico; Bugonovic, Dusan; Modaresi, Mohammadreza; Nogee, Larry; Craven, Daniel; Mohamadzadeh, Iraj; Rezai, Nima; Shahrooei, Mohammad; Boisson-Dupuis, Stephanie; Sepulveda, Fernando; Beziat, Vivien; Aladjidi, Nathalie; Abel, Laurent; Gros, Philippe; Malo, Danielle; Young, Lisa; Deterding, Robin; Deutsch, Gail; Carey, Brenna; Trapnell, Bruce; Casanova, Jean-Laurent; Bustamante, Jacinta Share Save Share Save 
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