Not logged in Kidney mitochondrial DNA contributes to systemic IL-6 release in sepsis-associated acute kidney injury Kumar, Avnee J.; Epler, Katharine; Wang, Jing; Shen, Alice; Samandari, Negin; Rolfsen, Mark L.; Barnes, Laura A.; Shadel, Gerald S.; Moyzis, Alexandra G.; Sainz, Alva G.; Ulubabyan, Karlen; Li, Kefeng; Jepsen, Kristen; Li, Xinrui; Fuster, Mark M.; Spragg, Roger G.; Sasik, Roman; Vallon, Volker; Goodluck, Helen; Ix, Joachim H.; Singh, Prabhleen; Hepokoski, Mark L. Share Save
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FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion Sainz, Alva G.; Rojas, Gladys R.; Moyzis, Alexandra G.; Donnelly, Matthew P.; Mangalhara, Kailash C.; Johnson, Melissa A.; Esparza-Molto, Pau B.; Grae, Kym J.; Shaw, Reuben J.; Shadel, Gerald S. Share Save
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal Newman, Laura E.; Weiser Novak, Sammy; Rojas, Gladys R.; Tadepalle, Nimesha; Schiavon, Cara R.; Grotjahn, Danielle A.; Towers, Christina G.; Tremblay, Marie-eve; Donnelly, Matthew P.; Ghosh, Sagnika; Medina, Michaela; Rocha, Sienna; Rodriguez-Enriquez, Ricardo; Chevez, Joshua A.; Lemersal, Ian; Manor, Uri; Shadel, Gerald S. Share Save
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Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT Al Khatib, Iman; Deng, Jingti; Lei, Yuanjiu; Torres-Odio, Sylvia; Rojas, Gladys R.; Newman, Laura E.; Chung, Brian K.; Symes, Andrew; Zhang, Hongliang; Huang, Shar-yin N.; Pommier, Yves; Khan, Aneal; Shadel, Gerald S.; West, Andrew Phillip; Gibson, William T.; Shutt, Timothy E. Share Save
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DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages Cobo, Isidoro; Tanaka, Tiffany N.; Mangalhara, Kailash Chandra; Lana, Addison; Yeang, Calvin; Han, Claudia; Schlachetzki, Johannes; Challcombe, Jean; Fixsen, Bethany R.; Sakai, Mashito; Li, Rick Z.; Fields, Hannah; Mokry, Michal; Tsai, Randy G.; Bejar, Rafael; Prange, Koen; de Winther, Menno; Shadel, Gerald S.; Glass, Christopher K. Share Save
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling Xian, Hongxu; Watari, Kosuke; Sanchez-Lopez, Elsa; Offenberger, Joseph; Onyuru, Janset; Sampath, Harini; Ying, Wei; Hoffman, Hal M.; Shadel, Gerald S.; Karin, Michael Share Save
Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions Hepokoski, Mark L.; Odish, Mazen; Lam, Michael T.; Coufal, Nicole G.; Rolfsen, Mark L.; Shadel, Gerald S.; Moyzis, Alexandra G.; Sainz, Alva G.; Takiar, Puja G.; Patel, Sagar; Leonard, Austin J.; Samandari, Negin; Hansen, Emily; Trescott, Samantha; Nguyen, Celina; Jepsen, Kristen; Cutter, Gary; Gillespie, Mark N.; Spragg, Roger G.; Sasik, Roman; Ix, Joachim H. Share Save
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The San Diego Nathan Shock Center: tackling the heterogeneity of aging Shadel, Gerald S.; Adams, Peter D.; Berggren, W. Travis; Diedrich, Jolene K.; Diffenderfer, Kenneth E.; Gage, Fred H.; Hah, Nasun; Hansen, Malene; Hetzer, Martin W.; Molina, Anthony J. A.; Manor, Uri; Marek, Kurt; O'Keefe, David D.; Pinto, Antonio F. M.; Sacco, Alessandra; Sharpee, Tatyana O.; Shokriev, Maxim N.; Zambetti, Stefania Share Save
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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 Lei, Yuyang; Zhang, Jiao; Schiavon, Cara R.; He, Ming; Chen, Lili; Shen, Hui; Zhang, Yichi; Yin, Qian; Cho, Yoshitake; Andrade, Leonardo; Shadel, Gerald S.; Hepokoski, Mark; Lei, Ting; Wang, Hongliang; Zhang, Jin; Yuan, Jason X. -J.; Malhotra, Atul; Manor, Uri; Wang, Shengpeng; Yuan, Zu-Yi; Shyy, John Y-J. Share Save
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