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Robert T. Sauer
Massachusetts Institute of Technology
109
H-index
541
Paper Count
4.0W
Citation Count
0
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Published Papers
129
Publication Date
Publication Date
Impact Factor
Citations
An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates
PROTEIN SCIENCE
IF
5.2
2025-12-23
0
OA
AI
Lyu, Yifei; Bolstad, Isabella; Davis, Joseph H.; Sauer, Robert T.; Ghanbarpour, Alireza
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Structural insights into the Pseudomonas aeruginosa ClpP1•ClpP2 heterocomplex and its interactions with the AAA+ ClpX unfoldase
Protein Science
IF
5.2
2025-09-22
0
OA
AI
Alireza Ghanbarpour; Jia Jia Zhang; Joseph H. Davis; Tania A. Baker; Robert T. Sauer
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A proteolytic AAA plus machine poised to unfold protein substrates
NATURE COMMUNICATIONS
IF
15.7
2024-11-08
0
OA
AI
Ghanbarpour, Alireza; Sauer, Robert T.; Davis, Joseph H.
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How the double-ring ClpAP protease motor grips the substrate to unfold and degrade stable proteins
JOURNAL OF BIOLOGICAL CHEMISTRY
IF
3.9
2024-11-01
0
PRE
AI
Shih, Tsai-Ting; Sauer, Robert T.; Baker, Tania A.
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The membrane-cytoplasmic linker defines activity of FtsH proteases in Pseudomonas aeruginosa clone C
JOURNAL OF BIOLOGICAL CHEMISTRY
IF
3.9
2024-02-01
1
OA
AI
Mawla, Gina D.; Kamal, Shady M.; Cao, Lian-Ying; Purhonen, Pasi; Hebert, Hans; Sauer, Robert T.; Baker, Tania A.; Romling, Ute
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A closed translocation channel in the substrate-free AAA plus ClpXP protease diminishes rogue degradation
NATURE COMMUNICATIONS
IF
15.7
2023-11-10
4
OA
AI
Ghanbarpour, Alireza; Cohen, Steven E.; Fei, Xue; Kinman, Laurel F.; Bell, Tristan A.; Zhang, Jia Jia; Baker, Tania A.; Davis, Joseph H.; Sauer, Robert T.
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Lon degrades stable substrates slowly but with enhanced processivity, redefining the attributes of a successful AAA plus protease
CELL REPORTS
IF
6.9
2023-09-01
2
OA
AI
Kasal, Meghann R.; Kotamarthi, Hema Chandra; Johnson, Madeline M.; Stephens, Hannah M.; Lang, Matthew J.; Sauer, Robert T.; Baker, Tania A.
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The SspB adaptor drives structural changes in the AAA plus ClpXP protease during ssrA-tagged substrate delivery
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF
9.1
2023-02-02
4
OA
AI
Ghanbarpour, Alireza; Fei, Xue; Baker, Tania A.; Davis, Joseph H.; Sauer, Robert T.
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AAA plus protease-adaptor structures reveal altered conformations and ring specialization
NATURE STRUCTURAL & MOLECULAR BIOLOGY
IF
10.1
2022-11-03
10
OA
AI
Kim, Sora; Fei, Xue; Sauer, Robert T.; Baker, Tania A.
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Structure and function of ClpXP, a AAA plus proteolytic machine powered by probabilistic ATP hydrolysis
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
IF
6.4
2021-12-19
20
OA
AI
Sauer, Robert T.; Fei, Xue; Bell, Tristan A.; Baker, Tania A.
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Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease
JOURNAL OF BIOLOGICAL CHEMISTRY
IF
3.9
2021-12-01
3
OA
AI
Zuromski, Kristin L.; Kim, Sora; Sauer, Robert T.; Baker, Tania A.
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Heat activates the AAA plus HslUV protease by melting an axial autoinhibitory plug
CELL REPORTS
IF
6.9
2021-01-01
7
OA
AI
Baytshtok, Vladimir; Fei, Xue; Shih, Tsai-Ting; Grant, Robert A.; Santos, Justin C.; Baker, Tania A.; Sauer, Robert T.
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ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
ELIFE
IF
0
2020-12-01
10
OA
AI
Kim, Sora; Zuromski, Kristin L.; Bell, Tristan A.; Sauer, Robert T.; Baker, Tania A.
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Multistep substrate binding and engagement by the AAA plus ClpXP protease
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF
9.1
2020-10-26
18
OA
AI
Saunders, Reuben A.; Stinson, Benjamin M.; Baker, Tania A.; Sauer, Robert T.
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Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates
ELIFE
IF
0
2020-10-22
33
OA
AI
Fei, Xue; Bell, Tristan A.; Barkow, Sarah R.; Baker, Tania A.; Sauer, Robert T.
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Modular and coordinated activity of AAA plus active sites in the double-ring ClpA unfoldase of the ClpAP protease
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF
9.1
2020-10-13
11
OA
AI
Zuromski, Kristin L.; Sauer, Robert T.; Baker, Tania A.
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Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
ELIFE
IF
0
2020-02-28
106
OA
AI
Fei, Xue; Bell, Tristan A.; Jenni, Simon; Stinson, Benjamin M.; Baker, Tania A.; Harrison, Stephen C.; Sauer, Robert T.
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Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro
ACS CHEMICAL BIOLOGY
IF
3.8
2020-02-21
11
OA
AI
Schmitz, Karl R.; Handy, Emma L.; Compton, Corey L.; Gupta, Shashank; Bishai, William R.; Sauer, Robert T.; Sello, Jason K.
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The Non-dominant AAA plus Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation
CELL REPORTS
IF
6.9
2020-02-01
23
OA
AI
Kotamarthi, Hema Chandra; Sauer, Robert T.; Baker, Tania A.
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Interactions between a subset of substrate side chains and AAA plus motor pore loops determine grip during protein unfolding
ELIFE
IF
0
2019-06-28
15
OA
AI
Bell, Tristan A.; Baker, Tania A.; Sauer, Robert T.
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Research Directions
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Co-authors
Cooperation Journals
S
Steven P. Gygi
H-index: 195 · Papers: 1.0K
M
Martin Karplus
H-index: 167 · Papers: 981
D
Dinshaw J. Patel
H-index: 135 · Papers: 837
S
Stephen C. Harrison
H-index: 128 · Papers: 502
C
Carl Nathan
H-index: 127 · Papers: 424
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