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How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion Tai, Xuguang; Indart, Alyssa; Rojano, Mirelle; Guo, Jie; Apenes, Nicolai; Kadakia, Tejas; Craveiro, Marco; Alag, Amala; Etzensperger, Ruth; Badr, Mohamed Elsherif; Zhang, Flora; Zhang, Zhongmei; Mu, Jie; Guinter, Terry; Crossman, Assiatu; Granger, Larry; Sharrow, Susan; Zhou, Xuyu; Singer, Alfred Share Save
The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells Gegonne, Anne; Tai, Xuguang; Zhang, Jinghui; Wu, Gang; Zhu, Jianjian; Yoshimoto, Aki; Hanson, Jeffrey; Cultraro, Constance; Chen, Qing-Rong; Guinter, Terry; Yang, Zhihui; Hathcock, Karen; Singer, Alfred; Rodriguez-Canales, Jaime; Tessarollo, Lino; Mackem, Susan; Meerzaman, Daoud; Buetow, Ken; Singer, Dinah S. Share Save
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Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus Shinzawa, Miho; Moseman, E. Ashley; Gossa, Selamawit; Mano, Yasuko; Bhattacharya, Abhisek; Guinter, Terry; Alag, Amala; Chen, Xiongfong; Cam, Maggie; McGavern, Dorian B.; Erman, Batu; Singer, Alfred Share Save
Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus Van Laethem, Francois; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I.; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M.; Hanada, Ken-ichi; Yang, James C.; Sun, Peter D.; Singer, Alfred Share Save
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E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex Kadakia, Tejas; Tai, Xuguang; Kruhlak, Michael; Wisniewski, Jan; Hwang, Il-Young; Roy, Sumedha; Guinter, Terry I.; Alag, Amala; Kehrl, John H.; Zhuang, Yuan; Singer, Alfred Share Save
Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire Lu, Jinghua; Van Laethem, Francois; Bhattacharya, Abhisek; Craveiro, Marco; Saba, Ingrid; Chu, Jonathan; Love, Nicholas C.; Tikhonova, Anastasia; Radaev, Sergei; Sun, Xiaoping; Ko, Annette; Arnon, Tomer; Shifrut, Eric; Friedman, Nir; Weng, Nan-Ping; Singer, Alfred; Sun, Peter D. Share Save
A TCR mechanotransduction signaling loop induces negative selection in the thymus Hong, Jinsung; Ge, Chenghao; Jothikumar, Prithiviraj; Yuan, Zhou; Liu, Baoyu; Bai, Ke; Li, Kaitao; Rittase, William; Shinzawa, Miho; Zhang, Yun; Palin, Amy; Love, Paul; Yu, Xinhua; Salaita, Khalid; Evavold, Brian D.; Singer, Alfred; Zhu, Cheng Share Save
CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation Kimura, Motoko Y.; Igi, Akemi; Hayashizaki, Koji; Mita, Yukiyoshi; Shinzawa, Miho; Kadakia, Tejas; Endo, Yukihiro; Ogawa, Satomi; Yagi, Ryoji; Motohashi, Shinichiro; Singer, Alfred; Nakayama, Toshinori Share Save
Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation Gegonne, Anne; Chen, Qing-Rong; Dey, Anup; Etzensperger, Ruth; Tai, Xuguang; Singer, Alfred; Meerzaman, Daoud; Ozato, Keiko; Singer, Dinah S. Share Save
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T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences Madi, Asaf; Poran, Asaf; Shifrut, Eric; Reich-Zeliger, Shlomit; Greenstein, Erez; Zaretsky, Irena; Arnon, Tomer; Van Laethem, Francois; Singer, Alfred; Lu, Jinghua; Sun, Peter D.; Cohen, Irun R.; Friedman, Nir Share Save
Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors Kimura, Motoko Y.; Thomas, Julien; Tai, Xuguang; Guinter, Terry I.; Shinzawa, Miho; Etzensperger, Ruth; Li, Zhenhu; Love, Paul; Nakayama, Toshinori; Singer, Alfred Share Save
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells Takada, Kensuke; Van Laethem, Francois; Xing, Yan; Akane, Kazuyuki; Suzuki, Haruhiko; Murata, Shigeo; Tanaka, Keiji; Jameson, Stephen C.; Singer, Alfred; Takahama, Yousuke Share Save
Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function Pobezinsky, Leonid A.; Etzensperger, Ruth; Jeurling, Susanna; Alag, Amala; Kadakia, Tejas; McCaughtry, Tom M.; Kimura, Motoko Y.; Sharrow, Susan O.; Guinter, Terry I.; Feigenbaum, Lionel; Singer, Alfred Share Save
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