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SavePharmacoscopy-guided discovery of vortioxetine as a repurposable neuroactive therapeutic for glioblastoma
Lee, Sohyon; Weiss, Tobias; Buhler, Marcel; Mena, Julien; Lottenbach, Zuzanna; Wegmann, Rebekka; Sun, Miaomiao; Bihl, Michel; Augustynek, Bartlomiej; Baumann, Sven P.; Goetze, Sandra; van Drogen, Audrey; Pedrioli, Patrick G. A.; Penton, David; Festl, Yasmin; Buck, Alicia; Kirschenbaum, Daniel; Zeitlberger, Anna M.; Neidert, Marian C.; Vasella, Flavio; Rushing, Elisabeth J.; Wollscheid, Bernd; Hediger, Matthias A.; Weller, Michael; Snijder, Berend Share Save High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activityLee, Sohyon; Weiss, Tobias; Buehler, Marcel; Mena, Julien; Lottenbach, Zuzanna; Wegmann, Rebekka; Sun, Miaomiao; Bihl, Michel; Augustynek, Bartlomiej; Baumann, Sven P.; Goetze, Sandra; van Drogen, Audrey; Pedrioli, Patrick G. A.; Penton, David; Festl, Yasmin; Buck, Alicia; Kirschenbaum, Daniel; Zeitlberger, Anna M.; Neidert, Marian C.; Vasella, Flavio; Rushing, Elisabeth J.; Wollscheid, Bernd; Hediger, Matthias A.; Weller, Michael; Snijder, Berend Share Save Extracellular sodium regulates fi broblast growth factor 23 (FGF23) formationRadvanyi, Zsuzsa; Yoo, Eun Jin; Kandasamy, Palanivel; Salas-Bastos, Adrian; Monnerat, Sophie; Refardt, Julie; Christ-Crain, Mirjam; Hayashi, Himeka; Kondo, Yasuhiko; Jantsch, Jonathan; Rubio-Aliaga, Isabel; Sommer, Lukas; Wagner, Carsten A.; Hediger, Matthias A.; Kwon, Hyug Moo; Loffing, Johannes; Pathare, Ganesh Share Save Share Save Share Save Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urineSchlosser, Pascal; Scherer, Nora; Grundner-Culemann, Franziska; Monteiro-Martins, Sara; Haug, Stefan; Steinbrenner, Inga; Uluvar, Burulca; Wuttke, Matthias; Cheng, Yurong; Ekici, Arif B.; Gyimesi, Gergely; Karoly, Edward D.; Kotsis, Fruzsina; Mielke, Johanna; Gomez, Maria F.; Yu, Bing; Grams, Morgan E.; Coresh, Josef; Boerwinkle, Eric; Koettgen, Michael; Kronenberg, Florian; Meiselbach, Heike; Mohney, Robert P.; Akilesh, Shreeram; Schmidts, Miriam; Hediger, Matthias A.; Schultheiss, Ulla T.; Eckardt, Kai-Uwe; Oefner, Peter J.; Sekula, Peggy; Li, Yong; Koettgen, Anna Share Save Dominant-negative variant in SLC1A4 causes an autosomal dominant epilepsy syndromePujol-Gimenez, Jonai; Mirzaa, Ghayda; Blue, Elizabeth E.; Albano, Giuseppe; Miller, Danny E.; Allworth, Aimee; Bennett, James T.; Byers, Peter H.; Chanprasert, Sirisak; Chen, Jingheng; Doherty, Daniel; Folta, Andrew B.; Gillentine, Madelyn A.; Glass, Ian; Hing, Anne; Horike-Pyne, Martha; Leppig, Kathleen A.; Parhin, Azma; Ranchalis, Jane; Raskind, Wendy H.; Rosenthal, Elisabeth A.; Schwarze, Ulrike; Sheppeard, Sam; Strohbehn, Samuel; Sybert, Virginia P.; Timms, Andrew; Wener, Mark; Bamshad, Michael J.; Hisama, Fuki M.; Jarvik, Gail P.; Dipple, Katrina M.; Hediger, Matthias A.; Stergachis, Andrew B. Share Save Share Save Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologsAugustynek, Bartlomiej; Gyimesi, Gergely; Dernic, Jan; Sallinger, Matthias; Albano, Giuseppe; Klesse, Gabriel J.; Kandasamy, Palanivel; Grabmayr, Herwig; Frischauf, Irene; Fuster, Daniel G.; Peinelt, Christine; Hediger, Matthias A.; Bhardwaj, Rajesh Share Save The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin ResistanceVerouti, Sophia N.; Pujol-Gimenez, Jonai; Bermudez-Lekerika, Paola; Scherler, Laeticia; Bhardwaj, Rajesh; Thomas, Aurelien; Lenglet, Sebastien; Siegrist, Mark; Hofstetter, Willy; Fuster, Daniel G.; Hediger, Matthias A.; Escher, Genevieve; Vogt, Bruno Share Save Share Save Share Save Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB-17 Fragment LibraryPujol-Gimenez, Jonai; Poirier, Marion; Buehlmann, Sven; Schuppisser, Celine; Bhardwaj, Rajesh; Awale, Mahendra; Visini, Ricardo; Javor, Sacha; Hediger, Matthias A.; Reymond, Jean-Louis Share Save Share Save Share Save Share Save Share Save Inactivation-mimicking block of the epithelial calcium channel TRPV6Bhardwaj, Rajesh; Lindinger, Sonja; Neuberger, Arthur; Nadezhdin, Kirill D.; Singh, Appu K.; Cunha, Micael R.; Derler, Isabella; Gyimesi, Gergely; Reymond, Jean-Louis; Hediger, Matthias A.; Romanin, Christoph; Sobolevsky, Alexander, I Share Save Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium EntryGibhardt, Christine Silvia; Cappello, Sabrina; Bhardwaj, Rajesh; Schober, Romana; Kirsch, Sonja Agnes; del Rio, Zurine Bonilla; Gahbauer, Stefan; Bochicchio, Anna; Sumanska, Magdalena; Ickes, Christian; Stejerean-Todoran, Ioana; Mitkovski, Miso; Alansary, Dalia; Zhang, Xin; Revazian, Aram; Fahrner, Marc; Lunz, Victoria; Frischauf, Irene; Luo, Ting; Ezerina, Daria; Messens, Joris; Belousov, Vsevolod Vadimovich; Hoth, Markus; Boeckmann, Rainer Arnold; Hediger, Matthias Albrecht; Schindl, Rainer; Bogeski, Ivan Share Save 
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