David G. Monroe - Publications, H-index & Citations

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David G. Monroe

mayo clinic

43H-index

137Paper Count

8.3KCitation Count

Published Papers 64

Publication Date

Transcription-independent induction of rapid-onset senescence is integral to healing

Nature Cell Biology

IF19.1

2026-05-28

OAAI

Karla Valdivieso; Tomaz Rozmaric; Stella Victorelli; Vaibhav Jadhav; Nadja Anneliese Ruth Ring; Sylwia Machcińska-Zielińska; Barbara Schädl; Helene Dworak; Eirini Klinaki; Ines Fischer; Agnieszka Gadecka; Iryna Moskalevska; Sara Kostrebic; Michaela Kienberger; Edyta Marzec; Christina Efraimoglou; Alessia Zanchetta; Julien Cherfils-Vicini; Oleh Lushchak; Andreas Löscher; Thomas Kolbe; Maik Dahlhoff; Nicholas E. Pirius; Aniko Gutasi; Sarolta Takacs; James Ferguson; Bruno K. Podesser; Paul Slezak; David Monroe; Bin Zhou; Sundeep Khosla; Johannes Grillari; Heinz Redl; Diana Jurk; Mikolaj Ogrodnik

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Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow

OBESITY

IF4.7

2025-12-01

OAAI

Zhang, Xu; Doolittle, Madison L.; Fan, Ting; Tripathi, Utkarsh; Ng, Yan Er; Jiang, Xinyi; Passos, Joao F.; Jurk, Diana; Monroe, David G.; Tchkonia, Tamara; Kirkland, James L.; Robbins, Paul D.; Khosla, Sundeep; LeBrasseur, Nathan K.

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Biomarkers of Cellular Senescence in Type 2 Diabetes Mellitus

Aging Cell

IF7.1

2025-05-30

OAAI

Caroline Hoong; Joshua N. Farr; David G. Monroe; Thomas A. White; Elizabeth J. Atkinson; Amanda Tweed; Allyson K. Palmer; Nathan K. LeBrasseur; Jad G. Sfeir; Sundeep Khosla

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Characterization of Human Senescent Cell Biomarkers for Clinical Trials

AGING CELL

IF7.1

2025-01-17

OAAI

Farr, Joshua N.; Monroe, David G.; Atkinson, Elizabeth J.; Froemming, Mitchell N.; Ruan, Ming; Lebrasseur, Nathan K.; Khosla, Sundeep

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Pharmacogenetic and microRNA mechanisms of beta blocker use on bone

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2024-12-13

PREAI

Lary, Christine W.; Atkinson, Elizabeth J.; Spillane, Jennifer; Nayema, Zannatun; Roy, Tyler A.; Peters, Rebecca; Scott, Griffin T.; Chen, Hongyu; Nagarajan, Archana; Brown, Aaron; Motyl, Katherine J.; Monroe, David G.; Khosla, Sundeep

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Isolation and characterization of bone mesenchymal cell small extracellular vesicles using a novel mouse model

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2024-08-22

PREAI

Monroe, David G.; Javeed, Naureen; Rowsey, Jennifer L.; Ruan, Ming; McCabe, Chantal E.; Piatkowski, Bryan T.; Roy, Abhishek; Bobbili, Madhusudhan R.; Grillari, Johannes; Khosla, Sundeep

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Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

NATURE MEDICINE

IF50

2024-07-02

PREAI

Farr, Joshua N.; Atkinson, Elizabeth J.; Achenbach, Sara J.; Volkman, Tammie L.; Tweed, Amanda J.; Vos, Stephanie J.; Ruan, Ming; Sfeir, Jad; Drake, Matthew T.; Saul, Dominik; Doolittle, Madison L.; Bancos, Irina; Yu, Kai; Tchkonia, Tamara; Lebrasseur, Nathan K.; Kirkland, James L.; Monroe, David G.; Khosla, Sundeep

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Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2024-05-16

OAAI

Saul, Dominik; Doolittle, Madison L.; Rowsey, Jennifer L.; Froemming, Mitchell N.; Kosinsky, Robyn L.; Vos, Stephanie J.; Ruan, Ming; LeBrasseur, Nathan K.; Chandra, Abhishek; Pignolo, Robert J.; Passos, Joao F.; Farr, Joshua N.; Monroe, David G.; Khosla, Sundeep

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Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia

JCI INSIGHT

IF6.1

2024-01-23

OAAI

Englund, Davis A.; Jolliffe, Alyssa M.; Hanson, Gabriel J.; Aversa, Zaira; Zhang, Xu; Jiang, Xinyi; White, Thomas A.; Zhang, Lei; Monroe, David G.; Robbins, Paul D.; Niedernhofer, Laura J.; Kamenecka, Theodore M.; Khosla, Sundeep; LeBrasseur, Nathan K.

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Estrogen-regulated miRs in bone enhance osteoblast differentiation and matrix mineralization

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2023-09-01

OAAI

Emch, Michael J.; Wicik, Zofia; Aspros, Kirsten G. M.; Vukajlovic, Tanja; Pitel, Kevin S.; Narum, Anders K.; Weivoda, Megan M.; Tang, Xiaojia; Kalari, Krishna R.; Turner, Russell T.; Iwaniec, Urszula T.; Monroe, David G.; Subramaniam, Malayannan; Hawse, John R.

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Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

NATURE COMMUNICATIONS

IF15.7

2023-07-31

OAAI

Doolittle, Madison L.; Saul, Dominik; Kaur, Japneet; Rowsey, Jennifer L.; Vos, Stephanie J.; Pavelko, Kevin D.; Farr, Joshua N.; Monroe, David G.; Khosla, Sundeep

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Modest Effects of Osteoclast-Specific ERa Deletion after Skeletal Maturity

JBMR PLUS

IF2.4

2023-07-13

OAAI

Doolittle, Madison L. L.; Eckhardt, Brittany A. A.; Vos, Stephanie J. J.; Grain, Sarah; Rowsey, Jennifer L. L.; Ruan, Ming; Saul, Dominik; Farr, Joshua N. N.; Weivoda, Megan M. M.; Khosla, Sundeep; Monroe, David G. G.

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MicroRNA-19a-3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence

JBMR PLUS

IF2.4

2023-04-18

OAAI

Kaur, Japneet; Saul, Dominik; Doolittle, Madison L.; Farr, Joshua N.; Khosla, Sundeep; Monroe, David G.

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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2023-04-17

OAAI

Farr, Joshua N.; Saul, Dominik; Doolittle, Madison L.; Kaur, Japneet; Rowsey, Jennifer L.; Vos, Stephanie J.; Froemming, Mitchell N.; Lagnado, Anthony B.; Zhu, Yi; Weivoda, Megan; Ikeno, Yuji; Pignolo, Robert J.; Niedernhofer, Laura J.; Robbins, Paul D.; Jurk, Diana; Passos, Joao F.; LeBrasseur, Nathan K.; Tchkonia, Tamara; Kirkland, James L.; Monroe, David G.; Khosla, Sundeep

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Estrogen opposes the apoptotic effects of bone morphogenetic protein 7 on tissue remodeling

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

OAAI

Monroe, DG; Jin, DF; Sanders, MM

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TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteclast differentiation in vitro

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

112

OAAI

Subramaniam, M; Gorny, G; Johnsen, SA; Monroe, DG; Evans, GL; Fraser, DG; Rickard, DJ; Rasmussen, K; van Deursen, JMA; Turner, RT; Oursler, MJ; Spelsberg, TC

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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

NATURE COMMUNICATIONS

IF15.7

2022-08-16

275

OAAI

Saul, Dominik; Kosinsky, Robyn Laura; Atkinson, Elizabeth J.; Doolittle, Madison L.; Zhang, Xu; LeBrasseur, Nathan K.; Pignolo, Robert J.; Robbins, Paul D.; Niedernhofer, Laura J.; Ikeno, Yuji; Jurk, Diana; Passos, Joao F.; Hickson, LaTonya J.; Xue, Ailing; Monroe, David G.; Tchkonia, Tamara; Kirkland, James L.; Farr, Joshua N.; Khosla, Sundeep

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Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2022-07-05

OAAI

Doolittle, Madison L.; Saul, Dominik; Kaur, Japneet; Rowsey, Jennifer L.; Eckhardt, Brittany; Vos, Stephanie; Grain, Sarah; Kroupova, Kveta; Ruan, Ming; Weivoda, Megan; Oursler, Merry Jo; Farr, Joshua N.; Monroe, David G.; Khosla, Sundeep

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Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity

AGING CELL

IF7.1

2022-04-01

OAAI

Chandra, Abhishek; Lagnado, Anthony B.; Farr, Joshua N.; Doolittle, Madison; Tchkonia, Tamara; Kirkland, James L.; LeBrasseur, Nathan K.; Robbins, Paul D.; Niedernhofer, Laura J.; Ikeno, Yuji; Passos, Joao F.; Monroe, David G.; Pignolo, Robert J.; Khosla, Sundeep

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Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2022-03-05

OAAI

Chandra, Abhishek; Lagnado, Anthony B.; Farr, Joshua N.; Schleusner, Megan; Monroe, David G.; Saul, Dominik; Passos, Joao F.; Khosla, Sundeep; Pignolo, Robert J.

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Research Directions