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Sirano Dhe‐Paganon

dana-farber cancer institute

61H-index
327Paper Count
1.4WCitation Count
Published Papers 96
Publication Date
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Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma
errNature Chemical Biology
IF13.7
err2026-05-28
err0
PREAI
errMichael P. Agius; Chen Song; Qi Liu; Tomoki Iemura; Laura Hevenor; N. Connor Payne; Romanos Sklavenitis Pistofidis; Lorena Pantano; Hongfang Zhao; Hyuk-Soo Seo; Daniel Heilpern-Mallory; Caleb Heaslip; Zhen-Yu J. Sun; Puspalata Bashyal; Michelle P. Aranha; Elizabeth Lightbody; Ralph Mazitschek; Sirano Dhe-Paganon; Constantine S. Mitsiades; Irene M. Ghobrial; Jun Qi
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errSave
Zanubrutinib and pirtobrutinib show synergistic killing and suppression of BTK signaling in MYD88-mutated lymphoma cells
errBlood Advances
IF7.1
err2026-04-17
err0
errOAAI
errDominic Pizzarella; Amanda Kofides; John M Hatcher; Xia Liu; Alberto Guijosa; Nickolas Tsakmaklis; Abigail L. Peachey; Jinhua Wang; Maria Luisa Guerrera; Christopher J Patterson; Zachary R Hunter; Hao Sun; Shayna R Sarosiek; Jorge J. Castillo; Sara J. Buhrlage; Sirano Dhe-Paganon; Andrew R. Branagan; Steven P. Treon; Shirong Liu
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Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells
errNature Chemical Biology
IF13.7
err2026-01-13
err0
PREAI
errLu Hu; Jinyu Lin; Liping Sun; Alison M. Berezuk; Katharine S. Tuttle; Xing Zhu; Hyuk-Soo Seo; Sirano Dhe-Paganon; Pan Li; Yang Sun; Lisheng Ni; Jianan Zhang; Dazhi Tan; Hiroaki Wakimoto; Daniel P. Cahill; Xiaochen Bai; Xuelian Luo; John M. Asara; Sriram Subramaniam; Yibing Shan; Xu Wu
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Discovery of a small molecule TLR3 agonist adjuvant
errNature Communications
IF15.7
err2025-12-04
err0
errOAAI
errBranden Lee; Danica Dong; Etsuro Nanishi; John Mark Awad; Kimia Z. Abedi; Yoshine Saito; Francesco Borriello; Soumik Barman; Byron Brook; Aisling Kelly; Manisha Menon; Constance Marques-Mourlet; Maansi V. Gupta; Ida Lister; Chiwoo Oh; Kevin Lyskawa; Morgan Goetz; Kristina Walker; Wing Ki Cheng; Spencer E. Brightman; Pankaj Sharma; Timothy R. O’Meara; Katherine Chew; Daniel Vieira; Kevin Ryff; Cali Sweitzer; Sanya Thomas; Simon D. van Haren; Matthew Pettengill; Hyuk-Soo Seo; Sirano Dhe-Paganon; Wei Zhang; Ofer Levy; David J. Dowling
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Author Correction: Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
errNature Cell Biology
IF19.1
err2025-11-17
err0
errOAAI
errDario F. De Jesus; Zijie Zhang; Natalie K. Brown; Xiaolu Li; Ling Xiao; Jiang Hu; Matthew J. Gaffrey; Garrett Fogarty; Sevim Kahraman; Jiangbo Wei; Giorgio Basile; Tariq M. Rana; Clayton Mathews; Alvin C. Powers; Audrey V. Parent; Mark A. Atkinson; Sirano Dhe-Paganon; Decio L. Eizirik; Wei-Jun Qian; Chuan He; Rohit N. Kulkarni
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Pharmacologic interrogation of USP28 cellular function in p53 signaling
errCell Chemical Biology
IF7.2
err2025-09-02
err0
PREAI
errAriana S. Bratt; Susan Kilgas; Maria I. Tarazona Guzman; Robert S. Magin; Isabella Jaen Maisonet; Cara A. Starnbach; Wei Pin Teh; Anthony C. Varca; Bin Hu; Esteban Tarazona Guzman; Hyuk-Soo Seo; Sirano Dhe-Paganon; Nicholas M. Girardi; Guillaume Adelmant; Jarrod A. Marto; Dipanjan Chowdhury; Sara J. Buhrlage
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Targeting transcription factors through an IMiD independent zinc finger domain
errEMBO MOLECULAR MEDICINE
IF8.3
err2025-05-14
err0
errOAAI
errLiu, Bee Hui; Liu, Miao; Radhakrishnan, Sridhar; Dai, Meng-Yuan; Jaladanki, Chaitanya Kumar; Gao, Chong; Tang, Jing Ping; Kumari, Kalpana; Go, Mei Lin; Vu, Kim Anh L.; Kwon, Junsu; Seo, Hyuk-Soo; Song, Kijun; Tian, Xi; Feng, Li; Tan, Justin L.; Melkonian, Arek, V; Liu, Zhaoji; Wulf, Gerburg; Arthanari, Haribabu; Qi, Jun; Dhe-Paganon, Sirano; Clohessy, John G.; Choong, Yeu Khai; Sivaraman, J.; Fan, Hao; Tenen, Daniel G.; Chai, Li
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Leveraging relaxation-optimized 1H-13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins
errNATURE CHEMISTRY
IF20.2
err2025-05-05
err0
PREAI
errBoeszoermenyi, Andras; Radeva, Denitsa L.; Schindler, Sebastian; Valadares, Veronica; Padmanabha Das, Krishna M.; Dubey, Abhinav; Viennet, Thibault; Schmitt, Max; Kast, Peter; Gelev, Vladimir M.; Stoyanov, Nikolay; Burdzhiev, Nikola; Petrov, Ognyan; Ficarro, Scott; Marto, Jarred; Geffken, Ezekiel A.; Dhe-Paganon, Sirano; Seo, Hyuk-Soo; Alexander, Nathan D.; Cooley, Richard B.; Mehl, Ryan A.; Kovacs, Helena; Anklin, Clemens; Bermel, Wolfgang; Kuprov, Ilya; Takeuchi, Koh; Arthanari, Haribabu
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Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST
errCELL METABOLISM
IF30.9
err2025-02-01
err0
PREAI
errSprenger, Hans-Georg; Mittenbuhler, Melanie J.; Sun, Yizhi; Van Vranken, Jonathan G.; Schindler, Sebastian; Jayaraj, Abhilash; Khetarpal, Sumeet A.; Smythers, Amanda L.; Vargas-Castillo, Ariana; Puszynska, Anna M.; Spinelli, Jessica B.; Armani, Andrea; Kunchok, Tenzin; Ryback, Birgitta; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; O'Young, Coby; Braithwaite, Chelsea; Dhe-Paganon, Sirano; Burger, Nils; Mills, Evanna L.; Gygi, Steven P.; Paulo, Joao A.; Arthanari, Haribabu; Chouchani, Edward T.; Sabatini, David M.; Spiegelman, Bruce M.
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Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors
errSLAS DISCOVERY
IF2.7
err2024-12-01
err0
errOAAI
errFicarro, Scott B.; Marto, Zachary H.; Girardi, Nicholas M.; Deng, Dingyu; Maisonet, Isabella Jaen; Adelmant, Guillaume; Fleming, Laura E.; Sharafi, Mona; Tavares, Isidoro; Zhao, Andrew; Kim, Hyojeon; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Buhrlage, Sara J.
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BAD BH3 Helices BCL-2 Mutants That Cause Venetoclax Resistance
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errDeangelo, Thomas M.; Adhikary, Utsarga; Korshavn, Kyle J.; Brotzen-Smith, Clara R.; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; Dhe-Paganon, Sirano; Wales, Thomas E.; Bird, Gregory H.; Walensky, Loren D.
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Structure-function mapping of DHODH shows deviations in protein structure
errCANCER RESEARCH
IF16.6
err2024-03-22
err1
PREAI
errPokhriyal, Ruchika; Evans, Laura; Seo, Hyuk-Soo; O'Neil, Jillian K.; Rouaisnel, Betty; Kamburov, Atanas; Guenther, Judith; Gradl, Stefan; Arthanari, Haribabu; Christian, Sven; Yang, Xiaoping; Dhe-Paganon, Sirano; Losman, Julie-Aurore
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Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
errNATURE CELL BIOLOGY
IF19.1
err2024-02-26
err8
errOAAI
errDe Jesus, Dario F.; Zhang, Zijie; Brown, Natalie K.; Li, Xiaolu; Xiao, Ling; Hu, Jiang; Gaffrey, Matthew J.; Fogarty, Garrett; Kahraman, Sevim; Wei, Jiangbo; Basile, Giorgio; Rana, Tariq M.; Mathews, Clayton; Powers, Alvin C.; Parent, Audrey V.; Atkinson, Mark A.; Dhe-Paganon, Sirano; Eizirik, Decio L.; Qian, Wei-Jun; He, Chuan; Kulkarni, Rohit N.
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errSave
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
errCANCER RESEARCH
IF16.6
err2024-01-17
err1
errOAAI
errHwang, Grace H.; Pazyra-Murphy, Maria F.; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Stopka, Sylwia A.; Dipiazza, Marina; Sutter, Nizhoni; Gero, Thomas W.; Volkert, Alison; Ombelets, Lincoln; Dittemore, Georgia; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Agar, Nathalie Y. R.; Scott, David A.; Segal, Rosalind A.
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Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
errJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
IF11.2
err2023-11-01
err6
errOAAI
errO'Meara, Timothy R.; Nanishi, Etsuro; Mcgrath, Marisa E.; Barman, Soumik; Dong, Danica; Dillen, Carly; Menon, Manisha; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Ernst, Robert K.; Levy, Ofer; Frieman, Matthew B.; Dowling, David J.
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BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA
errNEURO-ONCOLOGY
IF13.4
err2023-06-12
err0
errOAAI
errPanditharatna, Eshini; Marques, Joana G.; Wang, Tingjian; Trissal, Maria; Liu, Ilon; Jiang, Li; Beck, Alexander; Groves, Andrew; Dharia, Neekesh; Hoffman, Samantha; Kugener, Guillaume; Shaw, McKenzie; Hack, Olivia; Dempster, Joshua; Lareau, Caleb; Quezada, Michael; Stanton, Ann-Catherine; Wyatt, Meghan; Kalani, Zohra; Goodale, Amy; Vazquez, Francisca; Piccioni, Federica; Doench, John; Root, David; Anastas, Jamie; Jones, Kristen; Conway, Amy; Stopka, Sylwia; Regan, Michael; Liang, Yu; Seo, Hyuk-Soo; Song, Kijun; Bashyal, Puspalata; Mathewson, Nathan; Dhe-Paganon, Sirano; Suva, Mario L.; Carcaboso, Angel M.; Lavarino, Cinzia; Mora, Jaume; Nguyen, Quang-De; Ligon, Keith L.; Shi, Yang; Agnihotri, Sameer; Agar, Nathalie Y. R.; Stegmaier, Kimberly; Stiles, Charles D.; Monje, Michelle; Golub, Todd R.; Qi, Jun; Filbin, Mariella G.
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Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90a
errMOLECULAR CELL
IF16.6
err2023-06-01
err19
errOAAI
errMu, A.; Wales, Thomas E.; Zhou, Haixia; Draga-Coleta, Sorin-Valeriu; Gorgulla, Christoph; Blackmore, Katherine A.; Mittenbuhler, Melanie J.; Kim, Caroline R.; Bogoslavski, Dina; Zhang, Qiuyang; Wang, Zi-Fu; Jedrychowski, Mark P.; Seo, Hyuk-Soo; Song, Kijun; Xu, Andrew Z.; Sebastian, Luke; Gygi, Steven P.; Arthanari, Haribabu; Dhe-Paganon, Sirano; Griffin, Patrick R.; Engen, John R.; Spiegelman, Bruce M.
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Kinase activation through dimerization by human SH2-B
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err65
errOAAI
errNishi, M; Werner, ED; Oh, BC; Frantz, JD; Dhe-Paganon, S; Hansen, L; Lee, J; Shoelson, SE
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errSave
Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice (vol 8, 18, 2023)
errNPJ VACCINES
IF6.5
err2023-03-03
err0
errOAAI
errNanishi, Etsuro; Borriello, Francesco; Seo, Hyuk-Soo; O'Meara, Timothy R.; McGrath, Marisa E.; Saito, Yoshine; Chen, Jing; Diray-Arce, Joann; Song, Kijun; Xu, Andrew Z.; Barman, Soumik; Menon, Manisha; Dong, Danica; Caradonna, Timothy M.; Feldman, Jared; Hauser, Blake M.; Schmidt, Aaron G.; Baden, Lindsey R.; Ernst, Robert K.; Dillen, Carly; Yu, Jingyou; Chang, Aiquan; Hilgers, Luuk; Platenburg, Peter Paul; Dhe-Paganon, Sirano; Barouch, Dan H.; Ozonoff, Al; Zanoni, Ivan; Frieman, Matthew B.; Dowling, David J.; Levy, Ofer
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Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease
errNATURE MEDICINE
IF50
err2023-02-23
err60
errOAAI
errMehta, Raaj S.; Mayers, Jared R.; Zhang, Yancong; Bhosle, Amrisha; Glasser, Nathaniel R.; Nguyen, Long H.; Ma, Wenjie; Bae, Sena; Branck, Tobyn; Song, Kijun; Sebastian, Luke; Pacheco, Julian Avila; Seo, Hyuk-Soo; Clish, Clary; Dhe-Paganon, Sirano; Ananthakrishnan, Ashwin N.; Franzosa, Eric A.; Balskus, Emily P.; Chan, Andrew T.; Huttenhower, Curtis
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Lewis C. Cantley
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Kenneth C. Anderson
H-index: 199 · Papers: 3.1K
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Steven P. Gygi
H-index: 195 · Papers: 1.0K
B
Bruce M. Spiegelman
H-index: 186 · Papers: 471
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Todd R. Golub
H-index: 176 · Papers: 749
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