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D

Debora S. Marks

harvard medical school

66H-index
249Paper Count
3.4WCitation Count
Published Papers 68
Publication Date
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Hypervariable loop profiling decodes sequence determinants of antibody stability
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2026-04-30
err0
PREAI
errYue Wan; Jiahao Liang; Yile Dai; Karthik Srinivasan; Christian Billesbølle; Ju-Fen Zhu; Jung-Eun Shin; Steffanie Paul; Debora Marks; Yun S. Song; Benjamin R. Myers; Antoine Koehl; Aashish Manglik
errShare
errSave
Proteome-wide model for human disease genetics
errNature Genetics
IF29
err2025-11-24
err0
errOAAI
errRose Orenbuch; Courtney A. Shearer; Aaron W. Kollasch; Aviv D. Spinner; Thomas Hopf; Lood van Niekerk; Dinko Franceschi; Mafalda Dias; Jonathan Frazer; Debora S. Marks
errShare
errSave
Pancreatic cancer risk prediction using deep sequential modeling of longitudinal diagnostic and medication records
errCell Reports Medicine
IF10.6
err2025-09-16
err0
errOAAI
errChunlei Zheng; Asif Khan; Daniel Ritter; Debora S. Marks; Nhan V. Do; Nathanael R. Fillmore; Chris Sander
errShare
errSave
Results of the Protein Engineering Tournament: An Open Science Benchmark for Protein Modeling and Design
errproteins structure function and bioinformatics
IF0
err2025-06-23
err0
errOAAI
errChase Armer; Hassan Kane; Dana L. Cortade; Henning Redestig; David A. Estell; Adil Yusuf; Nathan Rollins; Aviv Spinner; Debora Marks; T. J. Brunette; Peter J. Kelly; Erika DeBenedictis
errShare
errSave
Computationally designed proteins mimic antibody immune evasion in viral evolution
errImmunity
IF26.3
err2025-05-08
err0
errOAAI
errNoor Youssef; Sarah Gurev; Fadi Ghantous; Kelly P. Brock; Javier A. Jaimes; Nicole N. Thadani; Ann Dauphin; Amy C. Sherman; Leonid Yurkovetskiy; Daria Soto; Ralph Estanboulieh; Ben Kotzen; Pascal Notin; Aaron W. Kollasch; Alexander A. Cohen; Sandra E. Dross; Jesse Erasmus; Deborah H. Fuller; Pamela J. Bjorkman; Jacob E. Lemieux; Jeremy Luban; Michael S. Seaman; Debora S. Marks
errShare
errSave
Machine learning prediction of enzyme optimum pH
errNATURE MACHINE INTELLIGENCE
IF23.9
err2025-04-29
err0
PREAI
errGado, Japheth E.; Knotts, Matthew; Shaw, Ada Y.; Marks, Debora; Gauthier, Nicholas P.; Sander, Chris
errShare
errSave
Guidelines for releasing a variant effect predictor
errGENOME BIOLOGY
IF9.4
err2025-04-15
err1
errOAAI
errLivesey, Benjamin J.; Badonyi, Mihaly; Dias, Mafalda; Frazer, Jonathan; Kumar, Sushant; Lindorff-Larsen, Kresten; Mccandlish, David M.; Orenbuch, Rose; Shearer, Courtney A.; Muffley, Lara; Foreman, Julia; Glazer, Andrew M.; Lehner, Ben; Marks, Debora S.; Roth, Frederick P.; Rubin, Alan F.; Starita, Lea M.
errShare
errSave
Toward trustable use of machine learning models of variant effects in the clinic
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2024-12-01
err1
PREAI
errDias, Mafalda; Orenbuch, Rose; Marks, Debora S.; Frazer, Jonathan
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errSave
An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome
errALZHEIMERS & DEMENTIA
IF11.1
err2024-06-26
err0
errOAAI
errSnyder, Allison; Ryan, Veronica H.; Hawrot, James; Lawton, Sydney; Ramos, Daniel M.; Qi, Y. Andy; Johnson, Kory R.; Reed, Xylena; Johnson, Nicholas L.; Kollasch, Aaron W.; Duffy, Megan F.; VandeVrede, Lawren; Cochran, J. Nicholas; Miller, Bruce L.; Toro, Camilo; Bielekova, Bibiana; Marks, Debora S.; Yokoyama, Jennifer S.; Kwan, Justin Y.; Cookson, Mark R.; Ward, Michael E.
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errSave
Simultaneous enhancement of multiple functional properties using evolution-informed protein design
errNATURE COMMUNICATIONS
IF15.7
err2024-06-20
err1
errOAAI
errFram, Benjamin; Su, Yang; Truebridge, Ian; Riesselman, Adam J.; Ingraham, John B.; Passera, Alessandro; Napier, Eve; Thadani, Nicole N.; Lim, Samuel; Roberts, Kristen; Kaur, Gurleen; Stiffler, Michael A.; Marks, Debora S.; Bahl, Christopher D.; Khan, Amir R.; Sander, Chris; Gauthier, Nicholas P.
errShare
errSave
Protein design using structure-based residue preferences
errNATURE COMMUNICATIONS
IF15.7
err2024-02-22
err7
errOAAI
errDing, David; Shaw, Ada Y.; Sinai, Sam; Rollins, Nathan; Prywes, Noam; Savage, David F.; Laub, Michael T.; Marks, Debora S.
errShare
errSave
Machine learning for functional protein design
errNATURE BIOTECHNOLOGY
IF41.7
err2024-02-15
err35
PREAI
errNotin, Pascal; Rollins, Nathan; Gal, Yarin; Sander, Chris; Marks, Debora
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errSave
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-02-07
err4
errOAAI
errHoppe, Nicholas; Harrison, Simone; Hwang, Sun-Hee; Chen, Ziwei; Karelina, Masha; Deshpande, Ishan; Suomivuori, Carl-Mikael; Palicharla, Vivek R.; Berry, Samuel P.; Tschaikner, Philipp; Regele, Dominik; Covey, Douglas F.; Stefan, Eduard; Marks, Debora S.; Reiter, Jeremy F.; Dror, Ron O.; Evers, Alex S.; Mukhopadhyay, Saikat; Manglik, Aashish
errShare
errSave
scPerturb: harmonized single-cell perturbation data
errNATURE METHODS
IF32.1
err2024-01-26
err15
errOAAI
errPeidli, Stefan; Green, Tessa D.; Shen, Ciyue; Gross, Torsten; Min, Joseph; Garda, Samuele; Yuan, Bo; Schumacher, Linus J.; Taylor-King, Jake P.; Marks, Debora S.; Luna, Augustin; Bluethgen, Nils; Sander, Chris
errShare
errSave
How can the protein design community best support biologists who want to harness AI tools for protein structure prediction and design?
errCELL SYSTEMS
IF7.7
err2023-08-01
err0
PREAI
errHoecker, Birte; Lu, Peilong; Glasgow, Anum; Marks, Debora S.; Chatterjee, Pranam; Slusky, Joanna S. G.; Schueler-Furman, Ora; Huang, Possu
errShare
errSave
An Atlas of Variant Effects to understand the genome at nucleotide resolution
errGENOME BIOLOGY
IF9.4
err2023-07-03
err29
errOAAI
errFowler, Douglas M.; Adams, David J.; Gloyn, Anna L.; Hahn, William C.; Marks, Debora S.; Muffley, Lara A.; Neal, James T.; Roth, Frederick P.; Rubin, Alan F.; Starita, Lea M.; Hurles, Matthew E.; Ahituv, Nadav; Bahcal, Orli G.; Baldridge, Dustin; Berg, Jonathan S.; Berger, Alice H.; Bianchi, Aisha Haley; Bolognesi, Benedetta; Boutros, Michael; Brenner, Steven; Brush, Matthew H.; Bryant, Vanessa; Bult, Carol J.; Bulyk, Martha; Call, Melissa; Carter, Hannah; Claussnitzer, Melina; Chen, Feng; Cline, Melissa S.; Cuperus, Josh T.; Dawood, Moez; De Jong, Hannah N.; Dias, Mafalda; Dunn, Michael; Engreitz, Jesse; Farh, Kyle; Febbo, Phillip G.; Fields, Stanley; Findlay, Gregory M.; Firth, Helen; Fraser, James S.; Frazer, Jonathan; Frontini, Mattia; Romero, Irene Gallego; Glazer, Andrew M.; Gueler, Murat; Hartmann-Petersen, Rasmus; Houlston, Richard; Huang, Kuan-Lin; Hutter, Carolyn M.; Jagannathan, Sujatha; James, Richard G.; Kampmann, Martin; Karchin, Rachel; Kinney, Justin B.; Komor, Alexis C.; Kosuri, Sriram; Lehner, Ben; Lindorff-Larsen, Kresten; Lombard, Zane; MacArthur, Daniel G.; Martin, Maria; McDermott, Ultan; McNulty, Shannon M.; Ba, Alex N. Nguyen; O'Donnell-Luria, Anne; O'Roak, Brian J.; Parikh, Victoria N.; Parts, Leopold; Pazin, Michael J.; Pesaran, Tina; Petrovski, Slave; Queitsch, Christine; Root, David E.; Shendure, Jay; Spurdle, Amanda B.; Taylor, Kevin L.; Turnbull, Clare; Villen, Judit; Vissers, L. E. L. M.; Wagner, Alex H.; Wakefield, Matthew J.; Weile, Jochen; Xiao, Jenny
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errSave
A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories
errNATURE MEDICINE
IF50
err2023-05-08
err82
errOAAI
errPlacido, Davide; Yuan, Bo; Hjaltelin, Jessica X.; Zheng, Chunlei; Haue, Amalie D.; Chmura, Piotr J.; Yuan, Chen; Kim, Jihye; Umeton, Renato; Antell, Gregory; Chowdhury, Alexander; Franz, Alexandra; Brais, Lauren; Andrews, Elizabeth; Marks, Debora S.; Regev, Aviv; Ayandeh, Siamack; Brophy, Mary T.; Do, Nhan V.; Kraft, Peter; Wolpin, Brian M.; Rosenthal, Michael H.; Fillmore, Nathanael R.; Brunak, Soren; Sander, Chris
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errSave
The relaxin receptor RXFP1 signals through a mechanism of autoinhibition
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-04-20
err7
errOAAI
errErlandson, Sarah C.; Rawson, Shaun; Osei-Owusu, James; Brock, Kelly P.; Liu, Xinyue; Paulo, Joao A.; Mintseris, Julian; Gygi, Steven P.; Marks, Debora S.; Cong, Xiaojing; Kruse, Andrew C.
errShare
errSave
An in silico method to assess antibody fragment polyreactivity
errNATURE COMMUNICATIONS
IF15.7
err2022-12-07
err15
errOAAI
errHarvey, Edward P.; Shin, Jung-Eun; Skiba, Meredith A.; Nemeth, Genevieve R.; Hurley, Joseph D.; Wellner, Alon; Shaw, Ada Y.; Miranda, Victor G.; Min, Joseph K.; Liu, Chang C.; Marks, Debora S.; Kruse, Andrew C.
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errSave
Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices
errSCIENCE ADVANCES
IF12.5
err2022-07-15
err12
errOAAI
errAkyuz, Nurunisa; Karavitaki, K. Domenica; Pan, Bifeng; Tamvakologos, Panos, I; Brock, Kelly P.; Li, Yaqiao; Marks, Debora S.; Corey, David P.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
A
Aviv Regev
H-index: 208 · Papers: 965
B
Bruce L. Miller
H-index: 201 · Papers: 2.1K
S
Steven P. Gygi
H-index: 195 · Papers: 1.0K
C
Chris Sander
H-index: 191 · Papers: 849
J
Joshua M. Stuart
H-index: 170 · Papers: 578
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