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A phase 1 clinical trial of the farnesyltransferase inhibitor KO-2806 in combination with cabozantinib in renal cell carcinoma Ayanambakkam, Adanma; Rosen, Lee S.; Garmezy, Benjamin; Pelster, Meredith; Hanna, Glenn J.; Thomas, Jacob; Patel, Manish R.; Bendris, Nawal; Johnson, Paria Mahboub; Dale, Stephen; Saunders, Andrew; Kuan, J. C.; Balsara, Binaifer; Seraj, Jabed; Singer, Adam E. Share Save
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Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies Bewersdorf, Jan Philipp; Mi, Xiaoli; Lu, Bin; Kuykendall, Andrew; Sallman, David; Patel, Manish; Stevens, Don; Philipovskiy, Alexander; Sutamtewagul, Grerk; Masarova, Lucia; Keiffer, Gina; Verma, Amit; Bhagwat, Neha; Wang, Min; Moore, Andrew; Rager, Joseph; Heiser, Diane; Ro, Sunhee; Hong, Wan-Jen; Abdel-Wahab, Omar; Stein, Eytan M. Share Save
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Open-Label, Multicenter, Phase I Study to Assess Safety and Tolerability of Adavosertib Plus Durvalumab in Patients with Advanced Solid Tumors Patel, Manish R.; Falchook, Gerald S.; Wang, Judy S.; Imedio, Esteban Rodrigo; Kumar, Sanjeev; Miah, Kowser; Mugundu, Ganesh M.; Jones, Suzanne F.; Spigel, David R.; Hamilton, Erika P. Share Save
Phase Ib Study of PRT543, an Oral Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, in Patients with Relapsed or Refractory, Splicing Factor-Mutant Myeloid Malignancies Bewersdorf, Jan Philipp; Mi, Xiaoli; Lu, Bin; Kuykendall, Andrew T.; Sallman, David; Patel, Manish; Stevens, Don A.; Philipovskiy, Alexander; Sutamtewagul, Grerk; Masarova, Lucia; Keiffer, Gina; Uerma, Amit; Bhagwat, Neha; Heiser, Diane; Ro, Sunhee; Hong, Wan-Jen; Abdel-Wahab, Omar; Stein, Eytan M. Share Save
Pirtobrutinib monotherapy in Bruton tyrosine kinase inhibitor-intolerant patients with B-cell malignancies: results of the phase I/II BRUIN trial Shah, Nirav N.; Wang, Michael; Roeker, Lindsey E.; Patel, Krish; Woyach, Jennifer A.; Wierda, William G.; Ujjani, Chaitra S.; Eyre, Toby A.; Zinzani, Pier Luigi; Alencar, Alvaro J.; Ghia, Paolo; Lamanna, Nicole; Hoffmann, Marc S.; Patel, Manish R.; Flinn, Ian; Gerson, James N.; Ma, Shuo; Coombs, Catherine C.; Cheah, Chan Y.; Lech-Maranda, Ewa; Fakhri, Bita; Kim, Won Seog; Barve, Minal A.; Cohen, Jonathon B.; Jurczak, Wojciech; Munir, Talha; Thompson, Meghan C.; Tsai, Donald E.; Bao, Katherine; Cangemi, Nicholas A.; Kherani, Jennifer F.; Walgren, Richard A.; Han, Hongmei; Ruppert, Amy S.; Brown, Jennifer R. Share Save
Clinical and biomarker data from a phase 1/2 trial of ifinatamab deruxtecan (I-DXd; DS-7300) in advanced solid tumors Doi, T.; Patel, M. R.; Koyama, T.; Falchook, G. S.; Friedman, C.; Piha-Paul, S. A.; Gutierrez, M.; Awad, M.; Mattour, A.; Satoh, T.; Takahashi, S.; Tsunoda, T.; Kadowaki, S.; Watanabe, Y.; Okamoto, N.; Goto, H.; Yoshizuka, N.; Qian, M.; Qian, X.; Johnson, M. Share Save
Increased therapeutic index of muzastotug (ADG126), a masked anti-CTLA-4 antibody, in combination with pembrolizumab (pembro) enables significant clinical benefits and supports further clinical development in patients with metastatic MSS CRC Li, D.; Kim, S. Y.; Kim, H. K.; Sharma, S.; Shin, S. J.; Lee, J.; Im, S-A.; She, X. K.; Li, Y.; Chung, L. E. C.; Xiao, P.; Liu, G.; Zeng, S.; HuLowe, D.; Chisamore, M.; Luo, P. P.; Zha, J.; Patel, M. R. Share Save
T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study Gainor, Justin F.; Patel, Manish R.; Weber, Jeffrey S.; Gutierrez, Martin; Bauman, Julie E.; Clarke, Jeffrey M.; Julian, Ricklie; Scott, Aaron J.; Geiger, Jessica L.; Kirtane, Kedar; Robert-Tissot, Celine; Coder, Brandon; Tasneem, Moomal; Sun, Jing; Zheng, Wei; Gerbereux, Lauren; Laino, Andressa; Porichis, Filippos; Pollard, Jack Russella; Hou, Peijie; Sehgal, Vasudha; Chen, Xing; Morrissey, Manju; Daghestani, Hikmat N.; Feldman, Igor; Srinivasan, Lakshmi; Frederick, Joshua P.; Brown, Michelle; Aanur, Praveen; Meehan, Robert; Burris III, Howard A. Share Save
Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors Chen, Jian Jenny; Vincent, Melanie Y.; Shepard, Dale; Peereboom, David; Mahalingam, Devalingam; Battiste, James; Patel, Manish R.; Juric, Dejan; Wen, Patrick Y.; Bullock, Andrea; Selfridge, Jennifer Eva; Pant, Shubham; Liu, Joyce; Li, Wendy; Fyfe, Susanne; Wang, Suming; Zota, Victor; Mahoney, James; Watnick, Randolph S.; Cieslewicz, Michael; Watnick, Jing Share Save
A Phase I/IIa clinical trial (TranStar101) to evaluate the safety, tolerability and pharmacokinetics of OSEMITAMAB administered as monotherapy or in combination with nivolumab or standard of care in patients with locally advanced or metastatic solid tumors Janjigian, Yelena; Tolcher, Anthony; Mehta, Rutika; Cecchini, Michael; Van Tine, Brian; Kundranda, Madappa; Olatunji, Alese; Patel, Manish R.; Berlin, Jordan; Rocha-Lima, Caio Max Sao Pedro; Monga, Dulabh; Ben George; Scott, Aaron; Xia, Zhenzhong; Elsafy, Mohamed; Jones, Erikca; Yao, Zhenling; Qi, Chuan; Germa, Caroline; Gabrail, Nash Share Save
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A Phase 1 trial evaluating AC699, an orally bioavailable chimeric estrogen receptor degrader, in patients with advanced or metastatic breast cancer Layman, Rachel M.; Patel, Manish R.; Cosgrove, David; Danso, Michael; Mota, Nancy; Zettler, Marjorie E.; Pehlivan, Katherine C.; Hamilton, Erika Share Save
mRNA-4157 (V940) individualized neoantigen therapy (INT) plus pembrolizumab (pembro) in advanced unresectable HPV- head & neck carcinoma (HNSCC): Clinical & translational analysis Bauman, Julie E.; Julian, Ricklie A.; Geiger, Jessica L.; Mehnert, Janice M.; Clarke, Jeffrey M.; Patel, Manish R.; Gutierrez, Martin; Gainor, Justin F.; Srivats, Shyam; Zhang, Zhaojie; Rao, Anjali; Sehgal, Vasudha; Hou, Peijie; Morrissey, Manju; Feldman, Igor; Srinivasan, Lakshmi; Aanur, Praveen; Brown, Michelle; Meehan, Robert S. Share Save
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FIT-001: A phase 1 clinical trial of the farnesyl transferase inhibitor KO2806 alone or as part of combination therapy for advanced solid tumors Hanna, Glenn J.; Adkins, Douglas R.; Thomas, Jacob S.; Bruce, Justine Y.; Patel, Manish R.; Sonpavde, Guru; Henry, Jason; Bendris, Nawal; Zhang, Zijing; Mitra, Amitava; Gasco, Amaya; Saunders, Andrew; Dale, Stephen Share Save
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