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K

Keith T. Flaherty

harvard medical school

146H-index
1.7KPaper Count
12.2WCitation Count
Published Papers 328
Publication Date
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Multimodal blood based proteomic profiling reveals insights into mechanisms of immunotherapy resistance
errNature Communications
IF15.7
err2026-06-24
err0
errOAAI
errSamuel J. Wright; Izabella Zamora; Milan Parikh; Deepika Yeramosu; Marijana Rucevic; Moshe Sade-Feldman; Thomas J. LaSalle; Emily M. Blaum; Baolin Liu; Lynn Bi; Sarah Kang; Steven M. Blum; Ngan Nguyen; Jamey Guess; Amrita Kar; Alexis M. Schneider; David Lieb; Elliot Woods; William Michaud; Aleigha R. Lawless; Tatyana Sharova; Sonia Cohen; Gyulnara Kasumova; Michelle S. Kim; Li-Chun Cheng; Alexandra-Chloé Villani; Ryan J. Park; Russell W. Jenkins; Samuel J. Klempner; Ryan J. Sullivan; Keith T. Flaherty; Nir Hacohen; Arnav Mehta; Genevieve M. Boland
errShare
errSave
Real-World Outcomes of Adjuvant Therapy in Stage III Melanoma and the Impact of Somatic Mutations
errCANCER MEDICINE
IF3.1
err2025-12-04
err0
errOAAI
errEffiom, Derek; Aprati, Tyler; Karneris, Anastasios; Lawless, Aleigha; Sharova, Tatyana; Johnson, Rebecca; Menzies, Alexander; Long, Georgina; Park, Benjamin; Jung, Seungyeon; Johnson, Douglas; Liu, David; Bai, Xue; Flaherty, Keith; Sullivan, Ryan; Boland, Genevieve M.; Cohen, Sonia
errShare
errSave
Retraction Note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
errNature
IF48.5
err2025-10-29
err0
errOAAI
errAmanpreet Kaur; Marie R. Webster; Katie Marchbank; Reeti Behera; Abibatou Ndoye; Curtis H. Kugel; Vanessa M. Dang; Jessica Appleton; Michael P. O’Connell; Phil Cheng; Alexander A. Valiga; Rachel Morissette; Nazli B. McDonnell; Luigi Ferrucci; Andrew V. Kossenkov; Katrina Meeth; Hsin-Yao Tang; Xiangfan Yin; William H. Wood; Elin Lehrmann; Kevin G. Becker; Keith T. Flaherty; Dennie T. Frederick; Jennifer A. Wargo; Zachary A. Cooper; Michael T. Tetzlaff; Courtney Hudgens; Katherine M. Aird; Rugang Zhang; Xiaowei Xu; Qin Liu; Edmund Bartlett; Giorgos Karakousis; Zeynep Eroglu; Roger S. Lo; Matthew Chan; Alexander M. Menzies; Georgina V. Long; Douglas B. Johnson; Jeffrey Sosman; Bastian Schilling; Dirk Schadendorf; David W. Speicher; Marcus Bosenberg; Antoni Ribas; Ashani T. Weeraratna
errShare
errSave
The rise of new targets in melanoma
errBRITISH JOURNAL OF DERMATOLOGY
IF9.6
err2025-08-01
err0
PREAI
errBai, Xue; Flaherty, Keith T.
errShare
errSave
Reduction of TRAIL-Induced Mcl-1 and cIAP2 by c-Myc or Sorafenib Sensitizes Resistant Human Cancer Cells to TRAIL-Induced Death
errCancer Cell
IF44.5
err2025-07-24
err0
PREAI
errM. Stacey Ricci; Seok-Hyun Kim; Kazuhiro Ogi; John P. Plastaras; Jianhua Ling; Wenge Wang; Zhaoyu Jin; Yingqiu Y. Liu; David T. Dicker; Paul J. Chiao; Keith T. Flaherty; Charles D. Smith; Wafik S. El-Deiry
errShare
errSave
Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants
errCell Reports Medicine
IF10.6
err2025-06-27
err0
errOAAI
errOr-Yam Revach; Angelina M. Cicerchia; Ofir Shorer; Claire A. Palin; Boryana Petrova; Seth Anderson; Baolin Liu; Joshua Park; Lee Chen; Arnav Mehta; Samuel J. Wright; Niamh McNamee; Aya Tal-Mason; Giulia Cattaneo; Payal Tiwari; Hongyan Xie; Johanna M. Sweere; Li-Chun Cheng; Natalia Sigal; Elizabeth Enrico; Marisa Miljkovic; Shane A. Evans; Ngan Nguyen; Mark E. Whidden; Ramji Srinivasan; Matthew H. Spitzer; Yi Sun; Tatyana Sharova; Aleigha R. Lawless; William A. Michaud; Martin Q. Rasmussen; Jacy Fang; Jeannette R. Brook; Feng Chen; Xinhui Wang; Cristina R. Ferrone; Donald P. Lawrence; Ryan J. Sullivan; David Liu; Uma M. Sachdeva; Debattama R. Sen; Keith T. Flaherty; Robert T. Manguso; Lloyd Bod; Manolis Kellis; Genevieve M. Boland; Keren Yizhak; Jiekun Yang; Naama Kanarek; Moshe Sade-Feldman; Nir Hacohen; Russell W. Jenkins
errShare
errSave
A plain language summary of POLARIS: a study to look at different doses of encorafenib plus binimetinib for people with BRAF V600-mutant melanoma with brain metastasis
errFUTURE ONCOLOGY
IF2.6
err2025-05-26
err0
errOAAI
errMenzies, Alexander M.; Long, Georgina V.; Kohn, Amiee; Tawbi, Hussein; Webe, Jeffrey; Flaherty, Keith; McArthur, Grant A.; Ascierto, Paolo A.; Pfluger, Yanina; Lewis, Karl; Tsai, Katy K.; Hamid, Omid; Prenen, Hans; Fein, Luis; Wang, Erjian; Guenzel, Carolin; Zhang, Fan; Kleh, Joseph F.; di Pietro, Alessandra; Davies, Michael A.
errShare
errSave
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
errNATURE
IF48.5
err2025-04-24
err0
PREAI
errJohannessen, Cory M.; Johnson, Laura A.; Piccioni, Federica; Townes, Aisha; Frederick, Dennie T.; Donahue, Melanie K.; Narayan, Rajiv; Flaherty, Keith T.; Wargo, Jennifer A.; Root, David E.; Garraway, Levi A.
errShare
errSave
A model for decoding resistance in precision oncology: acquired resistance to FGFR inhibitors in cholangiocarcinoma
errANNALS OF ONCOLOGY
IF65.4
err2024-12-01
err1
errOAAI
errGoyal, L.; DiToro, D.; Facchinetti, F.; Martin, E. E.; Peng, P.; Baiev, I.; Iyer, R.; Maurer, J.; Reyes, S.; Zhang, K.; Majeed, U.; Berchuck, J. E.; Chen, C. T.; Walmsley, C.; Pinto, C.; Vasseur, D.; Gordan, J. D.; Mody, K.; Borad, M.; Karasic, T.; Damjanov, N.; Danysh, B. P.; Wehrenberg-Klee, E.; Kambadakone, A. R.; Saha, S. K.; Hoffman, I. D.; Nelson, K. J.; Iyer, S.; Qiang, X.; Sun, C.; Wang, H.; Li, L.; Javle, M.; Lin, B.; Harris, W.; Zhu, A. X.; Cleary, J. M.; Flaherty, K. T.; Harris, T.; Shroff, R. T.; Leshchiner, I.; Parida, L.; Kelley, R. K.; Fan, J.; Stone, J. R.; Uboha, N. V.; Hirai, H.; Sootome, H.; Wu, F.; Bensen, D. C.; Hollebecque, A.; Friboulet, L.; Lennerz, J. K.; Getz, G.; Juric, D.
errShare
errSave
Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma
errJOURNAL OF TRANSLATIONAL MEDICINE
IF7.5
err2024-09-30
err0
errOAAI
errDuan, Hao; Xie, Yuan; Wu, Suwen; Zhao, Guangyin; Zeng, Zhen; Hu, Hongrong; Yu, Yanjiao; Hu, Wanming; Yang, Yuanzhong; Chen, Yukun; Xie, Haoqun; Chen, Zexin; Zhang, Gao; Flaherty, Keith T.; Hu, Shanshan; Xu, Haineng; Ma, Wenjuan; Mou, Yonggao
errShare
errSave
Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after de fi nitive surgery: a multicenter, retrospective cohort study (vol 65, 102290, 2023)
errECLINICALMEDICINE
IF10
err2024-05-01
err0
errOAAI
errBai, Xue; Shaheen, Ahmed; Grieco, Charlotte; Arienzo, Paolo D.; Mina, Florentia; Czapla, Juliane A.; Lawless, Aleigha R.; Bongiovanni, Eleonora; Santaniello, Umberto; Zappi, Helena; Dulak, Dominika; Williamson, Andrew; Lee, Rebecca; Gupta, Avinash; Li, Caili; Si, Lu; Ubaldi, Martina; Yamazaki, Naoya; Ogata, Dai; Johnson, Rebecca; Park, Benjamin C.; Jung, Seungyeon; Madonna, Gabriele; Hochherz, Juliane; Umeda, Yoshiyasu; Nakamura, Yasuhiro; Gebhardt, Christoffer; Festino, Lucia; Capone, Mariaelena; Ascierto, Paolo Antonio; Johnson, Douglas B.; Lo, Serigne N.; V. Long, Georgina; Menzies, Alexander M.; Namikawa, Kenjiro; Mandala, Mario; Guo, Jun; Lorigan, Paul; Najjar, Yana G.; Haydon, Andrew; Quaglino, Pietro; Boland, Genevieve M.; Sullivan, Ryan J.; Furness, Andrew J. S.; Plummer, Ruth; Flaherty, Keith T.
errShare
errSave
Plasma proteomic biomarkers identify non-responders and reveal biological insights about the tumor microenvironment in melanoma patients after PD1 blockade
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errWright, Samuel J.; Yeramosu, Deepika; Parikh, Milan; Rucevic, Marijana; Nguyen, Ngan; Jenkins, Russell W.; Flaherty, Keith T.; Hacohen, Nir; Boland, Genevieve M.; Mehta, Arnav
errShare
errSave
Analysis of biomarker and outcomes data: 7-year update from COLUMBUS
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errDummer, Reinhard; Flaherty, Keith; Deng, Shibing; Xie, Tao; Hamilton, Phineas; Pathan, Nuzhat; Robert, Caroline; Arance, Ana; de Groot, Jan Willem; Garbe, Claus; Gogas, Helen J.; Gutzmer, Ralf; Krajsova, Ivana; Liszkay, Gabriella; Loquai, Carmen; Mandala, Mario; Schadendorf, Dirk; Yamazaki, Naoya; Ascierto, Paolo A.; di Pietro, Alessandra; Davis, Craig B.
errShare
errSave
Spatiotemporal analyses of longitudinal specimens reveal mechanisms of response and resistance to immune checkpoint blockade in metastatic melanoma
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errZhang, Gao; Coussens, Lisa; Herlyn, Meenhard; Flaherty, Keith T.; Boland, Genevieve; Mills, Gordon
errShare
errSave
POLARIS: A phase 2 trial of encorafenib plus binimetinib evaluating high-dose and standard-dose regimens in patients with BRAF V600-mutant melanoma with brain metastasis
errNEURO-ONCOLOGY ADVANCES
IF4.1
err2024-03-18
err1
errOAAI
errMenzies, Alexander M.; Long, Georgina, V; Kohn, Amiee; Tawbi, Hussein; Weber, Jeffrey; Flaherty, Keith; McArthur, Grant A.; Ascierto, Paolo A.; Pfluger, Yanina; Lewis, Karl; Tsai, Katy K.; Hamid, Omid; Prenen, Hans; Fein, Luis; Wang, Erjian; Guenzel, Carolin; Zhang, Fan; Kleha, Joseph F.; di Pietro, Alessandra; Davies, Michael A.
errShare
errSave
MAESTRO-Pool Enables Highly Parallel and Specific Mutation-Enrichment Sequencing for Minimal Residual Disease Detection in Cohort Studies
errCLINICAL CHEMISTRY
IF6.3
err2023-12-09
err3
PREAI
errBlewett, Timothy; Rhoades, Justin; Liu, Ruolin; Xiong, Kan; Sridhar, Sainetra; Crnjac, Andjela; Cheng, Ju; Lawless, Aleigha R.; Frederick, Dennie T.; Flaherty, Keith T.; Makrigiorgos, Gerassimos Mike; Adalsteinsson, Viktor A.
errShare
errSave
Concordance between tumor tissue and plasma genotyping in NCI-MATCH Trial (EAY131)
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errGouda, Mohamed A.; Janku, Filip; Yuan, Ying; Drusbosky, Leylah; Chen, Alice P.; Patel, Keyur; Hamilton, Stanley R.; Routbort, Mark; Williams, P. Mickey; Iafrate, John; Sklar, Jeffrey; Coffey, Brent; Little, Richard F.; Arteaga, Carlos L.; Abrams, Jeffrey S.; O'Dwyer, Peter J.; Flaherty, Keith T.; Harris, Lyndsay N.; Meric-Bernstam, Funda
errShare
errSave
Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective cohort study
errECLINICALMEDICINE
IF10
err2023-11-01
err7
errOAAI
errBai, Xue; Shaheen, Ahmed; Grieco, Charlotte; d'Arienzo, Paolo D.; Mina, Florentia; Czapla, Juliane A.; Lawless, Aleigha R.; Bongiovanni, Eleonora; Santaniello, Umberto; Zappi, Helena; Dulak, Dominika; Williamson, Andrew; Lee, Rebecca; Gupta, Avinash; Li, Caili; Si, Lu; Ubaldi, Martina; Yamazaki, Naoya; Ogata, Dai; Johnson, Rebecca; Park, Benjamin C.; Jung, Seungyeon; Madonna, Gabriele; Hochherz, Juliane; Umeda, Yoshiyasu; Nakamura, Yasuhiro; Gebhardt, Christoffer; Festino, Lucia; Capone, Mariaelena; Ascierto, Paolo Antonio; Johnson, Douglas B.; Lo, Serigne N.; Long, Georgina L.; Menzies, Alexander M.; Namikawa, Kenjiro; Mandala, Mario; Guo, Jun; Lorigan, Paul; Najjar, Yana G.; Haydon, Andrew; Quaglino, Pietro; Boland, Genevieve M.; Sullivan, Ryan J.; Furness, Andrew J. S.; Plummer, Ruth; Flaherty, Keith T.
errShare
errSave
A twenty year perspective on melanoma therapy
errPIGMENT CELL & MELANOMA RESEARCH
IF2.6
err2023-09-28
err9
errOAAI
errFlaherty, Keith T.
errShare
errSave
Targeting Upregulated cIAP2 in SOX10-Deficient Drug Tolerant Melanoma
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-06-21
err6
errOAAI
errGlasheen, McKenna Q.; Caksa, Signe; Young, Amelia G.; Wilski, Nicole A.; Ott, Connor A.; Chervoneva, Inna; Flaherty, Keith T.; Herlyn, Meenhard; Xu, Xiaowei; Aplin, Andrew E.; Capparelli, Claudia
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Gordon B. Mills
H-index: 231 · Papers: 3.5K
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Lewis C. Cantley
H-index: 214 · Papers: 1.4K
R
Ralph Weissleder
H-index: 200 · Papers: 1.6K
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Kenneth C. Anderson
H-index: 199 · Papers: 3.1K
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