Not logged in Establishment and characterization of an orthotopic implanted lung cancer model to mimic human tumor structure, microenvironment, and metastatic spread Picabea, Benat; Orive, Daniel; Rodriguez, Covadonga; Mailharin, Miren; Sanguesa, Maria; Houry, Maeva; Arricibita, Andrea; Echepare, Mirari; Alava, Ane; Viu-Idocin, Cristina; Calvo, Alfonso; Fernandez-Irigoyen, Joaquin; Santamaria, Enrique; Ariz, Mikel; Montuenga, Luis M.; Valencia, Karmele Share Save
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G9a/DNMT1 co-targeting inhibits non-small cell lung cancer growth and reprograms tumor cells to respond to cancer-drugs through SCARA5 and AOX1 Exposito, Francisco; Redrado, Miriam; Serrano, Diego; Calabuig-Farinas, Silvia; Bao-Caamano, Aida; Gallach, Sandra; Jantus-Lewintre, Eloisa; Diaz-Lagares, Angel; Rodriguez-Casanova, Aitor; Sandoval, Juan; San Jose-Eneriz, Edurne; Garcia, Javier; Redin, Esther; Senent, Yaiza; Leon, Sergio; Pio, Ruben; Lopez, Rafael; Oyarzabal, Julen; Pineda-Lucena, Antonio; Agirre, Xabier; Montuenga, Luis M.; Prosper, Felipe; Calvo, Alfonso Share Save
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KRAS pharmacological blockade elicits tumoral homologous recombination deficiency exploitable with PARP inhibitors Welch, C.; Novoa, G.; Llorente Llorente, S.; Santos Ramos, A.; Sogari, A.; Fernandez Lagos, A.; Fileu, I.; Guruceaga, E.; Calvo, A.; Bakartxo Otegui, N.; Battuello, P.; Crisafulli, G.; Ambrogio, C.; Santamaria, D.; Bardelli, A.; Tian, T.; Ferrer, I.; Russo, M.; Vicent, S. Share Save
Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation Puyalto, Ander; Rodriguez-Remirez, Maria; Lopez, Ines; Macaya, Irati; Guruceaga, Elizabeth; Olmedo, Maria; Vilalta-Lacarra, Anna; Welch, Connor; Sandiego, Sergio; Vicent, Silvestre; Valencia, Karmele; Calvo, Alfonso; Pio, Ruben; Raez, Luis E.; Rolfo, Christian; Ajona, Daniel; Gil-Bazo, Ignacio Share Save
Strong antitumor effect elicited by inhibition of AKT or FOXP3 in combination with anti-PD-L1 in Pten mutant lung squamous cell carcinoma Houry, Maeva; Redrado, Miriam; Carnevalli, Larissa; Barry, Simon; Galan, Nuria; Otegui, Nerea; Leon, Sergio; Montuenga, Luis; Exposito, Francisco; Calvo, Alfonso Share Save
Nanomedicines loaded with TLR agonists and inhibitors of immunosuppression to reprogram the tumor microenvironment Andon, Fernando Torres; Pensado-Lopez, Alba; Anfray, Clement; Ummarino, Aldo; Fernandez-Marino, Iago; Sanjurjo, Lucia; Crecente-Campo, Jose; Fernandez-Megia, Eduardo; Castro, Flavia; Oliveira, Maria Jose; Calvo, Alfonso; Campelo, Rosario Garcia; Mantovani, Alberto; Alonso, Maria Jose; Allavena, Paola Share Save
Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors Anfray, Clement; Varela, Carmen Fernandez; Ummarino, Aldo; Maeda, Akihiro; Sironi, Marina; Gandoy, Sara; Brea, Jose; Loza, Maria Isabel; Leon, Sergio; Calvo, Alfonso; Correa, Juan; Fernandez-Megia, Eduardo; Alonso, Maria Jose; Allavena, Paola; Crecente-Campo, Jose; Andon, Fernando Torres Share Save
Trametinib and PD-1 combined blockade impairs tumor growth and improves survival of KRAS-mutant lung cancer through Id1 downregulation Puyalto, A.; Rodriguez-Remirez, M.; Lopez, I.; Lopez-Frias, M. Olmedo; Vilalta, A.; Macaya, I.; Welch, C.; Vicent, S.; Calvo, A.; Ajona, D.; Gil Bazo, I. Share Save
A novel [89Zr]-anti-PD-1-PET-CT to assess response to PD-1/PD-L1 blockade in lung cancer Puyalto, Ander; Rodriguez-Remirez, Maria; Lopez, Ines; Iribarren, Fabiola; Simon, Jon Ander; Ecay, Marga; Collantes, Maria; Vilalta-Lacarra, Anna; Francisco-Cruz, Alejandro; Solorzano, Jose Luis; Sandiego, Sergio; Penuelas, Ivan; Calvo, Alfonso; Ajona, Daniel; Gil-Bazo, Ignacio Share Save
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PTEN Loss Confers Resistance to Anti-PD-1 Therapy in Non-Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells Exposito, Francisco; Redrado, Miriam; Houry, Maeva; Hastings, Katherine; Molero-Abraham, Magdalena; Lozano, Teresa; Solorzano, Jose Luis; Sanz-Ortega, Julian; Adradas, Vera; Amat, Ramon; Redin, Esther; Leon, Sergio; Legarra, Naroa; Garcia, Javier; Serrano, Diego; Valencia, Karmele; Robles-Oteiza, Camila; Foggetti, Giorgia; Otegui, Nerea; Felip, Enriqueta; Lasarte, Juan J.; Paz-Ares, Luis; Zugazagoitia, Jon; Politi, Katerina; Montuenga, Luis; Calvo, Alfonso Share Save
Combined treatment with the epigenetic drug CM272 and an anti-BCL-XL proapoptotic drug sensitizes solid tumors to immune checkpoint blockade Senent, Yaiza; Fresquet, Vicente; Jimenez, Victoria; Valencia, Karmele; Remirez, Ana; Exposito, Francisco; Gonzalez-Huarriz, Marisol; de Cordoba, Borja Ruiz-Fernandez; Moreno, Haritz; Ajona, Daniel; Alonso, Marta M.; Lecanda, Fernando; Pineda-Lucena, Antonio; Prosper, Felipe; Calvo, Alfonso; Martinez-Climent, Jose Angel; Pio, Ruben Share Save
PTEN loss confers resistance to anti-PD-1 therapy in NSCLC by increasing tumor infiltration of T regulatory cells Exposito, Francisco; Redrado, Miriam; Houry, Maeva; Hastings, Katherine; Molero-Abraham, Magdalena; Lozano, Teresa; Solorzano, Jose L.; Ortega, Julian Sanz; Andradas, Vera; Amat, Ramon; Redin, Esther; Leon, Sergio; Legarra, Naroa; Garcia, Javier; Serrano, Diego; Valencia, Karmele; Robles-Oteiza, Camila; Foggetti, Giorgia; Felip, Enriqueta; Lasarte, Juan J.; Paz-Ares, Luis; Zugazagoitia, Jon; Politi, Katerina; Montuenga, Luis M.; Calvo, Alfonso Share Save
IL-6/STAT3 signaling in tumor cells restricts the expression of frameshift-derived neoantigens by SMG1 induction Meraviglia-Crivelli, Daniel; Villanueva, Helena; Zheleva, Angelina; Villalba-Esparza, Maria; Moreno, Beatriz; Menon, Ashwathi Puravankara; Calvo, Alfonso; Cebollero, Javier; Barainka, Martin; de los Mozos, Igor Ruiz; Huesa-Berral, Carlos; Pastor, Fernando Share Save
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